• Title/Summary/Keyword: Evidence base

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A COMPARISON OF THE SETTING CHARACTERISTICS BETWEEN RESIN-MODIFIED GLASS-IONOMERS AND COMPOMERS (Resin-Modified Glass-Ionomer와 Compomer의 경화 반응 특성의 비교에 관한 연구)

  • Ko, Yong-Joon;Yoo, Hyeon-Mee;Um, Chung-Moon
    • Restorative Dentistry and Endodontics
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    • v.25 no.1
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    • pp.123-132
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    • 2000
  • To overcome problems of conventional glass ionomers, resin components have been added to glass ionomers. On a continuum between glass ionomers and composites are a variety of blends, employing different proportions of acid-base and free radical reactions to bring about cure. Popular groups defined between the ends are resin-modified glass-ionomers(RMGIs), polyacid-modified composite resins(Compomers) and ionomer modified resins. These groups show different clinical properties, and in selecting these materials for a restoration, one should sufficiently understand these different setting properties. In this study, some difference in the setting characteristics of different groups of hybrid ionomers were examined. Two RMGIs (Fuji2 LC,GC / Vitremer, 3M), three Compomers (Dyract AP, Dentsply / F2000, 3M / Elan, Kerr) were involved in this study. The identification of the setting characteristics of different groups was achieved by a two-stage study. First, thermal analysis was performed by a differential scanning calorimeter, and then the hardness of each group at different depth and time were measured by a micro-hardness tester. Thermal analysis was performed to identify the inorganic filler content and to record the heat change during setting process. The setting process was progressed for each material by chemical set mode and light-cured mode. In the hardness test, samples of materials were prepared with a 6mm-diameter metal ring, and the hardness was measured at the top, and 1mm, 2.5mm, 4mm below at just after a 40 second-cure, and after 10 minutes, 24 hours, and 7 days. Statistical analysis was performed by Mann-Whitney rank sum test to assess significant differences between set modes and types of materials, and by ANOVA and T-test to evaluate the statistical meanings of data at different times and depths of each materials. Followings are findings and conclusions derived from this study. Thermal analysis; 1. Compomers show no evidence of chemical setting while RMGIs exhibit heat output during the process of chemical setting. 2. Heat of cure of RMGIs exceed Compomers. 3. The net heat output of RMGIs through light-cured mode is higher than through chemically set mode. Hardness test; 1. Initial hardness of RMGIs immediately after light cure is relatively low, but the hardness increases as time goes by. On the contrary, Comomers do not show evident increase of the hardness following time. 2. Compomers show a marked decrease of setting degree as the depth of the material increases. In RMGIs, the setting degree at different depths does not significantly differ.

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Bilateral Fasciocutaneous Sliding V-Y Advancement Flap for Meningomyelocele Defect (척수수막류 결손 재건을 위한 양측 V-Y 전진피판술)

  • Shin, Jong-Weon;Oh, Deuk-Young;Lee, Jung-Ho;Moon, Suk-Ho;Seo, Je-Won;Rhie, Jong-Won;Ahn, Sang-Tae
    • Archives of Plastic Surgery
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    • v.37 no.6
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    • pp.823-826
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    • 2010
  • Purpose: Meningomyelocele is the most common type of neural tube defect disease. Early surgical treatment is recommended to prevent central nervous system infection. Several reconstruction methods were reported previously regarding surgical wound defect closure following meningomyelocele excision. In this article, we report two successful patients using the bilateral fasciocutaneous sliding V-Y advancement flap as a covering for meningomyelocele defects. Methods: Two patients with meningomyelocele were evaluated. Both patients were male and received their operations on the 1st and 4th day of life. After neurosurgeons completed their part of the operation, the V-Y advancement flap was used to close the defect. Initially a bilateral V-shape incision design was made on the skin such that the base of the V-flap measures identical to the size of the wound defect. An incision was made down to the fascia in order to allow the V-flaps to slide into the defect. Subfascial dissection was performed up to 1/3 to 1/4 the length of the V-flap from the wound while minimizing injury to the perforating vessels. Results: Both patients were treated successfully and there was no evidence of complication in 2 months follow up. Conclusion: Several reconstruction methods such as local flaps, skin graft and myocutaneous flaps were reported regarding meningomyelocele surgical wound defect closure. Bilateral fasciocutaneous sliding V-Y advancement flap is an easy method without involving the underlying muscles or a secondary skin graft in a short operation time. Therefore we recommend this treatment option for reconstruction of the wound defect following meningomyelocele excision.

Chemical weathering in King George Island, Antarctica

  • Jeong, Gi-Young
    • Proceedings of the Mineralogical Society of Korea Conference
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    • 2003.05a
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    • pp.66-66
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    • 2003
  • King George island, Antarctica, is mostly covered by ice sheet and glaciers, but the land area is focally exposed for several thousand years after deglaciation. For a mineralogical study of chemical weathering in the polar environment, glacial debris was sampled at the well-developed patterned ground which was formed by long periglaclal process. As fresh equivalents, recently exposed tills were sampled at the base of ice cliff of outlet glaciers and at the melting margin of ice cap together with fresh bedrock samples. Fresh tills are mostly composed of quartz, plagioclase, chlorite, and illite, but those derived from hydrothermal alteration zone contain smectite and illite-smectite. In bedrocks, chlorite was the major clay minerals in most samples with minor illite near hydrothermal alteration zone and interstratified chlorite-smectite in some samples. Smectite closely associated with eolian volcanic glass was assigned to alteration in their source region. Blocks with rough surface due to chemical disintegration showed weathering rinds of several millimeter thick. Comparision between inner fresh and outer altered zones did not show notable change in clay mineralogy except dissolution of calcite and some plagioclase. Most significant weathering was observed in the biotite flakes, eolian volcanic glass, sulfides, and carbonates in the debris. Biotite flakes derived from granodiorite were altered to hydrobiotite and vermiculite of yellow brown color. Minor epitactic kaolinite and gibbsite were formed in the cleaved flakes of weathered biotite. Pyrite was replaced by iron oxides. Calcite was congruently dissolved. Volcanic glass of basaltic andesite composition showed alteration rim of several micrometer thick or completely dissolved leaving mesh of plagioclase laths. In the alteration rim, Si, Na, Mg, and Ca were depleted, whereas Al, Ti, and Fe were relatively enriched. Mineralization of lichen and moss debris is of much interest. They are rich of A3 and Si roughly in the ratio of 2:1 to 3:1 typical of allophane. In some case, Fe and Ti are enriched in addition to Al and Si. Transmission electron microscopy of the samples rich of volcanic glass showed abundant amorphous aluminosilicates, which are interpreted as allophane. Chemical weathering in the King George Island is dominated by the leaching of primary phyllosilicates, carbonates, eolian volcanic glass, and minor sulfides. Authigenesls of clay minerals is less active. Absence of a positive evidence of significant authigenic smectite formation suggests that its contribution to the clay mineralogy of marine sediments are doubtful even near the maritime Antarctica undergoing a more rapid and intenser chemical weathering under more humid and milder climate.

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A Study the effect of Cooking Activity as a Language Intervention on the Language Development of Language Delayed Infants. (요리활동을 통한 언어중재가 언어발달지연을 보이는 유아의 언어능력 향상에 대한 연구)

  • Seo, Eui-Jung;Kim, Yun-Hee
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.10
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    • pp.109-118
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    • 2016
  • Language intervention through cooking activity programs is designed to provide an efficient teaching method and improved educational environment in the field of teaching. This program addresses the effects of this program on the language development of three three-year-old infants (M;2, F;1) in the Center in Seoul. A cooking topic suitable for the age of this group was selected. The language Intervention was conducted for 50 minutes per week for a total of 25 times, and made use of vocabulary, verbs and nouns related to cooking which were evenly distributed. In this study, the Peabody Picture Vocabulary Test-Revised (PPVT-R), receptive language age (RLA) and expressive language age (ELA), and Preschool Receptive-Expressive Language Scale (PRES) were used to analyze the collected data. After the study, the cooking activity was accomplished with normal development outcomes appearing in the ability of vocabulary, receptive language, expressive language, and integrated language. There is now a solid evidence base supporting the efficacy of cooking activity in producing positive outcomes in the language development of language delayed infants. Consequently, cooking can induce their active participation and interest and extend their language abilities through various experiences.

Analysis of Congenital Postaxial Polydactyly of the Foot Using Magnetic Resonance Imagings (족부에 발생한 선천성 축후성 다지증에 대한 자기공명영상 검사 결과 분석)

  • Woo, Sang Hyun;Baek, Hyeon Seok;Kim, Young Kyu;Choi, Jun Young
    • Journal of the Korean Orthopaedic Association
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    • v.53 no.6
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    • pp.530-539
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    • 2018
  • Purpose: We aimed to evaluate the magnetic resonance imaging (MRI) findings of congenital postaxial polydactyly of the foot. Materials and Methods: Three-hundred and forty-seven feet of 288 patients who underwent congenital postaxial polydactyly or polysyndactyly correction were divided into five subtypes according to the radiographic shapes of deformity origins (widened metatarsal head, bifid, fused duplicated, incompletely duplicated, or completely duplicated). MRIs were assessed to determine whether they unrevealed areas were fused or separated. MRI was also used to assess cases with radiographic phalangeal aplasia. Results: Huge variations were noted in MRIs. Fusion or separation at the base or head between original and extra digits were observed, and MRI effectively depicted phalangeal aplastic areas. Conclusion: MRI evaluations of congenital postaxial polydactyly of the foot are useful for determining the anatomical statuses which were not visualized by plain radiography (level of evidence: 3).

Epigenetic Mechanisms of Depression: Role of Histone Modification and DNA Methylation in BDNF Gene (우울증의 후성유전기전: BDNF 유전자의 히스톤 변형 및 DNA 메틸화의 역할)

  • Park, Sung Woo
    • Journal of Life Science
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    • v.28 no.12
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    • pp.1536-1544
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    • 2018
  • Depression is a common, serious, and recurring mental disorder. The pathogenesis of depression involves many factors such as environmental factor, genetic factor and alteration of structure and function in neurobiological systems. Increasing evidence supports that epigenetic alteration may be associated with depression. The epigenetics is explained as the mechanisms by which environmental factor causes changes in chromatin structure and alters gene expression without changing DNA base sequence. DNA methylation and histone modification involving histone acetylation and methylation are the main epigenetic mechanisms. Animal studies have shown that stressful environment such as early life stress can leave persistent epigenetic marks in the genome, which alter gene expression and influence neural and behavioral function through adulthood. A potentially important gene in depression is brain-derived neurotrophic factor (BDNF). BDNF plays a central role in depression and antidepressant action. In studies of the rodent, exposure to stress at prenatal, postnatal, and adult stages alters BDNF expression through histone modification and DNA methylation of the BDNF gene which results in anxiety and depressive-like behavior. This review discusses recent advances in the study of the epigenetic mechanisms that contribute to depression, particularly histone modification and DNA methylation of the BDNF gene, that may help in the development of new targets for depression treatment.

A Study on Description about Archival Materials in Film Archives (영화 기록의 기술에 관한 연구)

  • Kim, Jin Sung
    • The Korean Journal of Archival Studies
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    • no.30
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    • pp.89-123
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    • 2011
  • Archival materials in film archives is a memories and archival documents of human which is generated from cultural activities of human being, and provided long-term relevant information. However, it is different general public audio-visual records because main purpose of representing culture to create the contents of private sector rather than evidence of the factual information of public service activities. Therefore, should determine the description principle and rule in order to reflect specific physical, intellectual characteristics. So as to control the description, that is need in the textual standards to base the specific purposes and rules thus analyzed the international description standards as Dublin Core, ISAD(G), FIAF Cataloguing Rules For Film Archives. As a result, more effectively to describe archival materials in film archives required significant modifications in the organizations of the areas and the elements. This study argues that first, to divide existence the concept and the reality (work/item) of archival materials in film archives. Second, to need understanding and indicating their content, context, structure. Third, to establish of the areas and the elements including a characteristic of it. The final suggestion organizes separately to 6th and 8th areas, 22th and 25th elements in two parts. This conclusion does not prepare to refer the status and/or policy of a particular film arhicve, can be set accordingly to a specific elements or sub-elements by the film archives.

Oral-Motor Facilitation Technique (OMFT): Part I-Theoretical Base and Basic Concept (구강운동촉진기술: 1 부-이론적 배경과 기초 요소)

  • Min, Kyoung Chul;Seo, Sang Min;Woo, Hee-soon
    • Therapeutic Science for Rehabilitation
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    • v.10 no.1
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    • pp.37-52
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    • 2021
  • Introduction : Oral motor function is basic function of sensory exploration, feeding, and communication, that develops from the fetal stage to childhood. Problems with oral motor function result in difficulty within handling food in the oral cavity, decreased swallowing and feeding skills, difficulty with communication, and problems with oral hygiene. To treat these symptoms, oral motor therapy is provided for normalizing sensory adaptation in the oral cavity, and increasing postural control, oral movement and oral motor function. Discussion : The oral motor facilitation technique (OMFT) was developed for increasing general and integrated oral motor function based on the following: 1) understanding orofacial muscular physiology; 2) a comprehensive approach to sensory·adaptation·behavior·cognition; 3) sensorimotor stimulation by a manual approach; 4) motor control and motor learning theory. The OMFT is a new evidence-based treatment protocol, for children and adults with neuromuscular and oral motor problems. Conclusion : The goal of this article is to provide a theoretical background for OMFT development and the basic concept for the clinical application of OMFT. We hope that this article will help oral motor therapy experts to provide effective therapy in a more professional way.

The Current Research Status of Complementary and Integrative Medicine in Practice-Based Research Networks: A Systematic Review (개원의중심연구망에서 수행된 보완통합의학 관련 연구 현황: 체계적 문헌고찰)

  • Won, Jiyoon;Han, Gajin;Kim, Yejin;Park, Jae Rang;Noh, Eunyoung;Ji, Yu-jin;Adams, Jon;Lee, Hyangsook
    • Korean Journal of Acupuncture
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    • v.37 no.4
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    • pp.209-230
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    • 2020
  • Objectives : Practice-Based Research Networks (PBRNs), collaborations of practitioners and academic researchers, have provided platforms for conducting research to address clinical questions generated from daily routine care. This review aimed to critically analyse articles from PBRNs that are related to complementary and integrative medicine (CIM) and to suggest future directions for a PBRN which is appropriate for Korean Medicine (KM). Methods : PubMed, PBRN registries in Agency for Healthcare Research and Quality and relevant PBRN websites were searched up to November 2019 for research articles from PBRNs that focused on CIM regardless of study design. Methodological quality of the included studies was assessed. The included studies were read in full, classified and summarised according to their topics. Results : A total of 51 articles published from 1998 through 2020 were included in this review. They were categorised into three principal themes based on research questions and findings: health services research (embracing researches examining characteristics of patients and CIM practitioners/practices, and communication between patients and practitioners); effectiveness and safety of CIM practices/interventions; and feasibility studies of instruments and interventions in PBRN settings. The study designs varied including surveys (n=30), prospective observational studies (n=6), 2ndary analyses of existing studies (n=7), protocols (n=7), retrospective chart review (n=1) and qualitative study (n=1). Quality of the included studies greatly varied. Conclusions : PBRNs can serve as a feasible platform for conducting practice-relevant research on KM and CIM. Considering growing demands on evidence-base for routine practice of KM amid various stakeholders, a PBRN in KM community and further researches nested within PBRN designs are warranted.

Second Asian Consensus on Irritable Bowel Syndrome

  • Gwee, Kok Ann;Gonlachanvit, Sutep;Ghoshal, Uday C;Chua, Andrew SB;Miwa, Hiroto;Wu, Justin;Bak, Young-Tae;Lee, Oh Young;Lu, Ching-Liang;Park, Hyojin;Chen, Minhu;Syam, Ari F;Abraham, Philip;Sollano, Jose;Chang, Chi-Sen;Suzuki, Hidekazu;Fang, Xiucai;Fukudo, Shin;Choi, Myung-Gyu;Hou, Xiaohua;Hongo, Michio
    • Journal of Neurogastroenterology and Motility
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    • v.25 no.3
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    • pp.343-362
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    • 2019
  • Background/Aims There has been major progress in our understanding of the irritable bowel syndrome (IBS), and novel treatment classes have emerged. The Rome IV guidelines were published in 2016 and together with the growing body of Asian data on IBS, we felt it is timely to update the Asian IBS Consensus. Methods Key opinion leaders from Asian countries were organized into 4 teams to review 4 themes: symptoms and epidemiology, pathophysiology, diagnosis and investigations, and lifestyle modifications and treatments. The consensus development process was carried out by using a modified Delphi method. Results Thirty-seven statements were developed. Asian data substantiate the current global viewpoint that IBS is a disorder of gut-brain interaction. Socio-cultural and environmental factors in Asia appear to influence the greater overlap between IBS and upper gastrointestinal symptoms. New classes of treatments comprising low fermentable oligo-, di-, monosacharides, and polyols diet, probiotics, non-absorbable antibiotics, and secretagogues have good evidence base for their efficacy. Conclusions Our consensus is that all patients with functional gastrointestinal disorders should be evaluated comprehensively with a view to holistic management. Physicians should be encouraged to take a positive attitude to the treatment outcomes for IBS patients.