• Archives of Plastic Surgery
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• v.42 no.3
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• pp.282-287
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• 2015

Background Morphological changes that accompany aging, such as wrinkles and skin laxity, are particularly prominent on facial skin. Recently, facial rejuvenation using the hydrofilling effect of hyaluronic acid (HA) filler has been employed for improvement of skin texture. In this study, we studied rejuvenating effects of stabilized HA (Restylane Vital) through direct intradermal injections. Methods A total of 30 female patients underwent a series of procedures on face, including three sessions at intervals of four weeks. A total of 2 mL of Restylane Vital was injected along the whole face using an automatic injector. Improvement of skin surface roughness, elasticity, brightness, moisture, and fine wrinkles was evaluated. Patient satisfaction was evaluated, and pictures of patients were taken at each visit and 6 months after last treatment session. Scoring for each patient was performed by three doctors according in five subjects. Moisture, oil and elasticity were measured before the procedure and before the last treatment in 10 patients. Results The majority of patients (77%) were satisfied with the therapeutic outcomes. Approximately 66% of patients responded that the effects of this procedure persisted for longer than four months, and the majority of patients (77%) wanted to undergo this procedure again and would recommend this procedure to acquaintances. Regarding doctors' evaluation, scores for improvement of skin surface roughness, elasticity, and brightness were significantly higher than those for improvement of moisture and fine wrinkle. Conclusions Intradermal injection of HA can have a rejuvenating effect on dry and tired facial skin, especially in improvement of skin surface roughness.

• Journal of Fashion Business
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• v.24 no.6
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• pp.120-134
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• 2020

Recently, the beauty industry has implemented personalized services based on skin big data. To increase competitiveness in the beauty industry, systematic data measurement and evaluation indicators are necessary to select data and obtain necessary knowledge. In response, this study sought to stably enhance the accuracy of skin diagnosis based on satisfaction and reliability. To this end, the research was conducted through focus group interviews (FGI), a case study of brands, and analysis of prior research results. In particular, as a result of analyzing keywords that classify skin types by brand, common survey items for skin types were oiliness and using moisturizer, cosmetic use and vascular of skin, external stimulus and blemish & freckles, facial wrinkle, outside activities, self-consciousness, and smoke. In additioin to the common questions of the preceding study and the brand survey items, the questions concerning complex skin types, seasonal change, facial color, wrinkles and elasticity were added, and the questions were presented in a total of 40 items. In particular, it suggested that skin measurement could be conducted by focusing on elasticity and pigmentation items by reflecting the results of prior research and the opinions of FGI, and based on this, a customized service with high satisfaction and high accuracy of beauty care based on this could be proposed. We hope that this study will facilitate active self-care by providing more satisfying skin stones and personalized cosmetics proposals, thus laying the foundation for the further development of the cosmetics industry.

• Archives of Plastic Surgery
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• v.37 no.6
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• pp.801-807
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• 2010

Purpose: Facial rejuvenating surgery has become a challenge to most plastic surgeons. Patients are demanding fewer complications, a prompt recovery, and more natural results. Current trend of the face lift surgery has been developed into less invasive procedures. Every aging patient in Asia wants to look younger without obvious evidence of surgical correction. Methods: The authors performed the limited dissection face lift with PDS quilting suture on twenty five patients. These five quilting sutures consist of sutures at 1~2 cm posterior to the prominent point of zygoma to the periosteum of the zygomatic arch, at the lateral border of Bichat's fat pad area to the zygomatic arch, at the lateral border of the orbicularis oculi muscle to the deep temporal fascia, at the upper lateral border of the platysma to the periosteum of the mastoid, and at the anterior lower margin of the earlobe to the deep temporal fascia by quilting suture technique to achieve rejuvenation. Results: These procedures could produce a balanced volumetric rejuvenation. This method gave considerable benefit of stable and satisfactory results. It provides reduced operative time, well corrected nasolabial fold and neck wrinkle, and swift recovery with minimal complications. Conclusion: Although it could not replace the classic facelift, this technique can be recommended as an option for patients who do not present with advanced facial aging or not want a more extensive procedure.

• Journal of Acupuncture Research
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• v.29 no.2
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• pp.29-36
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• 2012

The purpose of this article is to review all the wrinkle treatments reported so far, and to introduce a method of dermal subcision, especially localized fine wrinkles. In order to remove wrinkles, laser, ulthera and drug therapy are commonly used in western medicine while Miso facial rejuvenation acupuncture, $Jung-An$ acupuncture and needle-embedding therapy are used in oriental medicine. However, as researches on fine wrinkles have been insufficiently conducted until now. Dermal subcision stated in this study is considered to be a safe and effective way to ameliorate fine linear-shaped wrinkles around or below eyes and mouth by increasing the circulation of qi and blood. also, reproducing dermal layer. More and further related cases and researches are expected in the future.

• 한국생물공학회:학술대회논문집
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• 2003.04a
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• pp.591-594
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• 2003

In the present study, we developed a filling material composed of poly(lactic-co-glycolic) acid (PLGA) microspheres with applications in the treatment of facial wrinkle and urinary incontinence and studied the feasibility of injecting the filling materials in animal models for plastic surgical and urological applications. Former filling materials including Teflon, Silicon, and collagen have shown a few shortcomings such as inflammation reaction, particles migration or volume decrease. We injected PLGA microspheres into the subcutaneous dorsum of mice. Injected volume was constantly maintained after implanting. We hardly found either inflammation reaction or migration. This material overcomes the problems of the current filling materials and could be utilized as a new filling material for plastic surgical and urological applications.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.41
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• pp.45.1-45.9
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• 2019

Botulinum toxin (BTX) has various therapeutic indications: bruxism, square jaw, facial wrinkle, oral ulcer and maxillofacial pain, etc. In this paper, we will discuss the effectiveness of using BTX in dental implant surgery and orthognathic and orthodontic treatment. We summarized the clinical application of botulinum toxin in the maxillofacial field at the finale.

• Proceedings of the Korean Society of Computer Information Conference
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• 2023.01a
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• pp.365-368
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• 2023

본 논문에서는 타블렛을 이용해 사용자로부터 주름 스케치를 입력받아 피부 패턴을 고려한 사실적인 얼굴 주름을 생성 할 수 있는 인터페이스를 제안한다. 주름을 생성하고 싶은 모델의 normal map에 간단한 스케치를 하면 해당 모델의 피부 패턴을 고려해 스케치를 주름으로 생성해준다. 또한, 얼굴 부위별 주름 형태를 분석하여 부위별 생성되는 주름의 형태가 다르고, 나이 설정을 통해 나이에 맞는 잔주름 및 주름 형태를 변형 한다. 본 논문에서 제안하는 방법을 이용한 주름 생성 방식은 주름에 대한 자세한 지식이 없는 사용자라도 간단한 스케치만 한다면 자동 계산을 통해 실시간으로 주름을 생성해주며, 얼굴 패턴에 따른 사실적인 주름이 생성되는 결과를 보여준다.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.36 no.1
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• pp.65-69
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• 2010

Collagen is the most abundant animal protein in mammals, accounting for about 30 % of all proteins. It is present in connective tissue and contributes to the structural framework of most organs. The tripeptide (glycineproline-hydroxyproline) with the INCI name Tripeptide-29 is main component of collagen type I. The palmitoyl tripeptide (palmitoyl-glycine-proline-hydroxyproline) with the INCI name Paimitoyi Tripeptide-29 is a synthetic material that was designed as a topical agent to stimulate collagen production. We synthesized the palmitoyl tripeptide as a potential anti-wrinkle compound. This compound has been characterized using HPLC. This compound proved, through in vitro tests, to stimulate collagen production and fibroblast proliferation. These results were very promising, so human studies were subsequently performed. We investigated the skin improvement effect of the palrnitoyl tripeptide on human skin by using non-invasive instruments. We measured physiological effects such as skin wrinkles and elasticity after volunteers applied the cosmetic products for 8 weeks. We observed significant improvement in skin wrinkles and elasticity after use of the cosmetic products for 8 weeks. We concluded that the palmitoyl tripeptide had an anti-aging effect on human facial skin.

• Journal of KIISE
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• v.43 no.5
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• pp.516-523
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• 2016

For old-age makeups, makeup artists first make a mold cast of an actor's face using plaster and then sculpt wrinkles in clay on the plaster mold. After finishing the clay sculpture, its negative plaster mold is fabricated and silicone skin patches are finally made for application to the actor's face. This process takes a few days and is tedious for actors and makeup artists. With recent advances in 3D printing and scanning technology, it is becoming easier to scan and fabricate 3D faces. This paper presents a new pipeline composed of facial scanning, interactive wrinkle modeling, and mold printing stages to easily and efficiently fabricate silicone masks for old-age makeups without the use of plaster and clay. An intuitive sketch interface based on a normal map is proposed for the creation of wrinkles in real time, even with a high-resolution face model. Then the geometry of the final wrinkles is reconstructed using a depth map and the negative mold of the wrinkled face is printed. We also show that the presented pipeline can fabricate a silicone mask more conveniently than the traditional one that consists of pouring silicone into the prepared negative mold and then overlapping the mold with the original positive one.

• Proceedings of the SCSK Conference
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• 2003.09a
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• pp.13-34
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• 2003

Fructose-1, 6-diphosphate (FOP), a glycolytic metabolite is reported to ameliorate inflammation and inhibit the nitric oxide production in murine macrophages stimulated with endotoxin. It is also reported that FOP has cytoprotective effects against hypoxia or ischemia/reperfusion injury in brain and heart. In this study, we examined whether FDP has protective effects on UV-induced oxidative damage in skin cell culture system and human skin in vivo. FDP had a protective role in UVB-induced LDH release and ROS accumulation in HaCaT although it did not show direct radical scavenging effect in the experiment using 1, 1-diphenyl-2-picrylhydrazyl (DPPH). FDP also preserved cellular GSH content after UV irradiation in HaCaT and normal human fibroblast culture system. Cellular oxidative stress induces multiple downstream signaling pathways that regulate expression of multiple gene including MMP-1 and collagen, we examined the effects of FDP on UV-induced alteration of these protein expression in fibroblast culture and human skin in vivo. The increased MMP-1 expression in fibroblast and human skin by UV irradiation was significantly decreased by FDP. FDP also prevented the UV-induced decrease of collagen expression in fibroblast and human skin. Moreover, the decreasing the intracellular levels of reducing equivalents in human fibroblast by glutathione (GSH) depletion lowered the UVA dose threshold for reduction of procollagen expression, indicating that the differences of glutathione contents define the susceptibility of fibroblasts towards UV-induced reduction of procollagen expression. FDP also preserved cellular GSH content after UV irradiation, indicating that FDP has protective effects on UV-induced reduction of procollagen expression, which are possibly through maintaining intracellular reducing equivalent. Based on these premises, we examined the effect of daily use of a moisturizer containing FDP on facial wrinkle in comparison with vehicle moisturizer lacking FDP. In the clinical study, FDP significantly decreased facial wrinkle compared with vehicle alone after 6 months of use. Our results suggest that FDP has anti-aging effects in skin by increasing cellular antioxidant system and preventing oxidative signal and inflammatory reaction. Therefore FDP may be useful anti-aging agent for cosmetic purpose.