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Suppression of Fat Accumulation and Improvement of Glucose Tolerance in High-fat Diet-induced Obese Mice Treated with an Acanthopanax senticosus Extract  

Kim, Bobae (School of Life Science, Handong Global University)
Hyun, Chang-Kee (School of Life Science, Handong Global University)
Publication Information
Korean Journal of Pharmacognosy / v.46, no.1, 2015 , pp. 65-71 More about this Journal
Abstract
Although it has recently been reported that Acanthopanax senticosus has a protective effect against the development of metabolic disorders such as diabetes and hyperlipidemia, its underlying molecular mechanisms have remained to be elucidated. In this study, we observed that treatment of an extract of A. senticosus (ASE) reduced body weight and adiposity and improved glucose tolerance in high-fat diet (HFD)-induced obese mice. HFD-induced weight gain in white adipose tissues and liver was also significantly reduced in ASE-treated HFD-fed mice, which was found to be contributed by suppression of mRNA expression of genes involved in fatty-acid uptake and fat synthesis in white adipose tissue. ASE treatment also attenuated M1 macrophage activation, increased regulatory T ($T_{reg}$) cell population, and modulated leptin/adiponectin profile that might alleviate chronic inflammation to protect against HFD-induced insulin resistance. Our findings suggest a therapeutic potential of ASE for prevention and treatment of type 2 diabetes without adverse effects such as weight gain and dyslipidemia.
Keywords
Acanthopanax senticosus; Diet-induced obesity; Insulin resistance; Anti-diabetic; Anti-obesity; Chronic inflammation;
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