• Communications for Statistical Applications and Methods
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• v.19 no.6
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• pp.899-904
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• 2012

High-dimensional categorical data models with small sample sizes have not been used extensively in genomic sequences that involve count (or discrete) or purely qualitative responses. A basic task is to identify differentially expressed genes (or positions) among a number of genes. It requires an appropriate test statistics and a corresponding multiple testing procedure so that a multivariate analysis of variance should not be feasible. A family wise error rate(FWER) is not appropriate to test thousands of genes simultaneously in a multiple testing procedure. False discovery rate(FDR) is better than FWER in multiple testing problems. The data from the 2002-2003 SARS epidemic shows that a conventional FDR procedure and a proposed test statistic based on a pseudo-marginal approach with Hamming distance performs better.

• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2002.11a
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• pp.143-143
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• 2002

돼지 장염 바이러스를 동시에 감별 진단할 수 있는 새로운 진단법인 oligonicleotide microarray 기법을 돼지 설사 분변을 대상으로 바이러스 감염을 진단하고 기존의 진단법으로 널리 사용되고 있는 RT-PCR과 진단기법의 민감도와 특이도를 비교하고자 하였다. 32개 양돈장, 102 예의 포유 및 이유자돈의 설사분변에서 microarray를 이용한 검사결과 Transmissible gastroenteritis virus (TGEV) 9.8％, porcine epidemic diarrhea virus (PEDV) 28％, (porcine enteric calicivirus (PECV) 18.6％, porcine rotavirus (PRV) group A 6.9％, PRY group C 1％ 의 검출률을 확인하였다. 또한 RT-PCR 기법과의 비교에서도 100％의 민감도와 72.2％의 특이도를 보였으며 agreement는 85.3％, kappa value 0.71로 우수한 진단기법임을 확인하였다. 이를 통해 microarray 진단법은 RT-PCR 후의 전기영동 과정과 민감도를 높이기 위해 수행되는 nested PCR 수행의 번거러움을 없애면서 정확한 감별진단을 수행할 수 있는 진단 기법임을 확인하였다.

• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2002.11a
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• pp.142-142
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• 2002

돼지의 주요 장염 유발 바이러스인 돼지 전염성 위장염 바이러스 (transmissible gastroenteritis virus; TGEV), 돼지 유행성 설사증 바이러스 (porcine epidemic diarrhea virus; PEDV), 돼지 칼리시 바이러스 (porcine enteric calicivirus; PECV), 돼지 로타바이러스 A 형과 C 형 (porcine rotavirus; PRY, group A and C)을 동시에 감별 진단 할 수 있는 신속하고 정확한 oligonucleotide microarray 진단법을 개발하였다. 이 진단법은 유리슬라이드에 각각의 바이러스에 특이적인 부위에서 제작된 oligonucleotide probe를 찍은 DNA chip을 제작하여 여기에 각각의 바이러스를 역전사하고 cy5-dCTP를 포함한 multiplex PCR을 수행한 다음 hybridization 하였다. 이후 hybridization 결과는 fluorescence scanner를 이용하여 확인하였다. 이 새로운 microarray system은 RT-PCR과 같은 기존의 진단방법보다 소량의 바이러스를 민감하게 검사할 수 있을 뿐 아니라 hybridization을 통해 검사결과의 정확성을 확인할 수 있었다. 따라서 본 연구에서 개발한 microarray system은 돼지의 설사 유발 바이러스를 진단하는데 매우 유용한 진단 방법임을 확인하였다.

• Pediatric Infection and Vaccine
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• v.16 no.2
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• pp.107-114
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• 2009

Tuberculosis is a disease with high morbidity and mortality in children worldwide. Despite significant improvements in diagnostic methods, scientific researches and clinical trials for new regimens of treatment or prevention in adult tuberculosis, childhood tuberculosis has been relatively neglected. Children are at high risk of severe disease, and reactivation of latent infection in adulthood perpetuates the epidemic. Therefore, a policy of tuberculosis control in childhood should be emphasized to improve control in the total population. To understand the new view of childhood tuberculosis, this article describes changes in the disease's national epidemiology, new diagnostic tools and treatment strategies, and multi-drug resistance.

• Research in Plant Disease
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• v.11 no.2
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• pp.198-200
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• 2005

An epidemic of the white dusty covering of grape clusters and canes by dust-like particles occurred in many vineyards near Gimcheon, Gyeongbuk area since 2000. Although the covering was severe, it seldom resulted in appreciable damage to vine health except drastical reduction of grape quality. It appears that the abnormal growth of a resident yeast Hanseniaspora (Kloeckera) sp. is related to the white dusty covering on the grape surface.

• Korean Journal Plant Pathology
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• v.14 no.5
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• pp.467-472
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• 1998

Gray mold rot of perilla was epidemic at Kangdong, Pusan and Miryang, Kyungnam in 1997 and 1998. The incidence of this disease ranged form 21.3 to 68.1% at Kangdong area. Leaf necrosis initially appeared on the edge of the infected leaves, and it was developed to the center of the leaves forming typical V-shaped brown necrotic lesions. Under high moisture condition, abundant mycelia of the pathogen was formed on the surface of the lesions. Infected stems became slender and were completely blighted up to the top of the plant. Two isolates, LVF12 and SD7, were isolated from diseased lesions showing typical symptoms, and the pathogenicity was tested using mycelial disks and conidial suspension inoculation. The developed symptoms were same as the naturally produced ones. These two pathogenic fungi were identified as Botrytis cinerea based on the morphological characteristics using a microscope and a scanning electron microscope, and cultural characteristics. This is the first report of gray mold or perilla in Korea.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.1
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• pp.22-27
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• 2004

Seop-Gye divided up the constitution's strength and weakness, and so he cured disease by the 'cold and heat'. 'deficiency and excessiveness' means on the basis of the YINㆍYANG of constitution. He classified constitution with pathogenesis grounding in body formal distinction, flesh hardness and softness, face color and form, skin color. Therefore he grasped the rule of constitution connected with physiological function and pathological distinction, applied the rule of constitution in the diagnosis and cure of the chronic & epidemic febrile disease.

• Proceedings of the Korea Society for Industrial Systems Conference
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• 2002.11a
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• pp.490-501
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• 2002

기업의 생산성향상과 이익률에 영향을 줄 수 있는 지식이 경제 전반에 확산되어 나가는 과정은 한 나라의 경제발전속도에 영향을 미치는 중요한 요인이다. 기업 측면에서는 도입하려는 기술이 도입 후에 그 기업의 이익을 높여 줄 수 있다면 도입하지 않을 이유가 없다. 하지만 미래 수요의 불확실성이나 기술발전 방향의 불확실성 등으로 해서 기업으로서는 도입 후의 이익을 정확히 사전적으로 측정하기는 어렵다. 본 논문에서는 학계에서 일반적으로 사용되고 있는 두 가지 지식확산 모델을 설명하고자 한다. 그 하나는 하나의 새로운 기술이나 상품이 시간이 흐름에 따라 어떻게 전체 사용 가능자(population)에게 확산되는 지를 보여주는 1) Epidemic Diffusion Model (흔히 S자형 - Sigmoid - 모델이라고도 한다.)과 어떤 도입자가 어느 시점에서 대상이 된 새로운 기술을 도입할 것인지 아닌지를 결정하는 모델로서 2) Probit Diffusion Model (프로빗 모델)을 중심으로 한다. 그리고 이러한 지식확산과정과 속도에 영향을 줄 수 있는 기업 내부적 요인으로서 도입하고자 하는 기업의 누적된 경험이 중요하다는 것과 기업 외부적 요인으로서 네트웍 효과와 같은 요인들을 설명하였다.

• Proceedings of the KIEE Conference
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• 1998.07b
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• pp.699-702
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• 1998

This study investigates the population model of the spread of HIV/AIDS which the infection is generated by an infectious in dividual in a population of susceptibles. A mathematical model is presented for the transmission dynamics of HIV infection within the communities of homosexual males. The pattern on the epidemic character of HIV, the causative agent of AIDS, was analysed by the mathematical model of AIDS system which is derived according to the ecological relationship between five epidemilogic states of individuals. The computer simulation was performed using real data.

• The Korean Journal of Mycology
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• v.14 no.1
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• pp.89-91
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• 1986

Sixteen seed samples of nine vegetable crops imported from Japan were tested for plant quarantine by routine methods of seed health testing. Nineteen species of fungi including Alternara alternata were identified from the seed samples. Some species were very frequently detected in the seeds. In this experiment, Verticillium albo-atrum, V. dahliae and Macrophomina sp. from the seeds of spinach, and Cercospora capsici, Drechslera hawaiiensis and V. albo-atrum from the seeds of sweet pepper were detected for the first time, respectively. It has been reported that they had a pathogenicity on some vegetable crops in Japan and other countries. The data suggest that an epidemic damage may be occurred if the infected seeds are sown and cultivated in Korea.