• Asian Pacific Journal of Cancer Prevention
• /
• 제15권8호
• /
• pp.3383-3389
• /
• 2014

Background: Prostate cancer is rapidly increasing in Korea and professional societies have requested adding prostate specific antigen (PSA) testing to the National Cancer Screening Program (NCSP), but this started a controversy in Korea and neutral evidence on this issue is required more than ever. The purpose of this study was to provide economic evidence to the decision makers of the NCSP. Materials and Methods: A cost-utility analysis was performed on the adoption of PSA screening program among men aged 50-74-years in Korea from the healthcare system perspective. Several data sources were used for the cost-utility analysis, including general health screening data, the Korea Central Cancer Registry, national insurance claims data, and cause of mortality from the National Statistical Office. To solicit the utility index of prostate cancer, a face-to-face interview for typical men aged 40 to 69 was conducted using a Time-Trade Off method. Results: As a result, the increase of effectiveness was estimated to be very low, when adopting PSA screening, and the incremental cost effectiveness ratio (ICER) was analyzed as about 94 million KRW. Sensitivity analyses were performed on the incidence rate, screening rate, cancer stage distribution, utility index, and treatment costs but the results were consistent with the base analysis. Conclusions: Under Korean circumstances with a relatively low incidence rate of prostate cancer, PSA screening is not cost-effective. Therefore, we conclude that adopting national prostate cancer screening would not be beneficial until further evidence is provided in the future.

• 한국HCI학회:학술대회논문집
• /
• 한국HCI학회 2008년도 학술대회 1부
• /
• pp.195-199
• /
• 2008

We present an approach to detect real plane for line base recognition and pose estimation Given 3D line segments, we set up reference plane for each line pair and measure the normal distance from the end point to the reference plane. And then, normal distances are measured between remains of line endpoints and reference plane to decide whether these lines are coplanar with respect to the reference plane. After we conduct this coplanarity test, we initiate visibility test using z-buffer value to prune out ambiguous planes from reference planes. We applied this algorithm to real images, and the results are found useful for evidence fusion and probabilistic verification to assist the line based recognition as well as 3D pose estimation.

• 대한치과교정학회지
• /
• 제54권3호
• /
• pp.139-141
• /
• 2024

• 대한두경부종양학회지
• /
• 제40권1호
• /
• pp.15-17
• /
• 2024

Clear cell carcinoma is a rare variant of salivary gland carcinoma, and its occurrence in the tongue base is even rarer. We present a case of a 55-year-old female patient with clear cell carcinoma of the tongue base. The patient initially presented with a 3-month history of palpable tongue mass, leading to her visit to the otolaryngology outpatient clinic. The patient underwent a complete resection of the tumor under general anesthesia. Postoperative follow-up imaging studies showed no evidence of recurrence. This case report highlights the diagnostic and management challenges associated with clear cell carcinoma of tongue base and demonstrates that a high index of suspicion is required to diagnose clear cell caricnoma, given its rarity and overlapping features with other clear cell neoplasms.

• Restorative Dentistry and Endodontics
• /
• 제13권1호
• /
• pp.53-67
• /
• 1988

An investigation was carried out to compare the pulp responses against a few type of composite and streptococcus mutans contamination under the zinc oxide eugenol cement, and also confirmed pulpal responses of various composites with or without base. Seventy eight teeth from 6 dogs were employed and divided into 6 groups. Class V cavities were prepared on each tooth routinely with low speed dental engine. Paper disc about 0.3mm thick was immersed in the BHI broth in which streptococcus mutans had been enriched and the disc was inserted on the cavity floor prior to filling. Scotch bond puls Silux as Bis-GMA system composite resin and Helimolar as urethane system composite resin were adopted. Control group: Zinc-Oxide Eugenol cement filling Experimental groups: Group 1. Scotch bond + Silux filling with Dycal base Group 2. Heliomolar filling with Dycal base Group 3. Scotch bond + Silux filling without base Group 4. Heliomolar filling without base Group 5. Streptococcus mutans application. All cavities were sealed with thick ZOE cement to avoid marginal leakage. Postoperative intervals of 1, 2, 3, 4, 5 and 6 weeks teeth were carefully extracted, processed and stained with Hematoxylin and Eosin. The results were as follows: 1. S. mutans application group and composites without any base showed more severe pupal response than control group and dyca based groups. 2. The experimental group of S. mutans application showed severe response in the early stage compared to the two groups of composite resin without base, but no significant difference was found following periods. 3. The difference of pulpal response is not significant between Bis-GMA system and urethane system. 4. Streptococcus mutans application group and composites without base groups showed the evidence of histologic recovery at the six week cases and the large amount of reparative dentin was the prominent feature. 5. Pulp responses against every material were inclined to normal according to the time elapsed.

• 보건교육건강증진학회지
• /
• 제30권5호
• /
• pp.61-77
• /
• 2013

Objectives: The purpose of this study was to evaluate program methods for effective smoking cessation and prevention through systematic review of studies published during recent 3 years in Korea. Methods: Electronic searches were conducted in DBPIA, RISS, KISS and other databases looking for studies published from 2010 to 2012 that dealt with the effects of intervention on smoking prevention and cessation. A total of 25 studies were included in the final analysis. Three independent reviewers critically evaluated the study quality and evidence of effectiveness based on The Community Guide methodology. Results: Multi-component intervention showed strong evidence of effectiveness for adolescents and sufficient evidence for patient smokers. Cognitive-behavioral intervention for adolescents and child-parent interaction program for adults demonstrated sufficient evidence of effectiveness on the smoking cessation and its determinants. There was insufficient evidence showing effectiveness of smoking prevention programs. Conclusion: Improving the quality and quantity of the intervention studies on smoking could help to expand evidence base for effective intervention methods and strategies on smoking.

• Journal of Microbiology and Biotechnology
• /
• 제29권8호
• /
• pp.1221-1229
• /
• 2019

Mycobacterium tuberculosis, a causative pathogen of tuberculosis (TB), still threatens human health worldwide. To find a novel drug to eradicate this pathogen, we tested taurine-5-bromosalicylaldehyde Schiff base (TBSSB) as an innovative anti-mycobacterial drug using Mycobacterium smegmatis as a surrogate model for M. tuberculosis. We investigated the antimicrobial activity of TBSSB against M. smegmatis by plotting growth curves, examined the effect of TBSSB on biofilm formation, observed morphological changes by scanning electron microscopy and transmission electron microscopy, and detected differentially expressed proteins using two-dimensional gel electrophoresis coupled with mass spectrometry. TBSSB inhibited mycobacterial growth and biofilm formation, altered cell ultrastructure and intracellular content, and inhibited cell division. Furthermore, M. smegmatis adapted itself to TBSSB inhibition by regulating the metabolic pathways and enzymatic activities of the identified proteins. NDMA-dependent methanol dehydrogenase, NAD(P)H nitroreductase, and amidohydrolase AmiB1 appear to be pivotal factors to regulate the M. smegmatis survival under TBSSB. Our dataset reinforced the idea that Schiff base-taurine compounds have the potential to be developed as novel anti-mycobacterial drugs.

• 한국지능정보시스템학회:학술대회논문집
• /
• 한국지능정보시스템학회 2001년도 The Pacific Aisan Confrence On Intelligent Systems 2001
• /
• pp.343-351
• /
• 2001

World practice is evidence of that computer systems of an intellectual support of medical activities bound up with examination of patients, their diagnosis, therapy and so on are the most effective means for attainment of a high level of physician\`s qualification. Such systems must contain large knowledge bases consistent with the modern level of science and practice. To from large knowledge bases for such systems it is necessary to have a medical ontology model reflecting contemporary notions of medicine. This paper presents a description of an observation ontology, knowledge base for the physician of general tipe, architecture, functions and implementation of problem independent shell of the system for intellectual supporting patient examination and mathematical model of the dialog. The system can be used by the following specialist: therapeutist, surgeon, gynecologist, urologist, otolaryngologist, ophthalmologist, endocrinologist, neuropathologist and immunologist. The system supports a high level of examination of patients, delivers doctors from routine work upon filling in case records and also automatically forms a computer archives of case records. The archives can be used for any statistical data processing, for producing accounts and also for debugging of knowledge bases of expert systems. Besides that, the system can be used for rise of medical education level of students, doctors in internship, staff physicians and postgraduate students.

• 의료법학
• /
• 제9권2호
• /
• pp.181-207
• /
• 2008

With recent emphasis on evidence based medicine, clinical practice guidelines are seen as a potential mechanism by which unify various managerial and professional approaches to improving the quality of care. The development process of guidelines has been the subject of much research. and it is need translating the medical evidence of research into a clinical practice guidelines. the gathered evidence needs to be interpreted into a clinical, public health, policy, or payment context. The term 'clinical practice guidelines' can evoke a diverse range of responses from healthcare personnel. Clinical practice guidelines are increasingly used in patient management but some clinicians are not familiar with their origin or appropriate applications. Understanding the limitations as well as benefits of CPG could enable clinicians to have clearer view of the place of guidelines in every practice. In the context of increasing complaints and litigation in healthcare, the legal implications of clinical practice guidelines are of increasing importance. Clinical practice guidelines could, in theory, influence the manner in which the courts establish negligence by suggesting the doctor breached the duty of care by failing to provide the required standard of medical care. In several studies, the CPGs were relevent to and played a pivotal role in the proof of negligence. Much depends on the quality of guidelines and the tools developed and the authoritativeness of a guideline. Recently, there are several opinions the court also should review the validity and reliability of expert testimony including medical evidence. and widespread use of guidelines in malpractice lawsuit could lead the physicians to greater compliance with guidelines in the long term. In conclusion, Health care reformers, physicians as well as guidelines developers should understand that guidelines have both medical and legal aspects as a double-edges sword. so clinicians, legal representatives and decision-makers should not defer unduly to guidelines.

• Journal of Preventive Medicine and Public Health
• /
• 제46권4호
• /
• pp.201-209
• /
• 2013

Objectives: The goal of this study was to perform an economic analysis of a primary stenting with drug-eluting stents (DES) compared with bare-metal stents (BMS) in patients with acute myocardial infarction (AMI) admitted through an emergency room (ER) visit in Korea using population-based data. Methods: We employed a cost-minimization method using a decision analytic model with a two-year time period. Model probabilities and costs were obtained from a published systematic review and population-based data from which a retrospective database analysis of the national reimbursement database of Health Insurance Review and Assessment covering 2006 through 2010 was performed. Uncertainty was evaluated using one-way sensitivity analyses and probabilistic sensitivity analyses. Results: Among 513 979 cases with AMI during 2007 and 2008, 24 742 cases underwent stenting procedures and 20 320 patients admitted through an ER visit with primary stenting were identified in the base model. The transition probabilities of DES-to-DES, DES-to-BMS, DES-to-coronary artery bypass graft, and DES-to-balloon were 59.7%, 0.6%, 4.3%, and 35.3%, respectively, among these patients. The average two-year costs of DES and BMS in 2011 Korean won were 11 065 528 won/person and 9 647 647 won/person, respectively. DES resulted in higher costs than BMS by 1 417 882 won/person. The model was highly sensitive to the probability and costs of having no revascularization. Conclusions: Primary stenting with BMS for AMI with an ER visit was shown to be a cost-saving procedure compared with DES in Korea. Caution is needed when applying this finding to patients with a higher level of severity in health status.