• 종양간호연구
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• 제3권2호
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• pp.145-154
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• 2003

Purpose: The study was to furnish basic raw materials that evaluate the efficacy of meatal care according to the form and the relative importance of symptom distress which most of cancer sufferers have been experienced. For that, an investigation of five diverse major cancer symptom distress made a comparison between symptom distress and degree of suffering. Method: Study subjects were 138 inpatients with stomach cancer, lung cancer, hepatocellular carcinoma(HCC), large intestine cancer and breast cancer, except those in the terminal-stage, in 'H' university hospital in Seoul and 'K' center in Ilsan gathered from November 20, 2002 to February 20, 2003. To measure the correlation between feeling of discomfort and agony caused by cancer, 5 point scale (from zero to four), stood on the basis of Symptom Distress Scale (SDS, Rodes & Watson, 1987), was used for this study and the Cronbach's coefficient alpha was 0.95. Accumulated data was analyzed with SPSS 10.0 for window, also used by ANOVA and Duncan's Multiple Range Test. Pearson's Correlation Analysis. Results: 1. Symptom distress of cancer patients was noted and defined in their severity-fatigue, anorexia, pain, depression, dyspepsia, changing appearance and nausea. The degree of symptom distress was fatigue, dyspepsia, depression, anorexia, pain, changing appearance and the degree of suffering was nausea, pain, anorexia, dyspepsia, vomiting, breathing difficulty, changing appearance and fatigue. 2. Examining the difference of degree of symptom distress in each cancer cases, it takes the precedence of them. First, in case of stomach cancer, depression, pain, vomiting and nausea were shown in sequence. In case of lung cancer depression, pain, sleeping problem, anxiety, changing appearance, inattentiveness and vomiting were showed in sequence, depression, changing appearance, sleeping problem, pain in case of HCC, depression, pain in case of large intestine cancer and lastly in case of breast cancer changing appearance, depression, pain and anxiety were shown in sequence. The category of the degree of symptom distress that has a signifiant difference was anorexia, activity discomfort, fatigue, constipation or diarrhea, breathing difficulty, dyspepsia, caughing, fever or chillness, scotoma and urinary disorder. Verifying the highest degree of symptom distress in each cancer cases, anorexia was 1.94(F=4.00, p<.01) in stomach cancer, activity discomfort was 0.97(F=3.08, p<.01) in lung cancer and HCC, fatigue was 2.32(F=4.64, p<.01) in HCC, constipation or diarrhea was 1.83(F=22.31, p<.001) in large intestine cancer, breathing difficulty was 1.83(F=4.00, p<.01) in lung cancer, dyspepsia was 2.69(F=9.98, p<.001) in stomach cancer, coughing was 1.53(F=20.49, p<.001) in lung cancer, fever or chillness was 1.23(F=6.88, p<.001) in lung cancer, scotoma was 1.20(F=3.02, p<.05) in lung cancer and urinary disorder was 1.54(F=11.56, p<.001) in HCC. 3. Examining the difference degree of suffering on cancer cases, the result was as follows; depression of lung cancer was 1.17(F=3.76, p<.01), anorexia of stomach cancer was 1.61(F=3.89, p<.01), constipation or diarrhea of large intestine cancer was 1.42(F=10.43, p<.001), changing appearance of breast cancer was 1.65(F=5.43, p<.001), breathing difficulty of lung cancer was 2.27(F=18.57, p<.001), dyspepsia of stomach cancer was 1.97(F=13.56, p<.001), coughing of lung cancer was 1.70(F=22.07, p<.001), fever or chillness of lung cancer was 1.13(F=4.41, p<.01), scotoma of lung cancer was 0.87(F=3.34, p<.05), anxiety of lung cancer was 0.87(F=4.50, p<.001) and urinary disorder of HCC was 1.43(F=16.71, p<.001). 4. In consequence, comparing between symptom distress and degree of suffering on cancer patients undergoing chemotherapy, lung cancer patients showed the highest feeling of discomfort following stomach cancer, HCC, breast cancer and large intestine cancer(F=2.88, p<.05). On those undergoing radiotherapy, lung cancer, HCC, breast cancer, large intestine cancer was in sequence(F=3.78, p<.05) and those resisting radiotherapy, lung cancer, HCC, stomach cancer, large intestine cancer and breast cancer was in sequence(F=2.72, p<.05). 5. Correlation between symptom distress and degree of suffering on cancer patients was generally significant. Conclusion: this study not only defines a significant correlation between symptom distress and degree of suffering but also proffers basic data to evaluate the efficient meatal care depending upon diverse spectrums of symptom distress and degree of suffering.

• 대한기계학회논문집
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• 제19권9호
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• pp.2133-2141
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• 1995

The thermo-mechanical fatigue tests were performed on the specimens extracted from 1.5Cr-0. 67Mo-0.33V alloy. The characteristics of thermo-mechanical fatigue crack propagation were examined and reviewed in view of fracture mechanics. The results obtained from the present study are summarized as follows : (1) The propagation characteristics of isothermal low-cycle fatigue crack are dominated by .DELTA.J$_{f}$ in case of PP waveform, and .DELTA.J$_{c}$ in case of CP waveform. (II)The propagation characteristics of thermo-mechanical fatigue crack are dominated by .DELTA.J$_{c}$ for in-phase case, and by .DELTA.J$_{c}$ for out-of-phase. The present results were in good agreement with the equation of propagation law for isothermal low-cycle fatigue crack in case of thermo-mechanical fatigue.tigue.e.

• Bulletin of the Korean Chemical Society
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• 제28권3호
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• pp.373-378
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• 2007

A micro organism Agrobacterium tumifacient as an immobilized cell on a solid support was presented as a new biosorbent in a simple and sensitive spectrophotometry determination of Ni(II) in various samples using 4-hydroxy benzaldehyde-4-bromophenyl hydrazone as a color developing agent (λmax 497 nm) at pH 4.0 ± 0.2. Beer's law was obeyed over the range of 0.01-0.1 μg L-1. The molar absorptivity and Sandell's sensitivity were 1.285 × 105 L mol-1cm-1 and 0.007245 μg cm-2 respectively. Under these conditions, the preconcentration factor obtained was 82, and the detection limit achieved was 0.05 μg L-1. The detailed study of various interfering ions made the method more sensitive and selective. The recovery of Ni(II) from various samples range from 97.75 to 99.35%. The present method was successfully applied for the determination of Ni(II) in spiked, natural water and alloy samples. The proposed method was compared with reported methods in terms of Student's ‘t'-test and Variance ratio ‘f'-test which indicates that there is no significant difference between proposed and literature method at 95% confidence level.

• Transactions on Electrical and Electronic Materials
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• 제10권1호
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• pp.28-30
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• 2009

We have studied organic layer-thickness dependent electrical and optical properties of bottom- and top-emission devices. Bottom-emission device was made in a structure of ITO(170 nm)/TPD(x nm)/$Alq_3$(y nm)/LiF(0.5 nm)/Al(100 nm), and a top-emission device in a structure of glass/Al(100 nm)/TPD(x nm)/$Alq_3$(y nm)/LiF(0.5 nm)/Al(25 nm). A hole-transport layer of TPD (N,N'-diphenyl-N,N'-di(m-tolyl)-benzidine) was thermally deposited in a range of 35 nm and 65 nm, and an emissive layer of $Alq_3$ (tris-(8-hydroxyquinoline) aluminum) was successively deposited in a range of 50 nm and 100 nm. Thickness ratio between the hole-transport layer and the emissive layer was maintained to be 2:3, and a whole layer thickness was made to be in a range of 85 and 165 nm. From the current density-luminance-voltage characteristics of the bottom-emission devices, a proper thickness of the organic layer (55 nm thick TPD and 85 nm thick $Alq_3$ layer) was able to be determined. From the view-angle dependent emission spectrum of the bottom-emission device, the peak wavelength of the spectrum does not shift as the view angle increases. However, for the top-emission device, there is a blue shift in peak wavelength as the view angle increases when the total layer thickness is thicker than 140 nm. This blue shift is thought to be due to a microcavity effect in organic light-emitting diodes.

• 대한전자공학회논문지SD
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• 제49권7호
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• pp.23-29
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• 2012

디지털 PLL의 핵심블록이 되는 디지털 제어 발진기를 LC 구조를 기반으로 설계하고 $0.18{\mu}m$ RF CMOS 공정을 사용하여 제작하였다. 2개의 교차쌍 구조의 NMOS 코어를 이용하여 광대역 특성을 구현하였으며, PMOS 배랙터쌍을 이용하여 수 aF의 작은 캐패시터값의 변화를 얻을 수 있었다. 캐패시터 축퇴 기법을 사용하여 캐패시턴스 값을 감소시키어 고해상도 주파수 특성을 구현하였다. 또한, 노이즈 필터링 기법을 바이어스 회로 등에 적용하여 위상잡음에 강한 구조로 설계를 하였다. 측정결과 중심주파수 2.7GHz에서 2.5GHz의 주파수 대역의 출력이 가능하였으며 2.9 ~ 7.1kHz의 높은 주파수해상도를 얻을 수 있었다. 미세튜닝범위와 코어의 전류 바이어스는 4개의 PMOS 배열을 통하여 제어가 가능하도록 하여 유연성을 높였다. 1.8V 전원에서 전류는 17~26mA 정도를 소모하였다. 설계한 DCO는 다양한 통신시스템에 응용이 가능하다.

• 대한환경공학회지
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• 제29권7호
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• pp.783-792
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• 2007

부직포 여과막 생물반응조의 질산화 성능을 파악하기 위하여 주입폐수의 암모니아 농도를 $54\sim1,400$ mg/L 그리고 알칼리도를 $43\sim10,480$ mg/L로 변화시키면서 약 11시간의 체류시간에서 641일간 실험을 실시한 결과 반응조의 MLSS농도는 최초의 2,650 mg/L 에서 830 mg/L까지 감소하였다가 최고 8,340 mg/L까지 증가함으로써 반응조의 용적부하는 $0.120\sim3.130$ kg $NH_3-N/m^3-day$의 범위에서 변하였으나 F/M 비는 $0.067\sim0.414$ kg $NH_3-N/kg$ MLSS-day의 적은 변화를 보였다. 각 실험단계별 평균 질산화 효율이 $35.2\sim100%$로서, 최대 질산화율은 2.970 kg $N/m^3-day$ 또는 0.489 g N/g MLVSS-day로 나타났다. MLVSS의 질산화미생물 분율은 최초의 7.1%에서 최고 100%까지 변하였으나 부직포 여과막에 형성된 생물막의 경우에는 2.2%의 매우 낮은 값을 보였다. 미생물 성장계수는 0.117 g VSS/g N removed로 그리고 알칼리도 소모량은 평균 7.08 g alkalinity/g NOx-N produced로 측정되었다. 이러한 실험결과로 보아 부직포 여과막 생물반응조가 고농도 암모니아 폐수의 질산화에 적합한 공법으로 판단된다.

• Korean Chemical Engineering Research
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• 제51권6호
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• pp.685-691
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• 2013

이부프로펜은 비스테로이드성 소염진통제(Non-Steroidal Anti-Inflammatory Drugs; NSAIDs)의 대표적인 성분이다. 이부프로펜은 결정성이 크기 때문에 난용성이며, 따라서 생체이용률(bioavailability)도 낮다. 이와 같은 난용성을 개선하기 위해서는 이부프로펜의 입도를 감소시킬 필요가 있다. 본 연구의 목적은 이부프로펜의 분쇄조건을 최적화하는데 있다. 이부프로펜을 분쇄하기 위하여 유성밀을 사용하였으며, Box-Behnken 방법을 이용하여 분쇄변수들의 최적조건을 구하였다. 이부프로펜 분쇄생성물의 물성을 조사하기 위하여 입도, 결정크기 및 인장강도 측정에는 각각 입도분석기, XRD, tensile/compression tester를 사용하였다. 분쇄 최적조건은 밀회전수는 290 rpm, 시료장입량은 24.6 g, 분쇄시간은 10분이었으며, 이 조건에서 이부프로펜 분쇄생성물의 입도는 $13.5{\mu}m$이었다. 이부프로펜은 분쇄 후 결정크기가 감소하였다. 이부프로펜 분쇄생성물의 정제의 상대밀도가 0.85~0.90인 범위에서 그 정제의 인장강도는 $12{\sim}14Kg_f/cm^2$ 이었다.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 1999년도 추계학술대회 논문집
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• pp.252-255
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• 1999

The effect of calcination temperature(1st and 2nd calcining at 110$0^{\circ}C$ , 120$0^{\circ}C$ and 130$0^{\circ}C$ respectively) on physical properties of BMNT Ceramics ware investigated. The optimum 1st and 2nd calcination temperature were 120$0^{\circ}C$ , and sintering temperature was 155$0^{\circ}C$. In this condition, the sintering density was 7.53 [g/㎤] and the dielectric constant, Q.f$_{0}$ and $\tau$$_{r}$ were 26, 80, 300[GHz] and +1.5[ppm/$^{\circ}C$] respectively in the microwave range.e.e.

• Bulletin of the Korean Chemical Society
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• 제35권8호
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• pp.2342-2348
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• 2014

Poly(lactic-co-glycolic acid) (PLGA) were grafted to both ends of Pluronic$^{(R)}$ F68 ($(EO)_{75}(PO)_{30}(EO)_{75}$) triblock copolymer to produce poly{(lactic acid)$_m$-co-(glycolic acid)$_n$}-b-poly(ethylene oxide)$_{75}$-b-poly(propylene oxide)$_{30}$-b-poly(ethylene oxide)$_{75}$-b-poly{(lactic acid)$_m$-co-(glycolic acid)$_n$} (PLGA-F68-PLGA) pentablock copolymers. Molecular weights of PLGA blocks were controlled and five kinds of pentablock copolymers with different PLGA block lengths were synthesized using in-situ ring-opening polymerization of D,L-lactide and glycolide with tin(II) 2-ethylhexanoate ($Sn(Oct)_2$) catalyst. PLGA-F68-PLGA pentablock copolymers were characterized by $^1H$- and $^{13}C$-NMR, GPC, and TGA. The numbers (2m, 2n) of repeating units for lactic acid and glycolic acid inside PLGA segments were obtained as (48, 17), (90, 23), (125, 40), (180, 59), and (246, 64), with $^1H$-NMR measurement. From NMR data, the resultant molecular weights were determined in the range of 12,700-29,700, which were similar to those obtained from GPC. Polydispersity index was increased in the range of 1.32-1.91 as the content of PLGA blocks increased. TG and DTG thermograms showed discrete degradation traces for PLGA and F68 blocks, which indicate the weight fractions of PLGA blocks in pentablock copolymers can be calculated by TG profile and it is possible to remove PLGA block selectively. Hydrodynamic radius and radius of gyration of pentablock copolymer micelle were obtained in the range of 46-68 nm and 31-49 nm, respectively, in very dilute (i.e. 0.005 wt %) aqueous solution of THF:$H_2O$ = 10:90 by volume at $25^{\circ}C$.

• 한국안전학회지
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• 제9권4호
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• pp.29-41
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• 1994

High temperature tensiles tests, steady state creep tests, internal stress tests and creep rupture tests using Al 7075 alloy were performed over the temperature range of 9$0^{\circ}C$~50$0^{\circ}C$ and stress range of 0.64~17.2(kgf/$\textrm{mm}^2$) in order to investigate the creep behavior and predict creep rupture life From the apparent activation energy Qc and the applied stress exponent n measured, at the temperature range of 9$0^{\circ}C$~l2$0^{\circ}C$, the creep deformation seemed to be controlled by cross slip. On the other hand at the temperature of 20$0^{\circ}C$~23$0^{\circ}C$ the creep deformation seemed to be controlled by dislocation climb but at 47$0^{\circ}C$~50$0^{\circ}C$, by diffusion creep. And the rupture life(t$_{f}$) might be represented by anthermal process attributed to the difference of the applied stress dependence of Internal stress and the ratio of the Internal stress to the applied stress, the thermal activated process attributied to the temperature dependence of the internal stress. Also the ratio between stress dependence of primary creep rate and that of minimum creep rate was measured 0.46, the minimum creep rate is expected to be appromately obtained from master creep curve including the relationship primary creep rate and minumum creep rate. Finally the relationship new rupture parameter and logarithmic stress was represented with including the ratio between the dependence of primary creep rate and that of minimum creep rate, using the new rupture parameter the rupture life predition is exactly expected.d.