• The Korean Journal of Physiology and Pharmacology
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• v.12 no.6
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• pp.337-342
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• 2008

Human bone marrow mesenchymal stem cells (hBM-MSCs) represent a potentially valuable cell type for clinical therapeutic applications. The present study was designed to evaluate the effect of long-term culturing (up to $10^{th}$ passages) of hBM-MSCs from eight individual amyotrophic lateral sclerosis (ALS) patients, focusing on functional ion channels. All hBM-MSCs contain several MSCs markers with no significant differences, whereas the distribution of functional ion channels was shown to be different between cells. Four types of $K^+$ currents, including noise-like $Ca^{+2}$-activated $K^+$ current ($IK_{Ca}$), a transient outward $K^+$ current ($I_{to}$), a delayed rectifier $K^+$ current ($IK_{DR}$), and an inward-rectifier $K^+$ current ($K_{ir}$) were heterogeneously present in these cells, and a TTX-sensitive $Na^+$ current ($I_{Na,TTX}$) was also recorded. In the RT-PCR analysis, Kv1.1,, heag1, Kv4.2, Kir2.1, MaxiK, and hNE-Na were detected. In particular, ($I_{Na,TTX}$) showed a significant passage-dependent increase. This is the first report showing that functional ion channel profiling depend on the cellular passage of hBM-MSCs.

• Journal of the Korean Wood Science and Technology
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• v.43 no.4
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• pp.486-493
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• 2015

The ultrasonic nondestructive test (NDT) was applied to deck in-service to inspect and evaluate the performance of decking materials using ultrasonic pulse velocity. First, the measuring method between direct and indirect method according to transducer arrangement was studied. Second, the ultrasonic pulse velocity of decks in-service was compared with the passage of time. Finally, the change of ultrasonic pulse velocity was evaluated to expect service life of decking materials. The results of comparison between direct and indirect method was statistically insignificant and the ratio of direct to indirect method was 1.02. 1.05 respectively. The ultrasonic pulse velocity of decks in-service was decreased as the passage of time and the linear relationship in the ultrasonic pulse velocity to passage of time was found. From the results, The ultrasonic NDT will be helpful as an efficient method of on-site management of decks in-service.

• The Bulletin of The Korean Astronomical Society
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• v.36 no.2
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• pp.91-91
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• 2011

The passage of the interplanetary discontinuity (i.e., sudden increases in the solar wind speed, density, and IMF strength) was detected by ACE near GSE (x, y, z) ~ (222, -36, 3) Re upstream of Earth around 22:48 UT on November 24, 2008. About 55 min later, this solar wind discontinuity was observed by Geotail near GSE (x, y, z) ~ (23, 18, -7) Re in front of Earth's bow shock. From the propagation time of the solar wind discontinuity between ACE and Geotail, it is expected that the discontinuity front is aligned with the Parker spiral and strikes the postnoon dayside magnetopause first. Using coordinated multi-point measurements (THEMIS and GOES) at or in geosynchronous orbit, we observed a tailward propagating sudden impulse (SI), excited by the interplanetary discontinuity, around 23:50 UT with its front retaining alignment similar to that of solar wind discontinuity. The SI event appears a negative-then-positive variation in the H component at high latitude Chokurdakh (CHD: MLAT ~ 64.7 deg) in the prenoon sector, which is opposite sense of normal SI event. During the positive deflection at CHD, the SuperDARN Hokkaido radar detected the downward motion of the ionosphere, implying westward electric field enhancement, at subauroral latitudes near CHD meridian. In our study we will discuss magnetospheric and ionospheric responses to the passage of the solar wind discontinuity using multi-point observations in space and on the ground.

• Journal of the Korean Operations Research and Management Science Society
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• v.19 no.3
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• pp.93-109
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• 1994

Even though sojourn time distributions are essential information in analyzing queueing networks, there are few methods to compute them accurately in non-product form queueing networks. In this study, we model the location process of a typical customer as a GMPH semi-Markov chain and develop computationally useful formula for the transition function and the first-passage time distribution in the GMPH semi-Markov chain. We use the formula to develop an effcient method for approximating sojourn time distributions in the non-product form queueing networks under quite general situation. We demonstrate its validity through numerical examples.

• International Journal of Reliability and Applications
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• v.9 no.2
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• pp.167-182
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• 2008

The objective of this paper is to discuss the stochastic analysis and the statistical inference of a three-states semi-Markov reliability model. Using the maximum likelihood procedure, the parameters included in this model are estimated. Based on the assumption that the lifetime and repair time of the system are gener-alized Weibull random variables, the reliability function of this system is obtained. Then, the distribution of the first passage time of this system is derived. Many important special cases are discussed. Finally, the obtained results are compared with those available in the literature.

• Bulletin of the Korean Mathematical Society
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• v.50 no.5
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• pp.1659-1671
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• 2013

In this paper, we are concerned with the analysis of the waiting time distribution in the M/M/m retrial queue. We give expressions for the Laplace-Stieltjes transform (LST) of the waiting time distribution and then provide a numerical algorithm for calculating the LST of the waiting time distribution. Numerical inversion of the LSTs is used to calculate the waiting time distribution. Numerical results are presented to illustrate our results.

• International Journal of Reliability and Applications
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• v.6 no.1
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• pp.13-29
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• 2005

This paper deals with the stochastic analysis of a three-states semi-Markov reliability model. Using both the maximum likelihood and Bayes procedures, the parameters included in this model are estimated. Next, assuming that the lifetime and repair time are generalized exponential random variables, the reliability function of this system is obtained. Then, the distribution of the first passage time of this system is discussed. Finally, some of the obtained results are compared with those available in the literature.

• Smart Structures and Systems
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• v.2 no.4
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• pp.313-320
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• 2006

The reliability analysis of structures subjected to stochastic loading involves evaluation of time and probability of the system's residence in a reference domain. In this paper, we derive an asymptotic estimate of exit time for multi-degrees-of-freedom structural systems. The system's dynamics is governed by the Lagrangian equations with linear dissipation and fast additive noise. The logarithmic asymptotic of exit time is found explicitly as a sum of two terms dependent on kinetic and potential energy of the system, respectively. As an example, we estimate exit time and an associated structural performance for a rocking structure.

• Bulletin of the Korean Mathematical Society
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• v.56 no.5
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• pp.1355-1376
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• 2019

We investigate the valuation of participating life insurance policies with default risk under a geometric regime-switching jump-diffusion process. We derive explicit formula for the Laplace transform of the price of participating contracts by solving integro-differential system and then price them by inverting Laplace transforms.

• Journal of the Korea Institute of Military Science and Technology
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• v.12 no.2
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• pp.236-247
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• 2009

In Korea, the driving system restriction criteria is strictly applied(gross weight 400kN, axial load 100kN). Especially after the Seoungsu Bridge accident, safety factor has been strictly applied. The Safety factor is applied to the cumulative results for each steps like design, construction, maintenance of the Bridge. Because of it, the bridge is undervalued compared to its capacity. So, this generates loss for both private and military sector(eg. logistical delays, structural damage, etc.). But analyzing data from many existing researches we have confirmed that the military heavy vehicle may pass through the first class bridges. In consequence, this study have focused on determining whether HETS vehicles can pass over the first class bridge, without safety issues, using MIDAS structural analysis program. The results have confirmed that the military heavy vehicle may pass over the bridge.