• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6619-6623
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• 2013

Background:The aim of the research was to explore a cost effective, fast, easy to perform, and sensitive method for epidermal growth factor receptor (EGFR) mutation testing. Methods: High resolution melting analysis (HRM) was introduced to evaluate the efficacy of the analysis for dectecting EGFR mutations in exons 18 to 21 using formalin-fixed paraffin-embedded (FFPE) tissues and plasma free DNA from 120 patients. Results: The total EGFR mutation rate was 37.5% (45/120) detected by direct sequencing. There were 48 mutations in 120 FFPE tissues assessed by HRM. For plasma free DNA, the EGFR mutation rate was 25.8% (31/120). The sensitivity of HRM assays in FFPE samples was 100% by HRM. There was a low false-positive mutation rate but a high false-negative rate in plasma free DNA detected by HRM. Conclusions: Our results show that HRM analysis has the advantage of small tumor sample need. HRM applied with plasma free DNA showed a high false-negative rate but a low false-positive rate. Further research into appropriate methods and analysis needs to be performed before HRM for plasma free DNA could be accepted as an option in diagnostic or screening settings.

• 대한세포병리학회지
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• 제1권1호
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• pp.51-59
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• 1990

Fine needle aspiration biopsy cytology (FNA) for diagnosis of a variety of breast tumors has been proven to be a simple, safe, and cost saving diagnostic methodology with high accuracy. Cytologic specimens from 1,029 fine needle aspirations of the breast during last 3-year period were reviewed and subsequent biopsies from 107 breast lesions were reevaluated for cytohistological correlation. FNA had a sensitivity of 81.6% and a specificity of 98.3%. One oui of 107 cases biopsied revealed a false positive result (0.9%) and the case was due to misinterpretation of apocrine metaplastic cells in necrotic backgound as malignant cells. A false negative rate was 8.4% (9 of 107 cases biopsied). Six of 9 false negative cases were resulted from insufficient aspirates for diagnosis, and remaining three of 9 false negative cases revealed extensive necrosis with no or scanty viable cells on smears. The results indicate that for reducing false positive and false negative rates of FNA, an experienced cytopathologist and a proficient aspirator are of great importance.

• 정보보호학회논문지
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• 제16권6호
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• pp.111-121
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• 2006

인터넷이 빠르게 성장함에 따라 네트워크 공격기법이 변화되고 새로운 공격 형태가 나타나고 있다. 네트워크상에서 알려진 침입의 탐지는 효율적으로 수행되고 있으나 알려지지 않은 침입에 대해서는 오탐지(false negative)나 과탐지(false positive)가 너무 높게 나타난다. 또한, 네트워크상에서 지속적으로 처리되는 대량의 패킷에 대하여 실시간적인 탐지와 새로운 침입 유형에 대한 대응방법과 인지능력에 한계가 있다. 따라서 다양한 대량의 트래픽에 대해서 탐지율을 높이고 과탐지를 감소할 수 있는 방법이 필요하다. 본 논문에서는 네트워크 기반의 이상 침입 탐지 시스템에서 과탐지를 감소하고, 침입 탐지 능력을 향상시키기 위하여 다차원 연관 규칙 마이닝과 수정된 부정 선택 알고리즘(Negative Selection Algorithm)을 결합한 다중 레벨 이상 침입 탐지 기술을 제안한다. 제안한 알고리즘의 성능 평가를 위하여 기존의 이상 탐지 알고리즘과 제안된 알고리즘을 수행하여, 각각의 과탐지율을 평가, 제시하였다.

• 전기전자학회논문지
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• 제26권4호
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• pp.622-627
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• 2022

본 논문에서는 공격 횟수와 공격 유형을 모두 고려하여 차량 내 네트워크에서 해킹을 탐지하는 침입 탐지 시스템의 성능을 개선하는 기법을 제안한다. 침입 탐지 시스템에서 침입을 정상으로 잘못 인식하는 FNR(False Negative Rate)과 정상을 침입으로 잘못 인식하는 FPR(False Positive Rate)은 모두 차량의 안전에 큰 영향을 미친다. 본 논문에서는 일정 홧수 이상 공격으로 탐지된 데이터 프레임을 자동적으로 공격으로 처리하며, 자동 공격으로 판단하는 방법도 공격 유형에 따라 다르게 적용함으로서 FNR과 FPR을 모두 개선하는 침입 탐지 기법을 제안하였다. 시뮬레이션 결과 제안하는 기법은 DoS(Denial of Service) 공격과 Spoofing 공격에서 FNR과 FPR을 효과적으로 개선할 수 있었다.

• 정보보호학회논문지
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• 제12권4호
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• pp.29-39
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• 2002

침입행위에 대한 비정상행위 탐지방법은 탐지에 대한 오판율이 높게 나타난다. 즉, 실제 침입이 아닌데 침입으로 판정하는 과탐지와 실제 침입인데 탐지하지 못하는 미탐지에 대한 오판율의 경우이다. 침입탐지의 민감도를 향상시키기 위하여 오용행위 및 비정상행위 탐지센서들 사이의 관련성을 이용하여 오판율을 감소하는 통합탐지의 방법을 연구하였다. 정상행위 및 비정상행위에 대해 하나의 탐지센서로부터의 결과가 다른 탐지센서에 의한 결과와 어떠한 관련성을 갖고 있는지의 반영비율을 오프라인에서 생성하고, 이를 실시간에 탐지된 결과에 적용하여 오판율을 감소하도록 하였다.

• 대한건축학회논문집:구조계
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• 제36권3호
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• pp.113-120
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• 2020

The purpose of this study is to compare the models of Deep Learning-based Convolution Neural Network(CNN) for concrete crack detection. The comparison models are AlexNet, GoogLeNet, VGG16, VGG19, ResNet-18, ResNet-50, ResNet-101, and SqueezeNet which won ImageNet Large Scale Visual Recognition Challenge(ILSVRC). To train, validate and test these models, we constructed 3000 training data and 12000 validation data with 256×256 pixel resolution consisting of cracked and non-cracked images, and constructed 5 test data with 4160×3120 pixel resolution consisting of concrete images with crack. In order to increase the efficiency of the training, transfer learning was performed by taking the weight from the pre-trained network supported by MATLAB. From the trained network, the validation data is classified into crack image and non-crack image, yielding True Positive (TP), True Negative (TN), False Positive (FP), False Negative (FN), and 6 performance indicators, False Negative Rate (FNR), False Positive Rate (FPR), Error Rate, Recall, Precision, Accuracy were calculated. The test image was scanned twice with a sliding window of 256×256 pixel resolution to classify the cracks, resulting in a crack map. From the comparison of the performance indicators and the crack map, it was concluded that VGG16 and VGG19 were the most suitable for detecting concrete cracks.

• Asian Pacific Journal of Cancer Prevention
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• 제13권11호
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• pp.5385-5389
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• 2012

Introduction: Sentinel lymph node biopsy (SLNB) is a precise procedure for lymphatic staging in early breast cancer. In a valid SLNB procedure, axillary lymph node dissection (ALND) can be omitted in nodenegative cases without compromising patient safety. In this study, detection rate, accuracy and false negative rate of SLNB for breast cancer was evaluated in a setting with simple modified conventional pathology facilities without any serial sectioning or immunohistochemistry. Material and Medthod: Patients with confirmed breast cancer were enrolled in the study. SLNB and ALND were performed in all cases. Lymph node metastasis was evaluated in SLN and in nodes removed by ALND to determine the false negative rate. Pathologic assessment was carried out only by modified conventional technique with only 3 sections. Detection rate was determined either by lymphoscintigraphy or during surgery. Results: 78 patients with 79 breast units were evaluated. SLN was detected in 75 of 79 cases (95%) in lymphoscintigraphy and 76 of 79 cases (96%) during surgery. SLN metastases was detected in 30 of 75 (40%) cases either in SLNB and ALND groups. Accuracy of SLNB method for detecting LN metastases was 92%. False negative rate was 3 of 30 of positive cases: 10%. In 7 of 10 cases with axillary lymphadenopathy, LN metastastates was detected. Conclusion: SLNB is recommended for patients with various tumor sizes without palpable lymph nodes. In modified conventional pathologic examination of SLNs, at least macrometastases and some micrometastases could be detected similar to ALND. Consequently, ALND could be omitted in node-negative cases with removal of all palpable LNs. We conclude that SLNB, as one of the most important developments in breast cancer surgery, could be expanded even in areas without sophisticated pathology facilities.

• 대한세포병리학회지
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• 제19권2호
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• pp.111-118
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• 2008

Background : Cervicovaginal cytology is a screening test of uterine cervical cancer. The sensitivity of cervicovaginal cytology is less than 50%, but studies of cytologic/histologic correlation are limited. We analyzed the diagnostic accuracy of cervicovaginal cytology in the detection of the squamous epithelial lesions of the uterine cervix and investigate the cause of diagnostic discordance. Materials and Methods : We collected a total of 481 sets of cervicovaginal cytology and biopsies over 5 years. The cytologic diagnoses were categorized based on The Bethesda System and the histologic diagnoses were classified as negative, flat condyloma, cervical intraepithelial neoplasia (CIN) I, CIN II, CIN III, or squamous cell carcinoma. Cytohistologic discrepancies were reviewed. Results: The concordance rate between the cytological and the histological diagnosis was 79.0%. The sensitivity and specificity of cervicovaginal cytology were 80.6% and 92.6%, respectively. Its positive predictive value and negative predictive value were 93.7% and 77.7%, respectively. The false negative rate was 19.4%. Among 54 false negative cytology cases, they were confirmed by histology as 50 flat condylomas, 2 CIN I, 1 CIN III, and 1 squamous cell carcinoma. The causes of false negative cytology were sampling errors in 75.6% and interpretation errors in 24.4%. The false positive rate was 7.4%. Among 15 false positive cytology cases, they were confirmed by histology as 12 atypical squamous cells of undetermined significance (ASCUS) and 3 low grade squamous intraepithelial lesions (LSIL). The cause of error was interpretation error in all cases. The overall diagnostic accuracy of cervicovaginal cytology was 85.7%. Conclusions : Cervicovaginal cytology shows high overall diagnostic accuracy and is a useful primary screen of uterine cervical cancer.

• 한국방사선학회논문지
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• 제6권1호
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• pp.63-71
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• 2012

본 연구는 유방영상검사의 최고의 관심영역인 DR 방식의 유방영상에서 유방암 진단의 정확도를 평가하고, 유방암 환자들의 특성을 알아보고자 DR 방식으로 유방영상검사를 실시한 유방암 환자 57명을 대상으로 2010년 5월부터 2011년 6월까지 조사되었다. 유방암 환자들의 평균 나이는 50.8세이었고, 유방암의 발생 부위는 상외측(UOQ)이 전체의 33.3%로 가장 많은 것으로 조사되었다. 연령에 따른 유방암 발생은 40-49세에서 42.1%로 모든 연령대에서 가장 높게 나타났다. 유방암 환자들의 유방조직 밀도는 지방형 유방이 31.6%(18/57), 치밀유방이 68.4%(39/57)로 나타나, 70%에 가까운 유방암 환자들이 치밀유방의 형태를 띠고 있었다. 유방영상에서 방사선학적 병변 중 종괴와 미세석회화가 함께 동반된 경우 (45.3%)가 유방암 발견율이 가장 높은 것으로 조사되었고, 치밀유방에서 미세석회화를 동반하지 않는 종괴의 경우 지방형 유방에서보다 유방암의 발견율이 더 낮은 것으로 조사되었으며, 이러한 종괴는 치밀유방에서 위음성율을 높이는 원인이 되고 있다. Digital mammography의 위음성률은 7.0%이었고, 민감도는 93.0%인 것으로 조사되었다. 치밀유방의 위음성율은 12.8%, 민감도는 87.2%로 조사되었는데 이는 이전에 보고된 screen film mammography의 치밀유방에서 보다 유방암에 대한 민감도가 더 높은 것으로 조사되었다.

• 대한세포병리학회지
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• 제8권2호
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• pp.120-128
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• 1997

Fine needle aspiration cytology of breast lesion is well known as a simple, economic and effective diagnostic modality. For the evaluation of cytohistologic correlation, 256 cases of cytologic smears and subsequent histologic sections during 2-year period from Jan. 1995 to Dec. 1996 were reviewed. 1. Fifteen cases(5.9%) were proven as insufficient for evaluation, and 13 of them were fibrocystic change histologically. One case of carcinoma exhibiting sufficient amount of aspirates with no malignant cells on smear was regarded as inadequate. 2. Cytohistologic correlation of 240 cases revealed sensitivity 87.0%, specificity 100.0%, positive predictive value 100.0%, negative predictive value 97.0%, false positive rate 0.0% and false negative rate 13.0%. Total diagnostic accuracy is 95.7%. 3. Total 6 cases of negative were due to small amount of aspirates containing scantiness of malignant cells in two and underestimation in four. 4. Diagnostic concordance rates of fibrocystic change and fibroadenoma were 95.5% and 80.0%, respectively. Diagnostic discrepancies were noted in 7 cases of fibrocystic change and 6 cases of fibroadenoma, however, cytologic discrimination of two entities was not easy in seven of them. 5. In a case of phyllodes tumor and a case of duct ectasia, the discrepancy was due to targeting error. Other three cases(lymphoma, adenomyoepithelioma and granulomatous mastitis) were misinterpreted because of poor acquaintance with those entities. Diagnostic accuracy of fine needle aspiration cytology of breast lesions are relatively high. However, good technique on aspiration and adequate interpretation are necessary to reduce the false negative rate and the discrepancy between cytologic and histologic diagnoses.