• Laboraroty Animal Research
• /
• v.34 no.4
• /
• pp.203-210
• /
• 2018

Stress severely disturbs physiological and mental homeostasis which includes adult neurogenesis in hippocampus. Neurogenesis in hippocampus is a key feature to adapt to environmental changes and highly regulated by multiple cellular signaling pathways. The primary cilium is a cellular organelle, which acts as a signaling center during development and neurogenesis in adult mice. However, it is not clear how the primary cilia are involved in the process of restraint (RST) stress response. Using a mouse model, we examined the role of primary cilia in repeated and acute RST stress response. Interestingly, RST stress increased the number of ciliated cells in the adult hippocampal dentate gyrus (DG). In our RST model, cell proliferation in the DG also increased in a time-dependent manner. Moreover, the analysis of ciliated cells in the hippocampal DG with cell type markers indicated that cells that were ciliated in response to acute RST stress are neurons. Taken together, these findings suggest that RST stress response is closely associated with an increase in the number of ciliated neurons and leads to an increase in cell proliferation.

• Journal of Korean Society on Water Environment
• /
• v.25 no.1
• /
• pp.48-57
• /
• 2009

A two-dimensional (2D), laterally-averaged hydrodynamic and water quality model, CE-QUAL-W2 was applied to evaluate the performance on simulating the effect of flushing from Daecheong Reservoir on the downstream water quality variations during the flushing events held on November, 2003 and March, 2008. The hydraulic and water quality simulation results were compared with field measurement data, as well as a one-dimensional (1D), unsteady model (KORIV1) that revealed limited capability in the previous study due to missing the resuspension process of river bottom sediments. The results showed that although the 2D model made satisfactory performance in reproducing the temporal variations of dissolved matters including phosphate, ammonia and nitrate, it revealed poor performance in simulating the increase of biological oxygen demand and suspended sediment (SS) concentrations during the passage of the flushing flow. The reason of the error was that the resuspension process of the 2D model is only the function of shear stress induced by wind. In reality, however, as shown by significant correlation between bottom shear stress ($\tau$) and observed SS concentration, the resuspension process can be significantly influenced by current velocity in the riverine system, especially during flushing event. The results indicate that the resuspension of river bottom materials should be incorporated into the water quality modeling processes if $\tau$ is greater than a critical shear stress (${\tau}_c$) for better simulation of flushing effect.

• Journal of the Korean Geotechnical Society
• /
• v.27 no.11
• /
• pp.55-69
• /
• 2011

The importance of unsaturated state in various geo-engineering problems has led to the advance of mechanical constitutive model emulating behavior of unsaturated soils in response to thermo-hydro-mechanical loading. Elasto-plastic mechanical constitutive model for unsaturated soil is formulated based on Bishop's effective stress. Effective stress and temperature are main variables in constitutive equation, and incremental formulation of constitutive relationship is derived to compute stress update and stiffness tensor. Numerical simulations involving coupled THM processes are conducted to discuss numerical stability and applicability of developed constitutive model: one-dimensional test, tri-axial compression test, and clay-buffering at high level radioactive waste disposal. Numerical results demonstrated that developed model can predict very complex behavior of coupled THM phenomena and is applicable to geo-engineering problems under various environmental conditions, as well as interpret typical behavior of unsaturated soils.

• Journal of Korea Water Resources Association
• /
• v.38 no.10 s.159
• /
• pp.871-883
• /
• 2005

This paper investigates the impacts of turbulent anisotropy on the mean flow and turbulence structures in vegetated open-channel flows. The Reynolds stress model, which is an anisotropic turbulence model, is used for the turbulence closure. Plain open-channel flows and vegetated flows with emergent and submerged plants are simulated. Computed profiles of the mean velocity and turbulence structures are compared with measured data available in the literature. Comparisons are also made with the predictions by the k-$\epsilon$ model and by the algebraic stress model. For plain open-channel flows and open-channel flows with emergent vegetation, the mean velocity and Reynolds stress profiles by isotropic and anisotropic turbulence models were hardly distinguished and they agreed well with measured data. This means that the mean flow and Reynolds stress is hardly affected by anisotropy of turbulence. However, anisotropy of turbulence due to the damping effect near the bottom and free surface is successfully simulated only by the Reynolds stress model. In open-channel flows with submerged vegetation, anisotropy of turbulence is strengthenednear the vegetation height. The Reynolds stress model predicts the mean velocity and turbulence intensity better than the algebraic stress model or the k-$\epsilon$ model. However, above the vegetation height, the k-$\epsilon$ model overestimates the mean velocity and underestimates turbulence intensity Sediment transport capacity of vegetated open-channel flows is also investigated by using the computed profiles. It is shown that the isotropic turbulence model underestimates seriously suspended load.

• BMB Reports
• /
• v.52 no.4
• /
• pp.250-258
• /
• 2019

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by selective and progressive loss of dopaminergic neurons. Genetic and environmental risk factors are associated with this disease. The genetic factors are composed of approximately 20 genes, such as SNCA, parkin, PTEN-induced kinase1 (pink1), leucine-rich repeat kinase 2 (LRRK2), ATP13A2, MAPT, VPS35, and DJ-1, whereas the environmental factors consist of oxidative stress-induced toxins such as 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP), rotenone, and paraquat. The analyses of their functions and mechanisms have provided important insights into the disease process, which has demonstrated that these factors cause oxidative damage and mitochondrial dysfunction. The most invaluable studies have been performed using disease model organisms, such as mice, fruit flies, and worms. Among them, Drosophila melanogaster has emerged as an excellent model organism to study both environmental and genetic factors and provide insights to the pathways relevant for PD pathogenesis, facilitating development of therapeutic strategies. In this review, we have focused on the fly model organism to summarize recent progress, including pathogenesis, neuroprotective compounds, and newer approaches.

• Computers and Concrete
• /
• v.11 no.2
• /
• pp.169-182
• /
• 2013

One of the major benefits of the pre-stressed concrete pavements is the omission of tension in concrete that results in a reduction of cracks in the concrete slabs. Therefore, the life of the pavement is increased as the thickness of the slabs is reduced. One of the most important issues in dealing with the prestressed concrete pavement is determination of the magnitude of the pre-stress. Three dimensional finite element analyses are conducted in this research to study the pre-stress under various load (Boeing 777) and thermal gradient combinations. The model was also analyzed under temperature gradients without the presence of traffic loading and the induced stresses were compared with those from theoretical relationships. It was seen that the theoretical relationships result in conservative values for the stress.

• Computers and Concrete
• /
• v.1 no.4
• /
• pp.417-432
• /
• 2004

An analytical model which can simulate the post-cracking nonlinear behavior of reinforced concrete (RC) members such as bars and panels subject to uniaxial and biaxial stresses is presented. The proposed model includes the description of biaxial failure criteria and the average stress-strain relation of reinforcing steel. Based on strain distribution functions of steel and concrete after cracking, a criterion to consider the tension-stiffening effect is proposed using the concept of average stresses and strains. The validity of the introduced model is established by comparing the analytical predictions for reinforced concrete uniaxial tension members with results from experimental studies. In advance, correlation studies between analytical results and experimental data are also extended to RC panels subject to biaxial tensile stresses to verify the efficiency of the proposed model and to identify the significance of various effects on the response of biaxially loaded reinforced concrete panels.

• 한국도로학회:학술대회논문집
• /
• 2010.09a
• /
• pp.99-107
• /
• 2010

A permanent deformation model was developed in this study based on the shear properties of asphalt mixtures such as cohesion and friction angle. Triaxial compressive strength (TCS) and repeated load permanent deformation (RLPD) tests on the three types of asphalt mixtures are performed at various loading and temperature conditions to correlate shear properties of asphalt mixtures to rutting performance. It is observed from the tests results that the ratio of shear stress to strength accurately identifies the mixture rutting performance. It could take care of not only mixture types but also load and temperature conditions dependences. Three different versions of the permanent deformation model based on different input levels are proposed and verified using the tests data. The proposed model based on the ratio of shear stress to strength can successfully predict the permanent deformation of various asphalt mixtures all the way up to the 10% of permanent strain including all three stages of permanent deformation in a wide range of loading and temperature conditions without changing model coefficients.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
• /
• 2004.11a
• /
• pp.73-80
• /
• 2004

Recently, many maritime accidents have been increased and the collisions due to human error are given a great deal of proportions out if them We develop the Real-time Collision Risk Monitoring System (CRMS) for the navigational officers to cope with the emergency situation promptly and thus to reduce the probability if casualty. In this study, the risk of collision is evaluated by two kinds if method. The first method is based on Fuzzy algorithm, which evaluates the risk of collision between traffic ships. The second method is based on Environmental Stress (ES) Model, where the total risk if collision is evaluated by the environmental stress felt by human. The developed real-time CRMS has been installed to the ship handling simulator system and its capabilities have been tested through simulator experiments.

• Journal of Navigation and Port Research
• /
• v.33 no.1
• /
• pp.43-50
• /
• 2009

Recently, many maritime accidents have been increased and the collisions due to human error are given a great deal of proportions out of them We develop the Real-time Collision Risk Monitoring System (CRMS) for the navigational officers to cope with the emergency situation promptly and thus to reduce the probability of casualty. In this study, the risk of collision and grounding is evaluated by two kinds of method. The first method is based on Fuzzy algorithm, which evaluates the risk of collision between traffic ships. The second method is based on Environmental Stress (ES) Model, where the total risk of collision and grounding is evaluated by the environmental stress felt by human. The developed real-time CRMS has been installed to the ship handling simulator system and its capabilities have been tested through simulator experiments.