• Title/Summary/Keyword: Export Strategy

Search Result 329, Processing Time 0.033 seconds

Inhibitory Role of TRIP-Br1/XIAP in Necroptosis under Nutrient/Serum Starvation

  • Sandag, Zolzaya;Jung, Samil;Quynh, Nguyen Thi Ngoc;Myagmarjav, Davaajargal;Anh, Nguyen Hai;Le, Dan-Diem Thi;Lee, Beom Suk;Mongre, Raj Kumar;Jo, Taeyeon;Lee, MyeongSok
    • Molecules and Cells
    • /
    • v.43 no.3
    • /
    • pp.236-250
    • /
    • 2020
  • Currently, many available anti-cancer therapies are targeting apoptosis. However, many cancer cells have acquired resistance to apoptosis. To overcome this problem, simultaneous induction of other types of programmed cell death in addition to apoptosis of cancer cells might be an attractive strategy. For this purpose, we initially investigated the inhibitory role of TRIP-Br1/XIAP in necroptosis, a regulated form of necrosis, under nutrient/serum starvation. Our data showed that necroptosis was significantly induced in all tested 9 different types of cancer cell lines in response to prolonged serum starvation. Among them, necroptosis was induced at a relatively lower level in MCF-7 breast cancer line that was highly resistant to apoptosis than that in other cancer cell lines. Interestingly, TRIP-Br1 oncogenic protein level was found to be very high in this cell line. Up-regulated TRIP-Br1 suppressed necroptosis by repressing reactive oxygen species generation. Such suppression of necroptosis was greatly enhanced by XIAP, a potent inhibitor of apoptosis. Our data also showed that TRIP-Br1 increased XIAP phosphorylation at serine87, an active form of XIAP. Our mitochondrial fractionation data revealed that TRIP-Br1 protein level was greatly increased in the mitochondria upon serum starvation. It suppressed the export of CypD, a vital regulator in mitochondria-mediated necroptosis, from mitochondria to cytosol. TRIP-Br1 also suppressed shikonin-mediated necroptosis, but not TNF-α-mediated necroptosis, implying possible presence of another signaling pathway in necroptosis. Taken together, our results suggest that TRIP-Br1/XIAP can function as onco-proteins by suppressing necroptosis of cancer cells under nutrient/serum starvation.

The statistical analysis for cognizance on the Chinese oriental medical doctor of the pulse meter-analyzer (중의사의 맥진기 인식에 대한 통계 분석 연구)

  • Kim, Gyeong-Cheol;Kim, Jong-Hwan;Shin, Woo-Jin;Lee, Hai-Woong;Park, Ju-Yeon;Hong, Sang-Min;Doo, Seung-Hee;Kang, Hee-Jung;Yingri, Zhao
    • The Journal of the Society of Korean Medicine Diagnostics
    • /
    • v.13 no.2
    • /
    • pp.88-116
    • /
    • 2009
  • Background : EBM (the evidence based medicine) is the direction of the development for oriental medicine. The pulse meter-analyzer is the important part to standardize the pulse diagnosis. When we set up the direction of the study on the pulse meter-analyzer, the awereness about the pulse meter and analyzer of the clinical oriental medical doctors as consumers is very important. Objectives : In order to prepare for the mutual study and the export strategy on the pulse meter-analyzer of Korea and China, the attitude of the study and the grasp of the awereness about the pulse meter-analyzer of the Chinese medical doctors are very important. Methods : We developed the several items as the important factor of the development of the pulse meter and analyzer. They were translated by chinese medical doctor. The investigation for demend was conducted during 3 months in Guangzhou City, Guangdong Province, China. The results of the investigation was done the statistical method of frequency analysis, Chi-squared test, correspondence analysis. Results : The most important differentiation of symptom is the symptom of JANG-BU(臟腑). The method of the utility in the pulse diagnosis is Chon-Gu (寸口) pulse diagnosis and the research on Chon-Kwan-Cheok(寸關尺) is the most important measurement factor. And the typical the old pulse is the little-fine weak pulse. The pulse meter-analyzer is most suitable to the diagnosis of the hypertension and the arteriosclerosis. Conclusion : The development of the pulse analyzer including the requests of Korean and Chinese medical doctors is very important. Specially the researches on the influence factors of the traditional diagnosis and the environment of the measurement are important for developing the pulse analyze.

  • PDF

Impacts for Waste Management According to Waste Trade (폐기물 수출입 흐름 변화가 폐기물 관리에 미치는 영향)

  • Lee, Sang-hun
    • Resources Recycling
    • /
    • v.29 no.3
    • /
    • pp.43-50
    • /
    • 2020
  • This study reviewed the examples on analyses of the potential impacts to waste management, due to the recent trends of waste trade regulation, and summarized an analysis strategy of the impacts. As a result, a desirable analysis may begin with reasonable estimation of recent waste amounts and flows, and reasonable prediction of the future trends of waste amounts. Then, it is effective to list various key factors and derive future scenarios of the impacts, as well as employ the traditional viewpoints focusing on waste material flow or environmental regulations. The applicable analyses for each scenario can be largely divided into qualitative and quantitative methods. Due to a high uncertainty in the recent international situations with entailing possible innovative economic changes, qualitative methods may be considered in advance, and then quantitative techniques may be utilized to predict gradual changes at relieved uncertainty of the situations. Based on this review so far, proper methodology and procedures for the impact analysis were suggested on recent waste trade conditions in Korea. Given existence of the recent uncertainties such as the health and economic crises, the analysis preferably focused on deriving strategic scenarios with respect to various aspects, and suggested analysis methods applicable to each scenario.

Legal and Policy Tasks for Raising a Climate Fund in Response to a New Climate Regime (신기후체제 대응을 위한 기후기금 조성의 법·정책적 과제)

  • Ku, Ji Sun;Park, Chul Ho
    • Journal of Climate Change Research
    • /
    • v.9 no.2
    • /
    • pp.181-195
    • /
    • 2018
  • On December 12, 2015, the Conference of the Parties to the United Nations Framework Convention on Climate Change (UNFCCC) adopted the Paris Agreement, in which several developed and developing countries all committed to participating in the reduction of greenhouse-gas (GHG) emissions. South Korea has submitted an intended nationally determined contribution (INDC) proposal with a target to cut down 37% greenhouse gas business as usual (BAU) until 2030 in preparation for the 2030 GHG BAU. Under the post-2020 regime, which will be launched from 2021 as the agreement entered into force early, it is expected that efforts to support GHG reduction and adaptation to climate change in developing countries will be accelerated with the utilization of technologies and financial resources of developed countries. South Korea has established the Basic Plan for Climate Change Response and the Basic National Roadmap for Greenhouse Gas Reductions by 2030 to promote the response to climate change at the government level. The Ministry of Science and ICT, as the National Designated Entity designated by the UNFCCC, has come up with middle and long-term strategies for climate technology cooperation. South-Korea has an abundance of energy-consuming industries to support its export-oriented industrial structure; it is thus expected that achieving the GHG reduction target will incur a considerable cost. Moreover, in order to meet the reduction target (11.3%) of the intended nationally determined contribution proposed by South Korea, it is necessary for South Korea to actively promote projects that can achieve GHG reduction achievements, and financial resources are needed as leverage to reduce risks that can occur in the early stages of projects and attract private sector investment. This paper summarizes the theoretical discussions on climate finance and conducted a comparative analysis on the status of the funds related to climate change response in the UK, Germany, Japan and Denmark. Through this, we proposed the legal and policy tasks that should be carried forward to raise public funds that can be used for creation of new industries related to climate change as well as to reduce GHG emissions in South Korea. The Climate Change Countermeasures Act, which has been proposed by the National Assembly of South-Korea, stipulates the establishment of funds but there is no additional funding except for general account. In this regard, it is also possible to take measures such as the introduction of carbon tax or the collection and use of royalties through technology research and development projects for climate change, such as Industrial Technology Innovation Promotion Act. In addition, since funds are used in various fields such as domestic greenhouse gas reduction, technology development, and overseas projects, it is necessary to establish a system in which various ministries cooperate with the operation of the fund.

Effect of the U.S. Monetary Policy on the Real Economy of the Asia: Focusing on the impact of the exchange rate in Korea, China and Japan (미국의 통화정책이 아시아 실물경제에 미치는 영향: 한국, 중국, 일본의 환율충격을 중심으로)

  • Choi, Nam-Jin
    • International Area Studies Review
    • /
    • v.20 no.2
    • /
    • pp.3-23
    • /
    • 2016
  • In this study, we used actual proof analysis, based on SVAR model according to economy theory, to observe the impact of actual and financial market of Korea, Japan, and China that have adopted quantitative easing export based strategy of growth, an unconventional monetary policy of the U.S. As a result of estimation, it appears that real effective exchange rate rise shock of Korea, Japan, and China against U.S. dollar has a negative influence on current account and index of industrial product, which are real economy. It can be implied that the result is driven from the fact that strong home currency of Korea, Japan, and China decreases price competitiveness of exports, causing negative influence on real economy. The real effective exchange rate shock against U.S. dollar appeared to decrease national bond rate of Korea and Japan, while increasing that of China. In instances of Korea and Japan, it is implied that national bond rate decreases as foreigner investment funds flow in, considering foreign-exchange profit through advanced financial market with high opening extent. On the other hand, because there are strong regulation on opening extent of Chinese financial markets, the influence seems to be greater for domestic policy, rather than a foreign influence. Lastly, Korea showed a more dramatic variable reaction to exchange rate shock compared to Japan or China. It is implied from the result that Korea is relatively more susceptible and fragile in regards of international status of economic size and currency.

Derivation of Anti-Tamper System Requirements Based on CMVP Standard for Technology Protection of Weapon Systems (무기 시스템의 기술 보호를 위한 CMVP 표준 기반의 Anti-Tamper 시스템 요구사항 도출)

  • Lee, Min-Woo;Lee, Jae-Chon
    • Journal of the Korea Academia-Industrial cooperation Society
    • /
    • v.20 no.4
    • /
    • pp.470-478
    • /
    • 2019
  • As the growth of the domestic defense industry is remarkable regarding technology level and export size, technology protection is necessary. Particularly, there is a need to apply anti-tamper measures to prevent critical technologies from illegally being taken out of weapon systems. However, there is no security protection strategy and system built yet in ROK. Precedent studies discussed the trend analysis and technical research for specific protective techniques, and the application of anti-tamper using limited procedures was provided. Recently, methods of how to select the technology for protection were studied based on risk management. Nonetheless, these studies cannot be associated with the acquisition process for the whole life-cycle, having difficulty with actual development and evaluation of the weapon systems. The objective of our study is to derive the system requirements of the weapon system for which anti-tamper measures have been determined to apply. Specifically, requirements items suitable for the development of anti-tamper weapon systems were derived based on ISO/IEC 19790, the CMVP standard for the development and verification of cryptographic modules. Also, its utilization in technical reviews and test & evaluations was presented. The usefulness of the research results was confirmed through inductive inference and comparative evaluation. The result can be expected to play a role in initiating extensive activities needed for technology protection of the weapon systems.

A Study on the Characteristics of Global FDI on China's Balanced Development Strategy : Focusing on Korean FDI Characteristics by Major Cities in China (중국지역균형발전전략에 미치는 글로벌 FDI 특성에 관한 연구 :중국주요도시별 한국FDI 특성을 중심으로)

  • Ryoo, Sung-Woo;Mun, Cheol-Ju
    • Korea Trade Review
    • /
    • v.43 no.4
    • /
    • pp.155-175
    • /
    • 2018
  • This study estimates the technical efficiency and total factor productivity(TFP) of and analyzes the relationship between TFP and exports for Korean manufacturing companies from 2000 to 2016. Specially, TFP is decomposed into Technical Change(TC), Technical Efficiency Change (TEC), and Sale Effect(SE), and compared between large and small enterprises. First, in the case of technical efficiency, the Korean economy has been very vulnerable to external shocks, such as the sharp decline following the 2008 financial crisis. The efficiency of the electronics, automobile, and machinery sectors is low and needs to be improved. In addition, the technological efficiency of large enterprises is higher than that of SMEs in most manufacturing sub-sectors except for non-ferrous metals. In the case of TFP, most changes are due to TC, and the effective combination of labor, capital and the effect of scale have little effect, suggesting that improvement of internal structure is urgent. In addition, volatility due to the impact of the financial crisis in 2008 was much larger in SMEs than in large companies, so external economic impacts are more greater for SMEs than large enterprises. The relationship between TFP decomposition factors and exports shows that TC has a positive effect only on exports of SMEs. Therefore, in order to increase exports, in the case of SMEs, R&D support to promote technological development is needed. In the case of large companies, it is necessary to establish differentiated strategies for each export market, competitor company, and item to link efficiency and scale effect of exports.

  • PDF

Status and Development Strategy of the Seed Industry in China (최근 중국 종자산업의 현황 및 발전 전망)

  • Lee, Jung-Ro;Baek, Hyung-Jin;Choi, Yu-Mi;Lee, Sok-Young;Lee, Gi-An;Jung, Yeon-Ju;Kim, Chung-Kon;Lee, Myung-Chul
    • Journal of the Korean Society of International Agriculture
    • /
    • v.23 no.5
    • /
    • pp.552-559
    • /
    • 2011
  • China is a one of the largest agricultural countries in the world. China consumes around 12.5 billion kilograms of seeds each year. Suchhuge demand for seeds has made the Chinese seed market more and more attractive for investment. Through analysis on the present situation and existing problems of the seed industry in China and based on the current Chinese seed industry development, some future prospects for investments are indicated. This investigation was carried out to propose the appropriate strategies on the development of the Korea seed industry as it considers its entry into the China seed market as a new growth engine in the agricultural sector. The basic law regulating the Chinese seed industry is the PRC Seed Law that generally refers to the protection of germplasm resources, verification of varieties, seed quality issues, the import and export of seeds, seed administrative management, and various rights and obligations. The regulations were aimed at the protection of the rights concerning new varieties of plants. China has two main industry associations, the National Seed Association and the China Seed Industry IP Union, that are non-profit associations consisting of entities and people engaging in the seed scientific research, production, operation and management. The China National Seed Group Co., Ltd. ("Sino Seeds") is the market leader in China regarding the seed industry. The chinese government, however, encourages investment from multinational companies as well as importation of modern crop planting management technologies and equipment. It supports the entry of investors with proven experiences in breeding and germplasm resources expansion and R&D. There has never been a better time for multinational companies with proven seed industry experience to look at building relationships with the Chinese government and enterprises.

Technology Standards Policy Support Plans for the Advancement of Smart Manufacturing: Focusing on Experts AHP and IPA (스마트제조 고도화를 위한 기술표준 정책영역 발굴 및 우선순위 도출: 전문가 AHP와 IPA를 중심으로)

  • Kim, Jaeyoung;Jung, Dooyup;Jin, Young-Hyun;Kang, Byung-Goo
    • Informatization Policy
    • /
    • v.30 no.4
    • /
    • pp.40-61
    • /
    • 2023
  • The adoption of smart factories and smart manufacturing as strategies to enhance competitiveness and stimulate growth in the manufacturing sector is vital for a country's future competitiveness and industrial transformation. The government has consistently pursued smart manufacturing innovation policies starting with the Manufacturing Innovation 3.0 strategy in the Ministry of Industry. This study aims to identify policy areas for smart factories and smart manufacturing based on technical standards. Analyzing policy areas at the current stage where the establishment and support of domestic standards aligning with international technical standards are required is crucial. By prioritizing smart manufacturing process areas within the industry, policymakers can make well-informed decisions to advance smart manufacturing without blindly following international standardization in already well-established areas. To achieve this, the study utilizes a hierarchical analysis method including expert interviews and importance-performance analysis for the five major process areas. The findings underscore the importance of proactive participation in standardization for emerging technologies, such as data and security, instead of solely focusing on areas with extensive international standardization. Additionally, policymakers need to consider carbon emissions, energy costs, and global environmental challenges to address international trends in export and digital trade effectively.

The Changing Patterns of Demand-Supply and Role of Mineral Resources in Economic Growth during Industrialization of the Republic of Korea (한국공업화과정(韓國工業化過程)에서의 광물자원(鑛物資源)의 수급구조변화(需給構造變化)와 경제성장(經濟成長)에 있어서의 역할(役割))

  • Yun, Suckew
    • Economic and Environmental Geology
    • /
    • v.18 no.1
    • /
    • pp.65-92
    • /
    • 1985
  • A total of 12 mineral commodities significant in domestic output, economy and/or strategy of the Republic of Korea are chosen to examine the structural changes in production and demand-supply of these minerals during the last two decades of her industrialization. These include iron and manganese ores as the raw materials for iron and steel making, copper, zinc and tungsten ores among other non-ferrous metallic minerals, limestone (cement), kaolin, talc, pyrophyllite and graphite among other non-metallic minerals, and anthracite coal as the only domestic source of fossil energy. These are reviewed historically in time-series based on the statistical data which are tabulated and graphed in terms of domestic output, export, import, apparent demand-supply, its increasing rate, and self-sufficiency rate of each commodity. The increasing rates of demand-supply (IRDS) of some more important commodities are compared with those of Gross Domestic Production (GDP) and Economic Growth Rate (EGR) to evaluate how the IRDS contributed to the GDP and EGR. The major results revealed are as follows: Among the 12 commodities, the domestic output of 8 commodities appeared to have grown with steady upward trends: they are ores of lead, zinc and tungsten, limestone (cement), kaolin, talc, pyrophyllite and anthracite coal. Two commodities, ores of iron and copper, continued with unchanging or slightly declining trends and varied fluctuations, in spite of their cardinal importance to the heavy industry and strategy of Korea. The remaining two, graphite and manganese ore, have gradualy declined in domestic output in which the former has still enough resource potential but the latter has not and virtually ceased its domestic output. Trade patterns for mineral commodities in the Republic of Korea during the last two decades have changed greatly, being marked by a shift from mineral-exporting to mineral importing, mainly because of increasing consumption of mineral raw materials for industrialization rather than beceuse of decreasing output of domestic mineral commodities in quantity. In terms of trade patterns, the 12 commodities concerned in this study can be classified into the following four groups. The 1st group - ores of lead and tungsten have only been exported without imports. The 2nd group - amorphous graphite, and pyrophyllite have mainly been exported but partly been imported. The 3rd group - kaolin, talc and crystalline graphite have equally been exported and imported, but quantity of imports have rapidly been increased with time. The 4th group - ores of iron, manganese and zinc have shifted from exports to imports during the industrialization, particularly owing to the initiation of iron and steel making by the Pohang Iron and Steel Company in the middle 1970' s and the new establishment of the Onsan Zinc Refinery in the late 1970' s. All of the 12 commodities under considerations were far above 100% in self-sufficiency rate before or in the early 1960' s. Recently, however, most of them have been declined to below 100% except for those of limestone (cement) and pyrophyllite. It is particularly serious to identify that the self-sufficiency rates of the three important metallic minerals, iron, copper and manganese ores in 1982 appeared to be 5.1%, 0.5%, and 0.01%, respectively. The average self-sufficiency rate of the total domestic minerals produced in 1982 was 14.4% (in value) for that year. Mining industry appeared to be extremely high in its intermediate demand rate whereas its intermediate input rate to be quite low indicating that mineral raw materials have been exerted strong forward linkage effects upon the other industries rather than backward linkage effects. In comparing the curves of increasing rates of demand-supply of several major minerals - iron ore, manganese ore, copper ore, limestone (cement), kaolin, and anthracite coal - with those of Gross Domestic Production and Economic Growth Rate drawn on every graph, it is clearly shown that the curves of increasing rates of demand-supply comprise around 6 to 7 periods of cycles which roughly harmonious with those of the curves of GDP and EGR, except for the curve of anthracite coal of which the configuration seems to have resulted from the (artificial) government's mineral policy rather than from economic free market mechanism. The harmonic feature of these curves well suggests that the increasing rates of demand-supply of major minerals have been significantly contributed to the GDP and EGR. In addition, the wider amplitudes of the iron, manganese and copper curves than those of the limestone (cement) and kaolin curves indicate that the contribution of the former, metallic commodities, has been greater than that of the latter, non-metallic commodities.

  • PDF