• 한국시뮬레이션학회논문지
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• 제10권3호
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• pp.31-46
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• 2001

Repeated measurements on units under different conditions are common in biological and biomedical studies. In a number of growth and pharmacokinetic studies, the relationship between the response and the covariates is assumed to be nonlinear in some unknown parameters and the form remains the same for all units. Nonlinear random coefficient models are used to analyze such repeated measurement data. Extended least squares methods are proposed in the literature for estimating the parameters of the model. However, neither objective function has closed form expression in practice. This paper proposes Monte Carlo methods to estimate the objective functions and the corresponding estimators. A simulation study that compare various methods is included.

• 정보처리학회논문지D
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• 제13D권4호
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• pp.501-512
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• 2006

현재 널리 채택되고 있는 XML은 플랫폼에 의존하지 않는 데이터 표현 형식으로 B2B 응용 프로그램이나 워크플로우 상황에서처럼 느슨하게 연결된(loosely coupled) 이기종 시스템 간에 정보를 교환하는 데 매우 유용하게 사용되고 있다. XML의 이러한 장점 때문에 점차 증가하는 XML에 대한 관리 및 검색에 대한 요구 사항에 대처할 수 있도록 강력한 질의 언어인 XQuery가 만들어졌다. 문서의 검색을 위한 질의 언어인 XQuery는 다양한 데이터 소스로부터 가져온 XML 데이터를 고유한 구조를 가진 질의 결과로 구성할 수 있도록 설계되었으며 현재 XML 질의 언어의 표준이다. XQuery는 반복문 등을 포함하는 강력한 검색 기능을 지원하나 데이터를 그룹화 하는 경우에는 질의 표현이 상대적으로 어렵고, 복잡한 형태를 취한다. 따라서 본 논문에서는 XQuery에 그룹화 처리를 위한 명시적인 groupby절을 도입한 질의 표현 기법을 모색함으로써 XML 데이터의 재구성과 집계 함수 처리를 위한 그룹화를 보다 효율적으로 처리할 수 있도록 하였다. 이를 위해서 XQuery에 groupby절을 도입하기 위한 EBNF(Extended Backus-Naur Form)를 제안하고, 네이티브 XML 데이터베이스인 eXist 기반의 XQuery 그룹화 질의 처리 시스템을 구현하였다.

• 대한전기학회논문지
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• 제32권6호
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• pp.211-218
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• 1983

In this paper, an attempt is made to match the continuous state trajectory of the digital control system with that of its continuous data model. Matching the state trajectories instead of the output responses assures that the performances of the internal variables of the plant as well as the output variables are preserved in the discretization. The mathematical tool used in this research is an extended maximum principle of the Pontryagin type, which enables one to synthesize a staircase type of optimal control signals, such as the output signal of a zero-order hold asociated with a digital controller. A general mathematical expression of the digital controller which may be used to replace the analog controller of a general system while preserving as mauch as possible the performance characteristics of the original continuous-data control system is derived in this paper.

• 한국의상디자인학회지
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• 제19권3호
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• pp.17-32
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• 2017

Modern society has been transformed into a digital emotional society that could gradually be seen, felt, and enjoyed by the diversification of personal consumption desires due to digital development. Accordingly, in fashion, an original fashion sense that arose out of classical and conventional thinking has become important and there is an increasing interest in patchwork quilts. The purpose of this study lies in contributing to the development and utilization of creative and emotional fashion design by expanding the mental changes that have emerged in modern society to creative areas after analyzing the classification and expression characteristics of the type cases of patchwork quilt techniques expressed in modern fashion. In addition, it is meaningful to examine how the expressive characteristics of patchwork quilts are expressed in the digital emotion era. This study paralleled literature research and empirical case studies. In the scope and method of research, the theatrical research was centered on literature data. For visual data, website photos were collected, limited to women's clothing among the collections from Fall & Winter 2014 to Spring & Summer 2017. After drawing the expression types of patchwork quilts extracted from the previous research based on the design formative factors, the fashion-related expert group analyzed the expressive characteristics of 501 photographs in which the patchwork quilt of the designer clothing collection were reflected. As a result of analysis, the expressive types appeared in the order of diversification of techniques and materials, extended dual images, new formative composition, and reconstruction of traditional patchwork. In this study, the expressive characteristics of patchwork quilts expressed in contemporary fashion are analyzed and drawn as variability, compromise, convergence, and playfulness. Through this, it is hoped that this study can be used variously in the development of fashion design by expanding the interpretation of costume culture.

• 인터넷정보학회논문지
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• 제18권5호
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• pp.47-53
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• 2017

고처리 시퀀싱과 빅데이터 및 크라우드 컴퓨팅에 혁신이 일어나면서, RNA 시퀀싱도 획기적인 변화가 일어, RNAseq가 기존의 DNA 마이크로어레이를 대체하여, 빅-데이터를 형성하고 있다. 현재, RANseq 이용한 유전자 조절망(GRN) 까지 연구가 활성화 되고 있는데, 그 중 한 분야가 GRN의 기본 요소인 특징 유전자를 빅-데이터에서도 구별하고 기존에 알려진 것 외에 새로운 역할을 찾는 것이다. 그러나, 이러한 연구 방향에 부합하는 빅-데이터를 처리할 수 있는 컴퓨테이션 방법이 아직까지 매우 부족하다. 따라서 본 논문에서는 RNAseq 빅-데이터를 처리할 수 있도록 기존의 SVM-RFE알고리즘을 밀집도-의존 정규화에 병합하여, NCBI-GEO와 같은 빅-데이터에서 공개된 일부의 데이터에 개선된 알고리즘을 적용하고 해당 알고리즘에 의해 나온 결과의 성능을 평가한다.

• 한국IT서비스학회지
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• 제7권1호
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• pp.205-218
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• 2008

This paper proposes a geospatial data visualization system supporting validation of GML documents. GIS systems manage and use both of spatial and non-spatial data. Currently, most GIS systems represent spatial data in GML (Geography Markup Language) developed by OGC. GML is a language for representation and sharing of spatial information, and until now many systems have been developed in GML. GML does not support expression of non-spatial data, i.e., relational information of spatial objects, and thus most systems extend GML to describe non-spatial information. However, it causes an issue that the systems only accepting standard GML documents cannot process the extended documents. In this paper, we propose a new GIS data visualization system to resolve the aforementioned Issue. Our proposed system allows the representation of both types of data supporting independency of spatial data and non-spatial data. It enhances interoperability with other relevant systems. Therefore, we can develop a rich and high Quality geospatial information services.

• 지역사회간호학회지
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• 제28권2호
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• pp.196-205
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• 2017

Purpose: Art program has been found to enhance mood such as increasing motivation, self-expression and decreasing depression in older adults. This study was conducted to investigate the effects of clay art and drawing on depression and self-expression among elderly people at a long-term care center. Methods: The research was a pre-test and post-test non-equivalent design. Sixty older patients (clay art program=28. Drawing art program=32) over the age of 65 were recruited from 2 long-term care hospitals to participate in the 5 weeks program. Each group was scheduled with 10,120-minute evaluation sessions, twice per week. Test measures were completed before and after the 5 week intervention period for all participants. The data was collected from April 27 to May 29, 2015. It was analyzed with SPSS 22.0 using chi-square, t-test and paired t-test. Results: There were no significant difference in the levels of depression (t=0.21, p=.830) and total score of self-expression (t=-0.10, p=.919) between the two groups. However, the pre-post scores of self-expression in the clay art program (t=0.22, p=.826) were improved compared to the drawing art program (t=0.80, p=.430). Conclusion: Further studies are needed to evaluate the effectiveness of clay art program for extended senior care applications.

• Nutrition Research and Practice
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• 제10권1호
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• pp.3-10
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• 2016

BACKGROUND/OBJECTIVES: Oligonol, mainly found in lychee fruit, is an antioxidant polyphenolic compound which has been shown to have anti-inflammatory and anti-cancer properties. The detailed mechanisms by which oligonol may act as an anti-aging molecule have not been determined. MATERIALS/METHODS: In this study, we evaluated the ability of oligonol to modulate sirtuin (SIRT) expression in human lung epithelial (A549) cells. Oligonol was added to A549 cells and reactive oxygen species production, mitochondrial superoxide formation, and p21 protein levels were measured. Signaling pathways activated upon oligonol treatment were also determined by western blotting. Furthermore, the anti-aging effect of oligonol was evaluated ex vivo in mouse splenocytes and in vivo in Caenorhabditis elegans. RESULTS: Oligonol specifically induced the expression of SIRT1, whose activity is linked to gene expression, metabolic control, and healthy aging. In response to influenza virus infection of A549 cells, oligonol treatment significantly up-regulated SIRT1 expression and down-regulated viral hemagglutinin expression. Oligonol treatment also resulted in the activation of autophagy pathways and the phosphorylation of AMP-activated protein kinase (AMPK). Furthermore, oligonol-treated spleen lymphocytes from old mice showed increased cell proliferation, and mRNA levels of SIRT1 in the lungs of old mice were significantly lower than those in the lungs of young mice. Additionally, in vivo lethality assay revealed that oligonol extended the lifespan of C. elegans infected with lethal Vibrio cholerae. CONCLUSIONS: These data demonstrated that oligonol may act as an anti-aging molecule by modulating SIRT1/autophagy/AMPK pathways.

• BMB Reports
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• 제40권4호
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• pp.554-561
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• 2007

Shen and colleagues (Lin et al., 2004) have recently shown that overexpression of the Drosophila DNA methyltransferase 2 isoform C, dDnmt2c, extended life span of fruit flies, probably due to increased expression of small heat shock proteins such as Hsp22 or Hsp26. Here, I demonstrate with immunoprecipitations that overexpressed dDnmt2c interacts with endogenous Hsp70 protein in vivo in S2 cells. However, its C-terminal half, dDnmt2c(178-345) forms approximately 10-fold more Hsp70-containing protein complexe than wild-type dDnmt2c. Overexpressed dDnmt2c(178-345) but not the full length dDnmt2c is able to increase endogenous mRNA levels of the small heat shock proteins, Hsp26 and Hsp22. I provide evidence that dDnmt2c(178-345) increases Hsp26 promoter activity via two heat shock elements, HSE6 and HSE7. Simultaneously overexpressed Hsp40 or a dominant negative form of heat shock factor abrogates the dDnmt2c(178-345)-dependent increase in Hsp26 transcription. The data support a model in which the activation of heat shock factor normally found as an inactive monomer bound to chaperones is linked to the overexpressed C-terminus of dDnmt2c. Despite the differences observed in flies and S2 cells, these findings provide a possible explanation for the extended lifespan in dDnmt2c-overexpressing flies with increased levels of small heat shock proteins.

• KSBB Journal
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• 제17권3호
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• pp.283-289
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• 2002

Insulin-like growth factor-I(IGF-I)은 성장호르몬의 여러 가지 성정촉진 작용을 매개하는 분열 유발성 폴리펩티드이며, 조직의 수선과 재생, 창상치유 및 골대사와 같은 과정들에서 중요한 역할을 하는 것으로 알려져 있고, 비교적 여러 조직에서 발현되고 있는 IGF-I 유전자의 전사조절에 대한 정확한 분자적 기전과 호르몬 및 대사 상태가 그것을 어떻게 조절하는지 아직 밝혀져 있지 않다. 쥐를 절삭시키므로써 대사 상태를 변조시켰을 때, 간 조직내 IGF-I mRNA의 발현에 미치는 절식의 영향을 살펴보기 위하여 solution hybridizatioon/RNase protection 방법으로 분석 하였다. IGF-I의 exon 1 및 exon 2에 의하여 encode된 tran-scripts 모두가 감소된 결과를 얻었고, 이러한 감소는 전사 수준에서 일어난 것으로 nuclear run-on 분석에 의하여 확인하였다. 또한 절식시킨 쥐에서 IGF-I mRNA의 양을 조절하는 cia-acting elements를 IGF-I 유전자의 5'-flanking 지역과 exon 1과 econ 2에서 밝히고자 절식시킨 쥐의 신선한 간조직에서 핵 추출물을 얻어 IGF-I의 여러 가지 DNA fragments와 반응시켜 DNase I protection 분석을 한 결과, IGF-I 유전자의 주요한 전사 개 시점으로부터 downstream에 있는 sequences가 절식으로 변조시킨 대사상태에서 IGF-I의 발현 조절에 중요하며 이곳에는 전사인자인 C/EBP family의 isoform들을 포함한 간조직에 풍부하게 존재하는 여러 전사인자들이 결합할 것으로 제안하였다.