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Anti-lipogenic Effects of Tannic Acid in 3T3-L1 Adipocytes and in High Fat Diet-fed Rats  

Kim, Hyun-Ju (Department of Food Science and Nutrition/Kimchi Research Institute, Pusan National University)
Yun, Ye-Rang (Department of Food Science and Nutrition/Kimchi Research Institute, Pusan National University)
Song, Yeong-Bok (Sejeon Food Research Institute, Sejeon Co., Ltd.)
Song, Yeong-Ok (Department of Food Science and Nutrition/Kimchi Research Institute, Pusan National University)
Publication Information
Food Science and Biotechnology / v.17, no.2, 2008 , pp. 362-366 More about this Journal
Abstract
Anti-lipogenic effects of tannic acid on 3T3-L1 adipocytes as well as on rats fed high fat diet (HFD) were investigated. Tannic acid stimulated lipolysis through suppression of the leptin secretion and an increase of glycerol release in a dose dependent manner in 3T3-L1 adipocytes. For animal study, the rats were fed either HFD or HFD supplemented with 1%(w/w) tannic acid (HFDT) for 12 weeks, respectively. Body weight gain, liver weight, and visceral fat mass in rats fed HFDT were significantly decreased compared to those of rats fed HFD. The lipid profiles of HFDT group were significantly decreased compared with HFD group in the serum and liver, whereas fecal total cholesterol excretion was increased in HFDT group. These results suggest that anti-lipogenic effect of tannic acid in 3T3-L1 adipocytes and in rats fed HFD may be due to the stimulation of lipolysis and the reduction of lipid levels.
Keywords
tannic acid; 3T3-L1 adipocyte; high fat diet; fecal fat excretion; anti-lipogenic effect;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
Times Cited By Web Of Science : 1  (Related Records In Web of Science)
Times Cited By SCOPUS : 1
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