• Korean Journal of Clinical Pharmacy
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• v.30 no.3
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• pp.196-205
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• 2020

Background: The indication of denosumab for osteoporosis was expanded from second-line to first-line therapy in 2019. The aim of this study was to evaluate the efficacy of denosumab as both first- and second-line therapy in postmenopausal women with osteoporosis and osteopenia with risk factors by using the Fracture Risk Assessment Tool (FRAX). Methods: We conducted a medication use evaluation of denosumab in 98 patients who had been treated three or more times for osteoporosis or osteopenia at Chungnam National University Hospital from July 1^st, 2017 to January 31^st, 2020. Risk factors were identified using quantitative N-gram analyses of FRAX estimations. Patient information, including menopause status and results of bone mineral density tests (T-score), was obtained from electronic medical records. Results: Age, body mass index (BMI), prior medication use, and T-score were identified as risk factors and were included as variables in the evaluation of denosumab use. Since no significant differences were detected between groups, denosumab is likely effective regardless of age or BMI. In addition, no significant difference was detected in T-scores following denosumab treatment, between groups who took bisphosphonates and selective estrogen receptor modulators (SERMs) with denosumab as first-line therapy for postmenopausal osteoporosis. Denosumab may, therefore, be effective as second-line therapy. Conclusion: Efficacy of denosumab was evaluated in postmenopausal women with osteoporosis. Denosumab may be used as first- and second-line therapy regardless of age, BMI, and prior use of bisphosphonates and SERMs.

• Journal of Environmental Impact Assessment
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• v.30 no.5
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• pp.297-304
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• 2021

The environmental impact assessment(EIA) project in Korea has undergone changes and revisions in various evaluation items for about 30 years after the introduction of the Environmental Conservation Act (1997). However, despite the importance of land use evaluation items under the current EIA Act, there are insufficient studies to consider. Therefore, this study focused on the land-use evaluation items based on the EIA guidelines, reviewed 90 of the evaluation documents and consultation documents, and tried to suggest implications and supplementary points forthe domestic EIA land-use evaluation items. As a result, the paradigm was changing from land efficiency centered on development in the past to land efficiency centered on the natural environment and resource conservation. However, in spite of the manual for fitting the paradigm change, opinions on the conservation of the natural environment are still being drawn in the consultation document, so it needs improvement. Two improvements in the impact assessment process suggested in this study are the establishment of standardized spatial data and a quantitative impact and reduction method evaluation tool based on it. In particular, there is a need for a plan evaluation tool for land use arrangement and distribution that can solve the needs of minimizing damage to the natural environment and securing green space and a green network.

• Journal of Mechanical Science and Technology
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• v.20 no.3
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• pp.329-334
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• 2006

This paper presents the evaluation of LPG (Liquefied petroleum gas) regulators for home use. For the evaluation, several properties of the regulators were experimentally analyzed, such as the operation of safety device, the adjusting and lock-up pressure, the adjusting spring and the diaphragm, with respect to the used time of the regulators. Experimental results showed that the initial operation performances of regulators were degraded with increase of the service time and also showed that the degradation of the performance and material property could become serious after about six-year-use of the regulators.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.14 no.10
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• pp.854-862
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• 2002

In the previous research, a simplified correlation method was developed as an easy prediction tool for comparing energy use of cooling plants. The purpose of this paper is to test the applicability of this method for economic evaluation with two zones of a 20-story commercial building in Seoul. The results of this method were compared with the DOE-2 simulation and actual measured data. Then, Comparisons of life cycle cost were carried out for three types of cooling plants. Testing of one zone showed good agreement of within 10% error in cooling energy use and within 2% error in LCC. But testing of the other zone indicated that the use of this method were invalid when input variables were used beyond its valid range.

• YAKHAK HOEJI
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• v.53 no.3
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• pp.107-113
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• 2009

Since 2006, the Computerized Restricted Antibiotic Control Program (CRACP) has been incorporated to facilitate a more efficient approval process of vancomycin use at the Chonbuk National University Hospital. The purposes of the study were to evaluate proper use of vancomycin and to examine if there is any improvement when administering the CRACP. The use of vancomycin was retrospectively reviewed by a medical record review based on the American Society of Hospital Pharmacists (ASHP) criteria (i.e., indication, use of critical process indicators and use of outcome measurements) and compared before (Group I) and after the CRACP (Group II). Two hundred fifty six patient records were evaluated (138 in Group I and 118 in Group II). There was a statistically significant improvement in the report of justification for vancomycin use after CRACP (42.0% vs. 62.7%, p=0.001). Out of eight critical process indicators, two indicators (appropriate cultures prior to medication [68.8% vs. 85.6%, p=0.002] and serum vancomycin level measurement [0% vs. 7.6%, p=0.001]) were significantly improved after CRACP. The total incidence of adverse effects was decreased from 14.5% to 6.8%. In addition, there was a statistically significant difference in WBC count reduction within normal range (52.8% vs. 73.1%, p=0.024). The CRACP appears to be a promising approach to improve use of vacomycin in a hospital setting. However, further evaluation for the long-term period should be performed to confirm the performance of the program.

• Quality Improvement in Health Care
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• v.1 no.1
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• pp.32-43
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• 1994

The 'Pharmacy and Therapeutic Committee' decided to restrict the use of vancomycin which was categorized into restricted antimicrobials, among general, reserved and restricted antimicrobials. The committee also established prescribing guidelines of vancomycin in Seoul National University Hospital, May, 1991. Especially, the restricted antimicrobials should be used after approval by infectious disease specialist physician. A retrospective drug use evaluation (DUE) on vancomycin has been conducted to compare with the previous vancomycin DUE study in 1990. 'Criteria for DUE on vancomycin' was modified from Am J Hosp Pharm. Total 65 charts of patients were retrospectively reviewed from July 1991 to June 1992 in Seoul National University Children's Hospital. The justification of use was improved from 56% to 75% comparing with the previous study. In analyzing process indicators, several criteria including body temperature monitoring, WBC monitoring and use of concomitant antibiotics were well documented, but serum creatinine monitoring, culture and sensitivity test and level monitoring were infrequently performed, while the accepted level has been improved. Accepted level for appropriate initial dosage and duration of therapy were decreased. In outcome analysis, blood culture after discontinuing the drug was relatively well documented compared with the previous study. As the results, the approval vancomycin use was shown to be effective and rational in antibiotic therapy. And it is suggested that the above findings should be communicated to the medical staff, and a active intervention, such as feedback control, also be necessary for rational drug use.

• Korean Management Science Review
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• v.13 no.2
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• pp.49-59
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• 1996

The use of advanced electronic security system is growing quickly to protect properties and life. However, customers cannot select appropriate configuration of the system because there are no objective evaluation methods to measure the security ability of the system. Furthermore, the system suppliers cannot propose quantitative value of security ability of the system. This study suggests an objective evaluation and selection method that customers and suppliers can use to base his or her decision when choosing the most appropriate configuration of the system. Our method identifies 6 characteristics and 20 sub- characteristics of the electronic security system, calculates their weights, and decides the best configuration. We use AHP (Analytic Hierarchy Process) to assign the weights of characteristics. Finally, this paper gives an example to compare four alternative configurations of the system.

• Journal of the Korea Safety Management & Science
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• v.6 no.4
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• pp.227-238
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• 2004

This development has tried to scheme out the convenience for users to use the 3D modeling solution which is developed from the existing programs. The extended 3D modeling solution, to be developed through the use of the API which is provided and Microsoft Access, database is able to reuse the parts, subassemblies of parts, and assemblies. A methodology exhibits the possibility to use a Spinfire Professional Spinfire Reader program. The web evaluation system, which is used to connected with the Internet explorer and to construct a web service, will repeat the evaluations of the company staffs and customers about the new products which the company have designed. The furniture manufacturing company will adopt the 3D modelling solution in modelling the new products and go through the web evaluation system to collect dissatisfied facts of the customers or the company staffs against the new product. Finally, it will contribute to the enormous benefit creation of the enterprise.

• Journal of the Korean housing association
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• v.10 no.2
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• pp.259-268
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• 1999

This study aims to recognize the importance of the outdoor environment for the improvement in the residents' quality of life and analyze residents' outdoor behavior(physical and psychological) pattern in terms of relation to outdoor environment in Multi-Housing Complexes. Our survey was performed to the residents of 6 Multi-Housing Complexes located in Pusan, and analyzed residents' consciousness, use and evaluation in relation to outdoor space according to the characteristics of the Multi-Housing Complexes. The results are as follows: l. The outdoor space is classified into resting space, green space, parking space, play space and sport space. Most of residents recognize that green space and parking space are the most important of the outdoor space. 2. Mainly, wives use for stroll and talk, husbands use for sports and stroll, and children use for sports and play. 3. The parking space is the highest score and sport space is the lowest score according to the residents' evaluation of the outdoor space, and yet sport space must be considered in planning of outdoor space because the residents' needs are high.

• Management & Information Systems Review
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• v.7
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• pp.187-210
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• 2001

The purpose of this study is to develop an framework for the marketing performance evaluation of POS system by the theoretical model for evaluation of information system and the empirical data of Super-chains. This study were empirically examined an effect of POS system and its information quality on POS information use and another effect of POS information use on marketing performances of firms using POS system. Also, in order to achieve this purpose, a literature survey on MIS and marketing was conducted. In this study, the structural equation model(SEM) was established for verifying the relationship of above variables. And, several hypothesis were established and examined empirically from that SEM. In conclusion POS system and its information quality influenced positively on POS information use, and that information use influenced on marketing performance as the effectiveness of POS system operations.