• Journal of Ginseng Research
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• v.47 no.3
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• pp.458-468
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• 2023

Background: As a complication of Type II Diabetes Mellitus (T2DM), the etiology, pathogenesis, and treatment of cognitive dysfunction are still undefined. Recent studies demonstrated that Ginsenoside Rg1 (Rg1) has promising neuroprotective properties, but the effect and mechanism in diabetes-associated cognitive dysfunction (DACD) deserve further investigation. Methods: After establishing the T2DM model with a high-fat diet and STZ intraperitoneal injection, Rg1 was given for 8 weeks. The behavior alterations and neuronal lesions were judged using the open field test (OFT) and Morris water maze (MWM), as well as HE and Nissl staining. The protein or mRNA changes of NOX2, p-PLC, TRPC6, CN, NFAT1, APP, BACE1, NCSTN, and Ab1-42 were investigated by immunoblot, immunofluorescence or qPCR. Commercial kits were used to evaluate the levels of IP3, DAG, and calcium ion (Ca²⁺) in brain tissues. Results: Rg1 therapy improved memory impairment and neuronal injury, decreased ROS, IP3, and DAG levels to revert Ca²⁺ overload, downregulated the expressions of p-PLC, TRPC6, CN, and NFAT1 nuclear translocation, and alleviated Aβ deposition in T2DM mice. In addition, Rg1 therapy elevated the expression of PSD95 and SYN in T2DM mice, which in turn improved synaptic dysfunction. Conclusions: Rg1 therapy may improve neuronal injury and DACD via mediating PLC-CN-NFAT1 signal pathway to reduce Aβ generation in T2DM mice.

• The Journal of Engineering Geology
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• v.32 no.1
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• pp.41-57
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• 2022

A workflow is presented to estimate the size of a representative elementary volume and 3-D hydraulic conductivity tensor based on fluid flow analysis for a discrete fracture network (DFN). A case study is considered for a Cretaceous granitic rock mass at Gijang in Busan, Korea. The intensity and size of joints were calibrated using the first invariant of the fracture tensor for the 2-D DFN of the study area. Effective hydraulic apertures were obtained by analyzing the results of field packer tests. The representative elementary volume of the 2-D DFN was determined to be 20 m square by investigating the variations in the directional hydraulic conductivity for blocks of different sizes. The directional hydraulic conductivities calculated from the 2-D DFN exhibited strong anisotropy related to the hydraulic behavior of the study area. The 3-D hydraulic conductivity tensor for the fractured rock mass of the study area was estimated from the directional block conductivities of the 2-D DFN blocks generated for various directions in 3-D. The orientations of the principal components of the 3-D hydraulic conductivity tensor were found to be identical to those of delineated joint sets in the study area.

• 한국체육학회지인문사회과학편
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• v.57 no.3
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• pp.117-133
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• 2018

The purpose of this study was to explore integrated approaches to physical education in general education by examining methodology of physical education aiming for convergence education. This case study was conducted, using a qualitative approach during March, 2017 to November, 2017. Data were collected through non-participant observation, in-depth interviews, field-notes, students' journal, syllabus and lecture materials. The key findings are as follows: First, "Emotion Coaching through Movement" is a course of 'understanding of body' approaching integrated humanities science and natural science. Second, it is a convergence education, conducting 'text to daily practice' by approaching positive psychology and neurophysiology. Third, it is a physical education with 'integrated theory and practice' in higher education. These results indicate that students can understand their own body, observe their daily and fixed movement or reaction pattern, and enhance the ability of understanding others through a physical education in general education.

• Trans-
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• v.14
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• pp.35-63
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• 2023

Parkinson's disease is a degenerative neurological disease that affects even basic daily life movements due to impairment of body function caused by a lack of dopamine, which is charge of the body movement. Presently, it is hard to cure Parkinson's disease entirely with medical technology, so movement therapy as a solution to delay and prevent disease is getting more attention. Therefore, this study aims at desiging and disseminating a body movement program that concentrates on individual self-care and balacing the state of body and mind by applying the Feldenkrais Method® to patients with Parkinson's disease. The Feldenkrais Method® is a mind-body perceptual learning method using body movements. It is a methodology that re-educates the nervous system by connecting the brain and behavior as a function of neuroplasticity. In this study, the body movement program developed and verified by the researcher was modified and supplemented with a focus on the self-awareness of the Feldenkrais Method®. A 24-session physical exercise program was composed of 5 stages to improve the self-management ability of patients with Parkinson's disease. The stages include self-awareness, self-observation, self-organization, self-control, and self-care. The overall changes recognize one's condition and improve one's ability to detect modifications in the internal sense and external environment. In conclusion, the body movement program improves the body movement program improves mental and physical functions and self-care for Parkinson's disease patients through the Feldenkrais method. The availability of the program's on-site applicability remains a follow-up task. Furthermore, it is necessary to establish a systematic structure to spread it more widely through convergent cooperation with the scientific field applied with metaverse as a reference for the wellness of the elderly.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.43 no.1
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• pp.9-20
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• 2023

For highway concrete structures, the deterioration of the structure is accelerated due to the increase in the use of deicing materials, and sectional repair work is being frequently carried out to restore performance. However, after the repair work, re-damage such as cracks, delamination, and poor bond performance is exhibited in the repaired sectional area. In this study, overseas repair material requirements were first analyzed, and present domestic requirements were improved repair material performance through field surveys of common concrete structures, laboratory experiments, and test construction on a disused concrete bridge. In addition, performancebased quality requirements were presented so that all materials that meet the required performance can be applied, and different test methods for each material were unified into concrete test methods for consistent test results analysis. The considered performance requirements were compression strength, bending strength, and bond strength for structural properties, and length change rate, crack resistance, thermal expansion coefficient, and elasticity coefficient were for dimensional behavior. For resistance to chloride penetration resistance and freeze-thaw resistance were presented as durability. The proposed requirements for concrete repair materials are expected to contribute to the improvement of the quality of concrete sectional repair work in Korea.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.2D
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• pp.227-234
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• 2008

This study examines which models are more suitable for representing mechanical property of unbound materials to analyze behavior of asphalt pavement structure. Results from FWD (Falling Weight Deflectometer) test were used to apply to nonlinear elastic model. The new method which can deduct material constants of nonlinear elastic model is suggested from FWD test data rather than laboratory resilient modulus ($M_R$) test. It is confirmed that the material constants are within the common range in subbase. Test output from FWD and MDD (Multi-Depth Deflectometer) was used to verify reliability of the model. From the results of verification, this study shows that a non-linear elastic model agrees to MDD test data more than a linear elastic model does.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.2A
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• pp.301-310
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• 2006

Carbon fiber reinforced polymer (CRFP) materials are well suited to the rehabilitation of civil engineering structures due to their corrosion resistance, high strength to weight ratio and high stiffness to weight ratio. Their application in the field of the rehabilitation of concrete structures is increased due to the vast number of bridges and buildings in need of strengthening. However, RC members, strengthened with externally bonded CFRP plates, happened to collapse before reaching the expected design failure load. Therefore, it is necessary to develop the new strengthening method to overcome the problems of previous bonded strengthening method. This problems can be solved by prestressing the CFRP plate before bonding to the concrete. In this study, a total of 21 specimens of 3.3 m length were tested by the four point bending method after strengthening them with externally bonded CFRP plates. The CFRP plates were bonded without prestress and with various prestress levels ranging from 0.4% to 0.8% of CFRP plate strain. All specimen with end anchorage failed by a plate fracture regardless of the prestress levels while the specimen without end anchorage failed by the separation of the plate from the beam due to premature debonding. The cracking loads was proportionally related to the prestress levels, but the maximum loads of specimens strengthened with prestressed CFRP plates were insignificantly affected by the prestress levels.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.2C
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• pp.73-80
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• 2006

The shear behavior of four different interfaces consisting of four types of geosynthetics was investigated, and both static and dynamic test for the geosynthetic interfaces were conducted. The monotonic shear experiments were performed by using an inclined board apparatus and large direct shear device. The interface shear strength obtained from the inclined board test was compared with calculated values from large direct shear tests. The comparison results indicated that direct shear tests show high possibility to over-predict the shear strength in the low normal stress range where direct shear tests are not performed. Curved failure envelopes were also obtained for interface cases where two static shear tests were conducted. By comparing the friction angles measured from three tests, i.e. direct shear, inclined board, and shaking table test, it was found that the friction angle might be different depending on the test method and normal stresses applied in the research. Therefore, it was concluded that the testing method should be determined carefully by considering the type of loads and the normal stress expected in the field with using the geosynthetic materials installed in the site.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.30 no.3C
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• pp.167-174
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• 2010

In this study, numerical analysis has been performed to compare the ground movements in a single ground layer and multiple ground layers due to nearby tunnel excavation. The numerical analysis has been conducted in the different ground layer conditions considering different construction conditions (volume loss at excavation face), and the results of the maximum surface settlement and horizontal displacement have been compared considering the ground layer and construction conditions. In addition, the maximum surface settlement from the numerical analysis has been compared with the maximum settlement at tunnel crown considering the ground layer and construction conditions, and the maximum surface settlement has been also compared with the maximum horizontal displacement with the ground layer conditions. Besides, the volume loss($V_L$) at tunnel excavation face has been compared with the total surface settlement volume($V_s$) with the variation of ground layer condition. The results from the numerical analysis have been compared with field measurements and by this comparison it is believed that the numerical results in this study can be utilized practically in analyzing the nearby ground behavior in different ground layer and construction conditions due to tunnel excavation.

• Journal of Korea Entertainment Industry Association
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• v.13 no.7
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• pp.25-38
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• 2019

For many years, emotions have been regarded as dangerous as well as obstructive to reason and rationality. Even in the history of dramatic genres based on human behavior, emotions are often portrayed as errors or flaws that lead to the collapse of characters, even though they are presented as powerful motives to evoke the characters' actions. Based on the development of the cognitive science field today, it is revealed how emotion is important for human thinking, judgment and action, and how closely reason and emotion are combined. This study examines emotions dealt with in drama genres on the basis of the sociality of emotions. Emotions also play a crucial role in the change and judgment of the audience of drama. This study examines the sociality of emotions and looks at the social aspect of individual emotions through the movie as a text. Just as horror movies attempt to communicate using and expanding feelings of fear, the movie uses the emotions of 'Sad' and 'Losing' to try to expand and share it. And I look into the mechanism in which the emotions of the characters in drama are transmitted to the audience in the form of empathy.