• 생명과학회지
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• 제9권3호
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• pp.241-247
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• 1999

Antibiotics have been routinely used to control the disease of farm-raised animals in the aquaculture facilities without any criterion based on a pharmacokinetic study. This lack of information on the effective usage of antibiotics would have brought the farmers to use excessive and/or less dosages, causing the advent of drug-resistant bacteria as well as economic loss and possible contamination of the local farming area. Until recently, few studies on a detailed manual for the antibiotic usage including chemotherapy procedure, dosage, and treatment schedule of the aquatic antibiotics have been conducted throughout the world. To the worse, there is no available criterion for optimal usage of aquatic antibiotics to control diseases in aquatic farms in this country because every country has its own aquacultural system. Therefore, based on the previous studies on the usage of the various antibiotics, our studies are to focus on the development of optimal method for the detection of various antibiotics on the fate of antibiotics applied to the fish, including absorption, circulation, and secretion physiology. Pharmacokinetic study were to sep up the optimal detective condition against residual antibiotics of fish by HPLC. The grinding pefloxacin for 15 min is most effective in dissolution test and pharmacokinetic parameters. Pharmacokinetic parameters were satisfactory for 15 min-grinding products and they can be explained as one-compartment model.

• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.7219-7229
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• 2015

Background: Chromosomal aberrations identified in acute lymphoblastic leukemia (ALL) have an important role in disease diagnosis, prognosis and management. Information on karyotype and associated clinical parameters are essential to physicians for planning cancer control interventions in different geographical regions. Materials and Methods: In this study, we present the overall frequency and distribution patterns of chromosomal aberrations in both children and adult de novo B lineage ALL Indian patients using conventional cytogenetics, interphase FISH and multiplex RT-PCR. Results: Among the 215 subjects, cytogenetic results were achieved in 172 (80%) patients; normal karyotype represented 37.2% and abnormal 62.8% with a distribution as follows: 15.3% hypodiploidy; 10.3% hyperdiploidy; 15.8% t(9;22); 9.8% t(1;19); 3.7% t(12;21); 2.8% t(4;11); 2.8% complex karyotypes. Apart from these, we observed several novel, rare and common chromosomal rearrangements. Also, FISH studies using LSI extra-signal dual-color probes revealed additional structural or numerical changes. Conclusions: These results demonstrate cytogenetic heterogeneity of ALL and confirm that the incidence of chromosomal abnormalities varies considerably. To the best of our knowledge, this is one of the largest reported series of cytogenetic investigations in Indian B-lineage ALL cases. In addition, ongoing cytogenetic studies are warranted in larger groups of B-lineage ALL cases to identify newly acquired chromosomal abnormalities that may contribute to disease diagnosis and management.

• 한국해양생명과학회지
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• 제3권2호
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• pp.96-100
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• 2018

간흡충(Clonorchis sinensis)은 우리나라에서 인체 감염율이 가장 높은 기생충이며, 이는 담수어류를 중간숙주로 삼는다. 따라서 강 유역에 서식하는 담수어류를 대상으로 간흡충의 메타세르카리아(Clonorchis sinensis metacercariae, CsMc)가 감염되어 있는지를 조사한 연구가 많이 수행되었으나 호수에 서식하는 물고기를 대상으로 한 연구는 거의 없다. 본 연구에서는 주요 인공호수인 소양호, 남양호, 안동호, 춘천호에서 2016년부터 2017년까지 잉어과어류를 채집하여 CsMc의 감염 여부를 조사하였다. 이생흡충류의 메타세르카리아는 남양호에서 채집한 치리 및 붕어와, 소양호에서 채집한 피라미와 끄리에서 관찰되었다. 간흡충에 특이적인 프라이머를 사용하여 PCR을 수행한 결과, 남양호의 치리에서 관찰된 것이 CsMc 이었음을 확인할 수 있었다. 본 연구는 주요 인공호수에 서식하는 잉어과어류에서 CsMc의 감염 실태에 대한 정보를 제공하고 있으며, 남양호의 치리에서 CsMc 감염을 처음으로 보고하고 있다는 것에 의의가 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.2111-2114
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• 2016

Opisthorchiasis is a health problem in Thailand particularly in northeast and north regions where have been reported the highest of cholangiocarcinoma. Active surveillance is required, therefore a cross-sectional surveyed was conducted in Nong Bunnak sub-district of Nakhon Ratchasima province, Thailand. A total of 367 participants were selected by multistage sampling from 5 villages located near natural water resources. Participants completed a predesigned questionnaire containing behavior questions regarding liver fluke disease, covering reliability and validity knowledge (Kuder-Richardon-20) = 0.80, attitude and practice (Cronbach's alpha coefficient) = 0.82 and 0.79, respectively. Descriptive statistics included frequencies, percentages, means, and standard deviations. The majority of the participants were female (58.3%), age group between 21-30 years old (42.5%), with primary school education (59.9%), occupation in agriculture (38.1%), and married (80.9%). They had past histories of raw fish consumption (88.3%), stool examination (1.4%), anti-parasite medication used (4.6%). Heads of villages, village health volunteers, television, and village newstations were the main sources for disease information. Participants had a moderate level of behavior regarding liver fluke disease. The mean scored of knowledge regarding liver fluke life cycle, transmission, severities, treatment, prevention and control was 10.9 (SD=0.5), most of them had a moderate level, 95.1%. The mean score for attitude regarding liver fluke prevention and control was 45.7 (SD=9.7), and for practice was 30.6 (SD=10.5). Participants had a moderate level of attitude and practice, 94.5% and 47.7, respectively. This study indicates that health education is required in this community including stool examination for liver fluke as further active surveillance screening.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1433-1436
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• 2016

Background: Cholangiocarcinoma (CCA), a major problem of health in Thailand, particularly in Northeastern and Northern regions, is generally incurable and rapidly lethal because of presentation in stage 3 or 4. Early diagnosis of stage 1 and 2 could allow better survival. Therefore, this study aimed to provide a distribution map of populations at risk for CCA in BuaYai district of Nakhon Ratchasima province, Northeast Thailand. Materials and Methods: A cross-sectional survey was carried out in 10 sub-districts and 122 villages, during June and November 2015. The populations at risk for CCA were screened using the Korat CCA verbal screening test (KCVST) and then risk areas were displayed by using Google map (GM). Results: A total of 11,435 individuals from a 26,198 population completed the KCVST. The majority had a low score of risk for CCA (1-4 points; 93.3%). High scores with 6, 7 and 8 points accounted for 1.20%, 0.13% and 0.02%. The population at risk was found frequently in sub-district municipalities, followed by sub-district administrative organization and town municipalities, (F=396.220, P-value=0.000). Distribution mapping comprised 11 layers: 1, district; 2, local administrative organization; 3, hospital; 4, KCVST opisthorchiasis; 5, KCVST praziquantel used; 6, KCVST cholelithiasis; 7, KCVST raw fish consumption; 8, KCVST alcohol consumption; 9, KCVST pesticide used; 10, KCVST relative family with CCA; and 11, KCVST naive northeastern people. Geovisual display is now available online. Conclusions: This study indicated that the population at high risk of CCA in Bua Yai district is low, therefore setting a zero model project is possible. Key success factors for disease prevention and control need further study. GM production is suitable for further CCA surveillance and monitoring of the population with a high risk score in this area.

• 한국응용과학기술학회지
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• 제39권3호
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• pp.442-453
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• 2022

다양한 동물 모델이 인간 질병, 의약품의 효능 및 작용 메커니즘을 연구하는 데 사용되고 있다. Zebrafish(Danio rerio)는 여러 가지 장점이 있어 인간 질병에 대한 중개 연구의 모델로 점점 더 폭넓게 활용되고 있다. 본 논문은 Pubmed, Google Scholar, Scopus에서 2020년 12월까지 최근 10년간 zebrafish 모델, 천연물(한약), in vivo 스크리닝의 키워드를 사용하여 저널에 게재된 논문을 검토하여 필요한 정보를 얻었다. 이 리뷰에서 우리는 천연물(한약) 연구에 대한 다양한 제브라피쉬 질병 모델의 최근 경향에 대해 논의하였다. 특히, 암, 안질환, 혈관 질환, 당뇨병 및 합병증, 피부질환에 중점을 두었고, zebrafish 배아를 사용하여 이들 질병에 대한 의약품의 분자 작용 메커니즘에 관해 언급하였다. Zebrafish는 실험실에서 임상 연구까지의 격차를 줄이는 데 중추적 역할을 할 수 있는 중요한 동물 모델이다. Zebrafish는 의약품이나 화장품 개발, 질병의 병인론을 이해하기 위해 사용되고, 이로 인해 생의학 연구에서 설치류의 사용을 줄이는 데 크게 기여하고 있다.

• 동의생리병리학회지
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• 제23권1호
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• pp.34-40
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• 2009

After a research on appearance diagnosis and fish, bird, horse, and turtle types, this study concluded as following. Appearance diagnosis is a technique that exams five jang organs by color and shape of eye, nose, mouth, and ear. Four HyungSang types-including fish, bird, horse and turtle types-are evaluated upon the external shape that are created while type of seed changes. Appearance diagnosis focuses on five jang organs. Four HyungSang types focus on external shape, but are eventually related to five jang organs. Thus, two different techniques possess a point in common; five jang organs. The assignment of nose, eye, ear and mouth to the Five elements varies between two techniques. On the viewpoint of formation, appearance diagnosis assigns them to metal-water-wood-fire-earth and movement, and four HyungSang types do to wood-fire-earth-metal-water and constitution. On the viewpoint of body/use and static/dynamic, appearance diagnosis assigns them to metal-water-wood-fire-earth and constitution, and four HyungSang types do to wood-fire-earth-metal-water and movement. If nose, eye, ear, and mouth are assigned by on four HyungSang types, which are based on external shape, the assignment can be utilized in diagnosis. If, however, they are assigned by appearance diagnosis, it can be focus on treatment. Five jang organs and six fu organs are affected by internal conditions because they are located inside of human body, while four HyungSang types are affected by external conditions because it deals with external shape. If a disease occurs in the developed part of the body, it would be difficult to be cured because four HyungSang types depend on external shapes.

• Journal of Nutrition and Health
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• 제34권2호
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• pp.165-175
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• 2001

We performed case-control study to evaluate relationship between food intake and risk of breast cancer. We interviewed breast cancer cases(n=108) who were newly histologically identified and selected from Hanyang and Soonchunhyang University Hospital in Seoul. We used hospital-based control subjects(n=121), who were selected from the patients in the department of plastic surgery, general surgery and opthalmology of the same hospital by frequency matching. Matching variables were age($\pm$4 age) and menopausal status. We collected information on general characteristics of subjects, history of disease, family history of breast cancer, vitamin supplementation, alcohol intake, and food intake through individual interview. Dietary information was ascertained via a food frequency questionnaire method(total item=98). All analyses was conducted according to menopausal status. Especially, pepper and grape intake in premenopausal women, showed protective effect in breast cancer. Otherwise consumption of meat, pork, and fish was not associated with breast cancer risk in this study. At milk and dairy products, milk intake was associated with lower risk of breast cancer in postmenopausal women and overall intake of soy products was associated with breast cancer risk, but not significant. These findings suggested that consumption of some fruit and vegetable intake was a protective factor on breast cancer and further study with more number of subjects should be need to evaluate the breast cancer risk. (Korean J Nutrition 34(2): 165~175, 2001)

• 정보관리학회지
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• 제32권2호
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• pp.87-103
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• 2015

많은 연구들 가운데 살펴볼 가치가 있는 대상을 찾아 제시해주는 문헌기반 발견의 접근법은 연구자들에게 매우 유용할 것이다. 문헌기반 발견 연구의 대표 이론인 Swanson의 ABC 모델은 기존에 검증되지 않은 개체들의 관계를 연구할 것을 제안해 준다. 본 연구는 Swanson의 ABC 모델에 인용 정보를 고려하여 유의한 관계에 있는 개체들을 더 효율적으로 찾아내고자 하였다. 수집 논문들의 참고문헌 목록에서 인용 정보를 확인하고 논문의 표제와 초록을 대상으로 텍스트 마이닝 기법으로 중요한 단어들을 추출하였다. Swanson의 연구들 중 어유와 레이노드 질병 및 증상의 관계를 재현하였으며 기존의 접근법으로 확인되는 개체들과 어떤 차이가 있는지 분석하였다.

• Journal of Community Nutrition
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• 제5권4호
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• pp.209-217
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• 2003

The food and nutrition system is a network of processes linking agriculture, food, eating, nutrition, and health. The system includes a series of nine stages (production, processing, distribution, acquisition, preparation, consumption, digestion, transport, and utilization) and two types of contexts (biophysical and sociocultural). Analysis of whole food and nutrition systems provides information about the structure and processes involved in the complete scope of food and nutrition, assisting in the identification of ″upstream″ influences and ″downstream″ consequences in the system. The current analysis gathered existing data about the food and nutrition system in South Korea from public sources and professional publications, and interpreted that information to consider how different elements of the system contribute to health. The findings revealed that South Korea has substantial domestic food production and processing supplemented by imports, widespread food distribution in markets and a growing number of Korean and Western restaurants, a relatively low percentage of household income spent on food, growing use of new food preparation methods such as microwave ovens, a rice/vegetable/fish based three-meal consumption pattern, few recorded digestive problems, increasing calorie storage as body fat, and a relatively low chronic disease prevalence compared to other developed societies. Examination of the full scope of the food and nutrition system provides a broad perspective using whole system thinking that can identify potential strategies for future research and intervention.