• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.1787-1791
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• 2012

Objective: The p53 tumor suppressor pathway plays an important role in gastric cancer (GC) development. Auto-regulatory feedback control of p53 expression is critical to maintaining proper tumor suppressor function. So far, several studies between p53 Arg72Pro polymorphism and GC have generated controversial and inconclusive results. Methods: To better assess the purported relationship, we performed a meta-analysis of 19 publications. Eligible studies were identified by searching the Pubmed database. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess any link. Results: Overall, a significant association was detected between the p53 Arg72Pro polymorphism and GC risk (Pro-allele vs. Arg-allele: OR = 1.05, 95%CI = 1.01-1.08; Pro/Pro vs. Arg/Arg: OR = 1.13, 95%CI = 1.04-1.22). Moreover, on stratified analysis by race, significantly increased risk was found for Asian populations (Pro-allele vs. Arg-allele: OR = 1.06, 95%CI = 1.02-1.10; Pro/Pro vs. Arg/Arg: OR = 1.16, 95%CI = 1.07-1.26; Pro/Pro+Pro/Arg vs. Arg/Arg: OR = 1.58, 95%CI = 1.09-2.27). Conclusions: Our study provided evidence that the p53 72Pro allele may increase GC risk in Asians. Future studies with larger sample size are warranted to further confirm this association in more detail.

• The Journal of the Korea Contents Association
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• v.13 no.2
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• pp.235-243
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• 2013

This study analyzes the interaction of variables consisting of the local finance system based on the theory of system thinking regarding how financial decentralization can be understood as the political means for local decentralization and why it is needed. The results gained from this research are as follows: first, variables consisting of the local finance system form interactional relationship in the significant level, and it has been found that rapid growth and rapid decline repeat with five positive feedback loops as the center. Second, strategic points for the validity of local finance decentralization were discovered through causal map modeling. In particular, it has been shown that the virtuous cycle structure declines the local finance system through the constant operation of variables (government subsidies, taxation for real estate transactions, central government's local finance mediation system, and local government debt, etc.) that deteriorate the vicious cycle structure. Based on this, strategic policy tasks were drawn. It is expected that this study will help the understanding of the local finance system and increase academic width for local finance from the aspects of general knowledge, not the knowledge about local finance decentralization.

• Journal of KIISE:Software and Applications
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• v.32 no.5
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• pp.428-437
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• 2005

An ontology consists of a set and definition of concepts that represents the characteristics of a given domain and relationship between the elements. To reduce time-consuming and cost in building ontology, this paper proposes a semiautomatic method to build a domain ontology using the results of text analysis. To do this, we Propose a terminology processing method and use the extracted concepts and semantic relations between them to build ontology. An experiment domain is selected by the pharmacy field and the built ontology is applied to document retrieval. In order to represent usefulness for retrieving a document using the hierarchical relations in ontology, we compared a typical keyword based retrieval method with an ontology based retrieval method, which uses related information in an ontology for a related feedback. As a result, the latter shows the improvement of precision and recall by $4.97\%$ and $0.78\%$ respectively.

• Korean Journal of Crystallography
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• v.4 no.2
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• pp.100-104
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• 1993

Reduced glutathione (GSH) plays a vital role in the metabolism of all cells. Glutathions, a tripeptide cowfosed of glutamic acid, cysteane, and gtycina is synthesized by two synthesized reutions. The first is catalyzed by Y-glutamylcysteine synthetase (GSH-I) and the second by glutathione synthetase (GSH-ll). The glutathione biosynthetic pathway of E. coziis mainly controlled by nonallosteric feedback inhibition of GHS-I by GSH. Determination of the three-dimensional structure of GSH-I by X-ray crystallography is necessary in order to understand the structure-function relationship at the molecular level. As the (irst step toward its structure determination, crystallization of 5. coli V-glutamylcystfine synthetase (GSH-I) has been achived using the hanging drop vapor diffusion method and capillaw method. Crystals of GSH-I have been grown from ammonium sulfate solution. The crystals grew at room temperature within 10 days to dimensions of 0.2 m x 0.2 m x 0.2 ml by hanging drop vapor diffusion method and diffracted to about 4 A resolution using synchrotron X-rays. Another crystal, grown by the capillary method to dimensions of 0.25 mm x 0.25 mm x 0.3 mm within 40 days, diffracted to about 4 A resolution using X-rays from a rotating anode.

• Journal of Welding and Joining
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• v.12 no.1
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• pp.59-72
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• 1994

This paper presents an on-line quality monitoring and control method to obtain a uniform weld quality in gas metal arc welding (GMAW) processes. The geometrical parameters of the weld pool such as the top bead width and the penetration depth plus half back width are utilized to assess the integrity of the weld quality. Since a good quality weld is characterized by a relatively high depth-to-width ratio in its dimensions, the second geometrical parameter is regulated to a desired one. The monitoring variables are the surface temperatures measured at various points on the top surface of the weldment which are strongly related to the formation of the weld pool The relationship between the measured temperatures and the weld pool size is implemented on the multilayer perceptrons which are powerful for realization of complex mapping characteristics through training by samples. For on-line quality monitoring and control, it is prerequisite to estimate the weld pool sizes in the region of transient states. For this purpose, the time history of the surface temperatures is used as the input to the neural estimator. The control purpose is to obtain a uniform weld quality. In this research, the weld pool size is directly regulated to a desired one. The proposed controller is composed of a neural pool size estimator, a neural feedforward controller and a conventional feedback controller. The pool size estimator predicts the weld pool size under growing. The feedforward controller compensates for the nonlinear characteristics of the welding process. A series of simulation studies shows that the proposed control method improves the overall system response in the presence of changes in torch travel speed during GMA welding and guarantees the uniform weld quality.

• Molecules and Cells
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• v.39 no.3
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• pp.229-241
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• 2016

We have previously reported the role of miR-326-HDAC3 loop in anti-cancer drug-resistance. CAGE, a cancer/testis antigen, regulates the response to anti-cancer drug-resistance by forming a negative feedback loop with miR-200b. Studies investigating the relationship between CAGE and HDAC3 revealed that HDAC3 negatively regulated the expression of CAGE. ChIP assays demonstrated the binding of HDAC3 to the promoter sequences of CAGE. However, CAGE did not affect the expression of HDAC3. We also found that EGFR signaling regulated the expressions of HDAC3 and CAGE. Anti-cancer drug-resistant cancer cell lines show an increased expression of $pEGFR^{Y845}$. HDAC3 was found to negatively regulate the expression of $pEGFR^{Y845}$. CAGE showed an interaction and co-localization with EGFR. It was seen that miR-326, a negative regulator of HDAC3, regulated the expression of CAGE, $pEGFR^{Y845}$, and the interaction between CAGE and EGFR. miR-326 inhibitor induced the binding of HDAC3 to the promoter sequences in anti-cancer drug-resistant $Malme3M^R$ cells, decreasing the tumorigenic potential of $Malme3M^R$ cells in a manner associated with its effect on the expression of HDAC3, CAGE and $pEGFR^{Y845}$. The down-regulation of HDAC3 enhanced the tumorigenic, angiogenic and invasion potential of the anti-cancer drug-sensitive Malme3M cells in CAGE-dependent manner. Studies revealed that $PKC{\delta}$ was responsible for the increased expression of $pEGFR^{Y845}$ and CAGE in $Malme3M^R$ cells. CAGE showed an interaction with $PKC{\delta}$ in $Malme3M^R$ cells. Our results show that HDAC3-CAGE axis can be employed as a target for overcoming resistance to EGFR inhibitors.

• Journal of Korean Association for Spatial Structures
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• v.7 no.2 s.24
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• pp.115-124
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• 2007

The initial shape is arrived at by a self-formation process, which accomplishes a form in the natural world, or is determined analytically by considering the equilibrium of initial stress only. Therefore, the self-formation process, which accomplishes a form in the natural world is grasped and the types of modeling techniques available to find the shapes of soft structures are well investigated and classified. To establish a form-finding modeling techniques, the models of string, soap film, fabric, rubber, plaster, and etc. are used. These modeling techniques can be used as a method of understanding the characteristics of structures when the material of model shows similar characteristics. Generally, the model test confirms the structure based on numerical analysis, at the same time it is important preceding process to develop such a program. With the above process, the relationship between model test and numerical analysis becomes a feedback process. Therefore, in this study, two examples which have been accomplished from such a technique are investigated and considered according to modeling process.

• Journal of Convergence Society for SMB
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• v.3 no.1
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• pp.7-13
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• 2013

It will prove that with a more plausible specification of the relationship between income and the value of leisure, we can develop a more accurate model of the labor market without necessarily losing the primary merit of the received model. Moreover, with an improved understanding of labor market dynamic we can see that progressive era labor market legislation, designed to mitigate the effects of bargaining power inequality in low wage labor markets, was in fact based upon sensible economic foundations. The results of this study as follow; These low-wage dynamics present an example of a positive feedback system or "vicious circle" at work in the economy. With the revised labor supply schedule presented above, the market dynamic of the low wage sector push the wage away from the range that is consistent with a self-regulating market.

• Journal of Gifted/Talented Education
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• v.15 no.1
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• pp.37-48
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• 2005

Comparing to the other subject, the relationship among physics contents is strong from the perspective of knowledge order as grades go up. That is, The things already that students learned, are learning and will learn are closed related from grade to grade. We expect students to be proactive and creative in studying physics, which is the goal of 21th century, analyzing their knowledge structure based on the knowledge order through assessment. Especially, using computer system, we provide students with substantial feedback for the assessment as well as objective validity is increased along with speedy and exact process in a bid to help students' mathematical understanding grow. This paper seeks to analyze the data from assessment applying knowledge spaces of the scientifical gifted in selective examination and to applicate on development of evaluation method.

• Physical Therapy Korea
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• v.18 no.4
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• pp.19-25
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• 2011

The aims of this study were to investigate the correlation between the electromyographic (EMG) activity of the abductor hallucis (AbdH) and the amount of pressure measured by a pinch gauge (PG), and to compare the EMG activity of AbdH and the pressure measured by the PG during short foot (SF) exercise in subjects with pes planus and in subjects with a neutral foot alignment. Fourteen subjects were recruited for this study (pes planus group=7; neutral foot alignment group=7). A surface EMG was used to collect AbdH activity, and a PG was positioned under the first metatarsophalangeal joint to measure the pressure produced by the first metatarsal head during the SF exercise. The AbdH activity and the pressure measured by the PG showed a positive good correlation (r=.80, p<.05). The EMG activity of the AbdH and the pressure measured by the PG were significantly lower for subjects with pes planus than for subjects with a neutral foot alignment (p<.05). Based on these findings, the PG can be recommended as an effective instrument for evaluating the performance of the AbdH. It may also be beneficial for monitoring how well the SF exercise is performed, and for providing visual feedback to patients with pes planus during SF exercise in a clinical setting.