• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제21권4호
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• pp.355-360
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• 2018

Recently, fecal microbiota transplantation (FMT) has been attracting attention as a possible medical treatment of ulcerative colitis (UC). A randomized controlled trial of FMT for children with UC is currently underway. Therapeutic effects of FMT for adults with UC remain controversial. We report two cases of early-onset UC in children. A patient was diagnosed with UC at age 1-year 9-month and underwent FMT at age 2-year 3-month. He attained clinical remission for three weeks after FMT, but then relapsed at four weeks, ultimately undergoing a total colectomy. Another child was diagnosed with UC at 2-year 10-month and she underwent FMT at age 5 years. She has remained in clinical remission following FMT for 24 months and her UC has been maintained without complications with tacrolimus and azathioprine. We report that FMT for early-onset UC appears to be safe and potentially effective.

• 한국통신학회논문지
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• 제41권3호
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• pp.365-370
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• 2016

최근 수중통신의 성능 향상을 위해 육상의 이동통신 기술 중 하나인 다중반송파 방식을 수중채널 환경에 적용하기 위한 연구 사례가 증가 하고 있으며, 본 연구에서는 기존 다중반송파 방식에 비하여 우수한 통신 성능을 갖는 시스템 설계를 위해 자원 확산에 의한 주파수 다이버시티 효과와 반복(Repetition)효과를 갖는 RS(Resource Spreading) FMT-OFDM 시스템을 제안한다. 본 연구에서는 실해역에서 측정한 데이터를 기반으로 채널을 모델링하고 시스템 파라미터를 설정한 후 RS FMT-OFDM 시스템과 기존 FMT-OFDM 시스템의 성능을 시뮬레이션을 통해 검증 하였다. 성능검증 결과 기존의 FMT-OFDM 시스템에 비하여 BER $10^{-3}$ 기준 약 12dB정도 통신성능의 향상이 있었으며, 자원 확산률이 증가함에 따라 통신 성능 향상이 있음을 확인할 수 있었다.

• 한국통신학회논문지
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• 제35권6C호
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• pp.572-579
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• 2010

Filtered multi-tone (FMT) 다중 경로 페이딩에 강인하고 보호 구간 없이 전송됨으로 이동 통신 시스템에 효율적 방식이다. 이동 통신 시스템은 채널 추정과 링크 적응 성능의 향상을 위해서 도플러 주파수 정보를 필요로 하지만 기존 도플러 주파수 추정 연구는 직교 분할 다중 접속 (OFDM)에 집중되었고 FMT 방식에서 수행되지 않았다. OFDM에서 기존 연구는 잡음 회피를 위해서 시간 영역에서 처리함으로 상당한 복잡도를 갖고 또한 수신기의 동기 오차를 고려하지 않는다. 본 논문은 동기 오차로 인하여 발생하는 시간 영역과 주파수 영역에서 자기 상관의 위상 성분을 제거함으로써 동기 오차와 잡음에 강인한 도플러 주파수 추정 기법을 제안한다. 제안 기법이 FMT 방식의 상용화 시스템인 TETRA enhanced data service (TEDS)에 적용될 때 정확한 도플러 주파수를 추정한다.

• Journal of Microbiology and Biotechnology
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• 제30권8호
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• pp.1132-1141
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• 2020

Inflammatory bowel disease (IBD) is an increasing global burden and a predisposing factor to colorectal cancer. Although a number of treatment options are available, the side effects could be considerable. Studies on fecal microbiota transplantation (FMT) as an IBD intervention protocol require further validation as the underlying mechanisms for its attenuating effects remain unclear. This study aims to demonstrate the ameliorative role of FMT in an ulcerative colitis (UC) model induced by dextran sulfate sodium (DSS) and elucidate its relative mechanisms in a mouse model. It was shown that FMT intervention decreased disease activity index (DAI) levels and increased the body weight, colon weight and colon length of experimental animals. It also alleviated histopathological changes, reduced key cytokine expression and oxidative status in the colon. A down-regulated expression level of genes associated with NF-κB signaling pathway was also observed. The results of 16S rRNA gene sequencing showed that FMT intervention restored the gut microbiota to the pattern of the control group by increasing the relative abundance of Firmicutes and decreasing the abundances of Bacteroidetes and Proteobacteria. The relative abundances of the genera Lactobacillus, Butyricicoccus, Lachnoclostridium, Olsenella and Odoribacter were upregulated but Helicobacter, Bacteroides and Clostridium were reduced after FMT administration. Furthermore, FMT administration elevated the concentrations of SCFAs in the colon. In conclusion, FMT intervention could be suitable for UC control, but further validations via clinical trials are recommended.

• 한국군사과학기술학회지
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• 제10권2호
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• pp.100-106
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• 2007

In this paper, the performance of OFDM(Orthogonal Frequency Division Multiplexing) and FMT(Filtered Multi-tone) Systems is compared under jamming environment. Two systems are multi-carrier systems to improve data rates. Through the comparison of two systems under jamming environment, the characteristics and strong/weak points of each system are analyzed.

• Journal of Periodontal and Implant Science
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• 제35권3호
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• pp.597-608
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• 2005

The aim of this study is to determine whether full-mouth disinfection therapy(FMT) in our clinical setting would show better improvement of clinical parameters than partial mouth disinfection therapy(PMT) in chronic periodontitis and aggressive periodontitis patients. Among 12 patients, 6 were treated FMT and other 6 were treated PMT. Clinical parameters were calculated 3 months and 6 months after initial therapy. 1. There were no statistically significant differences between FMT and PMT in the reduction rate of bleeding on probing after 3 months, 6 months 2. Initial probing depth was 4-6mm, the mean probing depth after 3 months was 2.2mm vs 2.5mm(FMT vs PMT), after 6 months was 2.4mm vs 2.8mm. This was significantly lower in the FMT groups. 3. Initial probing depth was ${\geqq}$ 7mm, the reduction rate of mean probing depth during first 3 months was 4.8mm vs 4.1mm(FMT vs PMT), and 3 to 6 months was 0.5mm vs 0.3mm. This was significantly larger in the FMT groups. 4. Initial probing depth was 4-6mm, the mean clinical attachment level after 3 months was 2.3mm vs 2.7mm(FMT vs PMT), after 6 months was 2.7mm vs 3.0mm. This was significantly lower in the FMT groups. 5. Initial probing depth was ${\geqq}$ 7mm, the reduction rate of mean probing depth during first 3 months was 4.0mm vs 3.0mm(FMT vs PMT), and 3 to 6 months was 0mm vs -0.1mm. This was significantly larger in the FMT groups. Although the results provided us with succeccful clinical improvement in aggressive periodontitis, further research is needed to prove its additional benefit in the treatment of chronic periodontitis

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제19권3호
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• pp.214-220
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• 2016

Fecal microbiota transplantation (FMT) is a treatment designed to correct gut dysbiosis by administration of feces from a healthy volunteer. It is still unclear whether FMT for children with ulcerative colitis (UC) is effective or hazardous. Here we describe a young patient to have received FMT for UC. A three-year-old girl was admitted to our hospital with severe active UC, and treated with aminosalicylates and various immunosuppressive drugs. As remission was not achieved, we decided to try FMT before colectomy. We administered donor fecal material a total of six times by retention enema (${\times}2$) and via a nasoduodenal tube (${\times}4$) within 10 days. The patient developed abdominal pain and pyrexia after each FMT session. Analyses revealed the transferred donor fecal microbiota had not been retained by the patient, who ultimately underwent colectomy. The severity of the UC and/or timing of FMT may have partly accounted for the poor outcome.

• 한국멀티미디어학회논문지
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• 제12권9호
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• pp.1316-1322
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• 2009

광대역 통신을 위한 효율적 전송 방식으로 다중 반송파 시스템이 각광을 받고 있다. Filtered multitone(FMT) 시스템은 orthogonal frequency division multplexing(OFDM)과 달리 시간영역에서 필터의 길이가 여러 심볼 주기에 걸쳐 있으며, 이러한 긴 주기의 필터 사용으로 다중경로 환경에서 intersymbol interference(ISI)에 의한 성능열화 현상이 발생한다. 본 논문에서는 무선 채널 환경에서 필터에 의하여 발생한 ISI 성분을 제거하는 FMT 시스템을 위한 간단한 등화기법을 제안한다. 제안하는 등화기법은 직전 심볼과 직후 심볼에서 발생하는 ISI값을 추정하여, 현재 심볼에서 추정된 값을 빼줌으로써 ISI 성분을 제거해주는 방식으로 동작한다. 제안된 등화기의 성능을 이론적으로 분석하여 성능의 우수함을 보였으며, 컴퓨터 시뮬레이션을 통하여 제안된 시스템의 성능이 lower bound에 근접함을 보여주었다.

• 수산해양기술연구
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• 제41권2호
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• pp.122-128
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• 2005

The experiments were conducted to fine out the handling characteristics of the FMT(Frame Mideater Trawl) in the southern waters of Korea using a trawler "DONGBAEK" belongs to Yosu National University. The realtionship between the net depth D(m) and the warp length L(m) at the towing speeds of 2.5k't and 3.5k't werw as follows ; D(m) = 0.30L - 1.3(2.5k't), D(m) = 0.16L - 1.5(3.5k't). Therefore, the net depth was 3.0m deeper when the warp length was 10m longer at the towing speed of 2.5k't and was 1.6m deeper for 10m longer at the speed of 3.5k't, respectively. The sinking speed of FMT was 6.5m/min when the warp releasing speed was 24m/min at the towing speed of 2.5k't and was 3.8m/min for 25m/min at the towing speed of 3.5k't, respectively. The rising speed of FMT was 6.9m/min when the warp rewinding speed was 28m/min at the towing speed of 2.5k't and was 5.3m/min for 25m/min at the towing speed of 3.5k't, respectively. The mean elapsed time getting to the stable towing condition was 104sec at the towing speed of 2.5k't and was 105sec at the towing speed of 3.5k't, respectively, and there was no time difference for the towing speed variation. During the towing, the net depth was comparatively stable on the condition of no change for the warp length and the towing speed.

• 미생물학회지
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• 제50권4호
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• pp.265-274
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• 2014

장내 미생물은 사람의 장에 거주하는 미생물 집단으로 자신들의 효소를 이용해 사람에게 직접적인 에너지원이 되는 대사산물을 만들기도 하고 병원성 미생물의 침입에 대응하기도 하며 소화관의 구조와 기능유지 및 면역계의 발달에 영향을 미치는 등의 중요한 기능을 수행한다. 최근 다양한 분석기술을 통해 사람의 장에 있는 다종 및 다수의 미생물의 구성을 관찰하였고 그 결과 특정 질병을 지닌 사람의 장내 미생물 구성은 건강한 사람의 일반적인 구성과 다르다는 것을 확인하였다. 이러한 발견을 바탕으로 건강한 사람의 대변에 있는 장내 미생물을 질병을 지닌 수여자에게 이식하는 fecal microbiota transplantation (FMT) 시술이 각광을 받기 시작하였다. FMT는 장내 미생물의 구성변화로 인해 나타나는 여러 질병에 치료제로 적용할 수 있는데 특히 재발률이 높은 Clostridium difficile 감염에서 활발한 연구가 이루어지고 있다. 이 논문은 지금까지 밝혀진 장내 미생물과 관련된 질병들의 종류와 실제 질병에 FMT를 적용한 사례 등을 정리하고 장내 미생물을 이용하여 현재 연구개발 중인 치료제나 진단도구의 예를 기술함으로써 장내 미생물의 사람의 건강증진과 질병치료를 위한 차세대 생물학적 치료제로서의 가능성을 고찰하고자 한다.