• Neonatal Medicine
• /
• v.17 no.2
• /
• pp.207-216
• /
• 2010

Purpose: The aim of this study was to identify the effects of neonatal developmental intervention program (NDT) in promoting motor development and growth and to determine the usefulness of Hammersmith Neonatal Neurological Examination (HNNE) and Neonatal Behavioral Assessment Scale (NBAS) in premature infants. Methods: We performed NDT on selected premature infants (PI, n=42) and compared them with the full term control group (FC, n=20). NDT protocol and development assessment (HNNE, NBAS) were manipulated by the physical therapist in the neonatal intensive care unit. The data of this study were collected prospectively. Results: The PI with GA <34 weeks (VPI) subgroup showed a more use of mechanical ventilator and surfactant, severe bronchopulmonary dysplasia and intraventricular hemorrhage, and patent ductus arteriosus treated surgically than the PI with GA $\geq$34 weeks but less than 37 weeks (LPI) subgroup. The average scores improved significantly in the PI group between the 1st, 2nd, and 3rd assessment by repeated measure (P=0.000). Also, the PI group showed significantly higher total scores and average score at 40 weeks postmenstrual age, P=0.000, respectively than in the FC group. The LPI subgroup showed more weight gain and change in the head circumference between the 1st and 3rd assessment by repeated measure, respectively, P<0.05. The PI group showed no apnea, bradycardia and late sepsis associated with intervention and assessment. Conclusion: The NDT might be a safe and useful intervention to promote motor and growth outcomes in premature infants. Also, the HNNE and NBAS might be safe and useful tools for assessing neurodevelopment in premature infants.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.40 no.2
• /
• pp.257-264
• /
• 2020

Vectorization is currently the main method in feature collection (extraction) during digital mapping using UAV-Photogrammetry. However, this method is time consuming and prone to gross elevation errors when extracted from a DSM (Digital Surface Model), because three-dimensional feature coordinates are vectorized separately: plane information from an orthophoto and height from a DSM. Consequently, the demand for stereo plotting method capable of acquiring three- dimensional spatial information simultaneously is increasing. However, this method requires an expensive equipment, a Digital Photogrammetry Workstation (DPW), and the technology itself is still incomplete. In this paper, we evaluated the accuracy of low-cost stereo plotting system, Menci's StereoCAD, by analyzing its three-dimensional spatial information acquisition. Images were taken with a FC 6310 camera mounted on a Phantom4 pro at a 90 m altitude with a Ground Sample Distance (GSD) of 3 cm. The accuracy analysis was performed by comparing differences in coordinates between the results from the ground survey and the stereo plotting at check points, and also at the corner points by layers. The results showed that the Root Mean Square Error (RMSE) at check points was 0.048 m for horizontal and 0.078 m for vertical coordinates, respectively, and for different layers, it ranged from 0.104 m to 0.127 m for horizontal and 0.086 m to 0.092 m for vertical coordinates, respectively. In conclusion, the results showed 1: 1,000 digital topographic map can be generated using a stereo plotting system with UAV images.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
• /
• v.40 no.3
• /
• pp.207-215
• /
• 2022

This research has been focused on accessing precision and accuracy of UAV (Unmanned Aerial Vehicle)-derived 3-D surveying coordinates. To this end, a highly precise and accurate testing control network had been established by GNSS (Global Navigation Satellite Systems) campaign and its network adjustment. The coordinates of the ground control points and the check points were estimated within 1cm accuracy for 95% of the confidence level. FC330 camera mounted on DJI Phantom 4 repeatedly took aerial photos of an experimental area seven times, and then processed them by two widely used software packages. To evaluate the precision and accuracy of the aerial surveys, 3-D coordinates of the ten check points which automatically extracted by software were compared with GNSS solutions. For the 95% confidence level, the standard deviation of two software's result is within 1cm, 2cm, and 4cm for the north-south, east-west, and height direction, and RMSE (Root Mean Square Error) is within 9cm and 8cm for the horizontal, vertical component, respectively. The interest is that the standard deviation is much smaller than RMSE. The F-ratio test was performed to confirm the statistical difference between the two software processing results. For the standard deviation and RMSE of most positional components, exception of RMSE of the height, the null hypothesis of the one-tailed tests was rejected. It indicates that the result of UAV photogrammetry can be different statistically based on the processing software.

• Proceedings of the Korean Institute of Building Construction Conference
• /
• 2007.04a
• /
• pp.33-36
• /
• 2007

In order to select the optimum mix for the required fluidity and strength of mass concrete which is applied to transfer girder and to choose the optimum curing method depending on circumstances through hydration heat analysis of mass concrete, this study examined slump flow, air content and elapsed variation (0, 30, 60, 90) in unhardened concrete properties and reviewed compressive strength characteristics in hardening properties. And hydration heat analysis results through simulation are as follows; 1) Fluidity changes of unhardened concrete showed no significant difference, and those of elapsed variation also showed no difference but a bit of tendency to increase in comparison with the initial properties. 2) The higher the water-binder ratio was, the lower the compressive strength properties were, and the higher the fly ash replacement rate was, the lower the compressive strength development was. 3) In case of $Fc=40N/mm^2$, the optimum mix was fly ash replacement rate of 15% from water-binder ratio of 33.0%. 4) Hydration heat analysis results showed that in case of bundle cast, concrete temperature profile characteristics around transfer girder was unfavorable, and in case of separate cast, constant curing for at least seven days guaranteed thermal cracking index of 1.2.

• Journal of Ginseng Research
• /
• v.28 no.1
• /
• pp.33-38
• /
• 2004

This study was carried out to determine the effect of white and red Panak ginseng on body weight gain, feed efficiency, epididymal fat weight, and total serum cholesterol and triglyceride levels in male rats (Wister/ST, 8-week-old, 320 g) fed high fat diet. Rats were divided largely into two groups; normal control (NC) and high-fat-diet (HFD)-fed groups. HFD-fed animals were subdivided into 2 groups; HFD-fed control (FC), and HFD- and ginseng-fed groups. HFD and ginseng fed animals were furthor subdivided into white (WG)- and red ginseng (RG)-treated groups. Ginseng-treated groups received ethanol extract at daily doses of 250, 500, 1,000 mg/kg b.w. for 4 weeks. Consequently, a total of 40 rats were divided into 8 groups. Body weight gain of WG-500 (P<0.05), WG1000 (P<0.01) and RG500 (P<0.05) was significantly lower than that of the NC. Feed efficiency showed same result. The epididymal fat weight of WG500, WG1000 and RG250 was markedly lower (P<0.05) than that in FC. Total serum cholesterol level of WG250, WG500, WG1000 and RG1000 groups were significantly lower (P<0.05) than that of FC. Decrease in the total cholesterol level was most significant in WG100 group. Treatment of ginseng significantly reduced serum free cholesterol and triglyceride levels of the HFD-fed rats irrespective of white or red ginseng. Among the test groups, administration of ginseng at daily dose of 1,000 mg/kg b.w. showed the most potent free cholesterol and triglyceride lowering activity. These results led us to the conclusion that administration of ginseng lowers serum total or free cholesterol and triglyceride levels in HFD-fed animals. Moreover the beneficial effect of white ginseng was slightly more potent than that of the red ginseng.

• Food Science of Animal Resources
• /
• v.30 no.3
• /
• pp.504-511
• /
• 2010

This study was undertaken to investigate the effects of feeding complex probiotics (Lactobacillus casei, Bacillus subtilis, Saccharomyces cerevisiae, Aspergillus oryzae, Streptomyces griseus, $1.5{\times}10^{10}$ CFU/kg) and antibiotics (oxytetracycline (OTC), 110 ppm) on growth performance and meat quality characteristics of broiler chicks. In the experiment 1, 0.3% complex probiotics feeding level was chosen to be proper addition level due to better average daily gain (ADG), feed conversion (FC) and dressing percent (DP) results among 3 levels (0.1, 0.3 or 0.5%). In the experiment 2, 5 treatments (T1, no probiotics + no antibiotics; T2, probiotics 0.3% + no antibiotics; T3, probiotics 0.3% + antibiotics 50%; T4, probiotics 0.3% + antibiotics 100%; T5, no probiotics + antibiotics 100%) were investigated. In the growth performance of broilers, T5 (antibiotics 100% only) showed the highest (p<0.05) ADG and FC values while T1 (control) showed the worst growth performance. However, T3 (probiotics 0.3% + antibiotics 50%) showed higher ADG (p<0.05), FC (p<0.05) and DP (p>0.05) values compared to control. In the breast and leg meat quality, T3 showed similar pH, proximate composition, cooking loss and meat color values except shear force value compared to T5. Addition of 0.3% probiotics with 50% antibiotics (T3) tended to lower the blood cholesterol levels of broiler chicks and Escherichia coli or Salmonella counts in cecum microflora of broiler chicks compared to T5. In the residual antibiotics analysis, T3 contained 0.04 ppm of residual antibiotics in the breast meat while T4 or T5 contained 0.1 ppm of residual antibiotics and addition of 0.3% probiotics with 50% antibiotics in broiler diets could lower the residual antibiotics level to 40% in the meat. As a result, 0.3% probiotics addition with 50% antibiotics in the broiler diets could be recommended for the production of high quality broiler meat.

• Transactions of the Korean Society of Mechanical Engineers
• /
• v.18 no.2
• /
• pp.456-466
• /
• 1994

Experimental investigation was made to study the mechanism of fluid and thermal oscillation phenomena of surface-tension driven flow in a cylindrical liquid column heated from above which is the low-gravity floating zone simulated on earth. Hexadecane, octadecane, silicon oil (10cs), FC-40 and water are used as the test liquids. The onset of the oscillatory thermocapillary convection appears when Marangoni number exceeds its criteria value and is found to be due to the coupling among velocity and temperature field with the free surface deformation. The frequency of temperature oscillation decreases with increasing aspect ratio for a given diameter and Marangoni number and the oscillation level increases with Marangoni number. The flow pattern in the liquid column appears either as symmetric or asymmetric 3-D flow due to the oscillatory flow in the azimuthal direction. The free surface deformation also occurs either as symmetric or asymmetric mode and its frequency is consistent with those of flow and temperature oscillations. The amplitude of surface deformation also increases with Marangoni number.

• The Transactions of the Korean Institute of Power Electronics
• /
• v.6 no.6
• /
• pp.572-581
• /
• 2001

A heat pipe heat sink device which is to evacuate maximum heat of about 1800W from a powersemiconductor was designed and manufactured One set of cooling device os composed of an Aluminum block (130${\times}$160${\times}$35mm) 4 PFC heat pipes $(d_0 22.23mm)$ and 126 Aluminium fins (250${\times}$58${\times}$0.8mm) Experimental data obtained at a power of 1~2kW revealed that the total thermal resistance of the device varied 0.02~0.018$^{\circ}C$/W along with increasing air velocity from 2m/s to 3 m/s. The result represented a good satisfaction of requirement condition to maintain temperature rise of semiconductor lowe that $40^{\circ}C$ at 1800W and air velocity of 3 m/s Some important resistance such as convective resistances at both fins and heat pipes showed good agreement between mathematical predictions and measurement data.

• Bulletin of the Korean Chemical Society
• /
• v.22 no.12
• /
• pp.1361-1365
• /
• 2001

Recombinant immunotoxins are hybrid cytotoxic proteins designed to selectively kill cancer cells. A divalent immunotoxins, [B3(FabH1)-PE38]2, was constructed by recombining Fab domain of B3 antibody as a cell-targeting domain and Pseudo monas exotoxin A (PE) as a cytotoxic domain. Monoclonal antibody, B3, is the murine antibody (IgG1k) directed against Lewis Y-related carbohydrate antigens, which are abundant on the surface of many carcinomas. Fab fragment of this antibody was used in this study with the modified hinge sequence where last two cysteines out of three were mutated to serine. PE is a 66 kDa bacterial toxin that kills eukaryotic cells by inhibiting protein synthesis with ADP ribosylation of ribosomal elongation factor 2 (EF2). Fc region of B3 antibody was substituted with the truncated form of PE (38 kDa, PE38) on DNA level. [B3(FabH1)-PE38]2 was formed by disulfide bond between cysteines in the modified hinge region of B3(FabH1)-PE38. Each polypeptide for recombinant immunotoxins was overexpressed in Escherichia coli and collected as inclusion bodies. Each inclusion body was solubilized and refolded, and cytotoxic effects were measured. Divalent immunotoxins, [B3(FabH1)-PE38]2, had ID50 values of about 10 ng/mL on A431 cell lines and about 4 ng/mL on CRL1739 cell lines. Control immunotoxins, B3(scFv)-PE40, had ID50 values of about 28 ng/mL on A431 cell lines and about 41 ng/mL on CRL1739 cell lines. Divalent immunotoxins, [B3(FabH1)-PE38]2, had higher cytotoxic effects than B3(scFv)-PE40 control immunotoxins.

• Journal of Ginseng Research
• /
• v.42 no.2
• /
• pp.149-157
• /
• 2018

Background: Panax notoginseng leaves (PNL) exhibit extensive activities, but few analytical methods have been established to exclusively determine the dammarane triterpene saponins in PNL. Methods: Ultra-performance liquid chromatography coupled with time-of-flight mass spectrometry (UPLC/Q-TOF MS) and HPLC-UV methods were developed for the qualitative and quantitative analysis of ginsenosides in PNL, respectively. Results: Extraction conditions, including solvents and extraction methods, were optimized, which showed that ginsenosides Rc and Rb3, the main components of PNL, are transformed to notoginsenosides Fe and Fd, respectively, in the presence of water, by removing a glucose residue from position C-3 via possible enzymatic hydrolysis. A total of 57 saponins were identified in the methanolic extract of PNL by UPLC/Q-TOF MS. Among them, 19 components were unambiguously characterized by their reference substances. Additionally, seven saponins of PNL-ginsenosides Rb1, Rc, Rb2, and Rb3, and notoginsenosides Fc, Fe, and Fd-were quantified using the HPLC-UV method after extraction with methanol. The separation of analytes, particularly the separation of notoginsenoside Fc and ginsenoside Rc, was achieved on a Zorbax ODS C8 column at a temperature of $35^{\circ}C$. This developed HPLC-UV method provides an adequate linearity ($r^2$ > 0.999), repeatability (relative standard deviation, RSD < 2.98%), and inter- and intraday variations (RSD < 4.40%) with recovery (98.7-106.1%) of seven saponins concerned. This validated method was also conducted to determine seven components in 10 batches of PNL. Conclusion: These findings are beneficial to the quality control of PNL and its relevant products.