Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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A Case of Pulmonary Epithelioid Hemangioendothelioma

폐의 유상피성 혈관내피종 1예

  • Kim,, Kwan-Young (Department of Internal Medicine, College of Medicine, Kyungpook National University) ;
  • Kim, Chang-Ho (Department of Internal Medicine, College of Medicine, Kyungpook National University) ;
  • Sohn, Ji-Wung (Department of Internal Medicine, College of Medicine, Kyungpook National University) ;
  • Cha, Seung-Ick (Department of Internal Medicine, College of Medicine, Kyungpook National University) ;
  • Chae, Sang-Chul (Department of Internal Medicine, College of Medicine, Kyungpook National University) ;
  • Park, Jae-Yong (Department of Internal Medicine, College of Medicine, Kyungpook National University) ;
  • Jung, Tae-Hoon (Department of Internal Medicine, College of Medicine, Kyungpook National University) ;
  • Park, Tae-In (Department of Pathology, College of Medicine, Kyungpook National University) ;
  • Kwon, Keun-Yeung (Department of Pathology, College of Medicine, Kyemyung University)
  • 김관영 (경북대학교 의과대학 내과학교실) ;
  • 김창호 (경북대학교 의과대학 내과학교실) ;
  • 손지웅 (경북대학교 의과대학 내과학교실) ;
  • 차승익 (경북대학교 의과대학 내과학교실) ;
  • 채상철 (경북대학교 의과대학 내과학교실) ;
  • 박재용 (경북대학교 의과대학 내과학교실) ;
  • 정태훈 (경북대학교 의과대학 내과학교실) ;
  • 박태인 (경북대학교 의과대학 병리학교실) ;
  • 권건영 (경북대학교병원 호흡기센타)
  • Published : 1999.11.30
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Abstract

Epithelioid hemangioendothelioma(EH) is a rare pulmonary vascular malignancy. Clinically, EH has been considered as an indolent, generally non-aggressive tumor. We report a case of EH which was confirmed by open lung biopsy. A 34-year-old woman was admitted for further evaluation of multiple small(less than 2cm in size) nodules, incidentally detected on screening chest radiograph. The chest CT showed multiple, relatively well-marginated, variable sized nodules at both whole lung. Transbronchial lung biopsy and transthoracic needle aspiration were nondiagnostic and open lung biopsy was performed from right middle lobe of lung. On light-microscopic examination, the nodules were composed of a poorly cellular hyaline core and a more cellular peripheral zone which extended into air space in a micropolypoid fashion and obliterated blood vessels. The tumor cells at the peripheral zone had intracytoplasmic vacuoles which suggested primitive, vascular differentiation. Immuno-histochemical study revealed the cellular area which gave positive reaction to factor VIII-related antigen. She received no specific therapy after open lung biopsy and chest X-ray films had showed no change for about two years.

건강검진시 촬영한 단순흉부사진에서 우연히 발견된 다발성 결절로 내원한 34세 여자 환자에서 개흉술을 통한 조직검사상 미분화 혈관분화를 보이고 면역조직 화학염색상 제 VIII 인자-관련인자, CD34 와 vimentin에 양성반응을 보여 EH로 확진 되었던 1예를 경험하였기에 보고하는 바이다.

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