• Journal of Nutrition and Health
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• v.30 no.2
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• pp.123-131
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• 1997

The influence of (-0-Hydroxycitrate(HCA), shown to be a competitive inhibitor of adenosine 5-triphosphate(ATP) citrate lyase, on food intake and body weight, serum triglyceride and cholosterol level, in vivo rates of fatty acid and cholesterol synthesis, and fat cell number and size was investigated. 3 groups of female, 5 weeks old Sprague Dawley rats, 8 animals each, were ad libitum meal-fed or pair-fed(3 hours from 10 : 00 to 13 : 00) AIN based high glucose diet for a total period of 8 weeks. Providing normolipidemic rats orally with 400mg of HCA formula containing approximately 20mg of HCA 1 hour prior to daily feeding schedule significantly depressed in vivo hepatic rates of fatty acid and cholesterol synthesis in the liver and adipose tissue. Serum triglyceride and cholesterol levels were significantly reduced by HCA. At the end of treatment period, the rats administered with HCA resulted in a significantly reduction in body weight gain. The reduction in weights was attributable to a significant decrease in fat cell size with a smaller extent, but not significant, reduction in fat cell number. Rats receiving HCA demonstrated less food intake than the controls ; however, this decreased caloric intake was not fully responsible for the HCA induced depression of hepatic and adipocytic lipogenesis, since experiment using pair-fed cojntrol rats showed, less magnitude but similar results. Both a anorectic and an antilipogenic properties of HCA seem to be responsible for this weight reduction activity of HCA. The outcome of this study suggest that metabolic regulation may be a feasible approach to the control of obesity and hyperlipidemia.

• Preventive Nutrition and Food Science
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• v.14 no.2
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• pp.123-128
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• 2009

This study was conducted to evaluate the weight reduction effect of yeast hydrolysate-SR101. Thirty female college students participated in a 6 week weight control program. All subjects were randomly assigned to either the placebo group, YH-SR101 (yeast hydrolysate-SR101) group, or eX diet (product of yeast hydrolysate-SR101) group. The mean energy intake of the placebo group was 1445.2${\pm}$364.0 kcal (carbohydrate: 60.1%, protein: 25.6%, fat: 14.3%), while those of the YH-SR101 and the eX diet group were 1505.6${\pm}$296.2 kcal (carbohydrate: 60.5%, protein: 22.2%, fat: 14.8%) and 1353.8${\pm}$326.3 kcal (carbohydrate: 63.2%, protein: 20.9%, fat: 15.9%), respectively. The placebo group lost 0.19${\pm}$1.14 kg of body weight, while the treatment groups (YH-SR101 and eX diet) lost 1.13${\pm}$0.83 and 1.54${\pm}$0.74 kg of body weight, respectively. There were significant differences in the decrease in body weight between the placebo and the treatment group (p<0.05). There were also significant differences in the decrease in fat mass between the placebo and treatment group (p<0.05). Furthermore, the BMI of the YH-SR101 and the eX diet groups also differed significantly before and after the diet program (p<0.05). Additionally, the BMI and waist size reduction of the treatment groups (YH-SR101 and eX diet group) differed significantly when compared to the placebo (p<0.05). The reduction of the resting metabolic rate (RMR) blood glucose, total-cholesterol, HDL-cholesterol, LDL-cholesterol and triglyceride did not differ significantly among groups. Taken together, these findings indicate that consumption of yeast hydrolysate-SR101 and eX Diet may lead to decreased body weight and fat.

• Asian-Australasian Journal of Animal Sciences
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• v.9 no.3
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• pp.331-335
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• 1996

A study was conducted to determine the carcass composition of broilers when fed with three varying levels of dietary energy (3,000, 3,200 and 3,400 kcal/kg ME) at 20% crude protein and 0.79% Total Sulphur Amino Acid. The results showed that there was a significant (p < 0.05) increase in the ME intake of the chickens when the ME of the diet increased. Other factors like the protein intake, dressing percentage, weight gain and feed intake were not significantly affected. On the carcass, the increasing dietary ME levels resulted in a significant (p < 0.05) increase in the abdominal fat percentage and carcass fat percentage and a significant (p < 0.05) decrease in the carcass protein percentage. Similarly, the dietary ME produced a significant (p < 0.05) increase in the amount of and fat percentages of breast meat, thigh meat, and drumstick meat with a significant reduction in the protein percentage. There seemed to be an inverse relationship between the percentages of protein and fat. An increase in fat percentages always resulted in similar reduction in the protein content of the meat. These results also showed major differences between the white and red meat of the chicken.

• Journal of mucopolysaccharidosis and rare diseases
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• v.1 no.2
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• pp.44-48
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• 2015

Body fat distribution in patients with Prader-Willi syndrome (PWS) is characterized by reduce lean body mass (LBM), increased total body fat mass (FM), and lower percentage of visceral adipose tissue (VAT). Individuals with PWS seem to have a lower risk for insulin resistance with high levels of adiponectin, an anti-atherogenic adipocytokine that is decreased in visceral fat hypertrophy subjects compared to simple obese subjects, both in children and in adults. The mechanism of the reduction in visceral adiposity in PWS is still unclear. It might be related to qualitative intrinsic characteristics of adipocyte or novel genetic influences on the control of fat distribution. However, obesity remains a critical problem, and obesity status plays a crucial role in individual metabolic risk clustering and development of metabolic syndrome (Mets) in PWS children and adults. Long-term growth hormone (GH) treatment after cessation of skeletal growth improved body composition, with an increase in lean body mass and a reduction in total body fat and subcutaneous and visceral fat in PWS adults. Thus, the role of GH is important after childhood because it might attenuate obesity and Mets in PWS adult by adipocyte modification.

• Journal of the Korean Dietetic Association
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• v.2 no.2
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• pp.105-111
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• 1996

The trial was conducted to assess the impact of consulting through telephone on body weight reduction among 18 obese adult women. The degree of obesity, food intake pattern, and life style were examined through phone calls. Subjects visited our clinic and their body fat percentages were measured using impedance fat meter (model SIF-891), and were recommended and recorded to have a low calory diet with changes in the food habit and behavior. The study results are as follows: 1. There is a positive relationship between food habit, lifestyle, obese degree, and fat percentage. 2. 8-10kg and 5kg reductions in the body weight were observed among 14 subjects and 2 subjects, respectively. However, 2 subjects maintained their body weights. 3. The body reduction curve looked like a stairway (type) with low slope and was related with food intake amount. 4. It was possible to have the adequate protein intake only through the vegetable diet. 5. 15 out of 18 subjects were on the prescribed low calory diets for 3 days. Therefore, there is a time limitation to follow the diet treatment. 6. A body weight reduction altered dietary intake of foods which were rich in sweet taste, and the favorite foods were chocolate and candy.

• The Journal of Pediatrics of Korean Medicine
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• v.15 no.1
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• pp.183-194
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• 2001

Purpose : This Study was conducted to find out whether Gwakhyangjunggi-san gamibang has effects on obesity. Method : Before and after medication, we measured height, weight, Bioelectrical Impedance and calculate BMI, and obesity index from 9 obese children who participated in '2001 the 2nd Hur-jun children contest' sponsored by Kyunghee Oriental Medical Center and compared them. Results and Conclusions : 1) After medication, there was reduction of weight, but it has no statistical significance. 2) After medication, there was statistical significant reduction of BMI, obesity index. 3) After medication, there was statistical significant reduction of total fat weight and the percentage of body fat, and significant increase of muscle mass. As above statement, Gwakhyangjunggi-san gamibang has effects on obesity with significant and it is considered that additional and complement study is needed.

• The Journal of Korean Medicine
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• v.19 no.2
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• pp.391-400
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• 1998

This study was to investigate the effects of Bo-Jung-Chi-Seub-Tang administration on body composition, blood biochemistrical factors and hormonal changes during 2 weeks Weight Reduction in TaeKwonDo Athletes. 10 subjects were belong to be in elite athletes of KNUPE. They were divided two groups(administration group and non-administration) by 5 subjects in each group randomly. they were measured about body composition(% Fat, Fat Wt, LBM, TBW), Blood Biochemistrical Factors(glucose, TG, total protein, albumin, BUN, Uric acid, Ca, Pi, Mg) and Hormonal Changes(Renin, Aldosteron). As the results of the experiment, conclusions were made as follows: In terms of % Fat, Fat W.T., Mg, TG, Renin, it was shown significant differences between two groups. Although there were no significant differences, rate of weight reduction and levels of LBM, BUN in Bo-Jung-Chi-Seub-Tang administration group were changed more lower than non-administration group.

• Korean journal of food and cookery science
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• v.23 no.6
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• pp.824-831
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• 2007

This study was conducted to investigate the quality characteristics of low-fat pork patties containing fat replacers. Pectin(PE) and potato starch(PO) were added as fat replacers and physicochemical properties of the patties were evaluated after oven-roasting or pan-frying. Uncooked and cooked pork patties formulated with the fat replacers were higher in moisture and ash content and lower in fat content than those of the control. The cooking yield and reduction in diameter of the patties were significantly improved by the addition of PE or PO and oven-roasting exhibited a higher cooking yield and lower reduction in diameter than pan-frying (p<0.05). Water holding capacity(WHC) and fat retention were highest in the patties formulated with PE, while the control had the lowest WHC when cooked by oven-roasting. The Hunter L (lightness) values were not different among the patties but the Hunter a (redness) and b (yellowness) values of the low fat pork patties were higher than those of the control and oven-roasting produced higher redness values than pan frying. Hardness and brittleness were lowest in the patties with PE, while cohesiveness and springiness showed no difference among the patties (p<0.05). The sensory analysis results showed that the use of PE or PO improved the overall acceptability of the low-fat pork patties. After 30 days of storage at $-20^{\circ}C$, pH and cooking yield decreased slightly, while hardness increased in all the patties.

• Journal of Nutrition and Health
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• v.41 no.7
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• pp.634-664
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• 2008

This study investigated the effects of the nutrition education on body weight, visceral fat and diet quality in the postmenopausal women. The subjects (n = 101) were randomly divided into two groups: Nutrition education + Exercise (NEE) group (n = 51) and Exercise only (EO) group (n = 50). Nutrition education was consisted of counseling in portion control, food selection for low carbohydrate, high fiber food items and for the improvement in micronutrient intakes and diet quality. After 6 months, the reduction in the body weight and visceral fat area was significantly greater in the NEE than in the EO group. The NEE subjects were further divided into two groups according to the amount of visceral fat area reduction; high visceral fat area loss (HVL) group with a visceral fat area reduction 2.35% or greater and low visceral fat area loss (LVL) group with a reduction less than 2.35%. In the HVL group, the reduction in body weight, BMI, percent body fat, waist to hip ratio and visceral fat area was significantly greater than that in the LVL group. We observed a significant increase in the serum HDL-cholesterol level and a decrease in systolic blood pressure, fasting blood sucrose, total and LDL-cholesterol levels in the HVL group compared to the LVL group. The energyadjusted protein, fiber, calcium, vitamin $B_6$, vitamin C, vitamin E intakes were significantly increased in the HVL compared to LVL group. The index of nutritional quality (INQ) and mean adequacy ratio (MAR) were also increased in the HVL group compared to the LVL group. These results show that our nutrition education program was an effective intervention measure for the reduction of body weight and visceral fat, blood pressure, glucose and lipid levels in the blood and also for the improvement of nutrient intake and diet quality in postmenopausal women who are overweight.

• The Korean Journal of Physiology and Pharmacology
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• v.21 no.6
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• pp.633-641
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• 2017

The aim of this study is to investigate the effects of intermittent ladder-climbing exercise training on mitochondrial biogenesis and ER stress of the cardiac muscle in high fat diet-induced obese middle-aged rats. We induced obesity over 6 weeks of period in 40 male Sprague-Dawley rats around 50 weeks old, and were randomly divided into four experimental groups: chow, HFD, exercise+HFD, and exercise+chow. The exercising groups underwent high-intensity intermittent training using a ladder-climbing and weight exercise 3 days/week for a total of 8 weeks. High-fat diet and concurrent exercise resulted in no significant reduction in body weight but caused a significant reduction in visceral fat weight (p<0.05). Expression of $PPAR{\delta}$ increased in the exercise groups and was significantly increased in the high-fat diet+exercise group (p<0.05). Among the ER stress-related proteins, the expression levels of p-PERK and CHOP, related to cardiac muscle damage, were significantly higher in the cardiac muscle of the high-fat diet group (p<0.05), and were significantly reduced by intermittent ladder-climbing exercise training (p<0.05). Specifically, this reduction was greater when the rats underwent exercise after switching back to the chow diet with a reduced caloric intake. Collectively, these results suggest that the combination of intermittent ladder-climbing exercise training and a reduced caloric intake can decrease the levels of ER stress-related proteins that contribute to cardiac muscle damage in obesity and aging. However, additional validation is required to understand the effects of these changes on mitochondrial biogenesis during exercise.