• Title/Summary/Keyword: FSC

Search Result 170, Processing Time 0.028 seconds

Comparison of hemostatic efficacy and cytotoxicity of three ferric subsulfate- and chitosan-based styptics in different formulations using a rat tail bleeding model

  • Byun, Jae-Young;Lee, Soojung;Lee, Jeong Ik;Yoon, Hun-Young
    • Korean Journal of Veterinary Research
    • /
    • v.58 no.3
    • /
    • pp.119-124
    • /
    • 2018
  • This study was conducted to compare the hemostatic efficacy of three ferric subsulfate- and chitosan-based styptics as a powder and a gel containing ferric subsulfate and chitosan (FSC-PO and FSC-G, respectively) and a soaked pad containing ferric subsulfate and lidocaine (FSL-SP) using a rat tail bleeding model. The cytotoxicity of the styptics against L-929 mouse fibroblasts was also evaluated using a cell counting kit-8 assay. Four groups of 10 rats each were assigned to the three different styptics and a non-treated control groups. Rat tail tips were transected, after which styptics were applied with pressure. The wounds were observed for hemostasis for 3 min, then irrigated with saline to check for recurrent hemorrhage. L-929 mouse fibroblasts were exposed to extracts of the styptics (100 mg/mL) and their dilutions (1:10, 1:100, and 1:1,000). FSC-PO and FSC-G more effectively controlled initial hemorrhage than FSL-SP (p = 0.033). Additionally, FSC-PO and FSC-G more effectively maintained hemostasis than the control group (p = 0.02 and p < 0.01, respectively). However, all styptics showed enhanced cytotoxicity against L-929 cells in a dose-dependent manner. Therefore, although FSC-PO and FSC-G would be recommended to control hemorrhage, the benefits of styptics must be balanced against the clinical significance of their cytotoxicity.

Dynamics of a Globular Protein and Its Hydration Water Studied by Neutron Scattering and MD Simulations

  • Kim, Chan-Soo;Chu, Xiang-Qiang;Lagi, Marco;Chen, Sow-Hsin;Lee, Kwang-Ryeol
    • Proceedings of the Korean Vacuum Society Conference
    • /
    • 2011.02a
    • /
    • pp.21-21
    • /
    • 2011
  • A series of Quasi-Elastic Neutron Scattering (QENS) experiments helps us to understand the single-particle (hydrogen atom) dynamics of a globular protein and its hydration water and strong coupling between them. We also performed Molecular Dynamics (MD) simulations on a realistic model of the hydrated hen-egg Lysozyme powder having two proteins in the periodic box. We found the existence of a Fragile-to-Strong dynamic Crossover (FSC) phenomenon in hydration water around a protein occurring at TL=$225{\pm}5K$ by analyzing Intermediate Scattering Function (ISF). On lowering of the temperature toward FSC, the structure of hydration water makes a transition from predominantly the High Density Liquid (HDL) form, a more fluid state, to predominantly the Low Density Liquid (LDL) form, a less fluid state, derived from the existence of a liquid?liquid critical point at an elevated pressure. We showed experimentally and confirmed theoretically that this sudden switch in the mobility of the hydration water around a protein triggers the dynamic transition (so-called glass transition) of the protein, at a temperature TD=220 K. Mean Square Displacement (MSD) is the important factor to show that the FSC is the key to the strong coupling between a protein and its hydration water by suggesting TL${\fallingdotseq}$TD. MD simulations with TIP4P force field for water were performed to understand hydration level dependency of the FSC temperature. We added water molecules to increase hydration level of the protein hydration water, from 0.30, 0.45, 0.60 and 1.00 (1.00 is the bulk water). These confirm the existence of the FSC and the hydration level dependence of the FSC temperature: FSC temperature is decreased upon increasing hydration level. We compared the hydration water around Lysozyme, B-DNA and RNA. Similarity among those suggests that the FSC and this coupling be universal for globular proteins, biopolymers.

  • PDF

Study on FSC Requirement of AC/DC Converter for ITER Superconducting Magnet (ITER 초전도자석 전원장치의 FSC 요건에 관한 연구)

  • Park, H.;Liu, H.;Lee, S.;Jung, W.;Jo, S.;Oh, J.S.;Choi, J.;Suh, J.H.
    • Proceedings of the KIPE Conference
    • /
    • 2011.11a
    • /
    • pp.251-252
    • /
    • 2011
  • ITER 기구는 초전도자석 전원장치가 운전 중 발생 가능한 부하의 단락으로부터 장치를 보호하기 위하여 FSC(Fault Suppression Capability) 조건에 만족할 것을 요구하고 있다. 본 연구에서는 모의시험을 통해 FSC 조건에서 발생되는 단락 전류에 의한 소자 이상 유무 및 전자기력의 크기와 방향을 확인하였고, 해석을 통해 전자기력이 전원장치 구조물에 미치는 영향을 검토하였으며, 실제 시험을 통해 모의시험 및 해석 결과가 타당함을 검증하였다.

  • PDF

Effect of Dune Sand on the Properties of Flowing Sand-Concrete (FSC)

  • Bouziani, Tayeb;Bederina, Madani;Hadjoudja, Mourad
    • International Journal of Concrete Structures and Materials
    • /
    • v.6 no.1
    • /
    • pp.59-64
    • /
    • 2012
  • Sand-concrete is being researched for potential usage in construction in Saharan regions of Algeria, because of shortage in coarse aggregate resources. This research work deals with the effect of dune sand, available in huge quantities in these regions, on the properties of flowing sand-concrete (FSC) prepared with different proportions of dune and river sands. Mini-cone slump test, v-funnel flow-time test and viscosity measurements were used to characterize the behaviour of FSC in fresh state. The 28-day compressive strength was also determined. Test results show that an optimal content of dune sand, which makes satisfied fresh and hardened properties of FSC, is obtained. Moreover, the obtained flow index (constant b) calculated by the help of power-law viscosity model is successfully correlated to the experimental results of v-funnel flow time.

Airline Customer Satisfaction Analysis using Social Media Sentiment Evaluation: Full Service Carriers vs. Low Cost Carriers (소셜 미디어 감성평가를 활용한 항공사 고객만족도 분석 - 대형항공사와 저비용항공사 비교연구)

  • Lee, Ju-Yang;Jang, Phil-Sik
    • Journal of Digital Convergence
    • /
    • v.15 no.6
    • /
    • pp.189-196
    • /
    • 2017
  • This study investigates customer satisfaction with full service carriers (FSC) and low cost carriers (LCC) using social media sentiment evaluation. From 2008 to 2016, a total of 77,591 tweets about two FSC and six LCC were aggregated and classified as per airline choice factors. Sentiment evaluation was employed to assess customer satisfaction by three appraisers. The results showed that customer satisfaction with LCC was significantly higher (p<0.001) compared to FSC. Furthermore, overall customer satisfaction with both FSC and LCC has been facing a consistent downward trend since the last seven years. The results also highlighted low customer satisfaction with respect to booking and flight operation factors, and a steep decline in customer satisfaction across booking, onboard services, and marketing factors for FSC. The results of this study have practical implications for the airline industry, which can use this quantitative data to improve customer satisfaction with FSC and LCC.

Genetically Engineered Yeast by Heterologous Transformation and Intergeneric Two-Step Protoplast Fusion for Ethanol Fermentation

  • Kim, Young-Ho;Lee, Jae-Ran;Seu, Jung-Hwn
    • Journal of Microbiology and Biotechnology
    • /
    • v.3 no.4
    • /
    • pp.232-237
    • /
    • 1993
  • A strain of yeast which can convert starch directly to ethanol was developed by the intergeneric protoplast fusion between Schwanniomyces alluvius possessing $\alpha$ amylase as well as glucoamylase with debranching activity and FSC-14-75 which previously had been formed from a heterologous transformation and subsequent intergeneric protoplast fusion. Fusants were selected on minimal medium after protoplasts of auxotrophic mutant of S. alluvius fused with heat-treated protoplasts of FSC-14-75 in the presence of 30%(w/v) PEG and 20 mM $CaCl_2$. The fusion frequency was in the range of $10^{-6}$ order. All fusants tested were intermediate types of parental strains for carbon compound assimilation, and their cell volumes were approximately 1.1 times larger than FSC-14-75 and 1.8 times larger than S. alluvius. The fusants were unable to sporulate like FSC-14-75, while S. alluvius could sporulate. In flask scale the most promising fusant, FSCSa-R10-6, produced 7.83%(v/v) and 10.17%(v/v) ethanol from 15% and 20% of liquefied potato starch, respectively, indicating that the fermetation efficiency of each case increased 1.2 times and 1.6 times than that of FSC-14-75. The elution pattern on DEAE-cellulose chromatography showed that FSCSa-R10-6 has four distinct amylase peaks of which two peaks originated from S. alluvius and the other two from FSC-14-75. These results suggest that the enhanced fermentation efficiency of the fusant might be due to almost-complemented parental amylases.

  • PDF

Recognition of Forest Certification by Consumption Propensity and Socio-Economic Characteristics of Wood Cabinet Consumers (목재수납장 구매자의 소비성향 및 사회·경제적 특성에 따른 산림인증 인식도 조사)

  • Shin, Hye-Jin;Kim, Eui-Gyeong;Kim, Dong-Hyeon;Kim, Hyeon-Guen
    • Journal of agriculture & life science
    • /
    • v.45 no.6
    • /
    • pp.57-63
    • /
    • 2011
  • This study was performed to figure out the recognition on forest certification by consumption propensity and socio-economic characteristics of wood cabinet consumers. The mean score of recognition on SFM and FSC showed comparatively low, 2.25 and 2.20(5-point likert scale), from the analysis result on 88 valid questionnaires of 90. The respondents rate of eco and non eco-friendly group formed 80.7% and 18.2%, there is a significant gap between two groups on total questionnaires. The percentage of respondents recognizing on SFM and FSC was about 31% (eco-friendly), 5.6%(non eco-friendly, SFM) and 2.8%(non eco-friendly, FSC) within each group. It showed that the socio-economic characteristics on eco-friendly respondents were higher than the others about more 1.3 times in the married rate, average age and monthly householding income.

The Moderating Effect of Brand Power on the Effect of Service Quality on Customer Satisfaction and Recommendation in Aviation Industry (서비스 품질이 항공사 만족과 추천에 미치는 영향에 있어 브랜드 파워의 조절적 영향)

  • Park, Seunghae;Hong, Jaewon
    • Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
    • /
    • v.7 no.1
    • /
    • pp.35-44
    • /
    • 2017
  • In this paper, we attempt to investigate the moderating effect of brand power on the effect of in-flight service quality on customer satisfaction and recommendation in the aviation industry. The results were as follows. First, in the case of high brand power FSC(full service carriers), the cost-to-benefit ratio as well as all other flight service properties influence to customer satisfaction. However, in the case of low brand power FSC, the cost-to-benefit ratio showed a greater impact of customer satisfaction compared to other in-flight services. Second, as in the case of customer satisfaction, while the cost-to-benefit ratio more influence to customer recommendation than other in-flight services in low brand power FSC, the cost-to-benefit ratio as well as all other flight service properties influence to customer recommendation together in high brand power FSC. Therefore, low brand power FSC required tit-for-tat strategy against to LCC(low cost carriers) by pursuing disruptive innovation for price. And high brand power FSC required sustaining innovation strategy through improving flight services.

Evaluation of Robust Performance of Fuzzy Supervisory Control Technique (퍼지관리제어기법의 강인성능평가)

  • Ok, Seung-Yong;Park, Kwan-Soon;Koh, Hyun-Moo
    • Journal of the Earthquake Engineering Society of Korea
    • /
    • v.9 no.5 s.45
    • /
    • pp.41-52
    • /
    • 2005
  • Using the variable control gain scheme on the basis of fuzzy-based decision-making process, Fuzzy supervisory control (FSC) technique exhibits better control performance than linear control technique with one static control gain. This paper demonstrates the effectiveness of the FSC technique by evaluating the robust performance of the FSC technique under the presence of uncertainties in the models and the excitations. Robust performance of the FSC system is compared with that of optimally designed LQG control system for the benchmark cable-stayed bridge presented by Dyke et al. Parameter studies on the robust performance evaluation are carried out by varying the stiffness of the bridge model as well as the magnitudes of several earthquakes with different frequency contents. From the comparative study of two control systems, FSC system shows the enhanced control performance against various magnitudes of several earthquakes while maintaining lower level of power required for controlling the bridge response. Especially, FSC system clearly guarantees the improved robust performance of the control system with stable reduction effects on the seismic responses and slight increases in total power and stroke for the control system, while LQG control system exhibits poor robust performance.

Finite Small Clauses in Japanese and Their Theoretical Implications

  • Kuno, Masakazu
    • Proceedings of the Korean Society for Language and Information Conference
    • /
    • 2002.02a
    • /
    • pp.237-248
    • /
    • 2002
  • This paper investigates the internal structure of finite small clauses (FSC). I will propose that a FSC is base-generated at Spec-CP and a null operator is involved to check the formal features of the embedded T and turn a sentence into a predicate.

  • PDF