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http://dx.doi.org/10.5142/JGR.2004.28.1.033

Effect of White and Red Panax ginseng Extract on Serum Lipids Level in High-fat-diet Fed Rats  

Sung, Jong-Hwan (Central Research Institute, ILHWA Co. Ltd.)
So, Nam-Woo (Central Research Institute, ILHWA Co. Ltd.)
Jeon, Bo-Hyun (Department of chemistry, Kunsan National University)
Chang, Che-Chul (Department of chemistry, Kunsan National University)
Publication Information
Journal of Ginseng Research / v.28, no.1, 2004 , pp. 33-38 More about this Journal
Abstract
This study was carried out to determine the effect of white and red Panak ginseng on body weight gain, feed efficiency, epididymal fat weight, and total serum cholesterol and triglyceride levels in male rats (Wister/ST, 8-week-old, 320 g) fed high fat diet. Rats were divided largely into two groups; normal control (NC) and high-fat-diet (HFD)-fed groups. HFD-fed animals were subdivided into 2 groups; HFD-fed control (FC), and HFD- and ginseng-fed groups. HFD and ginseng fed animals were furthor subdivided into white (WG)- and red ginseng (RG)-treated groups. Ginseng-treated groups received ethanol extract at daily doses of 250, 500, 1,000 mg/kg b.w. for 4 weeks. Consequently, a total of 40 rats were divided into 8 groups. Body weight gain of WG-500 (P<0.05), WG1000 (P<0.01) and RG500 (P<0.05) was significantly lower than that of the NC. Feed efficiency showed same result. The epididymal fat weight of WG500, WG1000 and RG250 was markedly lower (P<0.05) than that in FC. Total serum cholesterol level of WG250, WG500, WG1000 and RG1000 groups were significantly lower (P<0.05) than that of FC. Decrease in the total cholesterol level was most significant in WG100 group. Treatment of ginseng significantly reduced serum free cholesterol and triglyceride levels of the HFD-fed rats irrespective of white or red ginseng. Among the test groups, administration of ginseng at daily dose of 1,000 mg/kg b.w. showed the most potent free cholesterol and triglyceride lowering activity. These results led us to the conclusion that administration of ginseng lowers serum total or free cholesterol and triglyceride levels in HFD-fed animals. Moreover the beneficial effect of white ginseng was slightly more potent than that of the red ginseng.
Keywords
Ginseng; high-fat-diet; cholesterol; triglyceride; weight gain;
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Times Cited By KSCI : 3  (Citation Analysis)
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