• 한국기계가공학회지
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• 제11권6호
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• pp.42-47
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• 2012

Followed by a paper on the Pig and Bone orthopedic prosthetic, this experiment using Phantom and Bone MRI imaging I, II of orthopedic prosthetic metal effect combines magnetic resonance imaging on metal signal-to-noise ratio(Signal to noise : SNR) and CNR(Contrast to noise: CNR), fat signal suppression(Fat-suppression) images was compared. Specimen trees to measure the reliability of the experimental reproducibility tests and statistical analysis using the SPSS statistical package was applied program SPSS(IBM SPSS Statistice 19) by * P = 0.000 < significance level $({\alpha})$ = 0.01 as a significant there was a correlation(** P < 0.01). SNR and CNR results did not directly proportional to the Titanium, Stainless, Clip CNR and fat signal suppression of the order of images of blood specimens was found to be close to the image. The impact of orthopedic prosthetic metals on magnetic resonance imaging in the diagnostic value of Titanium is relatively high and are meant more.

• 생약학회지
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• 제46권1호
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• pp.65-71
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• 2015

Although it has recently been reported that Acanthopanax senticosus has a protective effect against the development of metabolic disorders such as diabetes and hyperlipidemia, its underlying molecular mechanisms have remained to be elucidated. In this study, we observed that treatment of an extract of A. senticosus (ASE) reduced body weight and adiposity and improved glucose tolerance in high-fat diet (HFD)-induced obese mice. HFD-induced weight gain in white adipose tissues and liver was also significantly reduced in ASE-treated HFD-fed mice, which was found to be contributed by suppression of mRNA expression of genes involved in fatty-acid uptake and fat synthesis in white adipose tissue. ASE treatment also attenuated M1 macrophage activation, increased regulatory T ($T_{reg}$) cell population, and modulated leptin/adiponectin profile that might alleviate chronic inflammation to protect against HFD-induced insulin resistance. Our findings suggest a therapeutic potential of ASE for prevention and treatment of type 2 diabetes without adverse effects such as weight gain and dyslipidemia.

• Journal of Microbiology and Biotechnology
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• 제28권8호
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• pp.1391-1400
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• 2018

Angelica tenuissima root has historically been used as a traditional medicine in Korea. Previous studies have identified the anti-melanogenic effects of the extract of A. tenuissima root fermented by Aspergillus oryzae (FAT). This study investigated the protective effects of FAT against ultraviolet light B exposure (UVB; $30mJ/cm^2$) in HaCaT (human keratinocyte) or Hs68 (human foreskin fibroblast) skin cells. FAT treatment was able to stimulate wound healing rate at the basal condition. FAT also favored the maintenance and/or improvement of extracellular matrix impairment caused by UVB irradiation through: 1) upregulation of procollagen Type-1 synthesis and secretion; 2) suppression of MMP-1 and elastase expression. FAT was able to play a role in the attenuation of inflammatory responses caused by UVB irradiation via upregulation of photo-protective hemeoxygease-1 and suppression of proinflammatory cyclooxygenase-2 expression. After further verification of the anti-photoaging potential of FAT, it could be utilized as an effective ingredient in anti-aging and anti-wrinkle cosmetics.

• Journal of Nutrition and Health
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• 제32권5호
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• pp.533-539
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• 1999

The effects of capsaicin, a pungent principle of hot red pepper, on body fat gain, balance serum lipid values were investigated in rats fed a high-fat(30%) diet. Administration of capsaicin by dietary administration caused a complete cessation of increased in body weight and fat gain induced by the high-fat diet. However, energy intake and body protein gain were not affected by capsaicin. Therefore, the suppression of body fat gain by capsaicn was believed due to an increased in energy expenditure. Simultaneous administration of capsaicin and a $\beta$-adrenergic blocker, propranolo, resulted in the inhibition of changes in body fat gain by capsaicin without remained unchanged, indicating an increase in the number of mitochondria in brown adipose tissue. Therefore, it appears that capsaicin possesses potent body fat suppressive effects mediated by $\beta$-adrenergic stimulation in which brown adipose tissue may be involved. On the other hand, capsaicin had no effects on serum triglyceride, total cholesterol or HDL-cholesterol levels. These results are in contrast to those reported by other investigators. Perhaps expression of the effects of capsaicin on plasma lipids is a rather complicated process, dependent on the type of diet administered, fat content of the diet, period and route of capsaicin administration, and species and strain of animals used.

• Nutrition Research and Practice
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• 제7권4호
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• pp.267-272
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• 2013

The anti-obesity effects of a hot water extract from wasabi (Wasabia japonica Matsum.) leaves (WLE), without its specific pungent constituents, such as allyl-isothiocyanate, were investigated in high fat-diet induced mice. C57J/BL mice were fed a high-fat diet (control group) or a high-fat diet supplemented with 5% WLE (WLE group). Physical parameters and blood profiles were determined. Gene expression associated with lipid metabolism in liver and white adipose tissue were analyzed. After 120 days of feeding, significantly lower body weight gain, liver weight and epididymal white adipose tissue weight was observed in the WLE group compared to the control group. In liver gene expression within the WLE group, PPAR${\alpha}$ was significantly enhanced and SREBP-1c was significantly suppressed. Subsequent downstream genes controlled by these regulators were significantly suppressed. In epididymal white adipose tissue of the WLE group, expression of leptin, PPAR${\gamma}$, and C/EBP${\alpha}$ were significantly suppressed and adiponectin was significantly enhanced. Acox, related to fatty acid oxidization in adipocytes, was also enhanced. Our results demonstrate that the WLE dietary supplement induces mild suppression of obesity in a high-fat diet induced mice, possibly due to suppression of lipid accumulation in liver and white adipose tissue.

• Investigative Magnetic Resonance Imaging
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• 제17권2호
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• pp.110-122
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• 2013

목적: 발목관절 VISTA 자기공명영상을 이용하여 지방억제를 한 것과 하지 않은 VISTA 사이에서 정량평가를 하며, 발목 인대의 traceability 차이를 알아보고자 하였다. 대상과 방법: SNR의 비교를 위해 팬텀과 한명의 자원자에서 자기공명영상을 촬영하였다. CR (contrast ratio)과 인대 traceability 비교를 위해 발목 관절의 외상 과거력이 없는 10명의 자원자에서 자기공명영상을 촬영하였다. 모든 자기공명영상은 VISTA를 이용하였고 3T에서 촬영하였다. 지방억제는 SPAIR (Spectral Attenuated Inversion Recovery) 기법을 이용하였다. SNR은 피검자가 있을 때와 피검자 없이 촬영한 것으로 구하였다. CR은 열개의 오른쪽 발목관절의 관절액-힘줄, 관절액-연골, 관절액-인대, 지방-힘줄, 지방-연골, 지방-인대의 신호강도를 얻어 구하였다. 두 명의 근골격계 영상의학과 의사가 지방억제를 한 것과 하지 않은 영상을 calcaneofibular ligament (CFL)을 포함한 7개의 발목관절 인대에 대해서 점수를 매겼다 (1, not traceable; 2, barely traceable; 3, adequately traceable; 4, excellently traceable). VISTA 와 VISTA SPAIR 사이에 CR을 비교하는 데는 Wilcoxon signed-rank test를 이용하였다. VISTA 와 VISTA SPAIR사이에 인대 traceability를 비교하는 데에는 Fisher's exact test와 Pearson's chi-squared test를 이용하였다. 결과: 정량평가의 SNR을 보면 지방억제를 하지 않은 영상에 비해 지방억제를 한 자원자의 골수에서 더 낮은 수치를 나타내었다. (7.65 versus [vs.] 36.64). 관절액, 연골, 근육에서는 두 연쇄간에 SNR의 차이가 없었다. 지방억제 VISTA는 관절액-인대 사이 CR만 더 나은 결과를 보여주었지만 (p=0.04) VISTA는 지방-힘줄, 지방-연골, 지방-인대 간에서 모두 더 나은 CR값을 나타내었다(P=0.005). CFL 인대만 통계학적으로 의미 있는 값을 보였는데 지방억제를 하지 않은 VISTA 영상에서 traceability의 값이 더 우세 하였다(p <0.05). 결론: 지방 억제를 한 VISTA와 하지 않은 VISTA에서 유의한 SNR 차이는 골수를 제외하고 없었다. 지방억제를 하지 않은 VISTA에서 CFL을 trace하는데 있어서 더 유리하였다.

• 한국방사선학회논문지
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• 제8권5호
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• pp.271-278
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• 2014

상완신경총에서 STIR(short TI inversion recovery) 지방소거 강조영상과 SPAIR(spectral adiabatic inversion recovery) T2, T1 지방소거 강조영상기법을 비교 평가하여 최적의 지방소거 기법을 알아보고자 하였다. 총 30 명 상완신경총에 질환이 없는 정상인 지원자를 대상으로 3.0 T MRI 기기를 이용하여 검사를 하였고, 분석방법으로 세 기법에 대하여 SNR, CNR 및 4단계 점수로 평가를 하였다. 정량적 분석 결과로 SPAIR T1 기법에 대한 SNR, CNR 값은 상완신경총기시부($03.07{\pm}0.98$, $-2.25{\pm}0.54$), 상완신경총몸체($06.70{\pm}1.81$, $36.31{\pm}2.17$)에서 높은 값을 제공하였다 (p<0.05). 정성적 분석결과 상완신경총 묘출도와 지방소거 정도, 영상의 인공물은 SPAIR T1($3.2{\pm}0.70$, $3.6{\pm}0.51$, $3.4{\pm}0.10$)기법이 의미 있게 높게 나타났다(p<0.05).

• 대한방사선기술학회지:방사선기술과학
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• 제32권1호
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• pp.95-99
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• 2009

본 연구는 뇌의 T2고속스핀에코 3.0T 자기공명영상에서 지방조직의 억제능력을 유지하면서 동시에 지방조직의 불균일성을 최소화할 수 있는 SPAIR의 적정 반전시간(TI)을 찾아보고, 지방억제기법인 STIR기법과도 비교하고자 한다. SPAIR 프로토콜의 반전시간(TI)은 SPAIR TR(420 msec)의 1/2, 1/3, 1/6, 1/12, 즉 210 msec(8명), 140 msec(26명), 70 msec(26명), 35 msec(18명)로 설정하고, STIR의 TI는 250 msec(26명)로 설정하여 뇌의 축방향 영상(104개)을 획득하였다. 출력영상의 지방조직, 근육조직, 백그라운드의 ROI($50\;mm^2$)를 설정하여 신호강도(SI)를 측정하였고, 지방과 근육조직과의 CNR을 산출하고, 지방조직에서 불균일치는 측정된 지방 신호의 평균치(mean)에 대한 표준편차(SD)로서 그 산출은 SD/mean으로 계산하였다. 측정결과는 첫째, SPAIR TI가 70 ms일 때, 지방조직의 신호강도가 TI가 140 ms 보다 낮게 측정되어 지방억제능력이 우수하였다. 둘째, SPAIR TI가 140 ms일 때, 영상의 질 측면에서 지방조직의 불균일치는 70 ms 보다 낮아서 영상의 질은 우수하게 나타났다. 따라서 SPAIR TI의 선택은 TR(420 ms)의 1/3인 140 ms와 1/6인 70 ms에서 결정되어야 하는데 지방조직의 억제능력과 지방조직의 불균일치에서 각각 통계적으로 유의한 차이(p < .001)를 보여 화질 측면에서 TI : 140 ms를 선택하는 것이 바람직하다고 생각한다. 한편, SPAIR(TI : 140 ms)와 STIR의 비교는 지방억제는 통계적으로 유의한 차이가 없으나(p < .252), 화질 측면에서 SPAIR가 STIR보다 우수한 결과를 보였고, 통계적으로 유의한 차이를 보였다(p < .01).

• 대한방사선과학회:학술대회논문집
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• 대한방사선과학회 1993년도 학술대회
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• pp.32-32
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• 1993

• Food Science and Biotechnology
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• 제17권2호
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• pp.362-366
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• 2008

Anti-lipogenic effects of tannic acid on 3T3-L1 adipocytes as well as on rats fed high fat diet (HFD) were investigated. Tannic acid stimulated lipolysis through suppression of the leptin secretion and an increase of glycerol release in a dose dependent manner in 3T3-L1 adipocytes. For animal study, the rats were fed either HFD or HFD supplemented with 1%(w/w) tannic acid (HFDT) for 12 weeks, respectively. Body weight gain, liver weight, and visceral fat mass in rats fed HFDT were significantly decreased compared to those of rats fed HFD. The lipid profiles of HFDT group were significantly decreased compared with HFD group in the serum and liver, whereas fecal total cholesterol excretion was increased in HFDT group. These results suggest that anti-lipogenic effect of tannic acid in 3T3-L1 adipocytes and in rats fed HFD may be due to the stimulation of lipolysis and the reduction of lipid levels.