• Molecules and Cells
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• v.26 no.4
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• pp.329-337
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• 2008

Src-family kinases are critically involved in the control of cytoskeleton organization and in the generation of integrin-dependent signaling responses, inducing tyrosine phosphorylation of many signaling and cytoskeletal proteins. Activity of the Src family of tyrosine kinases is tightly controlled by inhibitory phosphorylation of a carboxy-terminal tyrosine residue, inducing an inactive conformation through binding with its SH2 domain. Dephosphorylation of C-ter tyrosine, as well as its deletion of substitution with phenylalanine in oncogenic Src kinases, leads to autophosphorylation at a tyrosine in the activation loop, thereby leading to enhanced Src activity. Beside this phophorylation/dephosphorylation circuitry, cysteine oxidation has been recently reported as a further mechanism of enzyme activation. Mounting evidence describes Src activation via its redox regulation as a key outcome in several circumstances, including growth factor and cytokines signaling, integrin-mediated cell adhesion and motility, membrane receptor cross-talk as well in cell transformation and tumor progression. Among the plethora of data involving Src kinase in physiological and pathophysiological processes, this review will give emphasis to the redox component of the regulation of this master kinase.

• Earthquakes and Structures
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• v.9 no.2
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• pp.339-352
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• 2015

Ancient masonry towers constitute a relevant part of the cultural heritage of humanity. Their earthquake protection is a topic of great concern among researchers due to the strong damage suffered by these brittle and massive structures through the history. The identification of the seismic behavior and failure of towers under seismic loading is complex. This strongly depends on many factors such as soil characteristics, geometry, mechanical properties of masonry and heavy mass, as well as the earthquake frequency content. A deep understanding of these aspects is the key for the correct seismic vulnerability evaluation of towers and to design the most suitable retrofitting measure. Recent tendencies on the seismic retrofitting of historical structures by means of prestressing are related to the use of smart materials. The most famous cases of application of prestressing in towers were discussed. Compared to horizontal prestressing, vertical post-tensioning is aimed at improving the seismic behavior of towers by reducing damage with the application of an overall distribution of compressive stresses at key locations.

• Journal of Korean Academy of Nursing
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• v.49 no.4
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• pp.486-494
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• 2019

Purpose: To investigate the effect of $Buzzy^{(R)}$ and $ShotBlocker^{(R)}$ on reducing pain induced by intramuscular penicillin injections in children. Methods: This was a randomized controlled study. A total of 150 Turkish children aged 7~12 years who presented to our pediatric emergency clinic and met the inclusion criteria were recruited. The children were randomly assigned to each group (control=50, $Buzzy^{(R)}=50$, $ShotBlocker^{(R)}=50$). Data were collected using an information form, the State-Trait Anxiety Inventory for Children, Visual Analog Scale, and Faces Pain Scale-Revised. Results: The children in the control group had significantly higher pain scores during the penicillin injection than the children in the $ShotBlocker^{(R)}$ and $Buzzy^{(R)}$ groups. The children in the $Buzzy^{(R)}$ group had significantly less pain than the children in both the $ShotBlocker^{(R)}$ and control groups (p<.001). Conclusion: $Buzzy^{(R)}$ was more effective compared with $ShotBlocker^{(R)}$ in this study.

• Archives of Craniofacial Surgery
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• v.20 no.1
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• pp.71-74
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• 2019

Schwannoma is a benign tumor rarely found in the head and neck and much less commonly found in the intraparotid facial nerve. It is a slow-growing encapsulated tumor originating from the Schwann cells or axonal nerve sheath. It can occur anywhere along the course of the facial nerve. Patients may present with symptoms of facial palsy, but the most common presenting symptom is an asymptomatic swelling. Diagnosis is usually difficult before surgical removal and histopathological examination. We report a rare case of intraparotid facial nerve schwannoma in a 57-year-old female who had sustained a mass of the right preauricular area for 3 years. She reported no pain or facial muscle weakness. Enhanced computed tomography findings revealed the impression of pleomorphic adenoma. However, intraoperative gross findings were not characteristic of pleomorphic adenoma, and a frozen biopsy was performed resulting in the impression of a nerve sheath tumor. We performed an extracapsular surgical excision without parotidectomy. Permanent histopathology and immunohistochemistry reports diagnosed the mass as schwannoma. There were no complications including facial palsy after surgery. No recurrence was found at 6 months after surgery.

• Journal of Microbiology and Biotechnology
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• v.29 no.9
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• pp.1412-1423
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• 2019

The filamentous fungus Aspergillus tubingensis that belongs to the black Aspergillus section has the capacity to produce high-value metabolites, for instance, naphtho-gamma-pyrones (NGPs). For these fungal secondary metabolites, numerous biological properties of industrial interest have been demonstrated, such as antimicrobial, antioxidant and anti-cancer capacities. It has been observed that production of these secondary metabolites is linked with fungal sporulation. The aim of this research was to apply osmotic and oxidative environmental stresses to trigger the production of NGPs in liquid cultures with CYB (Czapek Dox Broth). In addition, numerous parameters were tested during the experiments, such as pH value, incubation time, container geometry, and static and agitation conditions. Results demonstrate that the produced amount of NGPs can be enhanced by decreasing the water activity ($a_w$) or by adding an oxidative stress factor. In conclusion, this study can contribute to our knowledge regarding A. tubingensis to present an effective method to increase NGP production, which may support the development of current industrial processes.

• Archives of Craniofacial Surgery
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• v.22 no.6
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• pp.337-340
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• 2021

Full-thickness nasal tip reconstruction is a challenging process that requires provision of ample skin and soft tissue, and intricate cartilage structure that maintains its architecture in the long term. In this report, we describe reconstruction of a full-thickness nasal tip and ala defect using a posterior auricular artery perforator based chondrocutaneous free flap. The flap consisted of two lay ers of skin covering conchal cartilage, and was based on a perforating branch of the posterior auricular artery. A superficial vein was secured at the posterior margin. The donor perforator was anastomosed to a perforating branch of the lateral nasal artery. The superficial vein was connected to a superficial vein of the surrounding soft tissue. The donor healed well after primary closure. The flap survived without complications, and the contour of the nasal rim was sustained at follow-up 6 months later. As opposed to combined composite reconstructions using a free cartilage graft together with a small free flap or pedicled nasolabial flap, the posterior auricular artery perforator free flap encompasses all required tissue types, and is similar in contour to the alar area. This flap is a useful option in single-stage reconstruction of nasal composite defects.

• Archives of Craniofacial Surgery
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• v.22 no.6
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• pp.341-344
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• 2021

Reconstruction of submental defects is a challenge that needs to be approached carefully, since many important anatomical structures are located in this small space. Both aesthetic and functional outcomes should be considered during reconstruction. In this report, we describe a case where a superficial branch of the transverse cervical artery (STCA) perforator propeller flap was applied for coverage of the submental area. An 85-year-old woman presented with a 3-cm ovoid mass on her submental area. We covered the large submental defect with a STCA rotational flap in a 180° propeller pattern. The flap survived well without any complications at 1 year of followup. A STCA propeller flap is a useful surgical option in reconstruction for defect coverage of the submental area.

• Journal of the Korean Burn Society
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• v.24 no.2
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• pp.50-52
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• 2021

Iatrogenic electrical burns that occur from the use of a defibrillator, a paddle-type cardiac shock device, have been reported in various forms. Electrical burns are usually conducted directly through the skin and are more damaging than scald burns or contact burns. A transcutaneous cardiac pacing device is a patch-type cardiac shock device that automatically delivers a shock when an abnormal heart rhythm is detected. We introduce a unique case of iatrogenic electrical burns caused by the transcutaneous pacing patch of a cardiac shock device. Electrical energy was converted into a spark due to foreign bodies deposited around the patch, resulting in damage to the peripheral area of the skin.

• Wind and Structures
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• v.37 no.2
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• pp.133-151
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• 2023

This paper first provides a wide overview about the design codes and standards covering the use of Computational Wind Engineering / Computational Fluid Dynamics (CWE/CFD) for wind-sensitive structures and built environment. Second, the paper sets out the basic assumptions and underlying concepts of the new Annex T "Simulations by Computational Fluid Dynamics (CFD/CWE)" of the revised version "Guide for the assessment of wind actions and effects on structures" issued by the Advisory Committee on Technical Recommendations for Constructions of the Italian National Research Council in February 2019 and drafted by the members of the Special Interest Group on Computational Wind Engineering of the Italian Association for Wind Engineering (ANIV-CWE). The same group is currently advising UNI CT021/SC1 in supporting the drafting of the new Annex K - "Derivation of design parameters from wind tunnel tests and numerical simulations" of the revised Eurocode 1: Actions on structures - Part 1-4: General actions - Wind actions. Finally, the paper outlines the subjects most open to development at the technical and applicative level.

• Annual Conference of KIPS
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• 2009.04a
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• pp.195-199
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• 2009

NoC 시스템은 기본적으로 서로 다른 클럭 도메인에서 동작하는 여러 버스 시스템들이 NoC를 통해서 연결되는 것으로 간주할 수 있다. NoC에 다른 버스 인터페이스 IP를 부착하려면 별도의 래퍼를 사용해야 하며, 면적과 지연시간이 추가되는 것이 일반적이다. 본 논문에서는, 추가적인 래퍼의 필요성을 제거하기 위하여, 주어진 버스 인터페이스에 맞는 인터페이스 에이전트 또는 네트워크 인터페이스를 자동 생성하는 방법을 제안한다. 이를 위하여, 한가지 NoC 시스템을 위해 표준적인 패킷 포맷을 정의하였으며, 거기에는 패킷에 대한 라우팅 정보 뿐 아니라, 여러 종류의 버스 프로토콜의 데이터, 주소, 제어 정보도 포함될 수 있도록 정의되었다. 그리고, 인터페이스 에이전트는 표준 패킷 포맷과 특정 버스 인터페이스 프로토콜 간의 변환 작업을 수행한다. 실험을 통해서, PVCI, WISHBONE, AHB, OCP와 같은 몇 가지 버스 인터페이스에 대해 자동생성된 네트워크 인터페이스들 간에, 표준 패킷 포맷을 이용한 데이터 통신이 중요 정보의 손실 없이 잘 이루어짐을 보인다.