• Investigative Magnetic Resonance Imaging
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• 제22권3호
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• pp.158-167
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• 2018

Purpose: To investigate the surgical, perfusion, and molecular characteristics of glioblastomas which influence long-term survival after treatment, and to explore the association between MR perfusion parameters and the presence of MGMT methylation and 1p/19q deletions. Materials and Methods: This retrospective study was approved by our institutional review board. A total 43 patients were included, all with pathologic diagnosis of glioblastoma with known MGMT methylation and 1p/19q deletion statuses. We divided these patients into long-term (${\geq}60\;months$, n = 7) and short-term (< 60 months, n = 36) survivors, then compared surgical extent, molecular status, and rCBV parameters between the two groups using Fisher's exact test or Mann-Whitney test. The rCBV parameters were analyzed according to the presence of MGMT methylation and 1p/19q deletions. We investigated the relationship between the mean rCBV and overall survival using linear correlation. Multivariable linear regression was performed in order to find the variables related to overall survival. Results: Long-term survivors (100% [7 of 7]) demonstrated a greater percentage of gross total or near total resection than short-term survivors (54.5% [18 of 33]). A higher prevalence of 1p/19q deletions was also noted among the long-term survivors (42.9% [3 of 7]) than the short-term survivors (0.0% [0 of 36]). The rCBV parameters did not differ between the long-term and short-term survivors. The rCBV values were marginally lower in patients with MGMT methylation and 1p/19q deletions. Despite no correlation found between overall survival and rCBV in the whole group, the short-term survivor group showed negative correlation ($R^2=0.181$, P = 0.025). Multivariable linear regression revealed that surgical extent and 1p/19q deletions, but not rCBV values, were associated with prolonged overall survival. Conclusion: While preoperative rCBV and 1p/19q deletion status are related to each other, only surgical extent and the presence of 1p/19q deletion in GBM patients may predict long-term survival.

• 지질공학
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• 제20권1호
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• pp.89-100
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• 2010

암석의 손상상태를 평가하기위한 여러 방법들이 제안되어 있으나, 일부의 방법은 명확한 손상기준을 제시하기도 하지만 일부의 방법은 매우 모호하여 분석자의 주관에 따라 값이 달라지기도 한다. 그러므로 이 연구에서는 황등화강암을 대상으로 현재까지 제안된 모든 손상기준 결정방법을 적용하여, 각 방법의 적용성, 오차 및 최적의 손상기준결정 방법 등을 연구하였다. 또한 암석의 균열발달 및 파괴특성의 규명에 가장 중요한 손상기준인 균열개시응력과 균열손상응력을 FSR 및 장기 정하중 시험을 이용하여 검정하였다. 황등화강암의 균열닫힘응력과 균열개시응력은 각각 57.5 MPa, 77.6 MPa이며 균열체적변형률에서 측정하는 것이 가장 정확한 것으로 판단된다. 2차 균열개시응력은 90.6 MPa로 측정되었으며, 미소파괴음 계수 및 계수율이 균열개시응력의 측정에 가장 효과적인 것으로 판단된다. 균열결합응력 측정은 체적강성곡선, 미소파괴음 계수 및 미소파괴음 계수율이 가장 효과적인 방법으로 판단되며, 균열결합응력은 110.3 MPa이다. 균열손상응력은 체적강성곡선 및 미소파괴음 계수율에서 가장 명확히 측정되며, 약 127.5 MPa이다. 일축압축강도에 대한 비로서 나타낸 균열개시응력은 0.47로 FSR 값 0.46과 매우 유사하며, 균열손상응력은 0.77로 장기 정하중 시험을 통하여 측정된 장기 강도비 0.75~0.8과 거의 일치하여 균열개시응력 및 균열손상응력 값이 정확함을 검정하였다.

• 한국식품위생안전성학회지
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• 제27권1호
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• pp.37-41
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• 2012

현재 복어독의 표준 시험법은 다른 나라들과 마찬가지로 마우스를 이용한 동물시험법으로 명시되어 있다. 그러나, 살아있는 동물에게 고통을 주는 동물실험의 규제 확대로 인해 기기분석 시험법으로의 개선이 요구되고 있다. 또한, 동물시험법의 감도나 정밀성 및 정확성의 한계로 최근에 동물시험법을 대체할 수 있는 시험법에 대한 연구가 활발히 진행되고 있다. 본 연구에서 LC/MS/MS 시험법은 시료에서 테트로도톡신을 추출한 후 SPE(Solid phase extraction) 정제칼럼을 이용하여 정제하고 양이온 모드에서 MRM(multiple reaction monitoring)방법으로 분석하는 시험법으로서 밸리데이션 결과 검출한계(LOD)는 부위에 따라 $0.03{\sim}0.08{\mu}g/g$이었고, 정량한계(LOQ)는 $0.10{\sim}0.25{\mu}g/g$이었다. 검량선의 상관계수($r^2$)는 0.9986~0.9997이고, 회수율은 80.9%~103.0%이었으며 상대표준편차(RSD)는 4.3%~13.0%로서 적합한 시험법임을 확인하였다. 이 시험법을 이용하여 복어 검체의 부위별로 분석을 실시하였으며, 동물시험법의 시험결과와의 상관관계를 분석한 결과, 상관계수는 0.95이상의 상관성을 확인하였다.

• Archives of Reconstructive Microsurgery
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• 제16권2호
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• pp.113-118
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• 2007

Purpose: The purpose of this work was to describe the results of treatment for motor vehiclerelated crushing injuries among children and adolescents under sixteen years in Korea. Materials and Methods: A retrospective analysis was conducted of data from children who were under sixteen year and injured foot by motor vehicles. Cases were documented 1) age at the time of injury, 2) injured site, 3) the area of accident, 4) the kind of vehicle, 5) associated injuries, 6) methods of treatment for soft tissue reconstruction and 7) complications. The relationships between the area of accident and associated injuries, and the kind of vehicle and associated injuries were analyzed using Chi-square test and Fisher exact test. Results: There were 97 children who were 15 year and younger. The mean age was 7.4 years, and 65% were boys. The left foot was more dominant side of injury (57%). Seasonal variation was seen with the number of injuries peaking during the summer (43%, p<0.05). Among the vehicles, 78.3% were the large vehicles (bus, truck or van). The where of accident was more frequent at an alley or less than two lanes of traffic. But, the relationships between the place of accident and associated injury or the kind of vehicles and associated injury were not statistically significant. The associated injury were fracture or dislocation (23 cases, 35.9%), injury of tendon (21 cases, 32.8%). There were amputation or disarticulation of foot in 8 cases (8.2%) and post-traumatic deformities such as flatfoot, hindfoot varus or valus deformities by tendon injury in 7 cases (7.2%). Conclusion: More than 50% of crushing or degloving injuries of child's foot by traffic accidents happened in boys between 5 to 9 years old. The associated injury was unrelated with size of vehicles or accident place at the time of accident. But, even though foot injury happened in an alley or one lane by small vehicles, child who hurt feet by car need thorough investigation about associated injury. If a surgeon keep in mind and treat child to associated injury necessarily, can minimize complication. Microsurgical reconstruction for soft tissue defect was prior to other methods.

• 대한치과의사협회지
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• 제48권6호
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• pp.469-477
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• 2010

The purpose of this study was to evaluate the effect of two dentin desensitizers and Er,Cr:YSGG laser for dentinal tubule occlusion. Twenty recently extracted single-rooted human teeth were used to obtain root dentinal fragments. The crowns were cut approximately 1mm below the cementum enamel junction(CEJ). A second cut was used to remove the apex of the root. Subsequently, a longitudinal cut was made in order to obtain 2 fragments from each root sample. The cementum from the cervical portion was removed using a high-speed diamond-coated bur in order to expose the dentin. To open dentinal tubules, forty samples were treated with 50% citric acid for 2 min and then rinsed under distilled water for 1 min. These were divided into four groups of ten samples each. The first group served as a control group. In group 2, the samples were irradiated with the Er,Cr:YSGG laser(Waterlase MD, Biolase, USA). In group 3, the samples were treated with Bisblock and ONE-STEP PLUS(Bisco, USA). In group 4, the samples were treated with Gluma comfort bond & Desensitizer(Heraeus Kulzer, Germany). All the samples were examined using Scanning electron microscopy(Hitachi, S-4700, Japan) with two different magnifications(X2000, X5000). These images were assessed by one examiner who was blind to the experimental procedure, using the index of smear layer removal. The distribution of smear layer removal grades was tested using Fisher's exact test. On the order hand, in order to evaluate the occluding effect of two dentin desensitizers and Er,Cr:YSGG laser, the number of exposed dentinal tubules was counted in each group. These were evaluated using the Kruskal-Wallis test with significance predetermined $\alpha$=0.05. There were statistically significant differences between the three groups(Er,Cr:YSGG laser, Bisblock+ONE-STEP PLUS, Gluma comfort bond & Desensitizer) and control group.

• Clinical and Experimental Reproductive Medicine
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• 제25권2호
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• pp.141-151
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• 1998

Objectives: To determine whether the body weight, body mass index (BMI), and basal serum level of LH, FSH, testosterone (T), dehydroepiandrosterone sulfate (DHEA-S) are related to the ovarian response to clomiphene citrate (CC) in patients with polycystic ovarian syndrome (PCOS). Materials and Method: From January 1996 to June 1997, total 57 patients with PCOS were enrolled in the present study. Women who had other infertility factors were excluded from our study. The ovulation induction using CC was used in all patients. The patients were grouped into 50 mg group, 100 mg group, and 150 mg group according to their daily CC dose. The patients were also grouped to ovulatory and non-ovulatory group. The body weight, BMI, and basal serum level of LH, FSH, T, DHEA-S were measured in all patients on the 2nd or 3rd day of the menstrual cycle. Results were analysed with Student's t-test and Fisher's exact test. Results: The body weight and BMI of the nonovulating group were significantly higher than those of the ovulating group in all groups (50, 100, 150 mg of CC). However, there were no significant differences of the level of LH and FSH between ovulating and nonovulating groups in all CC groups (50, 100, 150 mg). The level of T of nonovulating group was significantly higher in 50 and 100 mg of CC groups, but not in 150 mg group. The level of DHEA-S of the non-ovulating group is significantly higher in 50 mg group, but not in 100 and 150 mg groups. Conclusion: The body weight and BMI could be useful predictors of ovarian response to CC in patients with PCOS, and basal T and DHEA-S also might be useful in cases of low-dose CC treatment.

• 디지털융복합연구
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• 제13권7호
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• pp.403-412
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• 2015

본 연구에서는 IPA(Importance-Performance Analysis) 기법을 이용하여 의료관광객들이 만족할 수 있는 의료기관의 융복합 의료관광서비스를 위한 개선방안 및 시사점을 제시하고자 하였다. 본 연구의 자료수집에 있어서는 의료관광서비스를 경험한 고객들을 대상으로 2014년 9월 1일-2014년 10월 30일까지 검진을 받은 의료관광 고객들을 대상으로 총 244부의 설문지를 유효표본으로 확보하였다. 의료관광서비스의 중요도와 만족도의 차이를 알아보기 위하여 대응표본 t-test를 실시한 결과, 의료관광 서비스의 중요도와 만족도에 있어 모든 항목에서 유의한 차이를 보이고 있었다. 의료관광서비스에 대한 IPA 분석결과, 중요도는 높게 인식을 하지만 실제로는 만족도가 높지 않은 서비스 항목들로 향후에 집중 관리가 필요한 항목으로 '정확한 의료관광서비스', '환자의 요구에 신속한 대응', '신속한 의료관광서비스', '의료관광코디네이터와의 의사소통'의 항목들로 도출되었다. 그러므로 의료기관들은 의료관광에 대한 신속성과 전문성을 가진 의료관광코디네이터를 배치하여야 할 필요성이 있다.

• Advances in pediatric surgery
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• 제8권2호
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• pp.126-132
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• 2002

Inguinal hernia is a major surgical disease in pediatric surgery, occurring in 3.5% to 5% of all mature newborns and 9% to 11% of all premature babies. The objective of this study is to analyze the predisposing factors in association with recurrences of inguinal hernias in infants and children. In the period from January 1995 to September 2001, 1,575 infants and children who had primary inguinal hernias or recurrent inguinal hernias operated on at the Department of Pediatric Surgery at Seoul National University Hospital were evaluated retrospectively. We evaluated the data by medical records and by telephone interview. The sex, age, location of hernia, comorbidity, prematurity, incarceration, interval to operation after incarceration, postoperative complications were analyzed as predisposing factors in associated with hernia recurrence. Operative findings of recurrent inguinal hernia were reviewed. The data were statistically analyzed with Pearson Chi-Square test and Fisher-exact test. A total of eighteen (1.14%) out of 1,575 patients underwent an operation due to recurrent inguinal hernia. In 5 (27.8%) out of 18 recurred patients, institution of the primary herniorrhaphy was our hospital and in the other 13 (72.2%) was outside hospital. No impact on the development of recurrences was seen for sex, age, interval to operation after incarceration, and postoperative complications. The significant predisposing factors of recurrent inguinal hernias were left inguinal hernias (p=0.002), comorbidity (p=0.002), prematurity (p=0.006), incarceration (p=0.017) and technical error of first herniorrhaphy. We expect that knowledge for predisposing factors of recurrent inguinal hernias and experienced skill of pediatric surgeons will decrease recurrence rate in primary inguinal hernia.

• 한국지반공학회논문집
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• 제21권5호
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• pp.187-196
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• 2005

풍화 및 절리가 발달한 암반에 근입된 말뚝의 허용지지력 결정에는 침하량이 매우 중요한 인자가 되며, 설계단계에서 말뚝두부의 침하량을 예측하기 위해서는 말뚝의 하중전이기구에 대한 이해가 필수적이다. 따라서 본 연구에서는 풍화된 암반에 근입된 현장타설말뚝의 하중전이기구에 대한 연구를 수행하였다. 이를 위해 직경 1m의 총 5본의 현장 타설말뚝을 풍화된 편마암 부지에 시공하구 재하시험 및 하중전이 계측을 수행하여 말뚝의 축방향 지지거동을 분석하였다. 암반상태를 정량적으로 파악하기 위하여 재하시험 부지의 암반에 대한 엄밀한 현장/실내시험을 수행하고, 이를 토대로 암반상태가 말뚝의 하중전이기구에 미치는 영향을 분석하였다. 하중전이 계측을 통해 얻은 주면하중전이 (f-w) 곡선은 풍화상태가 상대적으로 양호한(MW) 연암의 경우, 수 mm의 변위에서 항복에 도달하며, 이후 변위에 따른 지지하중의 증가율이 급격히 둔화되는 경향을 보였다. 반면 풍화암/풍화토에 근입된 말뚝의 f-w 곡선은 뚜렷한 항복점을 보이지 않으며, 상대적으로 큰(>15m) 변위까지 주면하중이 쌍곡선 형태로 증가하였다. 선단하중전이(q-w) 곡선은 암반상태에 관계없이 선단변위 (q-w)까지는 선형적인 거동을 보였다.

• 치위생과학회지
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• 제17권2호
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• pp.183-191
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• 2017

본 연구는 치과 임상의 예방진료실에서 임상예방진료를 받은 환자의 구강건강인식도, 지식도, 실천도, 만족도를 비교분석하였다. 구강건강지식, 인식, 실천은 임상예방진료 전후 유의한 차이가 있었다. 임상예방진료프로그램 중 가장 만족도가 높은 것은 계획단계의 개별 예방계획과 실행단계의 PTC였고, 그 다음으로 평가단계의 평가결과 알림이었다. 만족 이유는 의료진이 친절해서가 가장 높았고, 재방문 점수는 10점 만점에 9.34점, 지인 추천 점수는 9.75점이었다. 지인 추천과 정의 상관관계가 있는 것은 임상예방진료프로그램 중 치아확인, 사진촬영, 계획, PMTC, TBI, 평가였다. 위의 결과를 통해 치위생과정을 근거한 임상예방진료프로그램은 환자의 구강건강에 대한 지식, 인식, 실천에 긍정적으로 효과가 있었고, 임상예방진료프로그램에 대한 만족도가 높아 치과 재방문과 지인 추천에 긍정적인 효과가 있었다. 따라서 치위생과정을 근거한 임상예방진료프로그램을 예방진료실에서 적극 활용하여 널리 적용되기를 바란다.