• 약학회지
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• 제49권5호
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• pp.365-369
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• 2005

The inhibitory effect of ferulic acid and related phenolic compounds on the growth of normal cell lines and can­cer cell line was evaluated by the MTT and XTT methods. Ferulic acid decreased the cell viability of human skin melanoma cells by the MTT method and the cell adhesion activity of human oral epithelioid carcinoma cells by the XTT method. These results suggest that ferulic acid has a potential anticancer activity.

• 한국임상수의학회지
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• 제19권2호
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• pp.250-252
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• 2002

A 14-year-old female Gill's bottle-nosed dolphin died after having 1 month history of depression, anorexia, and respiratory insufficiency. At necropsy, numerous well-demarcated tan firm nodules in variable sizes ranging from 2 m to 3 cm in diameter were scattered throughout the lung lobes. Histologically, the pulmonary nodules formed typical granulomatous inflammation. Center of the granulomatous foci consisted of necrotic center with gram positive cocci surrounded by eosinophilic Splendore-Hoeppli material then by macrophages, epithelioid cells, multinucleated giant cells, a few lymphocytes and fibroblasts. The is the first report of pulmonary botryomycosis in dolphin in Korea.

• 대한수의학회지
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• 제48권2호
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• pp.181-185
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• 2008

Comparative studies of histopathologic lesions from 23 purified protein derivative (PPD) positive cattle, 21 slaughter cattle found with tuberculosis, and 11 tuberculosis-positive elk (Cervus elaphus) were performed. PPD positive cattle did not show specific histopathologic lesions in all 23 heads that were no visible lesion reactor. Slaughter cattle found with tuberculosis revealed microscopically classical granulomatous lesion (tubercle) with central caseous necrosis surrounded by mantle of epithelioid cells and Langhan's giant cells capsuled by connective tissue in lung. Elk was noted with some different lesion patterns with classical granulomatous lesion and suppurative abscesses that was composed of fibrin, degenerated cells without having connective tissue. In addition, many Langhan's giant cells infiltration in alveoli at peripheral lesion were observed in some cases of classical granulomatous lesion and suppurative abscesses.

• 한국어병학회지
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• 제16권3호
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• pp.165-173
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• 2003

감성돔 (Acanthopagrus schlegeli)의 비장에서 주화세포인 BSBS를 확립하고 세포의 특성을 검사하였다. BSBS세포는 60회 이상의 계대배양이 가능하였고 형태학적으로는 상피성 세포였다. 세포는 20℃, 10%의 FBS가 든 L-15배지에서 배양하는 조건에서 잘 자랐다. BSBS세포는 해양버나바이러스 (MABV Y-6), 잉어의 봄바이러스병바이러스 (SVCV), 넙치의 랍도바이스 (HIRRV)와 연어바이러스 (CSV)를 접종했을 때 세포변성효과가 나타났다. 새로 확립된 주화세포는 앞으로 많은 바이러스병의 연구에 유용하게 사용할 수 있을 것으로 생각된다.

• 한국동물위생학회지
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• 제30권3호
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• pp.407-414
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• 2007

There were eight Korean indigenous cattles affected with bovine tuberculosis (BTB) detected by inspectors at slaughterhouses located in Chungbuk province from May 2006 through July 2007. Postmortem finding of BTB cases was characterized by the presence of several caseous or calcified nodules encapsulated by connective tissue from the pleural/peritoneal surface, livers, lungs and regional lymph nodes On micro-scopic examinations, the characteristic lesion of BTB was the formation granulomatous nodules, which contains central calcified necrotic zone surrounded by epithelioid cells, macrophages and a few Langhans' type giant cells. In addition, mononuclear cells and fibroblasts were also infiltrated. At the periphery, encapsulation was formed that protect the neighboring healthy tissues.

• Tuberculosis and Respiratory Diseases
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• 제53권1호
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• pp.56-65
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• 2002

국내에서 폐 유상피 혈관내피종이 악성으로 진행하여 사망한 예는 1예만 보고되어 있다. 단일 폐결절이 있는 환자에서 개흉 폐절제술후 병리조직학적으로 종양세포의 유사분열과 괴사를 동반하여 악성 유상피 혈관내피종으로 진단하고 예후가 불량할 것으로 예상되는 1예와 단순 흉부 촬영상 양측 다발성 폐결절이 있는 무증상 환자에서 비디오 흉강경 폐생검으로 폐 유상피 혈관내피종을 진단 후 조직학적 및 임상적으로 악성 소견 없이 경과를 관찰 중인 1예 및 양측 폐의 다발성 결절성 병변과 늑막액을 동반하여 개흉 폐생검으로 폐 유상피 혈관내피종을 진단 후 호흡부전으로 사망한 1예의 폐 유상피 혈관내피종 3예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Tuberculosis and Respiratory Diseases
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• 제47권5호
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• pp.691-696
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• 1999

건강검진시 촬영한 단순흉부사진에서 우연히 발견된 다발성 결절로 내원한 34세 여자 환자에서 개흉술을 통한 조직검사상 미분화 혈관분화를 보이고 면역조직 화학염색상 제 VIII 인자-관련인자, CD34 와 vimentin에 양성반응을 보여 EH로 확진 되었던 1예를 경험하였기에 보고하는 바이다.

• 대한영상의학회지
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• 제83권5호
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• pp.1109-1115
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• 2022

신장의 혈관근지방종은 전형적으로 고형 종괴지만, 낭성 형태의 신장 혈관근지방종이 소수 보고되었다. 그중에서 대다수의 보고는 상피낭종을 동반한 혈관근지방종으로 입방상피조직으로 둘러싸인 낭종을 포함한다. 다음으로 상피모양 혈관근지방종은 호산성 세포질이 풍부한 상피모양세포를 포함하는데, 이것이 출혈이나 괴사로 인해 낭성변화를 일으킨 증례 보고도 있었다. 이런 낭성 형태의 신장 혈관근지방종은 영상검사에서 낭성 신세포암 등의 다른 낭성 종괴로 오인될 수 있다. 이 증례 보고에서는 58세 남성에서 발견된 상피낭종을 동반한 상피모양 혈관근지방종의 영상 소견을 살펴보려고 한다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권6호
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• pp.3625-3630
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• 2013

Reactive oxygen species (ROS) are known to promote mesothelial carcinogenesis that is closely associated with asbestos fibers and inflammation. Epithelial to mesenchymal cell transition (EMT) is an important process involved in the progression of tumors, providing cancer cells with aggressiveness. The present study was performed to determine if EMT is induced by $H_2O_2$ in human malignant mesothelioma (HMM) cells. Cultured HMM cells were treated with $H_2O_2$, followed by measuring expression levels of EMT-related genes and proteins. Immunohistochemically, TWIST1 expression was confined to sarcomatous cells in HMM tissues, but not in epithelioid cells. Treatment of HMM cells with $H_2O_2$ promoted EMT, as indicated by increased expression levels of vimentin, SLUG and TWIST1, and decreased E-cadherin expression. Expression of stemness genes such as OCT4, SOX2 and NANOG was also significantly increased by treatment of HMM cells with $H_2O_2$. Alteration of these genes was mediated via activation of hypoxia inducible factor 1 alpha (HIF-$1{\alpha}$) and transforming growth factor beta 1 (TGF-${\beta}1$). Considering that treatment with $H_2O_2$ results in excess ROS, the present study suggests that oxidative stress may play a critical role in HMM carcinogenesis by promoting EMT processes and enhancing the expression of stemness genes.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제32권6호
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• pp.573-576
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• 2010

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare benign vascular lesion that is characterized by proliferation of small to medium-sized vascular structures lined by histiocytoid or epithelioid endothelial cells and often accompanied by an inflammatory infiltrate comprising lymphocytes, plasma cells and eosinophils. A 34-year-old man without any generalized systemic conditions presented with a slowly enlarging painless swelling in the buccal area. An excisional biopsy was conducted and the diagnosis of Angiolymphoid hyperplasia with eosinophilia was confirmed. We report a case of angiolymphoid hyperplasia with eosinophilia of the buccal area in oral cavity and review the previously reported cases and literatures of angiolymphoid hyperplasia with eosinophilia.