Iron overload induces damage of global DNA and TP 53 in human lymphocytes

  • Park, Eunju (Kyungnam University, Division of Life Sciences) ;
  • Beatrice, L.Pool Zobel (Friedrich Schiller University Jena, Department of Nutritional toxicology)
  • Published : 2003.05.01

Abstract

High iron consumption is associated with an increased risk of cancer possibly via production of reactive oxygen species (ROS) which in turn induces oxidative damage to lipids, proteins and DNA. The aim of the study was to determine whether Fe-NT A causes DNA damage and targets TP 53 in human peripheral lymphocytes. (omitted)

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