• Asian Pacific Journal of Cancer Prevention
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• 제16권1호
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• pp.191-194
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• 2015

Purpose: To estimate the incidence of breast cancer in Yemeni female patients presenting with a breast mass. Materials and Methods: This retrospective study was carried out with 595 female patients with palpable breast lumps, attending to Alkuwait university hospital, Sana'a, Yemen. Triple assessment, including breast examination, mammography and biopsy (FNAC, core needle, or excision), for all patients were performed. Results: The incidences of benign and malignant lesions was calculated. Some 160 (26.9%) of 595 patients had malignancies; 213 (35.8%) were fibroadenomas; 12 (2.0%) were fibrocystic change; 143 (24.03%) were inflammatory lesions (including mastitis and ductectasia); 62 (10.4%) were simple cysts, while 5 (0.8%) were phyllodes tumors. The mean age of patients with malignant lumps was 44.3 years. Conclusions: Among Yemeni female patients with palpable breast lumps, the rate of breast cancer is high, with occurrence at an earlier age than in Western countries. Improving breast cancer awareness programs and increasing breast cancer screening centers inb different areas of Yemen are needed to establish early diagnosis and offer early and optimal treatment.

• 종양간호연구
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• 제7권2호
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• pp.169-178
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• 2007

Purpose: This study was to identify the relationship between depression and spiritual health in patients suffering from female cancer. Methods: The study utilized a cross-sectional descriptive study design. Data was collected by questionnaires from 106 female patients who were diagnosed with cancer of female organs at three university hospitals and one general hospital. The instruments used in this study included, "the Depression Scale" developed by Zung(1965) and "Spirituality Health Inventory" developed by Highfield(1992) and amended by Kim. The collected data were analyzed using frequency, percentage, t-test, ANOVA, and Pearson's correlation coefficients. Results: There was significantly negative correlation between spiritual health and depression in female cancer patients (r= -.65, p< .0001). There were significant differences in spiritual health according to the monthly income (F=4.30, p= .016), the degree of pain (F=2.85, p= .041), the degree of fatigue (F=3.42, p= .020), the frequency of attendance at worship services (F=3.26, p= .014), the effect of religion on personal life (F=9.41, p= .000). There were significant differences in depression, according to the residence type (F= .75, p= .012), the cancer insurance (t=7.86, p= .006), the degree of pain (F=2.78, p= .045). Conclusions: There is a necessity to develop strategies to improve the spiritual health and to reduce depression in female cancer patients. The significant several characteristics related to depression and spiritual health should be considered in psychsocial nursing intervention of female cancer patients.

• 한국융합학회논문지
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• 제8권4호
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• pp.279-285
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• 2017

본 연구는 여성암환우의 가발착용이 두피질환에 미치는 영향을 알아보고 향 후 암 환우들을 위한 가발 제작 시 필요한 기초자료를 제공하고자 실증 조사를 실시하였다. 그 결과 여성암 환우의 탈모용 가발 착용이 두피 가려움증에 미치는 영향은 가발착용 시 여러 가지 불편요소가 클수록 가려움을 유발하는 것으로 나타났으며 가발착용의 밀착성과 땀 분비, 심리적 위축성은 두피 가려움을 직접적으로 유발하지 않는 것으로 나타났다. 또, 여성암환우의 탈모용 가발 착용이 두피 트러블 유발에 미치는 영향에서도 가발의 탈착 시 불편 여부와 심리적 위축감이 높을 경우 두피 트러블을 유발시키는데 유의적인 영향을 미치는 반면 가발 탈착 시 밀착성과 땀 분비는 직접적인 연관이 없는 것으로 나타나 기각되었다. 이 같은 결과는 여성암 환우의 탈모용 가발 작용이 두피가려움과 트러블을 유발시킴에 있어 단순한 밀착여부와 땀 분비만으로 두피질환을 유발하지 않음을 시사한 것으로 볼 수 있다. 따라서 본 연구의 결과를 토대로 심적으로 고통 받는 여성 암 환우들을 위한 편리하고 우수한 가발 제작이 필요할 것으로 생각된다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권11호
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• pp.5525-5528
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• 2012

Introduction: Breast cancer is the most common cancer in women. Improvements of early diagnosis modalities have led to longer survival rates. This study aimed to determine the 5, 10 and 15 year mortality rates of breast cancer patients compared to the normal female population. Materials and Methods: The follow up data of a cohort of 615 breast cancer patients referred to Iranian Breast Cancer Research Center (BCRC) from 1986 to 1996 was considered as reference breast cancer dataset. The dataset was divided into 5 year age groups and the 5, 10 and 15 year probability of death for each group was estimated. The annual mortality rate of Iranian women was obtained from the Death Registry system. Standardized mortality ratios (SMRs) of breast cancer patients were calculated using the ratio of the mortality rate in breast cancer patients over the general female population. Results: The mean age of breast cancer patients at diagnosis time was 45.9 (${\pm}10.5$) years ranging from 24-74. A total of 73, 32 and 2 deaths were recorded at 5, 10 and 15 years, respectively, after diagnosis. The SMRs for breast cancer patients at 5, 10 and 15 year intervals after diagnosis were 6.74 (95% CI, 5.5-8.2), 6.55 (95%CI, 5-8.1) and 1.26 (95%CI, 0.65-2.9), respectively. Conclusion: Results showed that the observed mortality rate of breast cancer patients after 15 years from diagnosis was very similar to expected rates in general female population. This finding would be useful for clinicians and health policy makers to adopt a beneficial strategy to improve breast cancer survival. Further follow-up time with larger sample size and a pooled analysis of survival rates of different centres may shed more light on mortality patterns of breast cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제16권4호
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• pp.1545-1551
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• 2015

Purpose: Rectal cancers with high microsatellite-instable have clinical and pathological features that differentiate them from microsatellite-stable or low-frequency carcinomas, which was studied rarely in stage II rectal cancer, promoting the present investigation of the usefulness of microsatellite-instability status as a predictor of the benefit of adjuvant chemotherapy with fluorouracil in stage II rectal cancer. Patients and Methods: Data of 460 patients who underwent primary anterior resection with a double stapling technique for rectal carcinoma at a single institution from 2008 to 2012 were retrospectively collected. All patients experienced a total mesorectal excision (TME) operation. Survival analysis were analyzed using the Cox regression method. Results: Five-year rate of disease-free survival (DFS) was noted in 390 (84.8%) of 460 patients with stage II rectal cancer. Of 460 tissue specimens, 97 (21.1%) exhibited high-frequency microsatellite instability. Median age of the patients was 65 (50-71) and 185 (40.2%) were male. After univariate and multivariate analysis, microsatellite instability (p= 0.001), female sex (p<0.05) and fluorouracil-based adjuvant chemotherapy (p<0.001), the 3 factors were attributed to a favorable survival status independently. Among 201 patients who did not receive adjuvant chemotherapy, those cancers displaying high-frequency microsatellite instability had a better 5-year rate of DFS than tumors exhibiting microsatellite stability or low-frequency instability (HR, 13.61 [95% CI, 1.88 to 99.28]; p= 0.010), while in 259 patients who received adjuvant chemotherapy, there was no DFS difference between the two groups (p= 0.145). Furthermore, patients exhibiting microsatellite stability or low-frequency instability who received adjuvant chemotherapy had a better 5-year rate of DFS than patients did not (HR, 5.16 [95% CI, 2.90 to 9.18]; p<0.001), while patients exhibiting high-frequency microsatellite instability were not connected with increased DFS (p= 0.696). It was implied that female patients had better survival than male. Conclusion: Survival status after anterior resection of rectal carcinoma is related to the microsatellite instability status, adjuvant chemotherapy and gender. Fluorouracil-based adjuvant chemotherapy benefits patients of stage II rectal cancer with microsatellite-stable or low microsatellite-instable, but not those with high microsatellite-instable. Additionally, free of adjuvant chemotherapy, carcinomas with high microsatellite-instable have a better 5-year rate of DFS than those with microsatellite-stable or low microsatellite-instable, and female patients have a better survival as well.

• Journal of Digestive Cancer Research
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• 제11권2호
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• pp.61-65
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• 2023

Globally, esophageal cancer is the seventh most common cancer, and the male-to-female ratio in esophageal adenocarcinoma (EAC) is significantly imbalanced at 4:1 to 8:1. Obesity, reflux, and smoking are known risk factors for this sex difference; however, fully explaining this remains challenging. Studies have investigated the link between exogenous sex hormones and esophageal cancer occurrence. A meta-analysis revealed a lower risk of EAC in female who had undergone hormone replacement therapy. Androgen-deprivation therapy in patients with prostate cancer was associated with a decreased risk of EAC. Tissue-based studies have reported varied results regarding the relationship between estrogen receptor expression and survival in female patients with esophageal squamous cell carcinoma (ESCC). Circulating hormone studies have suggested that higher testosterone and luteinizing hormone levels decreased EAC risk in men, and free testosterone was inversely correlated in female with ESCC. However, a high androgen-estrogen ratio in male patients with EAC was linked to increased odds of EAC. Sex hormones influence carcinogenesis, affecting cell proliferation, differentiation, metabolism, inflammation, and cell death. The studies were limited by the small sample size and varying hormone measurement methods; thus, future studies with definitive conclusions on the association between esophageal cancer and sex hormones are warranted.

• 대한통합의학회지
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• 제8권2호
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• pp.29-39
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• 2020

Purpose : This study investigated the relationship among adjustment of cancer, mental health, and family problem solving communication of women with cancer. The purpose of this study was to determine how to improve the adjustment of cancer of women and improve women's mental health to form family problem solving communication. Methods : This correlational study was conducted among 101 women with cancer living in the Seoul region. Data collection occurred from August 1, 2018, to August 23. The data are reported as means and standard deviations and were analyzed with t tests, ANOVA, and Pearson's correlation regression using SPSS version 21.0. Results : The results of this study showed that adjustment to cancer significantly correlated with the education level of the participants (F=3.27, p<.05) and self-help group participation (F=3.156, p<.05). In this study, the mental health of female cancer patients significantly affected their adjustment to cancer (F=13.13, p<.001). These results explained 19.7% of the variance (F=13.13, p<.001) in mental health and adjustment to cancer in female cancer patients. Conclusion : In this study, mental health was significantly affected adjustment to cancer. The results suggest that adjustment to cancer can be promoted through the development and application of a nursing intervention program considering the mental health of female cancer patients. In addition, further research is required to identify the factors in consideration of various variables in addition to the sociodemographic and disease-related variables that may affect the adjustment to cancer of female cancer patients in nursing hospitals.

• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7277-7281
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• 2013

Background: Globally, there have been important changes in trends amongst gender, histology and smoking patterns of lung cancer cases. Materials and Methods: This retrospective study was conducted on 466 patients with lung cancer who were registered in Regional Cancer Center, Regional Institute of Medical Sciences, Manipur from January 2008 to December 2012. Results: Most were more than 60 years of age (67.8%) with a male: female ratio of 1.09:1. Some 78.8% of patients were chronic smokers with male smoker to female smoker ratio of 1.43:1. Consumption of alcohol was found in 29.4%, both smoking and alcohol in 27.5%, betel nut chewing in 37.9% and tobacco chewing in 25.3%. A history of tuberculosis was present in 16.3% of patients. The most frequent symptom was coughing (36.6%) and most common radiological presentation was a mass lesion (70%). Most of the patients had primary lung cancer in the right lung (60.3%). The most common histological subtype was squamous cell carcinoma (49.1%), also in the 40-60 year age group (45.9%), more than 60 year age group (51.6%), males (58.1%) and females (41.8%). As many as 91.9% of squamous cell carcinoma patients had a history of smoking. About 32.5% of patients had distant metastasis at presentation with brain (23.8%) and positive malignant cells in pleural effusions (23.1%) as common sites. The majority of patients were in stage III (34.4%), stage IV (32.5%) and stage II (30.2%). Conclusions: Our analysis suggests that the gender gap has been narrowed such that about half of the patients diagnosed with lung cancer are women in this part of India. This alarming rise in female incidence is mainly attributed to an increased smoking pattern. Squamous cell carcinoma still remains the commonest histological subtype. Most of the patients were elderly aged and presented at locally or distantly advanced stages.

• Asian Pacific Journal of Cancer Prevention
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• 제16권11호
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• pp.4531-4536
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• 2015

Objective: To investigate the influence of offspring-related characteristics on the prevalence of depressive disorders among cancer patients and those who survived cancer for at least 45 years. Materials and Methods: Data were obtained from the Korean Longitudinal Study of Aging (KLoSA). To investigate the association between offspring and depressive disorder among cancer patients and survivors, we analyzed data from 292 cancer patients and survivors drawn from a total subject pool of 16,613 individuals at baseline. Results: According to our results, the odds ratio (OR) for subjects with five or more offspring developing depressive disorder was -0.794 (p-value: 0.039, SE: 0.329) compared with that of those with two offspring. In addition, the adjusted effect of the number of male and female offspring on the presence of depressive disorder showed that the OR for those with three or more female offspring for developing depressive disorder was -0.958 lower (SE: 0.305, p-value: 0.012) than it was for those with no female offspring. Conclusions: This article provides evidence for an association between offspring-related characteristics and depressive disorders among cancer patients and survivors. Therefore, offspring may be important contributors to the emotional status of cancer patients and survivors. Further study should precisely need to measure depressive disorders because of self-reported data.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.3673-3676
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• 2015

To observe and analyze the characteristic trend of cancer patients hospitalized for the first time in Shanxi Tumor Hospital from 2001 to 2010, clinical data including case number, age, gender, and frequency of different tumor occurrences were collected and statistically analyzed. Results: (i) From 2001 to 2010, the number of cancer patients hospitalized for the first time increased by 1.3-fold; (ii) The patient overall average age also increased from 51.8 to 54.4, for males from 55.5 to 58.7 and females from 48.4 to 51.1, respectively. (iii) Male patients accounted for 43-48% and females accounted for 52-57% of the total. The percentage of female patients was higher than that of male patients in every year and showed an upward trend over the years, while that of the males showed a downward trend (${\chi}^2=7.031$, p=0.008); (iv) Among the top 6 most common cancers, lung, cervical, esophageal, colorectal and breast cancers tended to increase over the years (p<0.05), but not gastric cancer (p=0.423). Conclusions: (i) The number of cancer patients hospitalized for the first time during the past 10 years increased year by year, and was higher for female than male; (ii) the average age of patients increased year after year and was greater for male than female; (iii) the number of patients with lung cancer, cervical cancer, esophageal cancer, colorectal cancer and breast cancer increased over years.