• Toxicological Research
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• v.26 no.1
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• pp.9-14
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• 2010

The evaluation of eye and skin irritation potential is essential to ensuring the safety of human in contact with a wide variety of substances. Despite this importance of irritation test, little is known with respect to the irritation potency of lomefloxacin, a fluoroquinolone antibiotic, which has been known to cause phototoxicity with an abnormal reaction of the skin. Thus, to investigate the tendency of lomefloxacin to cause eye and skin irritation, we carried out in vitro eye irritation test using Balb/c 3T3, and in vitro skin irritation test using $KeraSkin^{TM}$ human skin model system. 3T3 neutral red uptake assay has been proposed as a potential replacement alternative for the Draize Eye irritation test. In this study, the $IC_{50}$ value obtained for lomefloxacin was 375 ${\mu}g$. According to the classification model used for determining in vitro categories, lomefloxacin was classified as moderately irritant. For evaluation of skin irritation, engineered epidermal equivalents ($KeraSkin^{TM}$) were subjected to 10 and 25 mg of lomefloxacin for 15 minutes. Tissue damage was assessed by tissue viability evaluation, and by the release of a pro-inflammatory mediator, interleukin- 1${\alpha}$. Lomefloxacin increased the interleukin-1${\alpha}$ release after 15 minutes of exposure and 42 hours of post incubation, although no decrease in viability was observed. Therefore, lomefloxacin is considered to be moderately irritant to skin and eye.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.17 no.2
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• pp.438-446
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• 2013

Generally, a camera isn't located at the center of display in a tele-presence system and it causes an incorrect eye contact between speakers which reduce the realistic feeling during the conversation. To solve this incorrect eye contact problem, we newly propose an intermediate view reconstruction algorithm using both a color camera and a depth camera and applying for the depth image based rendering (DIBR) algorithm. In the proposed algorithm, an efficient hole filling method using the arithmetic mean value of neighbor pixels and an efficient boundary noise removal method by expanding the edge region of depth image are included. We show that the generated eye-contacted image has good quality through experiments.

• Journal of Biomedical Engineering Research
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• v.37 no.5
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• pp.178-185
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• 2016

Tear is a promising biological fluid for non-invasive health monitoring. It has been studied in the past to be a possible candidate for the diagnosis of certain systemic diseases, such as breast cancer, multiple sclerosis, prostate cancer, and diabetes. However, currently existing methods for collecting and extracting tear from the human eye causes inconsistencies in the biomolecule concentrations of the tear sample due to the irritating nature of the process. In response, we designed and fabricated a microfluidic system embedded soft contact-lens for the purpose of tear sampling. The lens was then tested with artificial tear for its tear sampling capability, and found to be able to find concentration equilibrium within 50 minutes. Additionally, simulation was carried out to further optimize the design so that tear sampling rate matched the natural tear turn-over rate of 1 microliter per minute.

• Journal of Korean Clinical Health Science
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• v.6 no.1
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• pp.1089-1096
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• 2018

Purpose: To investigate the corneal thickness and anterior chamber depth (ACD) of eyes with Keratoconus in the Korean population with the Pentacam. Methods: The subjects consisted of 84 eyes from Keratoconic adults aged 7-59 years during 2010. The thinnest area, apex zone, and pupil centre of the corneal thickness were measured using the Pentacam pachymetry. ACD value was also measured with Pentacam. Results: There was a statistically significant relationship between thickness of the cornea at the apex area and the pupil centre (p=0.0001). However, there was no statistical difference (p>0.5) in the mean thickness of thinnest area, apex zone, pupil centre of cornea between right eye and left eye. Also, correlation between ACD and corneal thickness in all subjects had no statistical differences (p>0.05) in all subjects. Conclusion: These results suggested that the regional thickness of cornea and ACD with Pentacam can provide correct and useful diagnostic information of the morphology of Keratoconus for the RGP contact lens and diagnosis of abnormal corneal refraction surgery.

• Korean Journal of Microbiology
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• v.46 no.2
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• pp.152-156
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• 2010

Disposable contact lenses, which are one type of soft contact lenses, provide convenience in use, but also cause various ocular infectious diseases. Microorganisms that cause eye diseases include Acanthamoeba, bacteria, Fungi, and so on. It is impossible to prevent microorganism contamination completely due to the use of hands as wearing contact lenses. The contamination by various microorganisms leads to infectious keratitis, but it is not well known for the exact microorganisms that affect the disease. For this reason, to identify the microorganisms, two groups that are commonly used for disinfection of lenses were divided: normal saline solution and multiple purpose solution. Using these solutions the degree of microorganism contamination was observed according to the days of 1, 3, 5, 10, and 15. Twenty students by two groups from Ophthalmic Optics department at D college in Daegu Metropolitan city participated in the experiment after their ocular health conditions were checked. During they wore one-day disposable lenses for 1, 3, 5, 10, and 15 days, bacteria were cultured in media. The results, which were Gram stained by selecting the cultured colonies, show as followings: Gram positive cocci 33%, Gram-negative cocci 2%, Gram positive bacilli 34%, and the Gram negative bacilli 31%, respectively. As for the identification of potential pathogens, VITEK system and API kit methods were used. Keratitis caused by bacteria known as Staphylococcus aureus, Pseudomonas aeruginosa were detected as a result of wearing contact lenses. This study examined the distribution of bacteria as wearing one-day disposable contact lenses and pathogenic bacteria according to the duration of wearing them. In conclusion, the importance of hygiene when using contact lenses is suggested.

• Journal of Institute of Control, Robotics and Systems
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• v.15 no.11
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• pp.1122-1129
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• 2009

Recently taping robot with smart recognition function have been studied in the coil manufacturing field. Due to the difficulty of 3D surface processing from the complicated working environment, it is not easy to accomplish smart tape attachment motion with non-contact sensor. To solve these problems the applicable surface recognition algorithm and a flexible sensing device has been recommended. In this research, the fusion method between 1D displacement and 3D laser scanner is applied for robust tape attachment about cold rolled coil. With these sensors we develop a two-step exploration and the smart algorithm for the awareness of non-aligned coil's information. In the proposed robot system for tape attachment, the problem is reduced to coil's radius searching with laser displacement sensor at first, and then position and orientation detection with 3D laser scanner. To get the movement at the robot's base frame, the hand-eye compensation between robot's end effector and sensing device should be also carried out respectively. In this paper, we examine the auto-coordinate transformation method in the calibration step for the real environment usage. From the experimental results, it was shown that the taping motion of robot had a robust under the non-aligned cold rolled coil.

• Journal of the Institute of Convergence Signal Processing
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• v.5 no.1
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• pp.25-31
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• 2004

This paper is research about the improvement of recognition rate of the biometrics user identification system using the data previously stored in the non contact Ic smart card. The proposed system identifies the user by analyzing the iris pattern his or her us. First, after extracting the area of the iris from the image of the iris of an eye which is taken by CCD camera, and then we save PCA Coefficient using GHA(Generalized Hebbian Algorithm) into the Smart Card. When we confirmed the users, we compared the imformation of the biometrics of users with that of smart card. In case two kinds of information was the same, we classified the data by using SVM(Support Vector Machine). The Experimental result showed that this system outperformed the previous developed system.

• Proceedings of the KIEE Conference
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• 2001.07d
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• pp.2352-2354
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• 2001

본 논문에서는 컴퓨터의 사용자가 모니터의 스크린 상의 어느 곳을 바라보고 있는지 추정하는 새로운 알고리즘을 제시한다. 적외선 LED와 CCD카메라를 이용하는 이 방법은 기존의 방법과 다르게 5개의 적외선 LED를 사용하는데 적외선의 반사에 의해 눈의 각막에는 네 개의 밝은 점들이 나타나고 이 점을 꼭지점으로 하는 사각형 안에서 동공의 중심이 움직인다는 사실을 이용한다. 이 방법은 눈의 3차원 위치, 카메라의 위치, 모니터의 위치에 따른 관계식을 구할 필요 없이 간단한 계산으로 눈의 응시점을 찾아낼 수 있다는 장점을 가지고 있다. 여기서는 이 방법을 소개하고 실험결과를 보여준다.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.37 no.6A
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• pp.497-502
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• 2012

In this paper, we present an immersive videoconferencing system that enables gaze correction between users in the internet protocol TV (IPTV) environment. The proposed system synthesizes the gaze corrected images using the depth estimation and the virtual view synthesis algorithms as one of the most important techniques of 3D video system. The conventional processes, however, causes several problems, especially temporal inconsistency of a depth video. This problem leads to flickering artifacts discomforting viewers. Therefore, in order to reduce the temporal inconsistency problem, we exploit the joint bilateral filter which is extended to the temporal domain. In addition, we apply an outlier reduction operation in the temporal domain. From experimental results, we have verified that the proposed system is sufficient to generate the natural gaze-corrected image and realize immersive videoconferencing.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.26 no.9
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• pp.1279-1292
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• 2022

This study proposes a non-contact input method based on face recognition and Pyautogui mouse control as a system that can help users who have difficulty using input devices such as conventional mouse due to physical discomfort. This study includes features that help web surfing more conveniently, especially screen zoom, scroll function, and also solves the problem of eye fatigue, which has been suggested as a limitation in existing non-contact input systems. In addition, various set values can be adjusted in consideration of individual physical differences and Internet usage habits. Furthermore, no high-performance CPU or GPU environment is required, and no separate tracker devices or high-performance cameras are required. Through these studies, we intended to contribute to the realization of barrier-free access by increasing the web accessibility of the disabled and the elderly who find it difficult to use web content.