• Journal of Ginseng Research
• /
• v.46 no.6
• /
• pp.771-779
• /
• 2022

Background: As a kind of common complication of the surgery of perianal diseases, perianal ulcer is known as a nuisance. This study aims to develop a kind of 20(S)-ginsenoside Rg3 (Rg3)-loaded hydrogel to treat perianal ulcers in a rat model. Methods: The copolymers PLGA₁₆₀₀-PEG₁₀₀₀-PLGA₁₆₀₀ were synthesized by ring-opening polymerization process and Rg3-loaded hydrogel was then developed. The perianal ulcer rat model was established to analyze the treatment efficacy of Rg3-loaded hydrogel for ulceration healing for 15 days. The animals were divided into control group, hydrogel group, free Rg3 group, Rg3-loaded hydrogel group, and Lidocaine Gel® group. The residual wound area rate was calculated and the blood concentrations of interleukin-1 (IL-1), interleukin-6 (IL-6), and vascular endothelial growth factor (VEGF) were recorded. Hematoxylin and eosin (H&E) staining, Masson's Trichrome (MT) staining, and tumor necrosis factor α (TNF-α), Ki-67, CD31, ERK1/2, and NF-κB immunohistochemical staining were performed. Results: The biodegradable and biocompatible hydrogel carries a homogenous interactive porous structure with 10 ㎛ pore size and five weeks in vivo degradation time. The loaded Rg3 can be released sustainably. The in vitro cytotoxicity study showed that the hydrogel had no effect on survival rate of murine skin fibroblasts L929. The Rg3-loaded hydrogel can facilitate perianal ulcer healing by inhibiting local and systematic inflammatory responses, swelling the proliferation of nuclear cells, collagen deposition, and vascularization, and activating ERK signal pathway. Conclusion: The Rg3-loaded hydrogel shows the best treatment efficacy of perianal ulcer and may be a candidate for perianal ulcer treatment.

• Geomechanics and Engineering
• /
• v.27 no.6
• /
• pp.551-560
• /
• 2021

Due to the low strength and high compressibility characteristics, the loess deposits tunnels are prone to large deformations and collapse. An accurate stability evaluation for loess deposits is of considerable significance in deformation control and safety work during tunnel construction. 37 groups of representative data based on real loess deposits cases were adopted to establish the stability evaluation model for the tunnel project in Yan'an, China. Physical and mechanical indices, including water content, cohesion, internal friction angle, elastic modulus, and poisson ratio are selected as index system on the stability level of loess. The data set is randomly divided into 80% as the training set and 20% as the test set. Firstly, principal component analysis (PCA) is used to convert the five index system to three linearly independent principal components X1, X2 and X3. Then, the principal components were used as input vectors for probabilistic neural network (PNN) to map the nonlinear relationship between the index system and stability level of loess. Furthermore, Leave-One-Out cross validation was applied for the training set to find the suitable smoothing factor. At last, the established model with the target smoothing factor 0.04 was applied for the test set, and a 100% prediction accuracy rate was obtained. This intelligent classification method for loess deposits can be easily conducted, which has wide potential applications in evaluating loess deposits.

• Korean Journal of Agricultural Science
• /
• v.43 no.4
• /
• pp.595-602
• /
• 2016

In pigs, individuals in the same pen may show aggressive behavior toward each other, such as tail biting. Such social interactions among pen mates may considerably affect their welfare and performance, both in negative and positive ways. The present study was conducted to investigate social genetic effects on days to 90 kg using data from 12,208 Duroc and Yorkshire pigs that were born between 2008 and 2012. Heritability was estimated using the five following animal models: a basic model with direct heritable effects only (Model 1), a social model with direct and social heritable effects (Model 2), a model accounting for covariance between direct and social heritable effects (Model 3), and two models considering a dilution factor with direct and social heritable effects (Models 4 and 5). The optimal model to represent Duroc pigs was Model 1 which only uses direct heritable effects. Direct heritability (0.21) was higher than total heritability (0.09) and covariance was negative. Model 2 was evaluated as the optimum model for Yorkshire pigs. Yorkshire data showed that total heritability (0.5) was twice as high as direct heritability (0.25) and covariance was positive. Our results suggest that the efficiency of social effects differed among breeding lines. Further research on social effects related to breeds by group size would clarify which is the most efficient selection method that accounts for social genetic effects.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.34 no.2
• /
• pp.583-595
• /
• 2014

Currently, Korean transportation policies are aiming for increase of safety and environment-friendly and efficient operation, by avoiding construction and expansion of roads, and upgrading road alignments and facilities. This is revealed by that there have been 22 road expansion projects (30%) and 50 road improvement projects (70%) under the 3rd Five-Year Plan for National Highways ('11~'15), while there were 53 road expansion projects (71%) and 22 road improvement projects (29%) under the 2nd Five-Year Plan for National Highways. For more effective road improvement projects, there is a need of choosing projects after an objective and scientific safety assessment of each road, and assessing safety improvement depending on projects. This study is intended to develop a model for this road safety analysis and assessment. The major objective of this study is creating a road safety analysis and assessment model appropriate for Korean society, based on the HSM (Highway Safety Manual) of the U.S. In order to build up data for model development, the sections thought to have identical geometrical structure factors in 5 lines, Cheonbuk province, were divided as homogeneous sections, and representative values of geometric structures, facilities, traffic volume, climate conditions and land usage were collected from the 1,452 sections divided. In order to build up data for model development, the sections thought to have identical geometrical structure factors in 5 lines, Cheonbuk province, were divided as homogeneous sections, and representative values of geometric structures, facilities, traffic volume, climate conditions and land usage were collected from the 1,452 sections divided. The collected data was processed correlation analysis of each road element was implemented to see which factor had a big effect on traffic accidents. On the basis of these results, then, an accident model was established as a negative binomial regression model.Using the developed model, an Crash Modification Factor (CMF) which determines accident frequency changes depending on safety performance function (SPF) predicting the number of accident occurrence through traffic volume and road section expansion, road geometric structure and traffic properties, was extracted.

• Journal of the Society of Naval Architects of Korea
• /
• v.49 no.4
• /
• pp.359-366
• /
• 2012

This is the final one of the two companion papers dealing with accuracy of accumulated fatigue damage estimation under wide band process. It is stated that four kinds of wide band models exist: typed of equivalent stress, combined PDF, correction factor, and damage combination. For the idealized ESDs from full scale measurement data on an 8100TEU container vessel, fatigue damages are compared for a narrow band prediction model based on Rayleigh PDF and five wide band fatigue prediction models of Dirlik, Wirsching-Light, Jiao-Moan, Benasciutti and DNV. DNV model consistently overestimates fatigue damages regardless of variation of ESDs. Predictions by Jiao-Moan model, which is understood as standard method for design of offshore platforms, are also in conservative side. Best accuracy is found from the results by Dirlik and Benasciutti models, but Benasciutti model is preferred since it can easily combined with narrow band fatigue damage based on Rayleigh PDF.

• Fashion & Textile Research Journal
• /
• v.20 no.5
• /
• pp.495-508
• /
• 2018

The purpose of this study is to analyze the effect of characteristics of advertising model on brand personality and the effect of brand personality on brand attitude; and analyze whether the characteristics of the advertising model have a direct effect on the brand attitude or indirectly through the brand personality. A survey was conducted from August 10, 2017 until August 31, 2017, and 400 respondents' survey results were analyzed. For data analysis, SPSS 23.0 was utilized to perform descriptive statistics, factor analysis, t-test, and regression analysis. As a result, five brand personality factors were derived, which are aesthetics, safety/expertise, sophistication, pro-environment, youth, respectively. For advertising model characteristics, seven factors were derived, which are credibility, visibility, attractiveness, expertise, similarity, likeability, and familiarity, respectively. This study investigated the relationship between characteristics of cosmetics advertising model, brand personality, and brand attitude. Brand personality does not play a mediating role between advertising model's characteristics and brand attitude. Advertising model's characteristics have a direct effect on the brand attitude. Consequently, Cosmetics companies should recognize the importance of the characteristics of advertising model and implement the marketing strategy by carefully selecting the advertising model so that consumers can relate the characteristics of advertisement model to the brand attitude which will ultimately lead to positive evaluation of the brand.

• Journal of Korea Technology Innovation Society
• /
• v.10 no.2
• /
• pp.183-205
• /
• 2007

An investigation was undertaken of the optimal discriminant model for predicting the likelihood of insolvency in advance for medium-sized firms based on the technology evaluation. The explanatory variables included in the discriminant model were selected by both factor analysis and discriminant analysis using stepwise selection method. Five explanatory variables were selected in factor analysis in terms of explanatory ratio and communality. Six explanatory variables were selected in stepwise discriminant analysis. The effectiveness of linear discriminant model and logistic discriminant model were assessed by the criteria of the critical probability and correct classification rate. Result showed that both model had similar correct classification rate and the linear discriminant model was preferred to the logistic discriminant model in terms of criteria of the critical probability In case of the linear discriminant model with critical probability of 0.5, the total-group correct classification rate was 70.4% and correct classification rates of insolvent and solvent groups were 73.4% and 69.5% respectively. Correct classification rate is an estimate of the probability that the estimated discriminant function will correctly classify the present sample. However, the actual correct classification rate is an estimate of the probability that the estimated discriminant function will correctly classify a future observation. Unfortunately, the correct classification rate underestimates the actual correct classification rate because the data set used to estimate the discriminant function is also used to evaluate them. The cross-validation method were used to estimate the bias of the correct classification rate. According to the results the estimated bias were 2.9% and the predicted actual correct classification rate was 67.5%. And a threshold value is set to establish an in-doubt category. Results of linear discriminant model can be applied for the technology financing banks to evaluate the possibility of insolvency and give the ranking of the firms applied.

• Journal of Fashion Business
• /
• v.13 no.5
• /
• pp.110-120
• /
• 2009

The goal of this study was to investigate the influence of customer service quality on customer satisfaction. Also the object of this study is to indicate the influence on word of mouth and intention of repurchase which is a variable of customer satisfaction. The subjects were 357 female adults living in Suncheon City, Jeollanam Province. The questionnaires were conveniently sampled from June 1 to 30, 2006. The collected data was analyzed by percentage, frequency, mean, factor analysis, reliability, regression using the SPSS program. The five hypotheses set in the research model, all were selected through empirical analysis. Main findings are as follows: As a result of factor analysis, customer service quality of discount store verified four items, that is, personal service, VMD of stores/atmosphere, store policy, product assortment. As a result of regression analysis, customer service quality influenced customer satisfaction. The intention of repurchase and word of mouth received a positive influence from customer satisfaction. The intention of repurchase influenced the word of mouth, and it received a positive influence from the word of mouth.

• Korean Journal of Child Studies
• /
• v.34 no.4
• /
• pp.1-17
• /
• 2013

The purpose of this study was to determine the correlation between young children's picky eating behavior and mother's attitudes, beliefs and practices regarding the eating habits of children. Using a sample of 304 mothers of four or five year-old children, confirmatory factor analysis was conducted to test a 7 factor model, which included mother's beliefs and practices related to the feeding of their children. Following this, a t-test was conducted to examine the differences between the feeding behaviors of mothers of both of picky and non-oicky eaters, respectively. The results indicated that picky eater's eating behaviors were positively related to the pressures exerted by mothers and negatively related to the mother's concerns about their child's weight and child's BMI. These findings suggest that the pressures mothers exert upon their children to eat, their child's weight and picky eating behaviors are correlated to each other.

• The Journal of Asian Finance, Economics and Business
• /
• v.7 no.5
• /
• pp.185-194
• /
• 2020

The study aims to identify and measure factors affecting the perception of the selling price of luxury apartments in Hanoi. We conducted a questionnaire consisting of 29 observation variables with a 5-point Likert scale. Independent variables were measured from 1 "without effect" to 5 "strongly". Based on the desk review and results of interviews, a total of 500 questionnaires were sent to research participants for collection; 458 of them met standard and were subject to be analyzed. This study employs Cronbach's Alpha test, and regression model. The results of Exploratory Factor Analysis (EFA) and Multiple Regression Analysis (MRA) identify five main determinants influencing the perception of the selling price of luxury apartments in Hanoi, including Physical characteristics of a luxury apartment (PC); Location and position of an apartment (LP); Surrounding Area (SA); Quality of service provided by managers; (QS) and Demographics factor (DF). Based on the findings, some recommendations have been proposed to help the firm leaders design appropriate personnel policies for creating better price satisfaction for customers in the future. On this basis, the authors propose a number of recommendations to improve the quality of luxury apartments, thereby contributing to the development of the market for luxury apartments in Hanoi.