• 제목/요약/키워드: Expression patterns

검색결과 1,527건 처리시간 0.026초

Immunohistochemistry Subtypes (ER/PR/HER) of Breast Cancer: Where Do We Stand in the West of Saudi Arabia?

  • Khabaz, Mohamad Nidal
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권19호
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    • pp.8395-8400
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    • 2014
  • In Saudi Arabia, cancer of breast is ranked the most frequent neoplasm and second source of cancer death in the female population. Breast cancer (BC) fast diagnosis, prognosis and medication management necessitate, these days, immunohistochemistry (IHC) assessment of hormone receptors and HER2 expression profile. The present report defines the IHC profile of ER, PR and HER2 in Saudi female breast neoplasms of ductal and lobular types and associations ER, PR and HER2 expression patterns with various clinicopathological factors (age, type of tumor, size, laterality, histological grade, and involvement of axillaries lymph nodes). Ninety nine cases of breast tumors were recruited from the pathology department archive of King Abdulaziz University Hospital, Kingdom of Saudi Arabia. ER, PR and HER2 expression was assessed using IHC staining. Ductal carcinomas with a variety of histological grades constituted 88 (88.8%) of total cases. Seventy four (77.8%), 59 (62.1%), and 35 (36.8%) of ductal carcinomas showed positive staining for ER, PR and HER2, in that order. Remaining breast cancer cases were four (4%) lobular carcinomas and two (2%) mixed form of ductal and lobular types, which were ER+, PR+, and HER2-. Breast cancer expression pattern of ER, PR and HER2 in Saudi female is different from that of Tunisian and Jordanian female populations and closer to the expression pattern of Egyptian, Lebanese, Iraqi and western country females. Furthermore, the present study found two IHC patterns of breast cancer ER+/PR-/HER2+ (5%) and ER+/PR-/HER2- (11.1%), which had not been reported in other Arabic studies. Thus the rates of IHC expression patterns in breast cancer show some variation among Arabic female populations.

실시간 감정 표현 아바타의 설계 및 구현 (Design and Implementation of a Real-Time Emotional Avatar)

  • 정일홍;조세홍
    • 디지털콘텐츠학회 논문지
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    • 제7권4호
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    • pp.235-243
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    • 2006
  • 본 논문에서는 얼굴의 표정 변화를 인식하여 실시간으로 감정을 표현하는 아바타를 설계하고 구현하는 방법을 제안하였다. 실시간 감정 표현 아바타는 수동으로 아바타의 표정 패턴을 변화를 주는 것이 아니라 웹캠을 이용하여 실시간으로 입 모양 특징을 추출하고 추출한 입 모양의 패턴을 분석한 뒤, 미리 정의된 표정 패턴에 부합되는 것을 찾는다. 그리고 부합된 표정 패턴을 아바타에 적용하여 아바타의 얼굴 표정을 표현한다. 표정 인식 아바타는 웹캠에서 들어온 영상을 모델 접근 방법을 이용하여 보다 빠르게 입 부분을 인식할 수 있도록 하였다. 그리고 표정 패턴 추출은 표정에 따라 입 모양이 변하는 것을 이용하였다. 모델접근 방법을 이용하여 눈의 정보를 찾은 후 그 정보를 이용하여 입 모양을 추출하게 된다. 기본적으로 13가지 입 모양으로 각각의 표정을 유추하고 각 표정 패턴에 맞는 6개의 아바타를 미리 구현하여 보다 빠르게 아바타의 표정을 변할 수 있게 하였다.

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심층 패킷검사를 위한 정규표현식 패턴매칭 하드웨어 구조 (A Hardware Architecture of Regular Expression Pattern Matching for Deep Packet Inspection)

  • 윤상균;이규희
    • 한국컴퓨터정보학회논문지
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    • 제16권5호
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    • pp.13-22
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    • 2011
  • 최근의 네트워크 침입탐지 시스템들은 침입패턴을 나타내는 데 정규표현식을 사용하고 있으며 빠른 심층 패킷 검사를 위해서 하드웨어 기반의 패턴매칭이 필요하다. 하드웨어 기반 정규표현식 패턴매칭에 대한 많은 연구가 이루어졌으나 {10}과 같은 제한반복 연산자에 대한 구현은 제약이 있었다. 본 논문에서는 일반적인 정규표현식 서브패턴에 대한 제한반복을 더 낮은 하드웨어 복잡도로 구현할 수 있는 제한반복 블록 구조를 제시하였다. 제안된 제한반복 블록은 단일 문자, 고정길이 문자 뿐 만 아니라 일반적인 정규표현식 서브패턴의 제한반복 구현도 가능하다. 제안된 제한반복 블록 구조는 모든 제한반복을 펼치지 않고 구현할 수 있도록 하여 정규표현식 패턴매칭 하드웨어를 더 효율적으로 구현할 수 있도록 하였다.

감마선 변이체 스프레이 국화 'ARTI-purple'의 화색 관련 유전자 발현 분석 (Expression Analysis of Flower Color Related Genes in Spray-type 'ARTI-purple' Developed by Gamma-ray Mutagenesis)

  • 성상엽;이유미;김상훈;하보근;강시용;김진백;김홍기;김동섭
    • 방사선산업학회지
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    • 제6권2호
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    • pp.147-152
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    • 2012
  • Anthocyanins are major plant pigment and produced through phenylpropanoid pathway. In this study, anthocyanin biosynthesis mechanisms of chrysanthemum flowers were studied using 'Argus' and flower color mutant 'ARTI-purple' which were induced by 40 Gy gamma irradiation ($Co^{60}$). And, three chrysanthemums, 'Ford', 'Yeonja' and 'Orando' were additionally used as the check varieties to understand the relationship between flower color and expression patterns of genes. The expression patterns of the anthocyanin biosynthetic genes were matched with the flower color of the check varieties. High anthocyanin concentration of 'Orando' showed the high expression of anthocyanin biosynthetic genes. In the white flower of 'Ford', expressions of CHI, DFR and ANS were not identified. Despite different flower color, 'Argus' and 'ARTI-purple' showed different expression patterns compared with the check varieties. From the dot blot analysis, we screened the seven genes showing the different expressions between 'Argus' and 'ARTI-purple'.

Expression of B Cell Activating Factor Pathway Genes in Mouse Mammary Gland

  • Choi, S.;Jung, D.J.;Bong, J.J.;Baik, M.
    • Asian-Australasian Journal of Animal Sciences
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    • 제20권2호
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    • pp.153-159
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    • 2007
  • In our previous study, overexpression of extracellular proteinase inhibitor (Expi) gene accelerated apoptosis of mammary epithelial cells, and induced expression of B cell activating factor (BAFF) gene. In this study, we found induction of BAFF-receptor (BAFF-R) gene expression in the Expi-transfected cells. A proliferation-inducing ligand (APRIL) gene is another TNF family member and the closest known relative of BAFF. We found induction of APRIL gene expression in the Expi-overexpressed apoptotic cells. NF-${\kappa}$B gene was also induced in the Expi-overexpressed cells. Expression patterns of BAFF and APRIL pathway-related genes were examined in in vivo mouse mammary gland at various reproductive stages. Expression levels of BAFF gene were very low at early pregnancy, increased from mid-pregnancy, and peaked at lactation, and thereafter decreased at involution stages of mammary gland. Expression of BAFF-R gene was highly induced in involution stages compared to lactation stages. Thus, expression patterns of BAFF-R gene were correlated to apoptotic status of mammary gland: active apoptosis of mammary epithelial cells occurs at involution stage of mammary gland. Expression levels of NF-${\kappa}$B gene were higher in involution stages compared to lactation stages. We analyzed mRNA levels of bcl-2 family genes from different stages of mammary development. Bcl-2 gene expression was relatively constant during lactation and involution stages. There was a slight increase in bcl-xL gene expression in involution stages compared to lactation state. Bax gene expression was highly induced in involution stage. Our results suggest that signaling pathways activated by both BAFF and ARRIL in mammary gland point towards NF-${\kappa}$B activation which causes upregulation of bax.

문형 사전을 위한 문형 빈도 조사 (Studying the frequencies of sentence pattern for a entence patterns dictionary)

  • 김유미
    • 인지과학
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    • 제16권2호
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    • pp.123-140
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    • 2005
  • 이 논문은 한국어 교육에서 문형 전자 사전을 바탕으로 하는 자동문형 검사기를 설계하기 위해 문형의 출현 빈도와 사용 빈도 조사를 목적으로 하였다. 먼저 한국어 교육에서의 문형의 개념을 정의하고 그 유형을 구문 문형과 표현 문형으로 나누어 분류하였다. 서술어 중심의 구문 문형과 의존명사, 어미, 조사가 중심인 표현 문형이 학습자 코퍼스에서 어떻게 나타나는지 분석하였다. 학습자 코퍼스는 학습자들이 꼭 배워야 하는 것으로 표준 코퍼스와 학습자들의 생산물인 오류 코퍼스로 나누어 구축하였다. 한국어 교재로 구성된 표준 코퍼스에서의 문형 출현 빈도와 학습자들이 직접 작성한 글을 모은 오류 코퍼스에서 어떻게 문형이 사용되고 있는지 사용 빈도를 조사하였다. 학습자들의 문형 사용 빈도순은 문형 전자 사전에 기술되고, 이것은 문형 검색 속도를 최적화할 것이다.

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Comparative Analysis of Transgene Copy Numbers and Expression Characteristics across Multiple Transgenic Marine Medaka Oryzias dancena Strains carrying the β-Actin Promoter-Driven GFP Reporter

  • Cho, Young Sun;Lee, Sang Yoon;Vu, Nguyen Thanh;Kim, Dong Soo;Nam, Yoon Kwon
    • Fisheries and Aquatic Sciences
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    • 제18권2호
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    • pp.183-193
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    • 2015
  • Several transgenic marine medaka Oryzias dancena strains harboring a green fluorescent protein (GFP) reporter construct regulated by an endogenous ${\beta}$-actin promoter were established and their expression characteristics in relation to transgene copy numbers were examined in 21 transgene genotypes. Most of the transgenic strains displayed transgene insertion patterns typical of microinjection-mediated introduction of foreign DNA into fish embryos, characterized by the random integration of multiple transgene copies (ranging from 1 - 282 copies per cell), often accompanied by the formation of concatemer(s), as assessed by genomic Southern blot hybridization analysis and qPCR. Transgenic strains showed ubiquitous and continued temporal and spatial expression patterns of the transgenic GFP during most of their life cycle, from the embryonic stage to adulthood, enabling assessment of the expression pattern of the endogenous ${\beta}$-actin gene. However, a comparative evaluation of transgene copy numbers and expression levels showed that copy number-dependent expression, the stability of the ubiquitous distribution and expression efficiency per transgene copy varied among the transgenic strains. Fluorescence expression levels were positively correlated with absolute transgene copy numbers, whereas the expression efficiency per transgene copy was inversely related to the number of transgene integrant copies. Data from this study will guide the selection of potentially desirable transgenic strains with ubiquitous expression of a fluorescent transgene, not only in this marine medaka species but also in other related model fish species.

일본 전통문양의 특징에 관한 연구 (A Study on the Characteristics of Japanese Traditional Patterns)

  • 김세나;오경화
    • 한국의류산업학회지
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    • 제5권5호
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    • pp.511-519
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    • 2003
  • The traditional culture has been developed for a long time with an unique property according to folk character, custom and environment within an area. Especially in 1906, when the westerners were interested in oriental cultures more and more, Paul Poiret presented Japanese traditional dress of napping sleeve coats and harem pants, henceforth japanese fashion theme began to rise. The Japanese style rose as an important fashion item of the modern fashion, with various fashion themes such as orientalism, ethnic, folklore, ecology, etc., needless to say of activities of Japanese designers. The revealed patterns on Japanese dress and it's ornament plays a role of expressive decoration as well as stand for the nation, the ideology of the age and aesthetic consciousness. For this reason, it is necessary to study Japanese traditional patterns expressed in modern fashion systematically. Therefore, in this research, the demonstrated Japanese traditional patterns on the modern fashion were divided into natural, artificial and complex design and were looked out the characteristic, furthermore it was studied in regard that Japanese patterns were how to apply in modern fashion. It was concluded that the characteristics of the Japanese traditional patterns presented in the modern fashion were as follows: first, creation of environmental friendly design using plenty of natural materials; second, expression of paint-like impression and beauty of margins by simplifying of patterns; third, expression of amusing design by using bright colors and print; finally, various patterns were spreaded out complicated on dress. The characteristics of Japanese traditional patterns in the above were expressed in the modern fashion.

봉황문양 탐구 - 둔황 막고굴과 패션디자인 표현기법 - (Exploring phoenix patterns - Dunhuang Mogao Grottoes and fashion design expressions -)

  • 장정이;이명희
    • 복식문화연구
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    • 제31권4호
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    • pp.504-518
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    • 2023
  • The objective of this study was to explore the symbolism associated with phoenix patterns in China and the temporal aesthetic characteristics of these patterns found in Dunhuang Mogao Grottoes. The study involved collecting examples of clothing designs featuring phoenix patterns from China Fashion Week and the Vogue website, spanning from spring and summer of 2016 to fall and winter of 2022. After collecting and organizing these examples, representative cases were selected for analysis. The objective was to identify effective techniques for incorporating phoenix patterns within the context of Dunhuang Mogao Grottoes and provided insights for future clothing design and textile pattern design research. Phoenix patterns boasted a lengthy history and were laden with symbolic meaning. Early renditions of phoenix patterns found at Mogao Grottoes in Dunhuang were relatively simplistic in design, mainly employing elements like rhythm, coordination, balance and symmetry to convey a sense of nature and gravity. Over time, these patterns evolved under the influence of the prevailing cultural backdrop, employing repeated emphasis to portray notions of abundance and tenacity. Furthermore, regarding the use of phoenix patterns in clothing, there were four prevalent expression techniques: embroidery, beading, printing, and knitting. Traditional techniques like embroidery and beadwork often prioritized aesthetic features like coordination, emphasis, and symmetry, thereby showcasing the opulent characteristics of phoenix patterns. On the other hand, printing and knitting techniques used a single phoenix pattern or a modified version to simplify designs by emphasizing or repeating aesthetic characteristics while adhering to a modern artistic approach.

드리스 반 노텐의 컬렉션에 나타난 문양디자인 특성 (Characteristics of Pattern Design from Dries Van Noten Collection)

  • 김찬주;노미경
    • 복식
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    • 제63권5호
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    • pp.115-131
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    • 2013
  • Dries Van Noten, one of the Antwerp Six, focused on recreating traditional attire from each region to complex contemporary attire and has shown designs that interpreted ethnic image in contemporary perspective from his very first collection. He has positioned himself as a designer with creative expression of ethnic image through broad use of various patterns. This paper analyze the use of pattern in Dries Van Noten's designs by season and item, and reflects on the characteristics of pattern use and influence on fashion image. Total of 887 clothing items were collected from Noten's collections on the Internet. Through analysis of frequency and percentage and cross tab of expression techniques, types, patterns of each motif, and classifications of print combinations, it was shown that Noten has applied six aesthetic rules in the use of pattern design. Pattern played the most significant role in his design. It was possible to achieve the balance of ethnic image and modern image with the mix of flower and abstract motives. Overall pattern was mostly used for practical purpose: border patterns and spaced patterns played a vital role in rendering uniqueness. Noten exhibited unity and variation in combining prints. He expressed the beauty of Oriental style by inserting solid color blocks in between patterns and decorations along trim lines.