• Title/Summary/Keyword: Exposure modeling

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Neurobehavioral Deficits and Parkinsonism in Occupations with Manganese Exposure: A Review of Methodological Issues in the Epidemiological Literature

  • Park, Robert M.
    • Safety and Health at Work
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    • v.4 no.3
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    • pp.123-135
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    • 2013
  • Exposure to manganese (Mn) is associated with neurobehavioral effects. There is disagreement on whether commonly occurring exposures in welding, ferroalloy, and other industrial processes produce neurologically significant neurobehavioral changes representing parkinsonism. A reviewof methodological issues in the human epidemiological literature onMnidentified: (1) studies focused on idiopathic Parkinson disease without considering manganism, a parkinsonian syndrome; (2) studies with healthy worker effect bias; (3) studies with problematic statistical modeling; and (4) studies arising from case series derived from litigation. Investigations with adequate study design and exposure assessment revealed consistent neurobehavioral effects and attributable subclinical and clinical signs and symptoms of impairment. Twenty-eight studies show an exposure-response relationship between Mn and neurobehavioral effects, including 11 with continuous exposure metrics and six with three or four levels of contrasted exposure. The effects of sustained low-concentration exposures to Mn are consistent with the manifestations of early manganism, i.e., consistent with parkinsonism. This is compelling evidence thatMnis a neurotoxic chemical and there is good evidence that Mn exposures far below the current US standard of $5.0mg/m^3$ are causing impairment.

Exploration of relationship among Korean adolescents' sexual orientations, exposure to internet pornography and sexual behaviors after exposure: focused on PLS path modeling analysis (청소년의 성(性)정향성, 인터넷 음란물 노출 및 노출 후 행태 사이의 관계에 관한 탐색적 연구: PLS(Partial Least Square) 구조모형 분석을 중심으로)

  • Joo, Jihyuk;Kim, Hyung-Il
    • Journal of Digital Convergence
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    • v.11 no.6
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    • pp.11-21
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    • 2013
  • Though adolescents have the skillful ability to use internet and use it extensively, they have experienced sexually less than adults and are hard to have the right viewpoint toward sexuality. Because of these adolescents' characteristics, internet pornography cause them serious troubles with their sexual behavior. Based on the viewpoint, this research explores structural relationship among their sexual orientations, exposure to internet pornography, the sexual drive and behavior with PLS path modeling analysis. In result, androcentric and pornography-friendly sexual orientation have an influence on the exposure to internet pornography, in turn, the exposure to internet pornography affect the sexual drive and behavior directly and sexual behavior indirectly mediated by the drive. The significance of this research is to identify fact that sexual orientations, reconceptionalized from previous researches's dependent variables, predict the exposure to internet pro-pornographic and is to identify a popular myth indirectly that the exposure to internet pornography stimulates sexual drive to cause behavior, in turn leads to sex crimes finally.

Estimation of Extreme Heat Exposure at Outdoor Construction Sites through Wet Bulb Globe Temperature Modeling (습구흑구온도지수 모델링을 통한 옥외 건설 현장의 고열 노출수준 추정)

  • Saemi, Shin;Hea Min, Lee;Nosung, Ki;Jung Soo, Chae;Sang-Hoon, Byeon
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.32 no.4
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    • pp.402-413
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    • 2022
  • Objectives: In this study, the scale of exceeding the extreme heat exposure standard at the construction site was estimated using the nationally approved statistical data and wet bulb globe temperature modeling method. By comparing and analyzing the modeling results with the existing work environment monitoring results, the risk of heat exposure at outdoor construction sites was considered. Methods: Using the coordinates of second level administrative districts and meteorological observatories as the key, the automated synoptic observing system data and building permit data for 2021 were matched. The wet-bulb temperature was obtained using Stull's formula, and the globe temperature was obtained using the TgKMA2006 model. WBGT was calculated using these. Excess rates were obtained compared to exposure limits for heavy work-continuous work and moderate work-25% rest. It was compared with the results of the work environment monitoring in 2020. Results: As a result, 1,827,536 cases were estimated for 11,052 workplaces in one year. This is much higher than the 5,116 cases of 3818 workplaces of the existing work environment monitoring results. It is confirmed that the exposure limit was exceeded in 10.6~24.0% of the entire period and 70.2~84.1% of the peak period of the heat wave. It is very high compared to 0.9% of the existing work environment monitoring result. Conclusions: It is necessary to improve the system of monitoring and statistics related to extreme heat. Additional considerations are needed regarding WBGT estimation methods, meteorological data, and evaluation time. Various follow-up risk assessment studies for other industries and time series need to be continued.

Predicting Environmental Concentrations of Selected Pharmaceuticals Using the PhATETM Model in Keum-River, Korea (PhATETM 모형을 적용한 금강수계 중 의약물질 농도 추정)

  • Lim, Deuck-Soon;Park, Jeong-Im
    • Journal of Environmental Health Sciences
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    • v.35 no.1
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    • pp.45-52
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    • 2009
  • In recent years, pharmaceuticals in the aquatic environment have become a matter of increasing public concern. Environmental risk assessment (ERA), including an exposure assessment, is considered the best scientifically based approach for evaluating the potential effects of pharmaceuticals on ecosystems. Computerized exposure models constitute an important tool in predicting environmental exposures of pharmaceuticals. This paper presents the applicability of an exposure model by comparing measured data of selected pharmaceuticals with predicted environmental concentrations from an exposure model. $PhATE^{TM}$ (Pharmaceutical Assessment and Transport Evaluation) model developed by the Pharmaceutical Research and Manufacturers of America (PhRMA) was adapted to run simulations for the Keum River. A set of 7 pharmaceuticals of high production in Korea was modeled. The PECs generated by the $PhATE^{TM}$ model that were then compared to the measured concentrations. The $PhATE^{TM}$ model predicted concentrations for 7 pharmaceuticals including acetaminophen, acetylsalicylic acid, erythromycin, ibuprofen, lincomycin, mefenamic acid, and naproxen were in good agreement with actual measured concentrations, which demonstrated the utility of $PhATE^{TM}$ as a predictive tool. In conclusion, $PhATE^{TM}$, although it does not intend to accurately represent reality, could be utilized for rapid predictions of the environmental concentrations of pharmaceuticals.

Acquisition of HDR image using estimation of scenic dynamic range in images with various exposures (다중 노출 복수 영상에서 장면의 다이내믹 레인지 추정을 통한 HDR 영상 획득)

  • Park, Dae-Geun;Park, Kee-Hyon;Ha, Yeong-Ho
    • Journal of the Institute of Electronics Engineers of Korea SP
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    • v.45 no.2
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    • pp.10-20
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    • 2008
  • Generally, to acquire an HDR image, many images that cover the entire dynamic range of the scene with different exposure times are required, then these images are fused into one HDR image. This paper proposes an efficient method for the HDR image acquisition with small number of images. First, we estimated scenic dynamic range using two images with different exposure times. These two images contain the upper and lower limit of the scenic dynamic range. Independently of the scene, according to varied exposure times, similar characteristics for both the maximum gray levels in images that include the upper limit and the minimum gray levels in images that include the lower limit are identified. After modeling these characteristics, the scenic dynamic range is estimated using the modeling results. This estimated scenic dynamic range is then used to select the proper exposure times for the acquisition of an HDR image. We selected only three proper exposure times because entire dynamic range of the cameras could be covered by three dynamic range of the cameras with different exposure times. To evaluate the error of the HDR image, experiments using virtual digital camera images were carried out. For several test images, the error of the HDR image using proposed method was comparable to that of the HDR image which utilize more than ten images for the HDR image acquisition.

Modeling and Simulation of Line Edge Roughness for EUV Resists

  • Kim, Sang-Kon
    • JSTS:Journal of Semiconductor Technology and Science
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    • v.14 no.1
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    • pp.61-69
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    • 2014
  • With the extreme ultraviolet (EUV) lithography, the performance limit of chemically amplified resists has recently been extended to 16- and 11-nm nodes. However, the line edge roughness (LER) and the line width roughness (LWR) are not reduced automatically with this performance extension. In this paper, to investigate the impacts of the EUVL mask and the EUVL exposure process on LER, EUVL is modeled using multilayer-thin-film theory for the mask structure and the Monte Carlo (MC) method for the exposure process. Simulation results demonstrate how LERs of the mask transfer to the resist and the exposure process develops the resist LERs.

Construction of an Exposure Risk Map and Spatial Knowledge Base for Asbestos in Korea (석면 공간지식베이스 구축을 통한 석면 노출위험도 작성)

  • Hwang, Jae-Hong;Lee, Byung-Joo
    • The Journal of Engineering Geology
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    • v.21 no.4
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    • pp.393-402
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    • 2011
  • Asbestos is a toxic material that can lead to lung cancer and other diseases. There is no information regarding areas in Korea that contain asbestos in nature; consequently we need to manage such areas with care. The purpose of this study was to construct a local graded map of asbestos exposure risk based on the natural occurrence of asbestos in rocks. We first developed a means of evaluating the asbestos exposure risk and produced thematic maps based on a field survey. In addition, we constructed a knowledge base for asbestos through analysis, representation and processes about asbestos data and prepare for the development of an evaluation model for asbestos exposure risk. The spatial analysis of asbestos exposure risk is based on a weighted-overlay analysis using expert opinion and the literature, and a fuzzy-overlay analysis using the uncertainty in the data. The map of asbestos exposure risk, compiled according to the weighted and fuzzy operations, is expected to be used to ensure safety and to reduce the risk of exposure to asbestos.

Methodologies for Inhalation Exposure Assessment of Engineered Nanomaterial-containing Consumer Spray Products (분사형 소비자 제품 중 나노 물질의 흡입 노출 평가 방법)

  • Park, Jihoon;Park, Mijin;Yoon, Chungsik
    • Journal of Environmental Health Sciences
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    • v.45 no.5
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    • pp.405-425
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    • 2019
  • Objective: This study aimed to review the methodologies for evaluation of consumer spray products containing engineered nanomaterials (ENM), particularly focusing on inhalation exposure. Method: Literature on the evaluation methods for aerosolized ENM exposure from consumer spray products were collected through academic web searching. Common methodologies used in the literature, including research reports and academic articles, were also introduced. Results: The number of ENM-containing products have shown a considerable increase over recent years, from 54 in 2005 to 1,827 in 2018. Currently there is still discussion over the existing regulations with regard to product safety. Analysis of both ENM suspensions in the products and their aerosols is important for risk assessment. Comparison between the phases suggests how the size and concentration of particles change during the spray process. To analyze the ENM suspensions, dynamic light scattering, electron microscopy techniques, and inductively coupled plasma with mass spectrometry were used. In the aerosol monitoring, direct-reading instruments have been used to monitor the aerosols and conventional active sampling is used together to supplement the lack of real-time monitoring. There are also some models for estimating inhalation exposure. These models may be used to estimate mass exposure to nanomaterials contained in consumer products. Conclusion: Although there is no standardized method to evaluate ENM exposure from consumer products, many concerns about ENM have emerged. Every potential measure to reduce exposure to ENM from spray product use should be implemented through a precautionary recognition.

Estimation of Advertising Exposure Distribution by Zero-inflation Regression Models (영과잉 회귀모형을 이용한 광고노출분포 추정)

  • Lee, Dong-Hee
    • Journal of the Korean Data Analysis Society
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    • v.20 no.6
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    • pp.2841-2852
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    • 2018
  • This study examines regression modeling method using zero-inflated distribution in relation to estimation of exposure distribution required in advertisement media planning. Exposure distribution is the percentage of audiences that are exposed each time the ad is repeated. Such an exposure distribution plays a very important role in providing basic information necessary for calculating various indicators for quantitatively measuring the advertising effect. Especially, due to the decrease of advertising price and the spread of various media, the frequency of the advertisement or the broadcasting of specific advertisements has been greatly increased compared to the past. As a result, the frequency of exposure is relatively decreasing. In this situation, the number of individuals who are not exposed to the media, that is, are not exposed to advertising structurally is increasing. This research proposes advertising exposure distribution models using a zero-inflated regression model, and conducts a comparative study using actual cases.