• 한국식생활문화학회지
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• 제16권2호
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• pp.137-146
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• 2001

Purpose of this study was to investigate the health status and life style of middle-aged people in Daejon. The subjects expressed more fear for disease as getting older(p<0.01). Sixty six percent of the subjects have suffered in the past or suffer at present certain kinds of disease. The older they are, the more disease they have. The alimentary disease, neuralgia, and arthritis were the most popular disease. The eye strain and exhaustion of body were indicated more frequently in fifties than in thirties or forties(p<0.01). They considered excercise as the most important factor to maintain health status, and then moderation in diet, relaxation, rest, decrease of alcohol intake, no smoking. Forty three percent of them were non-drinker. The number of drinker was four times more in male than female and increased as getting younger(p<0.01). Only male revealed smoker and 29% of them smoked 10-20 cigarettes per day. The number of smoker decreased as getting older(p<0.01). Male played exercise more regularly than female and subjects have better exercise habit as getting older(p<0.01). This study suggests that practical programs for self-health control should be developed for playing exercise regularly for female and for considering nutrition, no smoking, and no drinking in the daily life for male.

• Structural Engineering and Mechanics
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• 제17권3_4호
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• pp.347-356
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• 2004

In order to extend the lifetime of buildings and civil infrastructure, patch type fibrous composite retrofitting materials are widely used. Retrofitted concrete columns and beams gain stiffness and strength, but lose toughness and show brittle failure. Usually, the cracks in concrete structures are visible to the naked eye and the status of the structure in the life cycle is estimated through visual inspections. After retrofitting of the structure, crack visibility is blocked by retrofitted composite materials. Therefore, structural monitoring after retrofitting is indispensable and self diagnosis method with optical fiber sensors is very useful. In this paper, we try to detect the peel out effect and find the strain difference between the main structure and retrofitting patch material when they separate from each other. In the experiment, two fiber optic Bragg grating sensors are applied to the main concrete structure and the patching material separately at the same position. The sensors show coincident behaviors at the initial loading, but different behaviors after a certain load. The test results show the possibility of optical fiber sensor monitoring of beam structures retrofitted by the composite patches.

• 한국직업건강간호학회지
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• 제6권1호
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• pp.5-13
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• 1997

For the purpose of investigating the subjective symptom of industrial fatigue, a questionnaire survey was carried out on 282 labor workers and 189 managerial workers who were employed at the manufacture of electronic products in two small scale industries. Checklist of industrial fatigue was composed of physical symptoms(10 items), mental symptoms(10 items), and sensory neurotic symptoms(10 items). The results were as follows : 1. Complain rate of fatigue was the highest in "eye strain" of physical symptom, "feel anxious about things" of mental symptom, and "feel stiffness in the neck or the shoulders" of sensory neurotic symptom in labor workers and managerial workers. 2. Managerial workers demonstrated II dominant type (mental or night work type), while labor workers demonstrated I dominant type of fatigue (general type). 3. Mean weighted score of fatigue complaints in labor workers (23.16) was significantly higher than that in managerial workers (20.34). 4. Mean weighted scores of fatigue complaints in male, 5~9 years of work duration, married, 4~5 hours of sleeping time, graduation of high school and college, and large of workload were significantly higher in labor workers than in managerial workers. 5. In poor work condition with temperature, ventilation, illumination and noise, the average weighted score was significantly higher in labor workers than in managerial workers.

• 한국안광학회지
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• 제12권4호
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• pp.101-106
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• 2007

본 연구는 폭주과다의 경우 시기능 훈련이 융합버전스와 안정피로 증상에 영향을 주는 효과적인 방법이 될 수 있는지 알아보기 위해 시행하였다. 폭주과다를 가진 대상자는 원거리와 근거리에서 내사위가 있으며, 수평방향의 복시, 눈의 긴장, 안정피로, 흐림 등의 증상을 가지고 있었다. 실험방법으로는 그 중 폭주과다를 가진 대상자를 1명 선택하여 시기능 훈련과 플러스 가입도를 처방하여 시기능 훈련을 7주 동안 실시하였다. 본 연구의 결과로는 7주 후 많은 효과가 있었는데, 즉 폭주과다의 경우 시기능 훈련은 증상을 경감시키고, 융합 범위를 증가시키고, 내사위를 감소시키는 효과적인 방법이었다. 그러므로 양안시이상에서 시기능 훈련에 대한 계속적인 연구가 필요하다.

• 한국산업보건학회지
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• 제24권3호
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• pp.330-335
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• 2014

Objectives: To evaluate the mutagenicity of lithium carbonate, a bacterial reverse mutation(Ames) test was carried out using four strains of S. typhimurium(TA1535; TA1537; TA98; and TA100) and one strain of E. coli(WP2uvrA). Materials: This was carried out in a dose range from 312.5 to $5,000{\mu}g/plate$ in triplicate with and without S9 activation, which is the most commonly used metabolic activation system supplemented by a post-mitochondrial fraction prepared from the livers of rodents treated with enzyme-inducing agents such as Aroclor 1254 or a combination of phenobarbitone and ${\beta}$-naphthoflavone. Results: No significant increases in the number of revertants were observed under the conditions examined in this study. Conclusions: Based on the above observations, it can be concluded that lithium carbonate has no mutagenic activity. Despite the results, it can have an effect by inducing acute oral toxicity, eye irritation and acute aquatic toxicity. Based on this study, we suggest that future studies should be directed toward chronic, carcinogenic testing and other related areas.

• IMMUNE NETWORK
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• 제11권6호
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• pp.399-405
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• 2011

Background: Endogenous uveitis is a chronic inflammatory eye disease of human, which frequently leads to blindness. Experimental autoimmune uveoretinitis (EAU) is an animal disease model of human endogenous uveitis and can be induced in susceptible animals by immunization with retinal antigens. EAU resembles the key immunological characteristics of human disease in that both are $CD4^+$ T-cell mediated diseases. Dendritic cells (DCs) are specialized antigen-presenting cells that are uniquely capable of activating naive T cells. Regulation of immune responses through modulation of DCs has thus been tried extensively. Recently our group reported that donor strain-derived immature DC pretreatment successfully controlled the adverse immune response during allogeneic transplantation. Methods: EAU was induced by immunization with human interphotoreceptor retinoid-binding protein (IRBP) $peptide_{1-20}$. Dendritic cells were differentiated from bone marrow in the presence of recombinant GM-CSF. Results: In this study, we used paraformaldehyde-fixed bone marrow-derived DCs to maintain them in an immature state. Pretreatment with fixed immature DCs, but not fixed mature DCs, ameliorated the disease progression of EAU by inhibiting uveitogenic $CD4^+$ T cell activation and differentiation. Conclusion: Application of iBMDC prepared according to the protocol of this study would provide an important treatment modality for the autoimmune diseases and transplantation rejection.

• 한국버섯학회지
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• 제7권4호
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• pp.141-149
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• 2009

본 연구는 신품종 '미소' 느타리버섯에 대한 성양식에서의 불화합성 체계를 이해하고자 수행하였으며 이 실험결과 자실체로부터 채취한 단포자의 교배를 통해 신품종 '미소' 느타리버섯이 자웅이체성이고 4극성 교배양식을 나타내는 것을 확인하였다. 꺽쇠연결이 없는 분리된 담자포자는 단핵균사로 판단되었고, 이러한 단핵균사간 화합, 불화합성 여부는 빠른 생육과 활력있는 발달형태를 통해 어느 정도 육안으로도 확인이 가능하였으며 두 단핵 균사체의 대치배양 후에 형성되는 꺽쇠연결을 현미경으로 관찰하여 명확히 확인되었다. 예외적으로 교배가 화합성인 경우 형성되는 이핵 균사체가 대치배양의 한쪽 가장자리에서만 꺽쇠연결이 발견되는 일방향 이핵화 현상이 관찰되었다. 이 실험결과로부터 4극성 교배에 있어서 $A_1A_2B_1B_2$의 이핵 균사체로부터 발생하는 네 가지 유전자 형태, 즉 $A_1B_1$, $A_1B_2$, $A_2B_1$, 그리고 $A_2B_2$가 화합성 테스트에 의해 결정되었으며 선발된 나머지의 단핵 균사체의 교배형은 Tester 계통을 이용하였다.

• 한국임상수의학회지
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• 제21권2호
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• pp.102-108
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• 2004

Orf virus (ORFV), a member of genus Parapoxvirus (family-Poxviridae), a causative agent of contagious ecthyma in sheep and goat leading to a condition commonly known as vesicular dermatitis. Recently, twelve goats from Iksan in Jeonbuk province were observed with clinical signs like necrotic vesicular lesions around the mucosa of mouth, nasal cavity, eye, ear, teats, abdomen and groin. Based on these clinical symptoms, contagious ecthyma infection was suspected. The skin scrapping was collected from lesions for isolation of DNA and subsequent PCR amplification of ORFV specific 235 bp region of B2L gene. All of the samples were found positive by PCR analysis. Sequencing and further phylogenetic analysis of the PCR product revealed 100% identity to Japan isolate of ORFV (Okinawa, GenBank accession number AB080769), and showed 99.6% of similarity to New Zealand strain (NZ-2, GenBank accession number U06671). It was concluded that ORFV strain detected in the present study is homologous to Japan isolate and New Zealand strain. The PCR test based on amplification of B2L gene is a highly useful tools for rapid and specific diagnosis of contagious ecthyma.

• 한국안광학회지
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• 제19권2호
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• pp.279-284
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• 2014

목적: 모니터 글자 색상에 따른 가독성을 측정하여, 모니터와 전자미디어 사용에서 안정피로를 감소시킬 수 있는 데이터를 제공하기 위한 기초 연구이다. 방법: 색각이상이 없으며 최대교정시력 1.0 이상의 피검자 50명(평균연령 $22.93{\pm}1.68$)을 대상으로 읽기속도 검사를 163개 단어 중 123개 이상의 단어를 읽은 피검자를 선정하였다. 모니터는 배경색을 white로 통일하였으며, 글자 색상은 black, blue, red, yellow 4가지 색상으로 가독성을 측정하였다. 결과: 글자 색상 Black, Blue, Red, Yellow인 경우 평균가독시간은 각각 41.89초, 42.89초, 45.32초, 56.28초로 측정되었다. 독서오류에서는 Black 1.94개, Blue 2.74개, Red 3.36개, Yellow 5.14개로 측정되었다. 평균고정시간에서는 Black 0.25초, Blue 0.26초, Red 0.27초, Yellow 0.32초로 측정되었다. 결론: 본 연구에서 가독성을 평가하는 항목인 가독시간, 독서오류, 평균고정시간에서 모두 Black, Blue, Red, Yellow순으로 가독성이 감소하는 경향을 보였다.

• 대한의용생체공학회:의공학회지
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• 제38권1호
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• pp.16-24
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• 2017

For the development of feasible retinal prosthesis, one of the important elements is acquiring proper judging tool if electrical stimulus leads to patient's visual perception. If evoked potential to electrical stimulus is recorded in primary visual (V1) cortex, it means that the stimulus effectively evokes visual perception. Therefore, in this study, we established VEP recording system on V1 cortex using BioPAC modules as the judging tool. And the measuring system was evaluated by recording VEP of mice. After anesthesia, normal mice (C57BL/6J strain; n = 6) were secured to stereotaxic apparatus (Harvard Apparatus, USA). For the recording of VEP, the stainless steel needle electrode (impedance: $2-5k{\Omega}$) was positioned on the surface of the cortex through the burr hole at 2.5 mm lateral and 4.6 mm caudal to bregma. DA 100C and EEG 100C BioPAC modules were used for the trigger signal and VEP recording, respectively. When left eye was blocked by black cover and right eye was stimulated by flash light using HMsERG (RetVet Corp, USA), VEP response at left V1 cortex was detected, but there was no response at right V1 cortex. Amplitudes and latencies of P2, N3 peaks of VEP recording varied according to the depths of the electrodes on V1 cortex. From the surface upto $600{\mu}m$ depth, amplitudes of P2 and N3 increased, while deeper than $600{\mu}m$, those amplitudes decreased. The deeper the insertion depth of the electrode, the latency of N1 peaks tends to be delayed. However, there was no statistically significant difference among the latencies of P2 and N3 peaks (P > 0.05, ANOVA). Our VEP recording data such as the insertion depth and the latency and amplitudes of peaks might be used as guidelines for electrically-evoked potential (EEP) recording experiment in near future.