• Journal of Korean Medical classics
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• v.20 no.4
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• pp.251-265
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• 2007

This study is a research on the etiology in Wu Youke's wenyi theory. In regard to the etiology of epidemic disease that had been spread on a very large scale at that time, Wu Youke denied the traditional theory which urged the irregular change of climate as the cause of epidemic disease, and proposed the concept of 'zaqi' which was considered by him to be something that could be the real cause of epidemic disease. And He treated the wenyi disease as something that has the same meaning with wenbing, so his concept on wenbing was basically the thing that treats 'zaqi' as the fundamental cause of wenbing and treats the concept of 'wen(溫)' as an environmental cause that could help activate the virulence of 'zaqi'. Such concept like this was the thing somewhat different from the traditional etiological theory that considers the change of climate as the principal cause of waigan(外感)-disease, and it must for the most part have been originated from the experience of Wu Youke himself. But this study, in contrast, based on the thing he denied the traditional theory on the irregular change of climate, has been done in the point of view that fundamental concept of his wenyi theory such as 'zaqi' was not only originated from his clinical experience but also from the influence of paradigm shift in the natural philosophy of that time. There had been so much change in cosmology and natural philosophy from the fundamental basis at that time, and the the most principal concept of it was that there always exists irregular faces in the change of nature. Such concept like this got into its stride from about 17th century, and it was expressed in the form of the severe criticism against the traditional natural philosophy. In regard to this, this study has outlined the academic thought of the leading scholars who made a significant progress in such a paradigm shift, and it includes the scholars like Wang Tingxiang, Wang Fuzhi, Hu Wei, Huang Zongxi, who played their role in the time of the latter period of Ming dynasty and the former period of Qing dynasty.

• The Pure and Applied Mathematics
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• v.30 no.2
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• pp.203-220
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• 2023

A new modification of the SIS epidemic model incorporating the adaptive host behavior is proposed. Unlike the common situation in most epidemic models, this system has two disease-free equilibrium points, and we were able to prove that as the basic reproduction number approaches the threshold of 1, these two points merge and a Bogdanov-Takens bifurcation of codimension three occurs. The occurrence of this bifurcation is a sign of the complexity of the dynamics of the system near the value 1 of basic reproduction number. Both local and global stability of disease-free and endemic equilibrium point are studied.

• Journal of Korean Medical classics
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• v.28 no.2
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• pp.33-45
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• 2015

Objectives : Through the study on Byeokyeoksinbang(辟疫神方), it would be expected to analyze Dokyeok(毒疫)'s characteristic and to comprehend how the changes in viewpoints of epidemic febrile disease were made. Methods : It has been done to analyze the original text of Byeokyeoksinbang(辟疫神方), and to compare the theory of Onbyeongjobyeon(溫病條辨) associated with the signature symptom of Dokyeok(毒疫). Results : Heo Jun(許浚) experienced a specific epidemic disease called 'Dokyeok(毒疫)', on which he made observations and analyzed its features and wrote Byeokyeoksinbang(辟疫神方). In Byeokyeoksinbang(辟疫神方), 'Dokyeok(毒疫)' is characterized by rash[疹], its pathogenesis is warm temperature, thus its treatment principle is removing interior and exterior heat. The book's pragmatic perspective is highly appreciated, as HeoJun improved and solidified existing medical knowledge up to date. In addition, Byeokyeoksinbang(辟疫神方) is significant in that it differentiated between macula[癍疹] and rash[疹], much earlier than the febrile disease school of the Qing dynasty. Conclusions : Between Byeokyeoksinbang(辟疫神方) and Onbyeongjobyeon(溫病條辨), there are differences in treatments and patterns of rash[疹]. Based on this, it will be able to compare each disease that is written in two books. And a study on comparing the development between epidemic febrile disease[瘟疫學] of the Joseon dynasty and febrile disease[溫病學] of the Qing dynasty will be carried out with a follow-up study.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.35 no.1
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• pp.97-107
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• 1990

The epidemiology of plant disease deals with the dynamic processes of host-pathogen interactions, which determine the prevalence and severity of the disease. Epidemic processes for most foliar diseases of plants follow a series of steps: arrival of pathogens on plant surfaces, initial infection, incubation period, latent period, sporulation, dissemination of secondary inoculum, and infectious period. These complex biological processes are influenced by the environment-Man also often interfers with these processes by altering the host and pathogen populations and the environment. Slowing or halting any of the epidemic processes can delay the development of the epidemic, so that serious losses in yield due to disease do not occur. It is generally recognized that the most effective and efficient method of minimizing disease damage is through the use of resistant cultivars, particularly when other methods such as fungicide applications are not economically feasible-Populations of plant pathogens are not genetically uniform nor are they necessarily stable. Cultivars bred for resistance to current populations of a pathogen may not be resistant in the future due to selection pressures placed on the pathogen populations. Understanding population development and genetic variability in the pathogen, and knowledge of the genetics of resistance in the plant should help in developing breeding strategies that wi1l provide effective and stable disease control through genetic resistance. In the United States, soybeans have ranked first in value of crops sold off the farm in recent years. Soybeans have been the leading U. S.

• Journal of applied mathematics & informatics
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• v.41 no.1
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• pp.107-121
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• 2023

An epidemic infectious disease model consists of six compartments viz. Susceptible, Exposed, Infected, Quarantine, Recovered, and Virus with nonlinear saturation incidence rate is proposed to know the viral disease dynamics. There exist two biological equilibrium points for the model system. The system's local and global stability is done through Lyapunov's direct method about equilibrium points. The sensitivity analysis has been performed for the basic reproduction number and equilibrium points through the normalized forward sensitivity index. Sensitivity analysis shows that virus growth and quarantine rates are more sensitive parameters. In support of mathematical conclusions, numerical experimentation has been shown.

• The Pure and Applied Mathematics
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• v.31 no.2
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• pp.131-158
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• 2024

This study investigates the impact of precautionary measures, such as isolating exposed individuals, wearing masks, and maintaining physical distance, on preventing infectious disease. A deterministic SEIQHRV epidemic model is employed for this purpose. The model's positivity, boundedness, disease-free, and endemic equilibrium points are identified. A sensitivity test assesses the impact of preventive measures on infected classes. Results show that a basic reproduction number less than unity drives disease eradiction, while a higher unity value encourages the adoption of preventive measures.

• Journal of the Korean Data and Information Science Society
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• v.26 no.1
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• pp.161-168
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• 2015

The epidemic is seemed to be extremely difficult for accurate predictions. The new models have been suggested that show quite different results. The basic reproductive number of epidemic for consequent time intervals are estimated based on stochastic processes. In this paper, we proposed a transmission distribution estimation for Ebola virus disease epidemic model. This estimation can be easier to obtain in real time which is useful for informing an appropriate public health response to the outbreak. Finally, we implement our proposed method with data from Guinea Ebola disease outbreak.

• Korean journal of applied entomology
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• v.26 no.1 s.70
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• pp.31-36
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• 1987

A piecewise linear regression model able to describe disease progress curves with simplicity and flexibility was developed in this study. The model divides whole epidemic into several pieces of simple linear regression based on changes in pattern of disease progress in the epidemic and then incorporates the pieces of linear regression into a single mathematical function using indicator variables. When twelve epidemic data obtained from the field experiments were fitted to the piecewise linear regression model, logistic model and Gompertz model to compare statistical fit, goodness of fit was greatly improved with piecewise linear regression compared to other two models. Simplicity, flexibility, accuracy and ease in parameter estimation of the piece-wise linear regression model were described with examples of real epidemic data. The result in this study suggests that piecewise linear regression model is an useful technique for modeling plant disease epidemic.

• The Journal of Pediatrics of Korean Medicine
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• v.18 no.2
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• pp.225-232
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• 2004

Objectives : Hand-Foot-Mouth disease is a highly contagious disease most often seen in children. It is caused most commonly by the coxsackievirus A16 and clinically characterized by vesicles appearing on the hands, feet and in the mouth. The purpose of this study is a approach to the oriental medical treatment of Hand-Foot-Mouth disease. Method : We studied the clinical literatures of traditional chinese medicine about Hand-Foot-Mouth disease after the year 2000. Result : Hand-Foot-Mouth disease are similar to epidemic febrile disease(溫病) dampwarm syndrome(濕溫), and epidemic disease(時疫) in Oriental Medicine. Conclusion : In oriental medical treatment is classified into the treatment of internal use, external use, and combination treatment of chinese and western medicine.

• Journal of the korean veterinary medical association
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• v.29 no.6
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• pp.360-365
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• 1993

Attempts to isolate porcine epidemic diarrhea virus(PEDV) were made by inoculating feces homogenates into Vero cells cultures with trypsin. Cytopathic effects(CPE), such as vacuolation, formation of syncytia, and fusion of cells, were detected even at fir