• 정보처리학회논문지B
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• 제14B권6호
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• pp.431-436
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• 2007

자기공명영상(Magnetic Resonance Imaging:MRI)은 물과 지방 사이에 화학적 이동 현상을 가지고 있고 지방에 의해 구조적 현상이 나타난다. 또한 지방은 기본적으로 강한 신호를 가지고 있어 잘못된 인공물을 형성한다. 그래서 지방소거(fat suppression)에 대해 연구하고자 한다. MRI에서 지방소거(fat suppression)방법만을 사용하여 진단하는데 약간의 어려움은 있지만 기본은 화학적 이동 선택 포화(chemical shift selective saturation : CHESS) pulse 방법을 이용하여 물과 지방 phantom을 가지고 지방소거(fat suppression)를 연구하는데 목적이 있다. 본 연구에서 CHESS pulse를 matlap 프로그램을 이용 Map pulse로 알맞게 design하고 Pre saturation을 하기 위한 pulse diagram이 가능하였고, fat phantom과 water phantom을 실험하여 지방소거 기법(fat saturation)의 효과를 볼 수가 있었으며 임상 적용 부위로 경추(C-SPINE), 요추(L-SPINE), 가습(BREAST)에 적용하여 의료영상진단에 있어 화학적 이동 선택 포화 CHESS pulse의 지방소거(fat suppression)는 유용한 방법임을 증명하였다.(충남대학병원 G.E 1.5T MR를 이용하여 실험하였다.)

• Journal of Magnetics
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• 제17권2호
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• pp.145-152
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• 2012

Patients who underwent hip arthroplasty using the conventional fat suppression technique (CHESS) and a new technique (IDEAL) were compared quantitatively to assess the effectiveness and usefulness of the IDEAL technique. In 20 patients who underwent hip arthroplasty from March 2009 to December 2010, fat suppression T2 and T1 weighted images were obtained on a 3.0T MR scanner using the CHESS and IDEAL techniques. The level of distortion in the area of interest, the level of the development of susceptibility artifacts, and homogeneous fat suppression were analyzed from the acquired images. Quantitative analysis revealed the IDEAL technique to produce a lower level of image distortion caused by the development of susceptibility artifacts due to metal on the acquired images compared to the CHESS technique. Qualitative analysis of the anterior area revealed the IDEAL technique to generate fewer susceptibility artifacts than the CHESS technique but with homogeneous fat suppression. In the middle area, the IDEAL technique generated fewer susceptibility artifacts than the CHESS technique but with homogeneous fat suppression. In the posterior area, the IDEAL technique generated fewer susceptibility artifacts than the CHESS technique. Fat suppression was not statistically different, and the two techniques achieved homogeneous fat suppression. In conclusion, the IDEAL technique generated fewer susceptibility artifacts caused by metals and less image distortion than the CHESS technique. In addition, homogeneous fat suppression was feasible. In conclusion, the IDEAL technique generates high quality images, and can provide good information for diagnosis.

• Journal of Korean Neurosurgical Society
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• 제29권6호
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• pp.810-814
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• 2000

We report two cases of spinal subdural hematoma in the lumbar region after trauma. They developed in a 27-years old man and a 32-year-old woman. They had no other causes such as bleeding tendency, preexisting spinal lesions, lumbar puncture, vascular malformation and anticoagulant therapy. There lesions were diagnosed with MRI(fat suppression) and treated by lumbar puncture.

• 대한디지털의료영상학회논문지
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• 제14권1호
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• pp.31-35
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• 2012

To test the real image quality of a spectral attenuated inversion-recovery (SPAIR) fat-suppression (FS) techniquein clinical abdominal MRI by comparison to turbo spin echo inversion-recovery (TSEIR) fat-suppression (FS) technique. 3.0T MRI studies of the abdomen were performed in 30 patients with liver lesions (hemangiomas n: 15; HCC n: 15). T2W sequences were acquired using SPAIR TSEIR. Measurements included retroperitoneal and mesenteric fat signal-to-noise (SNR) to evaluate FS; liver lesion contrast-to-noise (CNR) to evaluate bulk water signal recovery effects; and bowel wall delineation to evaluate susceptibility and physiological motion effects. SPAIR-TSEIR images produce significantly improved FS and liver lesion CNR. The mean SNR of the retroperitoneal and mesenteric fat for SPAIR were 20.5, 10.2 and TSEIR were 43.2, 24.1 (P<0.05). SPAIR-TSEIR images produced higher CNR for both hemangiomas CNR 164.88 vs 126.83 (P<0.05) and metastasis CNR 75.27 vs 53.19 (P<0.05). Bowel wall visualization was significantly improved using in both SPAIR-TSEIR (P< 0.05). The real image quality of SPAIR was better than over conventional TSEIR FS on clinical abdominal MRI scans.

• 디지털융복합연구
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• 제11권11호
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• pp.529-536
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• 2013

본 실험의 목적은 TSE-CHESS 지방소거와 TSE-SPAIR 지방소거 기법을 비교하여 인체굴곡부위 지방소거에 있어서 TSE-SPAIR 기법의 임상적 유용성을 알아보고자 하였다. 총 25명의 경추질환이 없는 정상인을 대상으로 3.0 T MRI 기기를 이용하여 검사를 하였고, 사용된 두 기법에 대한 인체굴곡 부위 지방소거에 대한 정량적 분석으로 PSNR과 CNR을 평가하였다. 실험결과로 굴곡부위에 대한 PSNRs 과 CNRs 값은 TSE-SPAIR 기법이 유의성 있는 결과를 얻었다. 결론적으로, TSE-CHESS 지방소거와 TSE-SPAIR 지방소거 기법을 비교했을 때, 인체굴곡 부위에 대한 지방소거 평가에서 증가된 PSNRs 과 CNRs 값을 얻었다. 이러한 결과는 향후 인체굴곡 부위 지방소거 진단에 유용성 있는 정보를 제공 할 것이다.

• 한국산학기술학회논문지
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• 제14권10호
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• pp.4962-4969
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• 2013

본 실험의 목적은 TSE-SPIR 지방소거기법과 GE-PROSET 지방소거기법을 비교하여 복부자기공명영상에서 최적의 T2 강조 지방소거기법을 평가하고자 한다. 자기공명영상 검사는 16채널 다중채널을 사용하여 1.5 T(Philips, Medical System, Achieva)기기로 수행하였다. 모든 영상은 TSE-SPIR과 GE-PROSET을 이용하여 축면상(axial plane)을 얻었다. TSE-SPIR과 GE-PROSET에 대한 후복막 지방의 평균 SNRs는 31.50, 4.15 이었으며, 장간막 지방에 대한 SNRs는 32.39, 7.03이었다. TSE-SPIR과 GE-PROSET에서 장과 후복막 지방, 장간막 지방의 CNRs는 152.69, 74.54 와 26.12, 68.78이었다. 장벽에 대한 묘출도는 TSE-SPIR(2.4), GE-PROSET(1.8)로 TSE-SPIR가 높게 나타났으며, 췌장벽(pancreas wall)에 대한 묘출도는 TSE-SPIR(1.90), GE-PROSET(2.80)로 GE-PROSET가 높게 나타났다. 결론적으로, T2 강조 지방소거 복부자기공명영상에서 GE-PROSET 지방소거기법 보다 TSE-SPIR 지방소거기법이 우위성 있은 평가를 얻었다.

• Investigative Magnetic Resonance Imaging
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• 제20권1호
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• pp.44-52
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• 2016

Purpose: To quantitatively and qualitatively compare fat-suppressed MRI quality using iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) with that using frequency selective fat-suppression (FSFS) T2- and postcontrast T1-weighted fast spin-echo images of the head and neck at 3T. Materials and Methods: The study was approved by our Institutional Review Board. Prospective MR image analysis was performed in 36 individuals at a single-center. Axial fat suppressed T2- and postcontrast T1-weighted images with IDEAL and FSFS were compared. Visual assessment was performed by two independent readers with respect to; 1) metallic artifacts around oral cavity, 2) susceptibility artifacts around upper airway, paranasal sinus, and head-neck junction, 3) homogeneity of fat suppression, 4) image sharpness, 5) tissue contrast of pathologies and lymph nodes. The signal-to-noise ratios (SNR) for each image sequence were assessed. Results: Both IDEAL fat suppressed T2- and T1-weighted images significantly reduced artifacts around airway, paranasal sinus, and head-neck junction, and significantly improved homogeneous fat suppression in compared to those using FSFS (P < 0.05 for all). IDEAL significantly decreased artifacts around oral cavity on T2-weighted images (P < 0.05, respectively) and improved sharpness, lesion-to-tissue, and lymph node-to-tissue contrast on T1-weighted images (P < 0.05 for all). The mean SNRs were significantly improved on both T1- and T2-weighted IDEAL images (P < 0.05 for all). Conclusion: IDEAL technique improves image quality in the head and neck by reducing artifacts with homogeneous fat suppression, while maintaining a high SNR.

• 대한한의학회지
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• 제30권1호
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• pp.17-25
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• 2009

Objectives: This study was on the pharmaceutical components in purified ginseng total saponin (GTS), coisis semen (CS), the combination of these drugs, and the major component of coicis coixol for the prevention and treatment of obesity. Methods: In this study, to evaluate the effect on the suppression of obesity, high fat diet-induced obese rats were treating with the drugs, the effects on the balance of energy and diet activity were examined, and the change of weight, the change of the intake of diet, body fat rate, etc. were assessed. Results: The results demonstrate that in high fat diet-induced obese white rats, the combination treatment of ginseng total saponin and coicis was effective in suppression of weight gain, reduction of intake of food, and reduction of body fat. Conclusions: The results suggest that a combination treatment with major components of red ginseng total saponin and coicis may be used therapeutically for the suppression and treatment of obesity.

• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회 1999년도 춘계학술대회 제3차 심포지움
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• pp.26-33
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• 1999

이 강의의 목적은 fat suppresion 과 water suppression에 관계되는 수소자기공명영상법의 기본 원리를 포괄적으로 이해하는데 있다. 임상적으로 이런 Technique의 수행이 필요한 가장 간단한 이유는 다른 병소의 신호와 구별을 하고 불필요한 artifact을 제거하기 위함이다.

• Fisheries and Aquatic Sciences
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• 제15권1호
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• pp.21-27
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• 2012

Ground seawater in the east area of the volcanic Jeju Island contains abundant minerals. We investigated the metabolic activity of electrodialyzed, desalted ground seawater (EDSW) from Jeju in both cultured cells and animals. The addition of EDSW to the culture medium (up to 20%, v/v) reduced the leakage of lactate dehydrogenase and increased MTT activity in CHO-IR cells. EDSW (10%) promoted insulin-induced glucose consumption in L6 muscle cells as well as the activities of the liver ethanol-metabolizing enzymes, alcohol dehydrogenase and aldehyde dehydrogenase. Moreover, EDSW suppressed palmitate-induced intracellular fat accumulation in human hepatoma $HepG_2$ cells. Activities of AMP-stimulated protein kinase and acetyl CoA carboxylase, enzymes that modulate fat metabolism, were altered by EDSW in $HepG_2$ cells toward the suppression of intracellular lipid accumulation. EDSW also suppressed hepatic fat accumulation induced by a high-fat diet in mice. Taken together, EDSW showed beneficial metabolic effects, including the enhancement of ethanol metabolism and insulin-induced glucose consumption, and the suppression of intrahepatic fat accumulation.