• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.5675-5680
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• 2013

Background: Preexisting type 2 diabetes mellitus (T2DM) affects the prognosis and mortality of patients with some cancers. Insulin like growth factor (IGF) and insulin receptor (IR) signaling axes play important roles in both cancer and diabetes development. We aimed to explore the expression characteristics of proteins in IGF/IR axis in non-small cell lung cancer (NSCLC) cases with preexisting T2DM. Methods: Fifty-five NSCLC patients with preexisting T2DM were retrospectively included and matched by 55 NSCLC without diabetes at a 1:1 ratio. The expression of proteins in IGF/IR axis was detected by immunohistochemical staining. Clinicopathological data were collected to analyze their relationship with the protein expression. Results: Both IGF 1 receptor (IGF-1R) and insulin receptor substrate 2 (IRS-2) showed higher expression in the NSCLC with T2DM group, compared with those without T2DM. The high expression of IGF-1R and IRS-2 were found to be negatively associated with lymph node metastases and T staging in the T2DM group, respectively, and IRS-2 expression was also found more in the subgroup whose T2DM duration was more than 4 years. No difference was detected in the expression of IRS-1, IGF-1, IGF-2, IGFBP3, IR and mTOR between groups with or without T2DM. Conclusion: Our study found higher expression of IGF-1R and IRS-2 proteins in NSCLC patients with preexisting T2DM, and that there was an association with early stage NSCLC, which suggested that IGF signaling may play an important early event in development of NSCLC associated with diabetes.

• Nuclear industry
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• v.6 no.12 s.46
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• pp.107-110
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• 1986

프랑스전력청(EdF)은 원자력발전소에서 적용되고 있는 비상시 운전절차를 변경중이다. 현행의 사상지향식 방법(Event-Orientated Approach)과는 대조적으로 새로운 방법은 플랜트의 기본적인 물리적인 특성(여기서는 '플랜트상태'라고 지칭한다)의 변동을 연속적으로 모니터하고 플랜트상태만을 기준하여 교정조치를 취하는 것을 기본으로 한다.

• Journal of Microbiology
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• v.34 no.1
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• pp.54-60
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• 1996

Taking advantage of the heat inducible HSP82 gene in yeast, chromatin structure after transcription cessation was investigated. Alteration of chromating conformation within the HSP82 gene transcription unit into an active state has been shown to correlate with its transcriptional induction. It was thus of interest to examine whether the active chromatin state within the HSP82 mRNA analysis, the gene ceased its transcription within a few hours of cultivation at a normal condition after heat induction. In this condition, an active chromatin conformation in the HSP82 gene body was changed into an inactie state which was revealed by DNase I resistance and by typical nucleosomal cutting periodicity in the corresponding chromatin. These results thus ruled out the possibility of a long-term maintenance of the DNase I sensitive chromatin after transcription cessation. DNA replication may be a critical event for the chromatin reprogramming.

• Journal of the Society of Naval Architects of Korea
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• v.58 no.2
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• pp.90-96
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• 2021

In this study, the method of determining the state of grid points in the adaptable surface particle method based on grid system developed as a free-surface tracing method was improved. The adaptable surface particle method is a method of determining the state of the grid point according to the shape of the free-surface and obtaining the intersection of the given free-surface and grid line where the state of the grid point changes. It is difficult to determine the state of grid points in the event of rapid flow, such as collision or separation of free-surfaces, and this study suggests a method for determining the state of current grid points using the state of surrounding grid points where the state of grid point are known. A grid layer value was assigned sequentially to a grid away from the free-surface, centering on the boundary cell where the free-surface exists, to identify the connection information that the grid was separated from the free-surface, and to determine the state of the grid point sequentially from a grid away from the free-surface to a grid close to the free-surface. To verify the improved method, a numerical analysis was made on the problem of dam break in which a sudden collision of free-surface occurred and the results were compared, and the results were relatively reasonable.

• Journal of Biomedical Engineering Research
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• v.41 no.1
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• pp.22-27
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• 2020

Auditory stimuli are commonly used in various electroencephalogram experiments, also in EEG-based brain-computer interface systems. However, using conventional earphones that blocks the ear canal attenuates or even blocks external environmental sound which might cause loss of crucial information from surroundings. Instead, bone-conductive earphones are able to deliver sound through vibration without blocking the ear canal. To investigate the feasibility of the bone-conductive earphones for auditory-stimuli based experiments, we compared N100 event-related potential features as well the event-related spectral perturbation and inter-trial coherence of auditory steady-state response between conventional and bone-conductive earphones. The results showed no significant differences between bone conduction and conventional earphones regardless of distinct sound pressures. This result shows that bone conductive earphones can be used for auditory experiments when the environmental sound is crucial to the user.

• Journal of Environmental Science International
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• v.21 no.10
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• pp.1171-1179
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• 2012

Headwaters initiate material export to downstream environments. A nested headwater study examined the flux of dissolved constituents and water from a perennial stream and four ephemeral/intermittent streams in the Upper Gulf Coastal Plain of Mississippi. Water was collected during storm and baseflow conditions. Multiple linear regression was used to model constituent concentration and calculate flux. Event was the major source of water discharged from the ephemeral and intermittent streams however, baseflow was the major source for water discharged by the perennial stream during events. The perennial stream had an area weighted average yields of 10.1, 0.01, 1.03, 0.65 kg/ha/yr of DON (dissolved organic nitrogen), $NO_3^-$-N, $NH_4^+$-N and $PO_4^{-3}$, respectively while large variabilities existed between the ephemeral and intermittent streams. These findings highlight the importance of headwaters in protecting the low order drainage basins as a key to water quality within perennial streams.

• Journal of Advanced Marine Engineering and Technology
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• v.19 no.1
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• pp.28-35
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• 1995

The fluid flow for a energy transfer is essential for the design and operation of power plants, petrochemical plants and ships including a process. When the operating conditions of a plant are changed or any transitional event occured, the flow controls of a fluid must be performed to follow the new operating state or mitigate the results of a event. Generally these flow controls to accommodate the new operating state of a plant are made by the use of various valves. The refore the design of valves and the related techniques are very important to the system and component designs. However the system and component design are not familiar with the practical theory of the valve since the derivative procedures of the flow equations in a valve are difficult and it is not easy to found the theoretical foundamentals and informations about the design of a valve from the present references. In this study the flow equations applicable to a valve for liquid are theoretically derived in detail. And the definition of valve reynolds number and its boundary values between the tubulent and laminar flow is described compared with the values of a circular pipe flow.

• Journal of Information Science Theory and Practice
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• v.8 no.1
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• pp.45-55
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• 2020

The purpose of this work was to study library website users' actions by tracking their behavior, determining popular content, and identifying browsing patterns and subsequent improvement of access to popular content. The study of behavior models and the use of web analytics has led to the emergence of solutions that improve the usability and functionality of the State Public Scientific-Technological Library of the Siberian Branch of the Russian Academy of Sciences (SPSTL SB RAS) website. These are: identifying user tasks as they are developed, conducting user testing to better understand the event. tracking data and collecting additional data to verify the effectiveness of the changes made. Examining data on the duration of the session and the number of visits will help determine the goals of user visits and develop new recommendations. Usability analysis and testing will make it possible to compare the data obtained using web analytics and the perception of the library site by the users themselves. Recommendations are offered to libraries on the use of data on the real behavior of the target audience of the library website to improve access to library resources and services, increase their relevance and improve information services.

• Nuclear Engineering and Technology
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• v.23 no.3
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• pp.285-298
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• 1991

An example application of the fuzzy set theory is first made to a simple portion of a given accident progression event tree with typical qualitative fuzzy input data, and thereby computational algorithms suitable for application of the fuzzy set theory to the accident progression event tree analysis are identified and illustrated with example applications. Then the procedure used in the simple example is extended to extremely complex accident progression event trees with a number of phenomenological uncertainty issues, i.e., a typical plant damage state‘SEC’of the Zion Nuclear Power Plant risk assessment. The results show that the fuzzy averages of the fuzzy outcomes are very close to the mean values obtained by current methods. The main purpose of this paper is to provide a formal procedure for application of the fuzzy set theory to accident progression event trees with imprecise and qualitative branch probabilities and/or with a number of phenomenological uncertainty issues.

• Journal of the Korean Operations Research and Management Science Society
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• v.20 no.2
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• pp.159-178
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• 1995

Supervisory control is an approach based on formal language. it is used to model and control discrete event systems in which each discrete event process is represented as an automation. A supervisor is a generator that switches control patterns in such a way that a given discrete evenet process behaves in obedience to various constraints. A flexible manufacturing cell (FMC) is one of discrete evenet systems. Functions necessary for the operation of an FMC are characterized by operational components and informational compoments. The operational components can be modeled using the finite state machines and the informational components can be modeled using the abstract formalism which describes supporting operations of the cell controller. In this paper, we addressed function required for FMC control specification, software engineering aspects on FMC control based on supervisory control, a concept of event queue for resolving synchronization problem, and complexity reduction. Based on the mathematical model of an FMC. we synthesized the controller by integrating a supervisor for FMC with control specification that specifies event-driven operation of the cell controller. The proposed control scheme is stable mathematically so that the system always behaves on a controlled way even under the existence of uncontrollable events. Furthermore, using an event queue concept, we can solve a synchronization problem caused by the violation of instantaneity assumption of supervisory control theory in real life situation. And also, we can propotype a control software rapidly due to the modularity of the proposed control scheme.