• Childhood Kidney Diseases
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• 제23권1호
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• pp.36-42
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• 2019

Purpose: We investigated whether a renal size discrepancy on a renal sonogram (US) in children with febrile urinary tract infection (UTI) was correlated with the presence of cortical defects on their dimercaptosuccinic acid (DMSA) renal scan. Methods: We examined 911 children who were admitted consecutively to our hospital with their first episode of febrile UTI from March 2001 to September 2014. All enrolled children underwent a US and DMSA scan during admission. According to the US findings, including the renal size discrepancy, data were compared between children with positive and negative DMSA scan results. A positive DMSA scan result was defined as reduced or absent tracer localization and indistinct margins that did not deform the renal contour. Results: Mean renal lengths of the right and left kidneys were larger in children with positive DMSA scan results than in children with negative DMSA scan results ($63.2{\pm}11.3mm$ vs. $58.4{\pm}7.8mm$, P<0.001; $64.9{\pm}11.2mm$ vs. $59.9{\pm}7.9mm$, P<0.001; respectively). A significant difference was observed in both renal lengths between children with positive and negative DMSA scan results ($4.6{\pm}3.8mm$ vs. $3.3{\pm}2.6mm$, P<0.001). A multiple logistic regression analysis, revealed that a small kidney, cortical thinning, and a renal length discrepancy on US findings were significant factors for predicting the presence of cortical defects on an acute DMSA scan [P=0.028, 95% confidence interval (CI) 1.054-2.547; P= 0.004, 95% CI 1.354- 4.810; P<0.001, 95% CI 1.077-1.190, respectively]. Conclusion: In conclusion, a renal size discrepancy on US findings in children with their first episode of febrile UTI was a helpful tool for predicting the presence of cortical defects on an acute DMSA scan.

• Parasites, Hosts and Diseases
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• 제60권1호
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• pp.39-43
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• 2022

Plasmodium vivax exhibits dormant liver-stage parasites, called hypnozoites, which can cause relapse of malaria. The only drug currently used for eliminating hypnozoites is primaquine. The antimalarial properties of primaquine are dependent on the production of oxidized metabolites by the cytochrome P450 isoenzyme 2D6 (CYP2D6). Reduced primaquine metabolism may be related to P. vivax relapses. We describe a case of 4 episodes of recurrence of vivax malaria in a patient with decreased CYP2D6 function. The patient was 52-year-old male with body weight of 52 kg. He received total gastrectomy and splenectomy 7 months before the first episode and was under chemotherapy for the gastric cancer. The first episode occurred in March 2019 and each episode had intervals of 34, 41, and 97 days, respectively. At the first and second episodes, primaquine was administered as 15 mg for 14 days. The primaquine dose was increased with 30 mg for 14 days at the third and fourth episodes. Seven gene sequences of P. vivax were analyzed and revealed totally identical for all the 4 samples. The CYP2D6 genotype was analyzed and intermediate metabolizer phenotype with decreased function was identified.

• Annals of Clinical Neurophysiology
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• 제17권1호
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• pp.28-30
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• 2015

We reported a 48-year-old man with Behcet disease, who presented with right hemiparesis. His first brain MRI showed multiple enhanced lesions. During the recovery, he had an episode of left 6th nerve palsy without new lesions in a follow-up MRI. Third episode was cervical myelitis, resulting in respiratory difficulty and quadriplegia without any reflexes. The myelitis was not responsive to immunotherapy. He died of respiratory failure complicated with pneumonia. This is a rare case of full-blown neuro-Behcet disease.

• 한국대기환경학회지
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• 제27권5호
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• pp.504-522
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• 2011

Simulations of CMAQ with the High-order Decoupled Direct Method (HDDM) for a 2010 June episode are applied to estimate the influence of local and neighborhood emissions on ozone concentrations in the Kwang-Yang Bay (KYB) area. In order to examine ozone response to reductions in $NO_x$ and VOC emissions from KYB and Gyeongsang, ozone isopleths are generated with the first and second-order sensitivity coefficients from HDDM simulations at three sites; Taein, Samil, and Gwangmoo. Simulations show that reduction in KYB $NO_x$ may increase ozone over the sites. On the contrary, $NO_x$ reduction from Gyeongsang may decrease ozone at the sites when transport of ozone and its precursors from upwind Gyeongsang is potentially high. However, VOC reductions from KYB and Gyeongsang are favorable to lower ozone over KYB. The study implies that emission reductions for both local and neighboring areas are likely more effective to bring KYB to ozone attainment.

• Ocean and Polar Research
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• 제30권3호
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• pp.313-324
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• 2008

In order to understand the variation of ENSO-related oceanic environments in the tropical and North Pacific Ocean, spatio-temporal variations of sea surface temperature anomaly (SSTA) and sea surface height anomaly (SSHA) are analyzed from distributions of complex empirical orthogonal functions (CEOF). Correlations among warm pool variation, southern oscillation index, and ocean surface currents were also examined with respect to interannual variability of the warm pool in western tropical Pacific. Spatio-temporal distributions of the first CEOF modes for SSTA and SSHA indicate that their variabilities are associated with ENSO events, which have a variance over 30% in the North Pacific. The primary reasons for their variabilities are different; SST is predominantly influenced by the change of barrier layer thickness, while SSH fluctuates with the same phase as propagation of an ENSO episode in the zonal direction. Horizontal boundary of warm pool area, which normally centered around $149^{\circ}E$ in the tropics, seemed to be expanded to the middle and eastern tropical regions by strong zonal currents through the mature phase of an ENSO episode.

• 아태비즈니스연구
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• 제11권4호
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• pp.83-101
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• 2020

Purpose - The purpose of this study is to identify the factors which affect the performance of Chinese web drama. Design/methodology/approach - For empirical investigation, 163 web dramas which were listed in AiQiyi platform were used as the sample. It was hypothesized that number of explanatory variables drawn from previous research, including the power of producing company, and star power of actors and actresses, average length of an episode, genre of the drama, viewer ratings, existence of exclusive SNS account and the use of existing IP, would influence the performance of the drama measured by cumulative hit number. A hierarchical regression analysis is conducted to test hypotheses. Findings - Results show that star power of actors and actresses, average length of an episode, viewer ratings and the use of IP indeed affect the performance of Chinese web drama. Research implications or Originality - As the first empirical study of this kind, this study may help not only domestic but also global participants of fast growing Chinese web drama industry.

• 한국과학교육학회지
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• 제34권5호
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• pp.469-478
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• 2014

본 연구에서는 학생들이 과학과 과학자에 대한 이미지를 다양화하기 위해 과학자들의 인간적인 면이 드러난 에피소드를 활용한 '과학자의 희로애락 프로그램'을 개발해 학생들의 반응을 파악했다. 과학자의 다양한 이미지를 학습자에게 제공함으로써 과학자에 대한 이미지가 어떻게 다양해졌는지, 자신의 과학 학습과 진로에 어떻게 영향을 주었는지 살펴보았다. 프로그램은 과학자의 희로애락 관련 총 5개 주제, 10차시로 구성되었고, 20명의 고등학생들이 참여했으며 이 중 5명의 수업 전후 조사지, 수업 중 상호 작용, 활동지 자료, 면담 자료, 수업현장 노트 등을 심층 분석했다. 과학자의 인간적인 면을 나타내는 수업의 흐름은 먼저 과학자에 대한 이미지 떠올리기, 과학사 에피소드 읽기, 과학자의 인간적 측면 탐색하기, 과학자의 상황 공감하기, 과학자의 인간적 측면 평가하기 등의 단계로 구성되었다. 프로그램에 참여한 학생들은 과학자도 감정을 가진 평범한 사람이라는 것을 알게 되었고, 과학자에게 친밀감을 느끼게 되었으며, 과학자가 될 수 있다는 자신감도 갖게 되었다. 학생들이 과학자의 다양한 측면을 이해하게 됨으로써 과학과 과학자에 대해 더 큰 지지를 보낼 수 있는 과학적 소양을 갖추게 될 것으로 기대된다.

• 한국연극학
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• 제40호
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• pp.5-27
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• 2010

The Korean Mask-Dance Theatre has been developed closely related to Korean Shaman rituals. As many scholars noticed, the performers of the Mask-Dance Theatre were closely related to the Shaman family. In addition, there are mask-dance performances in actual shaman rituals. and are the representative performances among them. This essay intends to compare these two mask-dance performances in the shaman rituals to the similar performance of Old Grandpa and Grandma episode in the regional Mask-Dance Theatre. This study would bring us further in proving the close relation between the shaman ritual and the Mask-Dance Theatre. is one episode, Keori, in the shaman ritual of 'Baeyeonsin-kut' and 'Taedong-kut' in the mid-west seashore area. 'Taedong-kut' is the village shaman ritual for fertility and prosperity, while 'Baeyeonsin-kut' is a private shaman ritual for a large catch of the ship. is held in the later part of the whole shaman ritual since the later part tend to be more for entertainment than actual ritual. The story of is very similar that of in Pongsan Mask-Dance Theatre of the mid-west region. In addition, some of their dialogues are very similar. Only the later part is different. These similarities indicate that the Mask-Dance Theatre, which came into being in later period than the shaman ritual, has likely taken the story motif of the shaman ritual. is also a performance in the shaman ritual of east coasts. is more elaborate and recreational than of the west coasts. is also performed near the end of the ritual, and sometimes it is not performed at all. This indicates that has little ritual meaning left. When we compare it with the regional Mask-Dance Theatres such as Keosung Okwangdae, Tongyong Okwangdae, and Suyong Yaryu, the structure and the story lines are also very similar. It is a question why only the motif of the Grandpa and Grandma isfound both in the shaman ritual and the Mask-Dance Theatre. Many other motifs of other episodes in the Mask-Dance Theatre are not found in the shaman rituals. It seems that the Grandpa and Grandma motif is related to the ur-belief in fertility. In other words, this motif seems to be originated from the old belief in the fertility couple of Chonha Taechanggun and Jiha Yeochanggun. The shaman ritual for fertility first picked up this motif, and then the mask-dance theatre also adapted this motif for its recreational purpose. When we compare with , still has more aspects of fertility ritual, while lost its ritualistic meaning and its main purpose is to develop dramatic needs. and are invaluable existent performances to prove theatre's origin in ritual. The existence of mask-dance performances in the shaman rituals shows us the transit performance between theatre and ritual.

• BMB Reports
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• 제51권9호
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• pp.427-428
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• 2018

Based on the piling reports of disruptions in the thalamus of patients with schizophrenia, the alteration in the thalamo-cortical system has been regarded as the core pathophysiology. As the thalamus is composed of distinctive nuclei with different cytoarchitecture and cortical connections, nuclei specific investigations have been actively conducted in post-mortem studies. In addition, the importance of early changes has been highlighted, which in turn has led to investigations of the thalamo-cortical system using non-invasive neuroimaging methods. From this perspective, the early structural changes in the thalamo-cortical system, such as the thalamo-cortical connection and nuclei specific microstructural changes (which are coherent with findings from post-mortem methods) will be briefly discussed. The main findings, which are the reduced thalamo-prefrontal connection and reduced microstructural complexity in the higher-order nuclei detected in first-episode psychosis patients, suggest the occurrence of early alterations within and between the communication hub of the brain and cortex. These findings suggest not only directions for further studies for unveiling the thalamo-cortical system related pathophysiology, but also the possibility of using the reduced microstructural complexity in the higher order nucleus as a biomarker for schizophrenia.

• Childhood Kidney Diseases
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• 제21권2호
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• pp.94-100
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• 2017

Purpose: The American Academy of Pediatrics provides guidelines for managing febrile urinary tract infection (UTI) in infants and children 2-24 months old, but little guidance is offered regarding UTIs in those younger than 8 weeks of age. The definition of UTI is unclear and whether to proceed with micturating cystourethrography (MCUG) or $^{99m}$technetium-dimercaptosuccinic acid (DMSA) scintigraphy scan in this age group is controversial. Methods: We retrospectively analyzed 29 neonates and infants younger than 2 months of age who underwent late DMSA scans 9 months following the first episode of febrile or symptomatic UTI between July 2009 and June 2016. Results: In total, 192 children aged 0-24 months underwent ultrasound and DMSA scans (MCUG in 174/192). Neonates and infants younger than 2 months of age were significantly less likely to develop fever, and had a lower fever peak, shorter duration of fever before admission and after starting antibiotics, longer hospitalization period, lower C-reactive protein, and greater incidence of nonEscherichia coli infection. There was no difference in pyuria response at diagnosis. The prevalence rates of an ultrasound abnormality (28%), vesicoureteral reflux (28%), UTI recurrence (38%), and renal scarring (10%) in infants younger than 8 weeks of age were similar to those in children 2-24 months old. Conclusion: Neonates and infants younger than 2 months of age with UTI warrant special consideration because the fever response used for diagnosis in older children may be absent or blunted. Clinical guideline is needed for the diagnosis and management of UTI in this age group.