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The Inhibitory Effect of Ferulic Acid and Related Phenolic Compounds against Cancer Cell Lines  

Han, Du Seok (Department of Oral Anatomy, School of Dentistry and Department of Herbal Resources)
Chun, Joo Won (Department of Oral Anatomy, School of Dentistry and Department of Herbal Resources)
Jeon, Sung Woo (Department of Oral Anatomy, School of Dentistry and Department of Herbal Resources)
Ba다, Seung Hwa (Department of Oral Anatomy, School of Dentistry and Department of Herbal Resources)
Publication Information
YAKHAK HOEJI / v.49, no.5, 2005 , pp. 365-369 More about this Journal
Abstract
The inhibitory effect of ferulic acid and related phenolic compounds on the growth of normal cell lines and can­cer cell line was evaluated by the MTT and XTT methods. Ferulic acid decreased the cell viability of human skin melanoma cells by the MTT method and the cell adhesion activity of human oral epithelioid carcinoma cells by the XTT method. These results suggest that ferulic acid has a potential anticancer activity.
Keywords
Inhibitory effect; phenolic compounds; MTT and XTT methods; ferulic acid; cell viability; cell adhesion activity;
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1 Kong, L. D., Abliz, Z., Zhou, C. X., Li, L. J., Cheng, C. H. and Tan, R. X. : Glycosides and xanthine oxidase inhibitors from Conyza bonariensis. Phytochemistry 58, 645 (2001)   DOI   ScienceOn
2 Andrade, P. B., Oliveira, B. M., Seabra, R. M., Ferreira, M. A., Ferreres, F. and Garcia-Viguera, C. : Analysis of phenolic compounds in Spanish Albrarino and Portuguese Alvarinho and Loureiro wines by capillary zone electrophoresis and high-performance liquid chromatography. Electrophoresis 22, 1568 (2001)   DOI   ScienceOn
3 Hirota, A., Taki, S., Kawaii, S., Yano, M. and Abe, N.: 1,1-Diphenyl-2-picrylhy-drazyl radical-scavenging compounds from soybean miso and antiproliferative activity of isoflavones from soybean miso toward the cancer cell lines. Biosci Biotechnol Biochem. 64, 1038 (2000)   DOI   ScienceOn
4 Sakaguchi, N., Inoue, M. and Ogihara, Y. : Reactive oxygen species and intracellular $Ca^{2+}$, common signals for apotosis induced by gallic acid. Biochem. Pharmacol. 55, 1973 (1998)   DOI   ScienceOn
5 De Heredia, J. B., Torregrosa, J., Dominguez, J. R. and Peres, J. A. : Kinetic model for phenolic compound oxidation by Fenton's reagent. Chemosphere. 45, 85 (2001)   DOI   ScienceOn
6 Dawidar, A. M., Ezmiriy, S. T., Abdel-Mogib, M., el-Dessouki, Y. and Angawi, R. F. : New stilbene carboxylic acid from Convolvulus hystrix. Pharmazie. 55, 848 (2000)
7 Cao, Y., Lou, C., Fang, Y. and Ye, J. : Determination of active ingredients of Rhododendron dauricum L. by capillary electrophoresis with electrochemical detection. J Chromatogr. 943, 153 (2002)   DOI   ScienceOn
8 Inoue, M., Suzuki, R., Sakaguchi, N., Li, Z., Takeda, T., Ogihara, Y., Jiang, B. Y. and Chen, Y. : Selective induction of cell death in cancer cells by gallic acid. Biol. Pharm. Bull. 18, 1526 (1995)   DOI   ScienceOn
9 Xu, L., Liu, J., Min, D., Wang, S., Zhang, Z., Guo, D. and Zheng, K. : Chemical constituent. Zhongguo Zhong Yao Za Zhi. 23, 293 (1998)
10 Li, Z., Inou, M., Nose, M., Kojima, K., Sakaguchi, N., Isuzugawa, K., Takeda, T. and Ogihara, Y. : Metabolic fate of gallic acid orally administered to rats. Biol. Pharm. Bull. 22, 326 (1999)   DOI   ScienceOn
11 Mosmann, T. : Rapid colorimetric assays for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55 (1983)   DOI   PUBMED   ScienceOn
12 채영암, 구자옥, 서학수, 이영만 : 기초생물학, 향문사, p. 179 (1991)
13 Heilmann, J., Calis, I., Kirmizibekmez, H., Schuhly, w., Harput, S. and Sticher, O. : Radical scavenger activity of phenylethanoid glycosides in FMLP stimulated human polymorphonuclear leukocytes: structure-activity relationships. Planta Med. 66, 746 (2000)   DOI   ScienceOn