• Title/Summary/Keyword: Environmental DNA

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8-Hydroxyguanine in DNA Mediates Cell Death of KG-1, a Human Leukemia Cell Line by Inducing Cell Cycle Arrest and Apoptosis

  • Hyun, Jin-Won
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.05a
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    • pp.89-93
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    • 2001
  • All that is presently known about the actions of 8-hydroxyguanine (8-oxoguanine; oh$^{8}$ Gua) in DNA is that it harms genetic integrity. This is even speculation based upon scattered in vitro experimental data such as the mismatch of oh$^{8}$ Gua with A in stead of C and the GC longrightarrow TA transversion observed in the DNA polymerase reaction using an oh$^{8}$ Gua containing oligonucleotide.(omitted)

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FRUITS AND FRUIT JUICE CONSUMPTION REDUCE OXIDATIVE DNA DAMAGE IN LYMPHOCYTES OF KOREAN HEALTHY YOUNG ADULTS

  • Kang, Myung-Hee;Park, Eunju
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.10a
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    • pp.120-120
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    • 2001
  • It is generally thought that continuous oxidative damage to DNA is a major contributor to the risk of cancer development. Epidemiological studies suggest that fruits and vegetables might reduce the risk of cancer through their antioxidant properties. This study was designed to investigate the protective effect of fruits and fruit juice consumption against the oxidative DNA damage in lymphocytes of healthy subjects. (omitted)

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Bootstrap Analysis of ILSTS035 Microsatellite Locus in Hanwoo Chromosome 6

  • Lee, Jea-Young;Lee, Yong-Won;Kim, Mun-Jung
    • Journal of the Korean Data and Information Science Society
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    • v.15 no.1
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    • pp.75-81
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    • 2004
  • We selected, in previous research, a major DNA Marker 235bp of ILSTS035 microsatellite locus in progeny test Hanwoo chromosome 6. We apply a major DNA Marker 235bp to perormance valuation Hanwoo chomosome 6. We use bootstrap BCa method and calculate confidence interval. A major DNA Marker 235bp is verified that it does not have environmental effect but affects primely economic trait factor.

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Iron overload induces damage of global DNA and TP 53 in human lymphocytes

  • Park, Eunju;Beatrice, L.Pool Zobel
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2003.05a
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    • pp.38-38
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    • 2003
  • High iron consumption is associated with an increased risk of cancer possibly via production of reactive oxygen species (ROS) which in turn induces oxidative damage to lipids, proteins and DNA. The aim of the study was to determine whether Fe-NT A causes DNA damage and targets TP 53 in human peripheral lymphocytes. (omitted)

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Identification and Analysis of Geosmin Production Potential of Anabaena stain Isolated from North Han River using Genetic Methods (유전자 기법을 이용한 북한강 수역 Anabaena strain의 동정 및 Geosmin 생산 잠재성 분석)

  • Kim, Keon Hee;Lim, Byung-Jin;You, Kyoung-A;Park, Myung-Hwan;Park, Jung Hwan;Kim, Baik-Ho;Hwang, Soon-Jin
    • Korean Journal of Ecology and Environment
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    • v.47 no.4
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    • pp.342-349
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    • 2014
  • This study was conducted to identify the bloom-forming Anabaena strains with two phenotypes (straight-type and coil-type) isolated from North Han River (Sambong-ri Joam-myun) using 16S rDNA sequence. The odor material producing potential was also examined using the geosmin-synthesizing gene cluster. Despite of striking morphological difference of the two stains, resembling A. circinalis and A. crassa species, the phylogenetic analysis using 16S rDNA identified the both strains as a single species of A. circinalis with high genetic similarity (98%~100%). Also, two Anabaena strains showed to possess the geosmin-synthesizing gene cluster, indicating that they are capable of producing the odor substance. This study is the first report that provides the direct evidence of geosmin production in the gene level by A. circinalis in Korea, and provides important basic information to identify the source alga of geosmin increase and its management in North Han River.