• 동의생리병리학회지
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• 제33권4호
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• pp.191-197
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• 2019

This study aims to evaluate the effects of the root bark of Morus alba (RMA) on the regulation of the Hippo-YAP pathway. Hippo-YAP signaling is a critical regulator in controlling organ size and tissue homeostasis. Hippo, the serine/threonine kinase phosphorylate the LATS. Phosphorylated LATS then phosphorylates and inactivates the YAP and TAZ, which are two closely related transcriptional co-activator. Here we report RMA activates the Hippo signaling, thereby inhibits the YAP/TAZ activity. First, we examine the cytotoxic effects of RMA by MTT assay. RMA was cytotoxic at concentrations higher than $50{\mu}g/ml$ in HEK293A cells. The reporter gene assay was performed to measure the activity of TEAD, a key transcription factor that controls cell growth and proliferation. RMA significantly suppressed the luciferase activity. By phos-taq gel shift assay, and western blotting, we showed that RMA enhanced the phosphorylation of YAP in wild type cells, but not in LATS1/2 knock out cells, which means RMA activates classical Hippo pathway. RMA induced the cytoplasmic sequestration of YAP. RMA also suppressed the mRNA expression of CTGF and CYR61; the two major YAP dependent genes. Taken together, RMA is considered to be a good candidate for proliferative disease such as cancer, by facilitating cell death through activating the Hippo signaling pathway.

• 한국ITS학회 논문지
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• 제20권1호
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• pp.40-53
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• 2021

공유 전동킥보드는 기존 'station 기반의 공유 교통서비스에 비해 편리한 dockless 방식으로 제공되어 이용이 급격하게 증가하고 있다. 이에 따라 교통사고, 보행환경 저해 등 새로운 도시문제가 발생하고 있다. 본 연구에서는 서울시를 대상으로 최근 급격하게 성장하고 있는 공유전동킥보드의 이용 특성을 분석하고, 음이항 회귀모형을 통해 서울시 집계구 단위의 공유 전동킥보드 이용수요에 영향을 미치는 요인에 대하여 규명하였다. 이용특성 분석결과 평균 이용거리는 1.5km, 이용시간은 9.4분, 이동속도는 10.3km/h로 나타났다. 공유 전동킥보드의 이용수요에 대한 영향요인을 살펴보면, 인구지표, 교통시설지표, 토지이용지표, 기상지표가 통계적으로 유의하게 영향을 미치는 것으로 분석되었다. 본 연구의 결과는 향후 공유 전동킥보드의 이용수요가 많은 지역에 대한 효율적인 운영 및 이용 활성화를 위한 교통정책 수립의 기초자료로 활용될 수 있을 것으로 기대된다.

• 의학교육논단
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• 제23권1호
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• pp.46-55
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• 2021

Since the emergence of coronavirus disease 2019 (COVID-19), medical schools have experienced a sudden, full-scale transition to online classes. As the COVID-19 pandemic continues, it is important to evaluate current educational programs and to assess their implications. This study explored perceptions of online classes and learning behavior among medical students. Twenty preclinical medical students were interviewed in focus groups for 2 months. They generally expressed positive perceptions about online classes, and in particular, positively assessed the ability to lead their individual lifestyles and study in comfortable environments with fewer time and space constraints. Students thought that the online environment provided a fair chance of facilitating positive interactions with the professor and considered communication with the professor to be an important factor only when it was related to the class content or directly helped with their grades and careers. Students also had negative views, such as feeling uncertain when they could not see their peers' learning progress and assess themselves in comparison and feeling social isolation. Learning behaviors have also changed, as students explored their learning styles and adapted to the changed learning environment. Students expanded their learning by using online functions. However, students sometimes abused the online class format by "just playing" the lecture while not paying attention and relying on other students' lecture transcripts to study. The results of this study are hoped to provide a useful foundation for future research on online class-based teaching and learning.

• Steel and Composite Structures
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• 제49권2호
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• pp.143-159
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• 2023

Recently, the design of scaffolding systems has garnered considerable attention due to the increasing number of scaffold collapses. These incidents arise from the underestimation of imposed loads and the site-specific conditions that restrict the application of lateral restraints in scaffold assemblies. The present study is committed to augmenting the buckling resistance of vertical support members, obviating the need for supplementary lateral restraints. To achieve this objective, experimental and computational analyses were performed to assess the axial load buckling capacity of steel props, composed of two hollow steel pipes that slide into each other for a certain length. Three full-scale steel props with various geometric properties were tested to construct and validate the analytical models. The total unsupported length of the steel props is 6 m, while three pins were installed to tighten the outer and inner pipes in the distance they overlapped. Finite Element (FE) modeling is carried out for the three steel props, and the developed models were verified using the experimental results. Also, theoretical analysis is utilized to verify the FE analysis. Using the FE-verified models, a parametric study is conducted to evaluate the effect of different inserted pipe lengths on the steel props' axial load capacity and lateral displacement. Based on the results, the typical failure mode for the studied steel props is global elastic buckling. Also, the prop's elastic buckling strength is sensitive to the inserted length of the smaller pipe. A threshold of minimum inserted length is one-third of the total length, after which the buckling strength increases. The present study offers a prop with enhanced buckling resistance and introduces an equation for calculating an equivalent effective length factor (k), which can be seamlessly incorporated into Euler's buckling equation, thereby facilitating the determination of the buckling capacity of the enhanced props and providing a pragmatic engineering solution.

• 정보처리학회 논문지
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• 제13권2호
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• pp.60-75
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• 2024

클라우드 환경에서 복잡한 가상 환경을 관리할 필요 없이 애플리케이션 본연의 작업에 집중하기를 원하는 사용자의 요구는 서버리스 컴퓨팅이라는 새로운 컴퓨팅 모델을 탄생시켰다. 서버리스 컴퓨팅 모델에서 사용자는 서버에서의 자원 할당이나 기타 서버 관리를 서비스 제공자에게 위임하고, 자신은 애플리케이션 코드 개발에만 집중하여 클라우드 서비스를 사용하는 것이 가능해졌다. 서버리스 컴퓨팅은 클라우드 서비스 사용자의 부담을 감소시킴으로써 클라우드 컴퓨팅의 활용도를 한 단계 업그레이드시켰으며, 향후 클라우드 컴퓨팅의 기반 모델로 자리 잡을 것으로 예상된다. 서버리스 플랫폼은 사용자를 대신하여 클라우드 가상 환경에 대한 관리를 담당하며, 애플리케이션을 구성하는 서버리스 함수를 클라우드 환경에서 실행시키는 역할을 담당한다. 사용하는 자원에 비례하여 사용자 과금이 이루어지는 서버리스 컴퓨팅의 특징을 고려 할 때 서버리스 플랫폼의 효율성은 사용자와 서비스 제공자 모두에게 매우 중요한 요소라고 볼 수 있다. 본 논문에서는 서버리스 컴퓨팅 성능에 영향을 미치는 다양한 요소를 판별하고, 관련된 최신 연구 동향을 분석하고자 한다. 그리고 분석 결과를 바탕으로 향후 서버리스 컴퓨팅의 발전 방향과 관련된 연구 방향을 논의한다.

• 대한지역사회영양학회지
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• 제29권2호
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• pp.114-128
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• 2024

Objectives: The purpose of this study was to investigate the perception of nutrition teachers and the factors influencing their intention toward sustainable dietary education utilizing the theory of planned behavior (TPB). Methods: The self-administered online survey was completed by nutrition teachers in Jeollanam-do, South Korea. A total of 151 valid questionnaires were analyzed. Factor analysis and multiple regressions were employed to test the research model. Results: The study findings demonstrated that all TPB variables significantly influenced the sustainable dietary educational intention, with the degree of influence ranking as follows: external perceived behavioral control (β = 0.417), attitude (β = 0.240), internal perceived behavioral control (β = 0.207), and subjective norms (β = 0.181). For external perceived behavioral control, nutrition teachers and elementary schools exhibited higher levels compared to dietitians and middle/high schools, respectively. The participants in sustainable dietary education training programs exhibited a higher level of internal perceived behavioral control compared to those who did not participate. The highest perception levels were reported for attitude (4.26), followed by subjective norms (4.02), internal perceived behavioral control (3.67), and external perceived behavioral control (3.20). Conclusions: This study affirmed that the TPB variables elucidated the sustainable dietary educational intentions of nutrition teachers. The significant impacts of external and internal perceived behavioral control, attitude, and subjective norms on educational intentions were confirmed. Consequently, proactive support from schools and governments is essential to enhance the facilitating factors and mitigate the barriers toward sustainable dietary education in schools.

• 한국IT서비스학회지
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• 제23권3호
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• pp.17-37
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• 2024

This study explores the tendency of corporations and organizations to continue with their current processes despite having incentives for better Information Technology (IT) innovation or transition. In this context, the study argues that organizations may struggle with 'outsourcing inertia,' a well-known concept referring to an organization's deficient adaptability to environmental changes, particularly defined here as the organization's slow adaptation to changes in outsourcing levels. To verify this, the study analyzes how key variables identified from existing IT Outsourcing (ITO) decision-making research and recent studies on cloud computing transitions actually affect a firm's transition intentions. In the process, this study investigates the moderating effect of a firm's outsourcing inertia, utilizing the Technology-Organization-Environment (TOE) framework and the Push-Pull-Mooring (PPM) model based on migration theory to propose a research model. The study aims to contribute to finding strategic approaches necessary for facilitating IT innovation and transition by understanding the impact of outsourcing inertia on the decision-making process related to IT outsourcing. It is important to note that the majority of domestic conglomerates own IT subsidiaries, which significantly influence the process of transitioning to cloud computing. Nevertheless, research on the impact of IT subsidiaries on cloud computing transition is relatively scarce. Based on this background, this study proposes that IT subsidiaries within domestic conglomerates can act as a significant mooring factor of organizational inertia in the decision-making process for adopting cloud computing. Through this, the study seeks to provide strategic insights for overcoming organizational inertia faced by IT subsidiaries during the cloud computing transition process.

• 벤처창업연구
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• 제9권5호
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• pp.69-81
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• 2014

기술이전 사업화에 대한 관심은 국내뿐만 아니라 세계적으로 확대되고 있는 추세이다. 이에 본 연구는 기술이전 사업화에 대한 개념의 고찰 및 기술이전 사업화를 가속화시키기 위하여 고려되어야 할 촉진요인을 도출하여 실증적인 분석을 실시하였다. 기존의 기술이전 사업화의 경우 그 범주에 대한 정의에 있어 기술 발굴, 기술의 이전 및 그에 따른 사업화의 범주로 국한시키는 경향이 있었다. 이에 본 연구에서는 기술이전 사업화에 대하여'무형의 축적된 기술 노하우 지식 등 지적재산 또는 특정 목표를 달성하기 위하여 시행된 기술개발이 기술이전 당사자 간의 계약 협상 등을 통하여 이전되어 무형의 기술이 유형의 상품으로 제품화되는 활동 및 그에 따른 경제적 이익을 획득하는 제반 활동'으로 그 범주를 확장하여 정의하였다. 또한, 기술이전 사업화에 대한 실증분석 결과를 살펴보면, 현재까지는 기술이전 사업화를 가속화시킴에 있어 대상 기술, 대상 기술에 대한 관리, 기술이전 사업화에 대한 제도 및 관련 조직의 효율성 확보에 초점이 맞춰져 있으며, 기술사업화 단계에 있어 금융지원에 대해서는 상대적으로 인식이 미흡한 것으로 나타났다. 이는 기존의 기술이전 사업화에 대한 관점이 기술이전과 기술사업화에 따른 특허등록 출원, 기술이전 건수, 기술료 등의 정량적 성과에 초점이 맞춰져 있어, 상대적으로 기술이전 사업화를 통한 기술창업, 양질의 고용창출 등 창조경제 실현과 직결된 경제적 성과 창출에는 다소 인식이 미흡한 현 상황을 반영한 결과로 판단된다. 이에 본 연구는 기술이전 사업화가 단순히 정량적 성과를 확보하기 위한 수단에 그치는 것이 아니라, 기술이전 사업화 주체들의 안정적인 생태계 조성 및 그에 따른 창조경제를 실현할 수 있는 환경 구축에 보다 관심을 갖아야 한다는 인식 전환의 필요성을 도출했다는 점에서 향후 기술이전 사업화의 활성화 방안 마련 등의 정책자료로 활용될 수 있을 것이다.

• 유통과학연구
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• 제12권4호
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• pp.11-22
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• 2014

Purpose - The domestic franchise industry has made significant contributions to industry such as investment, employment, and community economy development, facilitating growth potential. The franchise industry provides management knowhow transfer between parent companies and franchisees as per contracts addressing use of business signs, franchisees' independent position, franchisor support, and royalties to be paid to the franchisors. However, many franchisors lack management knowhow and provide insufficient support because of poor control of franchisees and not having a systematic approach to support. This results in dissatisfied franchisees and failure to establish long-term relationships. Few studies have examined relational commitment and/or re-contract intention by support resources between franchisors and franchisees, despite a considerable output of theories and studies of the growth of the franchise industry. The purpose of this study, therefore, was to examine the effects of the ability to provide resources on relational commitments and re-contract intention, and to suggest causal relationships and implications. Research design, data, and methodology - The subject was domestic franchisors registered with the Association of Franchise with more than 50 franchisees. Franchisees under contract for 2 years and considering re-contract of their franchise 2 years later were used. The subjects totaled 300 franchisees in Seoul. A questionnaire survey was used to investigate the subject of franchisees' concessions during the 10 days from November 21, 2013 to November 30, 2013. After excluding 16 surveys with poor answers, 284 responses were finally used. Four areas and 44 questions were used. A nominal scale was used for four common characteristics questions including gender, ages, educational background, and franchise managing time. Questions regarding ability, relational commitment, and re-contract intention made use of a Likert 5-point scale. Data coding and data cleaning were used. SPSS 18.0 was used as follows. First, frequency analysis was done to investigate demographic characteristics. Second, exploratory factor analysis was done to verify validity of testing tools, and Cronbach's α coefficient was used to verify reliability. Third, correlation analysis and multiple regression analysis were done. An exploratory factor analysis was done to verify validity of concepts. A correlation analysis was done to test relationships between the variables, and multiple regression analysis was done to verify franchisor's ability, franchisees' relational commitment, and re-contract intention. Results - The following were the outcomes. First, store operation management, finance operation management, and human resource management affected the calculated bond. Second, store operation management and finance operation management affected the emotional bond. Third, store operation management, finance operation management, human resource management, and marketing management affected the prescriptive bond. Fourth, calculated bond and prescriptive bond had an effect on re-contract intention. Conclusions - As stated above, in franchise management, parent companies' offer and instruction of core competence to their franchisees as an information resource could improve the relational bond by helping them grow together through the resource sharing. Consequently, core competence factors were promoting factors that could improve franchisees' re-contract intention for a long time.

• 유통과학연구
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• 제11권5호
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• pp.43-53
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• 2013

Purpose - The purpose of this study is to analyze the effectiveness of customer relationship management (CRM) support policies for facilitating traditional markets, especially with respect to customer acquisition and maintenance, and to investigate the factors affecting CRM. Research design, data, and methodology - We analyzed the CRM efficiency of traditional markets in 16 cities and provinces in Korea on the basis of DEA analysis and Malmquist productivity analysis. The DEA model calculates a ratio of the weighted mean of various inputs to the weighted mean of various outputs and measures the efficiency of a specific decision making unit (DMU), which is compared to the reference group that has a similar input-output structure. The input variables are coupon, event, parcel service, premiums, while is the number of customers per day. Further, through regression analysis, we analyzed CRM-related factors affecting traditional markets' customer appeal and revenue growth. Results - We obtained the results of the efficiency of traditional markets in 16 provinces. The traditional markets in Seoul, Busan, and Jeju were found to be efficient in a model CCR that used the number of customers per day as an output variable, while Chungbuk, Jeonbuk Province, and According to the results of the DEA analysis and Malmquist productivity analysis, large cities such as Seoul, Busan, and Jeju showed efficiency in CRM-related investment businesses in traditional markets for attracting customers. The Malmquist analysis results confirmed that the productivity of traditional markets increased from 2008 to 2010. The results of the regression analysis revealed that the "customer acquisition/maintenance factor" and the "offering of customer convenience facility factor" were significant to the daily average number of customers, which is a dependent variable. The results of the test with the mediating variable, "number of customers," and the final dependent variable, "sales revenue," were rejected. However, the variable "customer acquisition /maintenance" was found to affect sales revenue positively. Conclusions - It is necessary to enhance the business not only for promotional activities to attract customers, but also to strengthen customer relationships among CRM businesses, such as through the management of key customers. The regression analysis results showed that CRM businesses have yet to produce an increase in sales revenues in traditional markets. Therefore, to help customers who visit traditional markets to keep buying products, it is necessary to prepare various investment methods and provide support to improve "customer loyalty." This study has a limitation in terms of CRM-related statistics. Therefore, in the future, it is necessary to conduct a survey of customers who use traditional markets to analyze the markets by type and size as well as the CRM-related factors. Based on the analysis, we will try to perform a variety of statistical analyses, including structural equations.