• 한국산업보건학회지
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• 제29권3호
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• pp.298-309
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• 2019

Objectives: This study aimed to investigate stages of safety and health culture change through a reflection on 40 years of hearing conservation history at a multinational company. Methods: The target workplaces were multinational companies with more than 1,000 employees. The research used the clinical case study and system analysis methods based on direct observation of the research from 1994 to 2009. The latter method performed an analysis of the equilibrium state of the cross-section in the given period and the longitudinal profile of the change during the given period. Results: The stages of cultural change are divided into five stages and summarized as follows. In the first stage, workplace noise was not widely recognized as a hazard, while in the second stage, the measurement of noise levels and audiometric testing were conducted under the Korean Occupational Safety and Health Act (KOSHA). The driving force for change in the second stage was the amendment of the KOSHA. In the third stage, noise came to be recognized as a hazard factor through awareness training. The driving force of change during the third stage was the strong executive power exerted by the audit of the industrial hygiene program from the US head office. In the fourth step, there was a change to actually reduce noise. The driving force in this stage was a change in company executives' risk perception resulting from lawsuits over noise-induced hearing loss and the task force team activities for culture change based on the action learning protocol. At the fifth stage, a 'buy quiet policy' was institutionalized. The management's experience that noise reduction was difficult was the motivation to manage noise from the time of purchase of equipment. Conclusions: The activities of a hearing conservation program are determined by the improvement of the legal system and by the way it is enforced. Noise control activities to reduce noise areas may be possible through the shared risk perception of noise-induced hearing loss and by a change agent role as a facilitator to implement noise control.

• 한국자원식물학회지
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• 제28권2호
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• pp.279-289
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• 2015

소나무의 유전다양성과 유전구조를 추정하기 위해 9개의 ESTP 표지를 13개 소나무 집단에 적용하였다. 소나무 집단의 유전다양성은 관찰된 대립유전자 수(A)가 2.2개, 유효 대립유전자 수(A_e)가 1.8개, 다형적 유전자좌 비율(P)이 98.8%, 이형접합도 관찰치(H_o)가 0.391, 이형접합도 기대치(H_e)가 0.402로 나타났다. 안강과 강릉 집단을 제외한 11개 집단이 하디-바인베르그 평형을 만족하였다. 집단간 유전분화도(F_ST)는 0.057으로, 동위효소나 nSSR 표지분석 결과보다 강하게 나타났다. 군집분석에서 집단의 유전적 거리와 지리적 분포간에 뚜렷한 연관성은 확인할 수 없었으며, 집단의 유전분화와 지리적 인접성도 상관이 없는 것으로 나타났다(Mantel 검증, r = 0.017, P = 0.344). 유전자좌에 대한 F_ST-outlier 분석을 실시한 결과, 빈도주의 방법에서는 F_ST 값이 신뢰하한 이하인 3개 유전자좌와 신뢰상한 이상인 3개 유전자좌가 특이값으로 추정되었고, 베이즈 방법에서는 3개 유전자좌들만 특이값으로 확인되었다. 두 방법에서 공히 특이값으로 판정된 3개 유전자좌(sams2+AluⅠ, sams2+RsaⅠ, PtNCS_p14A9+HaeⅢ)중 sams2 표지에서 유래된 2개 유전자좌는 balancing selection의 영향을 받는 것으로 추정되었다.

• 기술혁신연구
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• 제28권4호
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• pp.151-163
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• 2020

포스트 코로나 시대 전통적 정형화된 업무는 지능화된 기계와 온라인 플랫폼 등 디지털 기술에 의해 대체되고, 디지털 전환 기술과 고숙련 근로자 및 비정형 업무 간 강한 상호 보완관계를 바탕으로 고용 없는 경기회복이 전개될 가능성이 크다. 특히, 우리나라 산업 내 직무 구성을 살펴보면, 반복업무 지수가 지속적으로 상승하는 추세다. 이는 포스트 코로나 시대 디지털 전환의 가속화에 따른 노동시장에 대한 부작용 및 파급효과가 우리나라 경제체제 내 고착화될 가능성이 큼을 시사한다. 이러한 배경 하, 본 연구에서는 우리 경제사회 시스템의 구조적 변화를 일으킬 디지털 전환의 내재적 속성에 대한 심층적 이해를 바탕으로, 잠재적 위기 극복 및 문제해결을 위한 개념적 틀을 제공하고자 한다. 특히, 포스트 코로나 시대 디지털 기술발전과 학습 간 상호작용에 주목하여, 혁신체제의 구조적 전환을 통한 새로운 균형점으로의 이행을 위한 혁신정책의 역할을 재정립하고자 한다. 이와 함께, 포스트 코로나 시대 우리나라 혁신체제가 미래 환경 변화에 능동적으로 대응할 수 있는 적절한 제도적 요소들로 구성되어 있는지 살펴보고, 포스트 코로나 시대 디지털 전환이라는 기술변화 흐름에 능동적으로 대응할 수 있는 미래지향적 혁신정책 수립 방향을 제시하고자 한다.

• 국제지역연구
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• 제17권4호
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• pp.89-106
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• 2013

본 연구의 대상지역은 대한민국 16개 광역시도이며, 분석기간은 2000년부터 2009년의 제조업 10개년도 시계열 데이터를 이용하여 지역총생산(GRDP)에 큰 영향을 미치는 제조업의 노동생산성을 분석대상으로 설정하여 지역패널회귀분석을 이용한 절대적 및 조건부 수렴여부 및 제조업 생산성 결정요인을 분석 하였다.분석결과를 살펴보면, 절대적 수렴 및 조건부 수렴가설 모두 귀무가설(H0)를 기각함에 따라 수렴가설이 성립하고 있으며, 전국의 제조업 생산성은 수렴하고 있음을 확인할 수 있었다. 수렴속도를 살펴보면 절대적 수렴모형에서 수렴속도는 연간 4.4%가 나왔고, 조건부 수렴에서는 연간 0.73%인 것으로 나타났다. 또한 지역별 제조업의 생산성 결정요인에 대한 분석결과, 종속변수를 1인당 부가가치로 이용했을 때, 인적자본 변수와 제조업 입지계수변수가 정(+)의 관계로 나타났고, 1인당 정부지출 변수가 부(-)의 관계로 나타났다. 연구개발변수의 경우 지식재산권변수만 정(+)의 관계로 나타났다. 총요소생산성의 경우 1인당 정부지출과 1인당 고정자본형성변수가 정(+)의 관계로 유의하였으며, 연구개발변수는 통계적으로 유의하지 않는 것으로 나타났다.

• Journal of Nutrition and Health
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• 제54권6호
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• pp.573-583
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• 2021

일반적으로 에너지 필요량은 에너지 평형 상태에서의 에너지소비량으로 정의된다. 이중표식수법 (doubly labeled water, DLW)은 총에너지소비량 (total energy expenditure, TEE)을 측정하는 가장 정확한 방법으로 알려져 있다. 2002년, 미국 Institute of Medicine (IOM)은 미국인과 캐나다인을 위한 영양소 섭취기준 (dietary reference intakes, DRIs)을 제안하고, 이중표식수법 (DLW)을 이용한 연구결과들을 모아서 에너지필요추정량 (estimated energy requirement, EER) 산출식을 개발하였다. 2005년부터 한국인 영양소 섭취기준에서도 이 산출식을 이용하여 에너지필요추정량을 설정해왔다. 연령대를 기준으로 한 이 산출식에서는 체중과 신장뿐만 아니라 신체활동수준 (physical activity level, PAL)에 따른 (sedentary, low active, active, and very active) 신체활동계수 (physical activity, PA)가 적용되었다. 이중표식수법과 신체활동일기를 이용하여 산출한 한국인의 신체활동수준은 '저활동적' (1.40-1.59)에 해당되었으므로, '저활동적'에 해당하는 신체활동단계별 계수 (PA)가 에너지필요추정량 (EER) 산출식에 적용되었다. 최근 한국에서도 규칙적으로 다양한 신체활동을 하는 사람들이 증가하고 있어 '활동적 (active)'인 사람들과 '매우 활동적 (very active)'인 사람들을 위한 에너지필요추정량을 별도로 제시하였다. 앞으로 미국과 일본처럼, 한국에서도 이중표식수법 (DLW) 연구를 확대하여 한국인을 위한 에너지필요추정량 산출식이 개발되어야 한다. 또한 신체활동 일기와 새로운(한국인을 위한) 신체활동 분류표를 이용하여 신체활동수준 (PAL)을 정확하게 평가할 수 있는 표준화된 가이드라인을 마련해야한다.

• 대한토목학회논문집
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• 제29권2B호
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• pp.111-120
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• 2009

교각주위의 국부세굴은 교량붕괴의 주원인 중 하나로 알려져 있다. 세굴심을 산정하는 방법에는 경험식에 의한 방법과 수치모형을 이용한 시뮬레이션이 있다. 하지만 경험식에 의한 방법은 공식이 적용될 수 있는 유사한 상황에서만 제한적으로 사용가능하며, 수치모형을 이용한 방법은 비용이 많이 든다는 단점을 가지고 있다. 그러므로 본 연구에서는 세굴심 예측을 위한 CSU 공식, 다중회귀분석, 다양한 인공신경망 모형의 유용성을 비교분석하였다. 또한 세굴심을 산정하는데 있어 넓은 범위의 오차를 발생시키는 인공신경망 모형의 단점을 보완하기 위하여 본 연구에서는 인공신경망 모형에 군집분석을 결합하여 오차를 감소시키고자 하였다. 세굴심 예측을 위해 CSU 공식, 다중회귀분석, 다양한 인공신경망 모형을 적용해 본 결과 역전파알고리즘을 이용하는 인공신경망 모형이 가장 높은 정확성을 보였으며, 인공신경망 모형에 군집분석을 적용한 세굴심 예측에서는 군집수가 3일 때 가장 높은 정확도를 보였다. 군집분석을 적용한 인공신경망 모형의 정확도는 다른 모형과 비교할 때 최고 42.73%가 향상된 결과를 보여 인공신경망 모형내의 군집분석의 적용이 인공신경망의 오차를 줄이는데 큰 역할을 할 수 있음을 알 수 있었다.

• 한국환경과학회:학술대회논문집
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• 한국환경과학회 1998년도 가을 학술발표회 프로그램
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• pp.2-4
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• 1998

Proliferation of Nocardia amarae cells in activated sludge has often been associated with the generation of nuisance foams. Despite intense research activities in recent years to examine the causes and control of Nocardia foaming in activated sludge, the foaming continued to persist throughout the activated sludge treatment plants in United States. In addition to causing various operational problems to treatment processes, the presence of Nocardia may have secondary effects on the fate of heavy metals that are not well known. For example, for treatment plants facing more stringent metal removal requirements, potential metal removal by Nocardia cells in foaming activated sludge would be a welcome secondary effect. In contrast, with new viosolid disposal regulations in place (Code o( Federal Regulation No. 503), higher concentration of metals in biosolids from foaming activated sludge could create management problems. The goal of this research was to investigate the metal sorption property of Nocardia amarae cells grown in batch reactors and in chemostat reactors. Specific surface area and metal sorption characteristics of N. amarae cells harvested at various growth stages were compared. Three metals examined in this study were copper, cadmium and nickel. Nocardia amarae strain (SRWTP isolate) used in this study was obtained from the University of California at Berkeley. The pure culture was grown in 4L batch reactor containing mineral salt medium with sodium acetate as the sole carbon source. In order to quantify the sorption of heavy metal ions to N amarae cell surfaces, cells from the batch reactor were harvested, washed, and suspended in 30mL centrifuge tubes. Metal sorption studies were conducted at pH 7.0 and ionlc strength of 10-2M. The sorption Isotherm showed that the cells harvested from the stationary and endogenous growth phase exhibited significantly higher metal sorption capacity than the cells from the exponential phase. The sequence of preferential uptake of metals by N. amarae cells was Cu>Cd>Ni. The specific surFace area of Nocardia cells was determined by a dye adsorption method. N.amarae cells growing at ewponential phase had significantly less specific surface area than that of stationary phase, indicating that the lower metal sorption capacity of Nocardia cells growing at exponential phase may be due to the lower specific surface area. The growth conditions of Nocardia cells in continuous culture affect their cell surface properties, thereby governing the adsorption capacity of heavy metal. The comparison of dye sorption isotherms for Nocardia cells growing at various growth rates revealed that the cell surface area increased with increasing sludge age, indicating that the cell surface area is highly dependent on the steady-state growth rate. The highest specific surface area of 199m21g was obtained from N.amarae cell harvested at 0.33 day-1 of growth rate. This result suggests that growth condition not only alters the structure of Nocardia cell wall but also affects the surface area, thus yielding more binding sites of metal removal. After reaching the steady-state condition at dilution rate, metal adsorption isotherms were used to determine the equilibrium distributions of metals between aqueous and Nocardia cell surfaces. The metal sorption capacity of Nocardia biomass harvested from 0.33 day-1 of growth rate was significantly higher than that of cells harvested from 0.5- and 1-day-1 operation, indicatng that N.amarae cells with a lower growth rate have higher sorpion capacity. This result was in close agreement with the trend observed from the batch study. To evaluate the effect of Nocardia cells on the metal binding capacity of activated sludge, specific surface area and metal sorption capacity of the mixture of Nocardia pure cultures and activated sludge biomass were determined by a series of batch experiments. The higher levels of Nocardia cells in the Nocardia-activated sludge samples resulted in the higher specific surface area, explaining the higher metal sorption sites by the mixed luquor samples containing greater amounts on Nocardia cells. The effect of Nocardia cells on the metal sorption capacity of activated sludge was evaluated by spiking an activated sludge sample with various amounts of pre culture Nocardia cells. The results of the Langmuir isotherm model fitted to the metal sorption by various mixtures of Nocardia and activated sludge indicated that the mixture containing higher Nocardia levels had higher metal adsorption capacity than the mixture containing lower Nocardia levels. At Nocardia levels above 100mg/g VSS, the metal sorption capacity of activate sludge increased proportionally with the amount of Noeardia cells present in the mixed liquor, indicating that the presence of Nocardia may increase the viosorption capacity of activated sludge.

• 인지과학
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• 제27권4호
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• pp.501-539
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• 2016

인간 정신은 외상 자극에 역동적으로 반응하여 다차원적 위계를 따라 진화적으로 발전하는 시스템이다. 평형상태에서 일원화되어 있는 정신 내에 외상 자극이 유입되면 그에 반대 쌍이 되는 반응 극성이 형성되어 이원화된다. 그 반대 쌍 사이에 초월적 상호작용이 일어나면 상위 차원에 제3의 극성이 출현하게 되어 정신은 삼위구조로 변형된다. 삼위 구조화된 정신에서는 비평형 상태가 극대화되어 가소성이 최대화됨에 따라 삼위 요인이 같은 기능을 하게 되는 동기화가 가능해지며 이로 인해 정신은 상위차원에서 다시 일원화된다. 만약 정신이 또 다시 새로운 자극을 받아들이게 되면 정신은 위의 위계적 변형과정을 따라 성장하게 된다. 이를 정신의 기본삼위체계의 동기화를 통한 순환적 성장과정이라 한다. 이번 이론 연구에서는 이 개념을 외상 후 성장 과정에 적용하여 외상 후 성장 시계를 제안하였다. 외상 후 성장 시계는 7개의 위계적 단계로 구성되어있으며 처음 6개의 단계들은 충격 대 마비, 공포 대 침습, 편집 대 회피, 강박 대 폭발, 불안 대 우울, 허무 대 의미추구 단계 등의 12분기로 구성되어 있고 마지막 7번째 단계에서는 이들 모든 단계들의 기능들이 동기화되는 거대 동기화 단계가 나타나게 된다. 거대 동기화 단계에서는 이전의 6 단계들로 구성된 개인 내의 생리-사회-실존 차원들 뿐 아니라 자아와 타아도 동기화를 통해 일원화됨으로써 자신의 외상경험 뿐 아니라 타인의 고통도 자신의 실제적 외상경험으로 작용하게 되어 정신은 상위 차원에서 또 다른 성장과정을 반복한다. 이 논문에서 제안된 외상 후 성장 시계의 변형과정에 대한 타당성을 Horowitz의 외상반응과정과 비교하여 논의하였다.

• 대한한의학회지
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• 제16권2호
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• pp.453-489
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• 1995

The research of the phrases related with physiology of stomach and spleen in the contents of Huang Di Nei Jing(黃帝內經) known as the Bible of oriental medicine will make a contribution to a deep understanding of disease of stomach and spleen and a proper clinical diagnosis and treatment of them. In this research of the most appropriate glosses recorded nine kinds of representative medical books including Huang Di Nei Jing Somoon(黃帝內經素問) of Wang Bing(王氷) were picked out: The summaries of the selected contents are as follows: 1. The word 'saliva(涎)' in 'the spleen controls saliva(脾爲涎)' can be viewed as a generic term referring to oral cavity secretion gland as well as the secretion fluid of salivary gland. 2. The phases 'a large reservoir(太倉)', barn organs', 'a reserboir of food stuff', 'a stomach as the market(胃爲之市)', etc mean the function of stomach to receive food(胃主受納). 3. The phase 'generation of five tastes(五味出焉)' means both 'the function of stomach to transform food into chyme(胃主腐熟)' and 'the channelling function of spleen.(脾主運化)' 4. The flowing of the food-Qi(食氣) into stomach brings about spreading Jung(精) into liver and then percolating Jung(精) flow into channel. The channel-Qi(脈氣) flows into lung through channel. As a result, all kinds of channels gather together in lung and Jung(精) is sent into skin and hair. The assembly of Jung(精) with skins and channels moves Qi(氣) into fu-organ and so jung(精) and mental activity(神明) in fu-organ(府) come to be in four organs(四臟). Then if Qi(氣) comes back to power balance unit(權衡) being in the state of equilibrium(權衡以平), the hole of Qi(氣口) comes to determine the matter of life and death through achieving Chun-quan-chi(-寸-關-尺). The above mentioned phrases means the digestion, asorption and transmission of food. When food is taken in stomach, Jung-Qi(精氣) comes to be over flowed upward into spleen, back into lung, finally downward into bladders through water-conduit(水道) controlled by lung. When water- Jung(水精) radiates into whole body with channels of five organs(五臟), both of them fit together with and yin-yang(陰-陽). Therefore, the grasping of the rise and decline of yin-yang(陰C-陽) is necessary to consult patients. The above mentioned phrases is properly viewed to designate the asorption, transmission and excretion of food. 5. Spleen controls flesh(脾之合肉也), the state of spleen is known by human lips, and what this means is that liver plays functions of spread and expansion(肝主疏泄). 6. The phrase 'Jung Jung'((中精)) in 'gallbladder dominates Jung jung(膽主中精)', which in one of the specific expression of 'liver plays functions of spread and expansion(肝主疏泄). 7. It is right that the phase 'The eleven organs in all are determined by gallbladder'(凡十,一臟取決於膽也) is correctly paraphrased as 'only one of ten organs, spleen, is determined by gallbladder'.(凡十,一臟取決於膽也), 8. The small intestine is an organ. which receives the materials digested and sends them out. This means that the function of transforming materials(化物) factually refers to that of separating clearity and blur(泌別淸濁). And it is also thought to have the function of ascending clearity and descending blur(升淸降濁), 9. A large intestine is a transmitting organ(傳導之官) from which a change comes out(變化出焉). the phrase 'change'(變化) in this sentence means both the intake of water and nutrition and the formation procedure of stool through excretion of mucocele.

• The Korean Journal of Physiology
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• 제2권2호
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• pp.21-31
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• 1968

The appearance rates of antipyrine and urea into cerebrospinal fluid from blood were studied in the rabbits which were in the state of hypotension and of high permeability in the capillary beds following injection of histamine. The alteration in the distribution of electrolytes among various compartments of the brain and the permeability characteristics in the blood-cerebrospinal fluid barrier were also observed. Adult male rabbits, weighing around 2 kg, were used. Twenty four rabbits were divided into 3 groups. Besides the control group, histamine treated rabbits were categorized into 2 groups. $H_1$ consisted of the rabbits showing moderate responses to histamine and ranging from 62 to 80 mmHg in their mean anterial blood pressure. The animals which belong to $H_2-group$ showed severe responses to histamine and the mean anterial blood pressures dropped to 30-50 mmHg. Animals were anesthetized with nembutal, 30mg/kg i.v. The mean arterial blood pressure was read by means of the mercury manometer connected to the femoral artery. The animals, treated with histamine, were kept in hypotensive state at least for 40 minutes before the administration of the test-substances. The test-substances, 300 mg of urea and 200 mg of antipyrine, were dissolved in 3 ml of distilled water and were injected into the ear vein of the rabbit. After 10 minutes elapsed arterial blood sample was taken from the femoral artery and cerebrospinal fluid from the cisterna magna. Brain tissues were also analysed with respect to electrolytes in order to observe the disturbances in the electrolytes balance as well as in the function of the central nervous system. The results obtained were as follow: 1. The ratio of antipyrine concentration in cerebrospinal fluid to that of arterial blood plasma, that was the distribution ratio, was close to unity, revealing a well established equilibrium between the compartments of blood and cerebrospinal fluid in 10 minutes. In other words, there was no diffusion barrier with regard to antipyrine. The ratios over unity which were frequently seen in the histamine treated animals were attributable to the early penetration of the substance into the cerebrospinal fluid. 2. The appearance rates of urea into the cerebrospinal fluid in the histamine treated rabbits were higher in comparison with those of in the control animals. The increasing tendency in the rates was particularly remarkable in the $H_2-group$, showing the enhanced penetration of urea across the boondary. 3. In the htisamine treated $H_2-group$ the concentration of potassium in the blood plasma and cerebrospinal fluid well exceeded the control values and showed 8.5 and 9.0 mEq/l in average, respectively. Simultaneous drops in the brain tissue water were noticed, suggesting the leakage of intracellular potassium. 4. There was a coincidence in the rising pattern of potassium in the blood plasma and in the cerebrospinal fluid of $H_2-group$ and at least partial removal of the blood-cerebrospinal fluid barrier with respect to potassium was suggested in these animals. 5. The concentration of sodium in the blood plasma or in the cerebrospinal fluid showed no significant changes following histamine injection. However, sodium in the brain tissue revealed slight elevation in the histamine treated groups. 6. The ratios of the concentrations of potassium to those of sodium, [K]/[Na] in the brain tissues, were 1.92 in the control 1.82 in the $H_1$ and 1.52 in the $H_2-group$, respectively. The marked drop in the $H_2-group$ might represent neural dysfunction in the extremely hypotensive rabbits.