• 대한치과기공학회지
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• 제17권1호
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• pp.72-81
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• 1995

The study was performed to compare the raliablity of two Korean version questionaires for respiratory symptoms and ilness being used in Korea. The subjects were 103 dental laboratory technician who divided into two groups as SUN-81-AL and SUN-93. The duration of test-retest was one two month. The differences between two groups interms of average age, height, and weight were negligible. The SUN-93 showed higher agreement compared to SUN-81-AL except items cough and smoking. The Sun-93 deserved to prefer to be used in resporatory epidemiologic study.

• Environmental Analysis Health and Toxicology
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• 제11권3_4호
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• pp.75-87
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• 1996

There are numerous and evidential findings that TCDD (2, 3, 7, 8-tetrachlorodibenzo-Pdioxin, or dioxin) is a potential carcinogen and general toxin in rodents. flowever, human risk assessment for dioxin exposure has been a topic of debate, owing in part to the large animal interspecies differences in its toxicity. We review dioxin-related reports indicating its toxicity, toxic effects in animal, and human epidemiologic findings. The intent of this paper does not provide a causal inference about chronic human diseases related to dioxin exposure. This summary would give a valuable clue for a researcher to conduct or design a further dioxin-related study.

• Environmental Analysis Health and Toxicology
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• 제19권2호
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• pp.119-134
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• 2004

Human exposure to highly nickel-polluted environments, such as those associated with nickel refining, electroplating, and welding, has the potential to produce a variety of pathologic effects. Among them are skin allergies, lung fibrosis, and cancer of the respiratory tract. The exact mechanisms of nickel-induced carcinogenesis are not known and have been the subject of numerous epidemiologic and experimental investigations. This review provides the evidence of the current state for the genotoxic and mutagenic activity of Ni (II) particularly at high doses. Such doses are best delivered into the cells by phagocytosis of sparingly soluble nickel-containing dust particles. Ni (II) genotoxicity may be aggravated through the generation of DNA-damaging reactive oxygen species (ROS) and the inhibition of DNA repair by this metal. The epigenetic effects of nickel includes alteration in gene expression resulting from DNA hypermethylation and histone hypoacetylation, as well as activation some signaling pathways and subsequent transcrziption factors.

• 환경위생공학
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• 제14권4호
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• pp.99-109
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• 1999

Enteropathogenic Yersina enterocolitica is an important cause of human and animal disease. Phenotypic and genotypic characteristics currently used to identify Yersinia enterocolitica are not necessarily sufficient to differentiate pathogenic from non-pathogenic strains or to analyze the epidemiology of yersiniae at a molecular level. To improve the characterization of Yersinia enterocolitica, A total of 65 isolates of Yersinia enterocolitica were examined with bioserotyping, antibiotic susceptibilities, PFGE, PCR-ribotyping. Genomic DNA pattern generated by PFGE are highly specific for different strains of an organism and have significant value in epidemiologic investigations. The PFGE analysis of Not I-digested chromosomal DNA of Y. enterocolitica were performed with a CHEF Mapper(Bio-Rad, USA). Not I generated 19 restriction endonuclease digestion profiles(REDP). PCR-ribotyping, performed with primers complementry to conserved regions of 16S and 23S rRNA gene, generated 13 ribotypes. PCR-ribotyping can be considered a good technich for subtyping strains of Y.enterocolitica.

• 한국동물위생학회지
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• 제27권1호
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• pp.31-39
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• 2004

This study was performed to investigate the rabies surveillance in Gangwon-do from 1997 to 2001. Of 185 laboratory submissions for rabies diagnosis, 65(35.1%) cases were determined to be infected with the rabies virus. Annual incidence of animal rabies was 10 cases in 1997, 20 cases in 1998, 16 cases in 1999, 3 cases in 2000, and 16 cases in 2001, respectively. The total number of the reported cases were increased 382% compared with that of the previous period from 1993 to 1996(7 cases). The relative contributions of infected animals in this period were as follows: cattles(24 cases), dogs(26 cases), and raccoons(15 cases). Rabies outbreak in raccoon were steadily expanded. Epidemiologic surveillance showed the rabies outbreaks spreaded to the southern area in Gangwon-do. All rabies cases were showed positive results to rabies tests such as clinical signs, histopathological findings, indirect flourescent antibody test, and mouse inoculation test. Further studies such as genetic and phylogenetic analysis of the isolates should be performed in order to figure out accurate rabies outbreak.

• 대한치과의사협회지
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• 제38권1호통권368호
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• pp.86-93
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• 2000

Water fluoridation in conjunstion with wide use of fluoride dentifrices has been a major factor responsible for the decline in dental caries during the second half of the 20th century throughout the world. The history of water of water fluoridation is a classic public health program leading to epidemiologic investigation and community-based public health dentistry program. Although other fluoride-containing products are available, water fluoridation remains as the most safe and cost-effective method of delivering fluoride to omost communities. regardless of age. educational attainment. or income levels,. This review deals with pros and cons of water fluoridation and prospective analysis of state-of-the-art on issues related to the use of fluoride. An "optimal" fluoride concentration of 0.7-1.2 ppm has been recommended for preventing dental caries with a minimal dental fluorosis and no systemic health consequences.

• Journal of Preventive Medicine and Public Health
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• 제40권2호
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• pp.108-113
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• 2007

When conducting large-scale cohort studies, numerous statistical issues arise from the range of study design, data collection, data analysis and interpretation. In genomic cohort studies, these statistical problems become more complicated, which need to be carefully dealt with. Rapid technical advances in genomic studies produce enormous amount of data to be analyzed and traditional statistical methods are no longer sufficient to handle these data. In this paper, we reviewed several important statistical issues that occur frequently in large-scale genomic cohort studies, including measurement error and its relevant correction methods, cost-efficient design strategy for main cohort and validation studies, inflated Type I error, gene-gene and gene-environment interaction and time-varying hazard ratios. It is very important to employ appropriate statistical methods in order to make the best use of valuable cohort data and produce valid and reliable study results.

• Journal of Microbiology
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• 제43권5호
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• pp.424-429
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• 2005

In previous studies, it has been reported that both S. enteritidis, the most common serotype, and S. enteritidis Phage Type 4 (SEPT 4) isolates were identified as the most prevalent PT in domestic poultry and also in humans in Korea until 2002. The aim of this study was to analyze the genetic diversity and epidemiological properties of both PT isolates, and also to trace the source of SEPT 4 isolates from domestic poultry and humans by Pulsed-field gel electrophoresis (PFGE). In order to understand the molecular epidemiologic properties of SEPT 4 isolates, which have very similar phenotypic properties to our preliminary investigations (serotyping, phage typing, large plasmids and antibiograms), PFGE analysis with XbaI enzyme was performed on the representative SEPT 4 isolates. Thirty-six SEPT 4 isolates were analyzed and differentiated with 10 pulsed-field profiles (PFP) expressing very high discriminative ability (SID: 0.921). In PFP, SEPT 4 isolates from human patients showed a perfect genetic match with those from broiler chickens and meats. Therefore, this study was able to successfully trace the major source of SEPT 4 isolates and also to determine the usefulness of the PFGE method for genetic analysis of epidemic strains.

• 지역사회간호학회지
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• 제30권2호
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• pp.161-173
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• 2019

Purpose: This study was conducted to develop and test a measurement of the suicidal protection(MSP) for high school students in Korea. Methods: Thirty-four preliminary items were initially developed based on literature review and focus group interviews. Those items were evaluated by experts for content validity with 31 items yielded. For testing validity and reliability of the measurement, data were collected from 330 high school students in Korea. Results: The item analysis selected 26 items. One item was deleted additionally through the primary exploratory factor analysis. The final exploratory factor analysis yielded 26 items in six factors such as fear of suicide, self-esteem, emotion regulation, support from others, support from family, and school life, explaining 66.6% of the total variance of the suicidal protection for high school students in Korea. Convergent validity and discriminant validity were supported by construct reliability, average variance extracted estimate, and standardized regression weight. MSP scores were positively associated with economic status, academic record and suicidal ideation. Also, criterion validity was supported through a significant correlation with the Reason for Living Inventory for Adolescent. The Cronbach's ${\alpha}$ reliability coefficient was .93 for the overall measurement and .72~.86 for the six factors. Conclusion: The results show that MSP may be valid and reliable for assessing suicidal protection of high school students.

• 디지털융복합연구
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• 제15권10호
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• pp.349-356
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• 2017

본 연구는 병원행정직의 직무소진(MBI-GS: Maslach Bunout Inventory-General Survey)과 관련된 융복합적 요인들을 조사하고자 수행되었다. 조사대상은 임의로 선정된 J지역 9개 종합병원의 재직자 201명으로 하였으며, 자료수집은 2017년 7월 3일부터 2017년 7월 29일까지 무기명 자기기입식 설문지를 통해 이루어졌다. 위계적 다중회귀분석 결과, 조직헌신(OCQ: Organizational Commitment Questionnaire) 점수가 낮을수록, A형행동유형(TABP: Type A Behavior Pattern) 점수가 높을수록, 우울수준(CES-D: Center for Epidemiologic Studies Depression scale)이 높을수록 직무소진이 높았으며 이들의 설명력은 52.1%이었다. 이상의 연구결과를 볼 때, 병원행정직의 직무소진을 낮추기 위해서는 조직헌신을 높이고, A형행동유형과 우울수준을 낮추는 노력이 필요하다. 이러한 결과는 병원행정직의 직무소진을 낮추는 프로그램 및 인적자원관리에 활용이 기대된다. 향후연구에서는 병원행정직의 직무소진에 영향을 미치는 추가요인에 대한 구조방정식 모형의 분석이 필요하다.