• Bulletin of the Korean Chemical Society
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• 제31권11호
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• pp.3291-3296
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• 2010

A gelastatins (1), natural MMP inhibitors, and their hydroxamate analogues (2) in TACE enzyme evaluated for discovery of potent TACE inhibitors. We have employed molecular dynamics simulations to compute the relative free energy of hydration and binding to TACE for gelastatin (1) and its hydroxamate analogue (2). The relative free energy difference is directly described in this article using the free energy perturbation approach as a means to accurately predict the TACE inhibitor of gelastatin analogues. The results show that the good agreement between the experimental and theoretical relative free energies of binding, gelastatin hydroxamate (2) binds stronger to TACE by -3.37 kcal/mol. The desolvation energy costs significantly reduced binding affinity, hydroxamate group associated with high desolvation energy formed strong favorable interactions with TACE with more than compensated for the solvation costs and therefore led to an improvement in relative binding affinity.

• The Journal of Korean Physical Therapy
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• 제22권3호
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• pp.45-48
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• 2010

Patients with the pusher syndrome show severe misperception of their own upright body orientation although visual vestibular processing is almost intact. They recognize their body as oriented upright when it is actually tilted nearly 20 degrees to the affected side. These patients resist any attempts to passively correct their tilted body posture towards an earth vertical upright orientation. They use the non-affected side arm and/or leg to actively push towards the affected side. Pusher syndrome patients have different prognoses and symptoms than general stroke patients without pusher syndrome. Pusher syndrome patients have a poor prognosis, so they need a long duration of treatment. Therefore, accurate diagnosis and proper treatment are important. In this study, we reviewed the symptoms, causes, evaluation, and treatment for pusher syndrome.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2002년도 합동 추계학술대회 논문집 정보 및 제어부문
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• pp.434-438
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• 2002

Profibus is a open industrial communication system for a wide range of applications in manufacturing and process automation. In this study presented in this article, implementation of Profibus master board is implemented. Using an experimental model, this study investigates the relationship between network parameter in the Profibus data link layer and the network performance. Base on the results, this study suggests some factors that should be considered when a Profibus-based automation system is designed and implemented.

• 한국과학교육학회지
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• 제24권4호
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• pp.675-686
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• 2004

The enhancement of the quality of the teaching practice is a major factor in securing better schooling opportunities for students. In this article, initial teacher preparation of secondary school Earth science teachers, in-service science teacher education, and improving teacher policy are discussed. Data from in-depth interviews with exemplary science teachers were used to explore how to improve the quality of science teacher education in Korea. In terms of preservice teacher education, most exemplary teachers contended that teacher education programs should provide preservice teachers with practical knowledge by translating theory into practice. Their suggestions for how to improve in-service education are also discussed. Regarding directions of improving teacher policy in Korea, the teachers proposed an alternative teacher-promotion structure that incorporates the master-teacher position. Implications for introducing action research courses into teacher (re)education programs are also discussed.

• 한국멀티미디어학회논문지
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• 제23권8호
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• pp.1030-1039
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• 2020

The biggest feature of the online environment is anonymity. So it is difficult to identify the sender accurately in Email. So we use PGP to enhance the security of email. PGP is an e-mail encryption program that has become the standard for email security worldwide. But PGP has a weak point in security. PGP can identify users, but it is difficult to verify reliability. In PGP, the more reliable other users guarantee that user are, the more reliable they are. In the previous study, the PGP structure was implemented by utilizing the block chain to lay the foundation, and in this paper, the structure of the previous article is applied to the e-mail environment to measure up the sender's reliability, and a system is proposed that allows users to distinguish the reliability of the message.

• Journal of Multimedia Information System
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• 제1권1호
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• pp.45-53
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• 2014

This article describes a two wheelers detection system riding on people based on modified histogram of oriented gradients (HOG) for vision based intelligent vehicles. These features used correlation coefficient parameter are able to classify variable and complicated shapes of a two wheelers according to different viewpoints as well as human appearance. Also our system maintains the simplicity of evaluation of traditional formulation while being more discriminative. In this paper, we propose an evolutionary method trained part-based models to classify multiple view-based detection: frontal, rear and side view (within $60^{\circ}C$). Our experimental results show that a two wheelers riding on people detection system based on proposed approach leads to higher detection accuracy rate than traditional features.

• 대한기관식도과학회지
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• 제4권1호
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• pp.142-147
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• 1998

Retained wooden foreign bodies following penetrating trauma are a difficult diagnostic problem. However, penetrating wooden foreign bodies of head and neck have the potential for misinterpretation or failure to detect such foreign bodies on CT. Given the likelihood that such a miss will result in an abscess or neurovascular injury, we present the method with higher window settings, they had a higher attenuation with a unique striated internal architecture and different Hounsfield numbers readily differentiate air and non-air hypodense material such as fat, or possibly wood. Being aware of the potential appearance of wood, we may also find CT useful in excluding small retained fragments in postoperative patients with persistent symptoms. This article presents two cases in which wooden foreign bodies of head and neck were present with CT evaluation.

• Ocean Systems Engineering
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• 제10권2호
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• pp.163-179
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• 2020

Considering the huge demand of several types of subsea equipment, as Christmas Trees, PLEMs (Pipeline End Manifolds), PLETs (Pipeline End Terminations) and manifolds for instance, a critical phase is its installation, especially when the equipment goes down through the water, crossing the splash zone. In this phase, the equipment is subject to slamming loads, which can induce impulsive loads in the installation wires and lead to their rupture. Slamming loads assessment formulation can be found in many references, like the Recommended Practice RP-N103 from DNV-GL (2011), a useful guide to evaluate installation loads. Regarding to the slamming loads, RP-N103 adopt some simplifying assumptions, as considering small dimensions for the equipment in relation to wave length, in order to estimate the slamming coefficient C_S used in load estimation. In this article, an experimental investigation based on typical subsea structure dimensions was performed to assess the slamming coefficient evaluation, considering a more specific scenario in terms of application, and some reduction of the slamming coefficient is achieved for higher velocities, with positive impact on operability.

• 대한안전경영과학회지
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• 제4권3호
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• pp.141-156
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• 2002

This article deals with the multiple alternative proposal of Venture Business policy. when Decision makers meet a very complex and important business to take a good choice. It might not be easy that we make a decision and accept the decision as an exact result of analysis at a complication and uncertain situation. This is the reason why the original research use Statistical Survey method and Visual Decision Making Process(VDMP) to improve decision analysis method. Therefore, Our research suggests that the VDMP utilized in the strategic decision making situation as a group decision adding tool, can be applied in the development of a process vision and implementation plan. as a result, researcher describe step by step the process of VDMP

• 대한안전경영과학회지
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• 제3권2호
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• pp.133-144
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• 2001

This article deals with the multiple alternative proposal of Strategy. when Decision makers meet a very complex and important problems to take a good choice. It might not be easy that we make a decision and accept the decision as an exact result of analysis at a complication and uncertain situation. Although the decision under unpredictable state is many existence and each field is classified to support it. he can not provide exact estimations and be able to specify a result and forecasting. This is the reason why the original research use Statistical Survey method and Visual Decision Making Process(VDMP) to improve decision analysis method. Therefore, Our research suggests that the VDMP utilized in the strategic decision making situation as a group decision adding tool, can be applied in the development of a process vision and implementation plan. as a result, researcher describe step by step the process of VDMP.