• Childhood Kidney Diseases
• /
• v.1 no.1
• /
• pp.17-23
• /
• 1997

After the first description of IgA nephropathy by Berger in 1968, the prognosis of this disease was considered favourable. However recent studies have revealed that IgA nephropathy result in end stage renal desease in 25-30% by 20 years. Heavy proteinuria, hypertension, histological high class are regarded as poor prognostic factors. In 1996, Yagame et al reported the new histopathologic grading with a strong correlation between the grading, heavy proteinuria, high s-Cr level and renal survival. The aims of this study are to determine whether the pathological grading and other clinical parameters could contribute to predicting the outcome of this disease eventhough pediatric patients. Seventy nine patients (59 males, 20 females) with IgA nephropathy were examined. Patients were 2.08-15.17 years of age ($9.85{\pm}2.83$). The mean follow-up duration were $27{\pm}28$ months. Six of seventy nine patients progressed to chronic renal failure during the follow-up periods. High 24h urinary protein excretion at diagnosis were significantly higher in chronic renal failure patients (p<0.05). Hypertension at diagnosis were the significant associated factors in progression of chronic renal failure (p<0.05). Histological changes of IgA nephropathy in light microscopy were classified into five classes by WHO classification, four grades in Yagame's gradings. Among the seventy nine patients, 24 were as class 1, 30 as class 2, 23 as class 3; 4 as class 4, 0 as class 5 by WHO classification. 23 were classified grade 1, 31 as grade 2, 24 as grade 3, 1 as grade 4 by Yagame's grading. Among six patients who progressed to chronic renal failure, 1 clssified as class 1, 1 as class 2, 3 as class 3, 1 as class 4, 0 as class 5 by WHO Classification. 1 patients were classified as grade 1, 1 as grade 2, 3 as grade 3, 1 as grade 4 by Yagame's grading. (p>0.05) In conclusion, hypertension and heavy proteinuria at initial presentation were significantly associated with progression of chronic renal failure. The classification of WHO & Yagame's grading has no significant association with the progression of chronic renal failure in pediatric patients.

• Journal of Applied Reliability
• /
• v.11 no.4
• /
• pp.387-398
• /
• 2011

$217Plus^{TM}$, a newly developed as a surrogate of the MIL-HDBK-217, may be widely applied for reliability predictions of electronic systems. In this study, we performed sensitivity study of the $217Plus^{TM}$ system model to various parameters. Specific attention was put to logistics model and its behavior has been examined in terms of non-component failure causes. We first briefly explained the $217Plus^{TM}$ methodology with system level failure rate evaluation. We then applied experimental designs with several failure causes as factors. We used an orthogonal array with three levels of each parameter. Our results indicate that cannot duplicate, induced, and wear-out causes have dominant effects on the system failures and design, parts, and system management have much less but a little strong effects. The results in this study not only figure out the behavior of the predicted failure rate as functions of failure causes but provide meaningful guidelines for practical applications.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.1
• /
• pp.515-521
• /
• 2013

Purpose: To evaluate the efficacy and toxicity of induction chemotherapy followed by concurrent chemoradiotherapy (the treatment group) versus concurrent chemoradiotherapy with or without adjuvant chemotherapy (the control group) for locoregionally advanced nasopharyngeal carcinoma. Methods: The search strategy included Pubmed, Embase, the Cochrane Library, China National Knowledge Internet Web, Chinese Biomedical Database and Wanfang Database. We also searched reference lists of articles and the volumes of abstracts of scientific meetings. All randomized controlled trials were included for a meta-analysis performed with RevMan 5.1.0. The Grading of Recommendations Assessment, Development, and Evaluation system (GRADE) was used to rate the level of evidence. Results: Eleven studies were included. Risk ratios of 0.99 (95%CI 0.72-1.36), 0.37 (95%CI 0.20-0.69), 1.08 (95%CI 0.84-1.38), 0.98 (95%CI 0.75-1.27) were observed for 3 years overall survival, 3 years progression-free survival, 2 years loco-regional failure-free survival and 2 years distant metastasis failure-free survival. There were no treatment-related deaths in either group in the 11 studies. Risk ratios of 1.90 (95%CI 1.24-2.92), 2.67 (95%CI 0.64-11.1), 1.04 (95%CI 0.79-1.37), 0.98 (95%CI 0.27-3.52) were found for grade 3-4 leukopenia, grade 3-4 thrombocytopenia, grade 3-4 mucous membrane, and grade 3-4 hepatic hematologic and gastrointestinal toxicity, the most significant toxicities for patients. Conclusion: Compared with the control group, induction chemotherapy followed by concurrent chemoradiotherapy was well tolerated but could not significantly improve prognosis in terms of overall survival, loco-regional failure-free survival or distant metastasis failure-free survival.

• Proceedings of the Korean Reliability Society Conference
• /
• 2011.06a
• /
• pp.257-264
• /
• 2011

In this study, we performed sensitivity study of the $217Plus^{TM}$ system model to various parameters. Specific attention was put to logistics model and its behavior has been examined in terms of non-component failure causes. We first briefly explained the $217Plus^{TM}$ methodology with system level failure rate evaluation. We then applied experimental designs with several failure causes as factors. We used an orthogonal array with three levels of each parameter. Our results indicate that cannot duplicate, induced, and wear-out causes have dominant effects on the system failures and design, parts, and system management have much less but a little strong effects. The results in this study not only figure out the behavior of the predicted failure rate as functions of failure causes but provide meaningful guidelines for practical applications.

• Smart Structures and Systems
• /
• v.26 no.2
• /
• pp.147-156
• /
• 2020

This numerical study demonstrates the porosity conditions and the intensity of the interactions with the aggressive agents. It is established that the density as well as the elastic modulus are correlated to ultrasonic velocity The following investigation assessed the effects of cement grade and porosity on tensile strength, flexural and compressive of Ultra High Performance Concrete (UHPC) as a numerical model in PLAXIS 2d Software. Initially, the existing strength-porosity equations were investigated. Furthermore, comparisons of the proposed equations with the existing models suggested the high accuracy of the proposed equations in predicting, cement grade concrete strength. The outcome obtained showed a ductile failure when un-corroded reinforced concrete demonstrates several bending-induced cracks transfer to the steel reinforcement. Moreover, the outcome also showed a brittle failure when wider but fewer transverse cracks occurred under bending loads. Sustained loading as well as initial pre-cracked condition during the corrosion development have shown to have significant impact on the corrosion behavior of concrete properties. Moreover, greater porosity was generally associated with lower compressive, flexural, and tensile strength. Higher cement grade, on the other hand, resulted in lower reduction in concrete strength. This finding highlighted the critical role of cement strength grade in determining the mechanical properties of concrete.

• Structural Engineering and Mechanics
• /
• v.59 no.5
• /
• pp.853-866
• /
• 2016

This paper examines a methodology for computing the probability of structural failure of reinforced concrete beams subjected to fire. The significant load variables considered are dead load, sustained live load and fire temperature. Resistance is expressed in terms of moment capacity with random variables taken as yield strength of steel, concrete class (or grade of concrete), beam width and depth. The flexural capacity is determined based on the design equations recommended in Indian standard IS456:2000. Simplified method named $500^{\circ}C$ isotherm method detailed in Eurocode 2 is incorporated for fire design. A transient thermal analysis is conducted using finite element software ANSYS$^{(R)}$ Release15. Reliability is evaluated from the initial state to 4h of fire exposure based on the first order reliability method (FORM). A procedure is coded in MATLAB for finding the reliability index. This procedure is validated with available literature. The effect of various parameters like effective cover, yield strength of steel, grade of concrete, distribution of reinforcement bars and aggregate type on reliability indices are studied. Parameters like effective cover of concrete, yield strength of steel has a significant effect on reliability of beams. Different failure modes like limit state of flexure and limit state of shear are checked.

• Journal of the Korean Society of Safety
• /
• v.15 no.2
• /
• pp.103-110
• /
• 2000

This paper deal with the stability evaluation and suggestion of progressive failure slope in biotite granite area of Andong. Based on geological site investigation and field test, stability analysis of slope was performed in conjunction with limit equilibrium methods and stereographic projection. Additionally, initial design and construction procedure was critically evaluated. Series of the slope stability analysis reveals the detection of local wedge and plane failure under the current slope condition. It is additionally appeared that a certain synthetic behavior of circle and plane failure exists on the right spot where the overall failure's going in progress. In order to construct more stable slope based on the suitability for the real state of the slope circumstances, this study issues a solution to eliminate the primary factors which cause the instability, by means of the grade of weathering and RMR classification of rock mass.

• Journal of the Korean Society of Safety
• /
• v.24 no.4
• /
• pp.53-58
• /
• 2009

The importance of process for repair and reinforcement of the bridge is increasing because of the lack of the fatigue load and stress, a lowering of the bridge load carrying capacity owing to impact and oscillation, deterioration on cultivation periods of the bridge, etc. Typically the experimenter values the bridge load carrying capacity by the real rating factor and response modification factor in bridge load rating through static load test and dynamic load test. But the error occurred in reliability of response modification factor in bridge load rating according to experience of experimenter. so tests of connecting probability theory and valuation of the bridge recently. The study is to compute the real load carrying capacity of the bridge and the rating factor and response modification factor on grade of the bridge, and calculate the probability of over-loaded truck load from Weigh In Motion(WIM) Data in FORTRAN programming applying to Monte-Carlo Simulation. At the result of this study, it is acquired that the new grade is computed for the probability of over-loaded truck load and surface inspection. The A grade is over 1.95, B grade is $1.55{\sim}1.94$, C grade is $1.26{\sim}1.54$, D grade is $1.14{\sim}1.25$, E grade is under 1.13 of rating factor, respectively.

• Journal of Korean Elementary Science Education
• /
• v.36 no.4
• /
• pp.439-446
• /
• 2017

The purpose of this study was to compare Grit, failure tolerance and psychological well-being between elementary science gifted and general students. The subjects of this study were 48 science gifted students and 70 general students in the 5th and 6th grade of elementary school in Gyeonggi province. The results of this study were as follows: First, Grit, failure tolerance and psychological well-being of science gifted students were higher than those of the general students, there was a statistically significant difference. Second, science gifted students showed higher correlation between grit and failure tolerance, grit and psychological well-being than general students. Grit of science gifted students had a positive correlation with all sub-factors of academic failure tolerance and psychological well-being. In general students, there was a positive correlation with all sub-factors of Grit, academic failure tolerance, and psychological well-being except for the emotion sub-factor of academic failure tolerance. Thirdly, as a result of the regression analysis on the elements of failure tolerance affecting the Grit, science gifted students showed emotional factor but general students had behavioral factors. Also, as a sub-factor of psychological well-being on Grit, both science gifted and general students showed autonomy.

• Journal of Dental Anesthesia and Pain Medicine
• /
• v.16 no.3
• /
• pp.185-191
• /
• 2016

Background: Failure to maintain a patent airway can result in brain damage or death. In patients with mandibular prognathism or retrognathism, intubation is generally thought to be difficult. We determined the degree of difficulty of airway management in patients with mandibular deformity using anatomic criteria to define and grade difficulty of endotracheal intubation with direct laryngoscopy. Methods: Measurements were performed on 133 patients with prognathism and 33 with retrognathism scheduled for corrective esthetic surgery. A case study was performed on 89 patients with a normal mandible as the control group. In all patients, mouth opening distance (MOD), mandibular depth (MD), mandibular length (ML), mouth opening angle (MOA), neck extension angle (EXT), neck flexion angle (FLX), thyromental distance (TMD), inter-notch distance (IND), thyromental area (TMA), Mallampati grade, and Cormack and Lehane grade were measured. Results: Cormack and Lehane grade I was observed in 84.2%, grade II in 15.0%, and grade III in 0.8% of mandibular prognathism cases; among retrognathism cases, 45.4% were grade I, 27.3% grade II, and 27.3% grade III; among controls, 65.2% were grade I, 26.9% were grade II, and 7.9% were grade III. MOD, MOA, ML, TMD, and TMA were greater in the prognathism group than in the control and retrognathism groups (P < 0.05). The measurements of ML were shorter in retrognathism than in the control and prognathism groups (P < 0.05). Conclusions: Laryngoscopic intubation was easier in patients with prognathism than in those with normal mandibles. However, in retrognathism, the laryngeal view grade was poor and the ML was an important factor.