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Do the Rotating Hinge-Flexible Intramedullary Nail Composites Alleviate Junctional Osteolysis in Megaprothesis Reconstruction for Bone Tumor? (탄력성 있는 골수강 내고정물과 회전경첩형 슬관절 전치환물을 조합한 종양인공관절로 자가골의 골 용해를 감소시킬 수 있는가?)

  • Song, Won-Seok;Cho, Wan-Hyeong;Cho, Sang-Hyun;Jeon, Dae-Geun
    • The Journal of the Korean bone and joint tumor society
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    • v.13 no.2
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    • pp.96-104
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    • 2007
  • Purpose: The authors investigated whether 35 flexible nail-rotating hinge composite reconstructions around knee joint minimize junctional osteolysis of host bone. Material and Method: The reconstructive technique was as follows: 1) en bloc tumor resection, 2) filling of the host bone marrow cavity with multiple Ender nails, 3) assembling the Ender nails and an Endo-Link type total knee component with wire and bone cement. Result: Mean follow-up was 53 months (ranged 30~79). At final follow-up, 29 patients retained a mobile joint. Resection of more than 40% of bone showed a positive relationship with junctional hypertrophy (p=0.028). Eight patients showed nail breakage and eight prostheses were removed due to early or late infection. The cumulative prosthetic survival rate was 33% at 6 year. Average functional score according to the MSTS criteria was 26.8. Conclusion: Mid-term evaluations showed that results were fair. The revision process was straightforward. Junctional hypertrophy observed appears to give some clues as to how to minimize osteolysis at the prosthesis-host junction after modular prosthesis fixation.

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Prognostic Factor Analysis of Overall Survival in Gastric Cancer from Two Phase III Studies of Second-line Ramucirumab (REGARD and RAINBOW) Using Pooled Patient Data

  • Fuchs, Charles S.;Muro, Kei;Tomasek, Jiri;Van Cutsem, Eric;Cho, Jae Yong;Oh, Sang-Cheul;Safran, Howard;Bodoky, Gyorgy;Chau, Ian;Shimada, Yasuhiro;Al-Batran, Salah-Eddin;Passalacqua, Rodolfo;Ohtsu, Atsushi;Emig, Michael;Ferry, David;Chandrawansa, Kumari;Hsu, Yanzhi;Sashegyi, Andreas;Liepa, Astra M.;Wilke, Hansjochen
    • Journal of Gastric Cancer
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    • v.17 no.2
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    • pp.132-144
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    • 2017
  • Purpose: To identify baseline prognostic factors for survival in patients with disease progression, during or after chemotherapy for the treatment of advanced gastric or gastroesophageal junction (GEJ) cancer. Materials and Methods: We pooled data from patients randomized between 2009 and 2012 in 2 phase III, global double-blind studies of ramucirumab for the treatment of advanced gastric or GEJ adenocarcinoma following disease progression on first-line platinum- and/or fluoropyrimidine-containing therapy (REGARD and RAINBOW). Forty-one key baseline clinical and laboratory factors common in both studies were examined. Model building started with covariate screening using univariate Cox models (significance level=0.05). A stepwise multivariable Cox model identified the final prognostic factors (entry+exit significance level=0.01). Cox models were stratified by treatment and geographic region. The process was repeated to identify baseline prognostic quality of life (QoL) parameters. Results: Of 1,020 randomized patients, 953 (93%) patients without any missing covariates were included in the analysis. We identified 12 independent prognostic factors of poor survival: 1) peritoneal metastases; 2) Eastern Cooperative Oncology Group (ECOG) performance score 1; 3) the presence of a primary tumor; 4) time to progression since prior therapy <6 months; 5) poor/unknown tumor differentiation; abnormally low blood levels of 6) albumin, 7) sodium, and/or 8) lymphocytes; and abnormally high blood levels of 9) neutrophils, 10) aspartate aminotransferase (AST), 11) alkaline phosphatase (ALP), and/or 12) lactate dehydrogenase (LDH). Factors were used to devise a 4-tier prognostic index (median overall survival [OS] by risk [months]: high=3.4, moderate=6.4, medium=9.9, and low=14.5; Harrell's C-index=0.66; 95% confidence interval [CI], 0.64-0.68). Addition of QoL to the model identified patient-reported appetite loss as an independent prognostic factor. Conclusions: The identified prognostic factors and the reported prognostic index may help clinical decision-making, patient stratification, and planning of future clinical studies.

Effects of Maternal Role Education Program on the Mother-Infant Interaction and Infant Development (영아기 어머니역할 교육 프로그램이 모아상호작용과 영아발달에 미치는 효과)

  • Bang Kyung Sook
    • Child Health Nursing Research
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    • v.7 no.1
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    • pp.21-34
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    • 2001
  • The impact of childhood experience has lifelong significance on subsequent health and development. Especially, the experience of infant is mostly affected by the quality of parental care and rearing environment. But the new mothers usually do not know what to do because of the lack of experience in these days. Therefore, an educational program regarding maternal role would be necessary. This study was conducted to evaluate the effectiveness of the maternal role education program for mother-infant interaction, child-rearing environment, and infant development. Non-equivalent control group time-series design was used, and Barnard's mother-infant interaction model was used as a conceptual framework of this study. The subjects were the healthy infants weighing over 2,500gm at birth, whose gestational age was more than 37 weeks, and their mothers. The final sample consisted of 19 mother-infant dyads for intervention group and 18 dyads for control group. Data were collected from March 15th to September 3rd in 1999. For the intervention group, programmed education which focused on mother-infant interaction, breast feeding, and infant care was provided before discharge. Telephone counselling was provided within one week after discharge. Home visiting for maternal role education was provided twice, one month and three months postpartum. For the control group, home visiting was also conducted but only for data collection. The data were analyzed using chi-square test and t-test to test the equivalence of two groups, and the effectiveness of intervention program was determined with repeated measure ANCOVA and t-test. The results were as follows: 1. Significant differences were found in mother-infant interaction between two groups(p=.000). It indicates that intervention program was effective in improving mother- infant interaction. In subscale analysis, four out of six subscale showed significant differences between the groups: sensitivity to cues (p=.000), social-emotional growth fostering (p=.000), cognitive growth fostering(p=.000) in mothers, and responsiveness to caregiver (p=.019) in infants. 2. The difference in the mean score of childrearing environment (HOME) between the intervention group and control group was significant(p=.003). When each subscale of HOME was examined individually, intervention group showed significantly higher scores in the diversity of stimulation(p=.000), and mother's involvement(p=.001). 3. Three-month-Infants of the intervention group showed higher GQ in the Griffiths mental development scale(p=.026). In subscale analysis, significant differences were found in the personal-social(p=.005), and the hearing and speech(p=.003). In conclusion, the maternal role education program proved to be effective in promoting the mother-infant interaction, organizing the childrearing environment, and fostering the infant development. These results are very meaningful that we found maternal role education necessary for normal infants' mothers, and that nurses can make a great contribution in promoting health of infants and mothers.

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Properties of Jeonbyeong Containing Letinus edodes Powder (표고버섯 가루를 첨가한 전병의 특성)

  • Park, Jung-Suk;Na, Hwan-Sik
    • Food Science and Preservation
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    • v.14 no.4
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    • pp.337-344
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    • 2007
  • Lentinus edodes (Shiitake mushroom) powder was added to Jeonbyeong dough in an effort to improve the quality and functional properties of the dough. The water absorption increased as the amount of L. edodes powder increased, while the time taken for gelatinization, and the valorimeter value of the final dough, both decreased. The temperature at gelatinization and the highest temperature attained during dough preparation were both similar to control values. The extensogram showed that the resistance of the dough to extension, and the maximum extensibility, both decreased with addition of L. edodes powder. The total contents of crude protein and ash increased with increasing amounts of L. edodes powder, while the dough carbohydrate levels decreased. Addition of the mushroom powder to Jeonbyeong (a kind of Korean traditional snack) decreased dough lightness, and decreased yellowness, as measured on Hunter's color scale. The hardness of Jeonbyeong was increased by adding 15% (w/v) L. edodes powder, but was decreased when 20% (w/v) L. edodes powder was used. The sensory score of Jeonbyeong containing 10% (w/v) L. edodes powder was the highest of all shack tested, in both overall quality characteristics and sensory evaluation.

Effects of Active Oral Play and Ayres Sensory Integration (ASI®) for Child With Oral Defensiveness: Single Subject Research (구강방어아동을 위한 능동적 구강놀이와 ASI적용효과 : 단일사례연구)

  • Sung, Ga-young;Choi, Jeong-Sil;Jung, Hyerim
    • The Journal of Korean Academy of Sensory Integration
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    • v.17 no.3
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    • pp.1-13
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    • 2019
  • Objective : The purpose of the present study is to investigate the effects of Ayres Sensory Integration (ASI®) with play-centered oral defensiveness reduction activities on the oral sensitivity of a child with oral defensiveness. Methods : The subject was a three-and-a-half year-old boy with a developmental delay. The study was performed from August to September, 2018. The research design used in this study is the design for single-subject research. The experimental period was divided into three phases: three sessions for the initial baseline phase (A), 15 sessions for the treatment phase (B), and three sessions for the final baseline phase (A'). Ayres Sensory Integration (ASI®) with active oral play was conducted in the treatment phase. The Measuring Oral Sensitivity in Practice was used to test changes in the oral sensitivity level. The Korean Children's Eating Behavior Inventory and Food Checklist were used to assess the difference in functions related to oral sensitivity before and after the intervention. Results : In comparison with the baseline phase, the Measuring Oral Sensitivity in Practice and Korean Children's Eating Behavior Inventory were improved during the treatment phase, but the Food Intake checklist score was not changed after the treatment phase. Conclusion : The use of Ayres Sensory Integration (ASI®) with active oral play produced positive results and reduced the child's oral sensitivity and eating problems.

A Study on the Enterprise Value Analysis using AHP and Logit Regressions (AHP와 로짓회귀분석을 활용한 기업가치 분석방법)

  • Gu, Seung-Hwan;Shin, Tack-Hyun;Yuldashev, Zafar
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.16 no.9
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    • pp.5810-5818
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    • 2015
  • The dissertation presents the portfolio construction method using the score sheet so that general investors can utilize it easily. This study draws the significant variables to contribute the enterprise value and suggests the combined models by applying the single methodology, which private investors can easily utilize. The results of the research can be classified into 2 areas. Firstly, the significantly affecting variables were selected for analyzing the enterprise value. The variables and the method for the enterprise value analysis were studied from the existing researches to choose the optimal variables. The variables were identified by using AHP method and the structure equation method from the investigation of the previous researches. And the critical variables were added extracted from the common denominator of variables which the 3 grue investors used for their investment. The final variables identified are dividend yield, PER, PBR, PCR, EV/EBITDA, ROE, net income, sales growth rate, net current asset, debt ratio, current ratio, rate of operating profits, ratio of operating profit to net sales, ratio of net income to net sales, net profit to total assets, EPS growth rate, inventory turnover ratio, and receivables turnover. Second, the new methodologies for forecasting enterprise value modifying the existing methods were developed. The result of the Logistic regression analysis for forecasting showed that the equation could not be suitable as the accuracy with 91.98%.

Seeking Alternative Models and Research Trends for Big Deals in the Electronic Journal Consortium (전자저널 빅딜 계약의 연구 동향과 대안 탐색)

  • Kim, Sang-Jun;Kim, Jeong-Hwan
    • Journal of Information Management
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    • v.42 no.1
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    • pp.85-111
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    • 2011
  • The purpose of this study was to seek a workable alternative to replace a big deal related to the journal budget for the maintenance of academic libraries with the largest issue on the E-journal consortium. The contents of this study was to present it. It had examined the current situation, strengths, weaknesses and corresponding to replace the big deal contract. After reviewing the literature, we looked into the alternative activities for the big deal such as open access-based, usage-based, consortium improvement-based, publishers lead, and other models. As a result, the 'consortium cost reapportion model' was an alternative for the KESLI. The alternative was in the short term for cost division format, but long-term oriented for a consortium single(bloc) payment type or national licence model. The model was based on the data from the last year. It had evaluated download the PDF and HTML documents, but the three times weighting more than others, and the rest of 14 factors of 0.5 to 5 out of 100 total score. The total amount negotiated by national units 10, 20 and 30 grades for the final step was allocated to the participating library on the KESLI consortium.

Discrimination of geographical origins of raw ginseng using the electronic tongue (전자혀를 이용한 수삼의 원산지 판별)

  • Dong, Hyemin;Moon, Ji Young;Lee, Seong Hun
    • Korean Journal of Food Science and Technology
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    • v.49 no.4
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    • pp.349-354
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    • 2017
  • The geographical origins of raw ginseng (RG) were discriminated using an electronic tongue. Taste screening, DFA (discriminant function analysis), and CDA (canonical discriminant analysis) were used to statistically analyze the data. The taste profile patterns of umami, bitterness, and sweetness of the Korean RG was different from those of the Chinese RG. The Korean RG was stronger than the Chinese RG regarding the taste of umami. DFA discriminated the geographical origins of 154 samples, with a few overlapping samples, between the Korean and Chinese RG. CDA showed that the accuracy of origin discrimination for the Korean and Chinese RGs were 87.01 and 94.81%, respectively. The final accuracy of origin discrimination was 90.91%. The distance between the centroids of each group was 2.7463. Thus, the electronic tongue analysis can be used to efficiently differentiate the geographical origins of RG.

Sensory Characteristics of Citrus Vinegar fermented by Gluconacetobacter hanenii CV1 (Gluconacetobacter hansenii CV1에 의해 발효된 감귤식초의 관능적 특성)

  • Kim Mi-Lim;Choi Kyung-Ho
    • Korean journal of food and cookery science
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    • v.21 no.2 s.86
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    • pp.263-269
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    • 2005
  • Citrus juice, a concentrate manufactured by the Jeju Provincial Corporation, was converted into vinegar orderly by alcohol and acetate fermentation. The juice with 6 folds dilution by distilled water was used as the sole nutrient source through out experiments. Diluted juice contained $12.96^{\circ}Brix$ of total sugar, $0.632\%$ of total acid and $20.23{\mu}g/m{\ell}$ of hesperidin. Naringin was not detected from the juice. Citrus wine having $5.6\~6.3\%$ alcohol was produced from diluted juice by 3 days of fermentation at $28^{\circ}C$. A kind of malomelo yeast CMY-28 was used for wine fermentation. The wine was succeedingly fermented for 8 days at $30^{\circ}C$ after inoculation of seed vinegar which contained active cells of acid producing bacteria CV1. Inoculum size of seed vinegar was controlled to $10\%$(v/v) of citrus wine. The wine converted into vinegar by the fermentation. Citrus vinegar, the final product of fermentation, was colored with very thin radish-yellow and transparent. It's acidity ranged between $5.8\~6.2\%$ as acetic acid. The vinegar got the best score by sensory test among several natural fruit vinegars. It was clear from the results that citrus vinegar in high quality could be produced from concentrated citrus juice, however fermentation conditions should be improved to reduce the amount of reducing alcohol.

A Study on Oral Health Literacy and Oral Health Behavior among Adults (일부 성인의 구강건강문해력과 구강보건행태)

  • Kim, Sun-Il;Par, Hyun-Kyung;Song, Ji-Na;Ko, Su-Youn;Kim, Hye-Jin
    • The Journal of Korean Society for School & Community Health Education
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    • v.18 no.3
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    • pp.69-82
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    • 2017
  • Objectives: This study was conducted to investigate the relationship between general characteristics and oral health behavior, oral health knowledge, and oral health literacy for adult workers. Methods: This study chose some adult workers located D City by convenience sampling method, and accepted those who understood the purpose of the study and agreed with a survey as subjects. The final study subjects were 297 except 24 with unsound questionnaires among a total of 321 questionnaires. The contents of a survey were demographic characteristics, oral health behavior, oral health knowledge, and oral literacy, and the survey was done by a self-administered questionnaire. Results: In the verbal oral health literacy distribution based on REALM standard of the subjects, a scale of 7-8, 45-60 points by score was the highest with 62.0%. In average monthly household income and oral health knowledge level of general characteristics, oral health literacy was statistically significant, and was statistically significant according to oral health literacy, monthly income of house hold, and marital status as well, and was statistically significant in oral health knowledge and oral health literacy level according to oral health behavior and in the oral health knowledge level depending on a regular checkup. And In experience existence and nonexistence of oral health education and understanding and misunderstanding of dentistry and dental health education, and main body of the decision of dental treatment, verbal oral health literacy of oral health knowledge and oral health literacy was significant. It can be seen that based on correlation among general characteristics, oral health knowledge level, verbal oral health literacy, and functional oral health literacy, there is a correlation among gender and education level, age and average monthly income, and age and marital status. Conclusions: This study presented the need for oral health literacy along with the oral health knowledge of oral health behavior affecting adult workers' oral health, and tried to establish the connection among them. Accordingly, it is thought that an improvement plan of oral health literacy for the prevention and promotion of adult workers' dental disease in the future.

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