• Molecules and Cells
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• v.39 no.10
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• pp.722-727
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• 2016

Cardiomyopathy is a major cause of death worldwide. Based on pathohistological abnormalities and clinical manifestation, cardiomyopathies are categorized into several groups: hypertrophic, dilated, restricted, arrhythmogenic right ventricular, and unclassified. Dilated cardiomyopathy, which is characterized by dilation of the left ventricle and systolic dysfunction, is the most severe and prevalent form of cardiomyopathy and usually requires heart transplantation. Its etiology remains unclear. Recent genetic studies of single gene mutations have provided significant insights into the complex processes of cardiac dysfunction. To date, over 40 genes have been demonstrated to contribute to dilated cardiomyopathy. With advances in genetic screening techniques, novel genes associated with this disease are continuously being identified. The respective gene products can be classified into several functional groups such as sarcomere proteins, structural proteins, ion channels, and nuclear envelope proteins. Nuclear envelope proteins are emerging as potential molecular targets in dilated cardiomyopathy. Because they are not directly associated with contractile force generation and transmission, the molecular pathways through which these proteins cause cardiac muscle disorder remain unclear. However, nuclear envelope proteins are involved in many essential cellular processes. Therefore, integrating apparently distinct cellular processes is of great interest in elucidating the etiology of dilated cardiomyopathy. In this mini review, we summarize the genetic factors associated with dilated cardiomyopathy and discuss their cellular functions.

• Applied Microscopy
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• v.44 no.3
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• pp.96-99
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• 2014

Study on the egg envelope of an endemic Korean freshwater fish, Coreoleuciscus splendidus was carried out by light and scanning electron microscopes during its spawning season. The egg envelope on the entire egg is filled with plenty of long cylinder-like villi before and after fertilization. The fertilized eggs consist of two regions, the attaching and non-attaching parts to stick to the substrates. The villi covering the fertilized eggs have three kinds of villi in its length: 1) normal- sized villi of an average of $10.6{\mu}m$ on the non-attachment part; 2) longer and more slender villi over about $20{\mu}m$ on the attachment part, at least being two times longer than those of the non-attachment; and 3) shorter villi under about $5.0{\mu}m$ around the micropyle, with half the size of the non-attachment villi. The micropyle rotated in a counter-clockwise direction with five pieces of the ridges.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.29 no.2
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• pp.89-95
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• 2017

This study aimed to compare the primary heating energy consumption of regional apartment houses based on the enhanced thermal insulation performance of building envelope standards. The difference of the heating energy consumption based on the enhanced thermal insulation performance of building envelope standards in the southern region, the largest regional difference in primary heating energy consumption, is $10.3kWh/(m^2{\cdot}year)$. The difference of the heating energy consumption based on the enhanced thermal insulation performance of building envelope standards in the central region is $8.0{\sim}8.5kWh/(m^2{\cdot}year)$ and that of the Jeju region is $0.5kWh/(m^2{\cdot}year)$. These energy consumption differences do not result in building energy efficiency ratings changing. The building energy efficiency ratings have the possibility to be changed.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.21 no.9
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• pp.2470-2480
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• 1996

The energy efficiency and bandwidth efficiency are two important criterion in designing a modulation scheme Especially the constant envelope property must be considered as in the non-linear channel tht exit, for example in the nonlinear amplifiers for satellite repeater. The Q$^{2}$AM(Quadrature Quadrature Amplitude Modulation) is a new modulation scheme which combines the Q$^{2}$PSK(Quadrature Quadrature Phase Shift Keying) scheme which increases the signal space dimension and the QAM scheme which increases the bandwidth efficiency using the multi-level signal. The Q$^{2}$AM scheme has by far superior spectrum efficiency compared with the existing modulation schemes. Applying this scheme in the non-linear communication system increses the bandwidth efficiency but cannot envelop property. In this paper, a new system architecture is suggested which satisfies the large spectrum efficiency and constant envelope property by implementing the linear block coding prior to the Q$^{2}$AM modulation. the system has improved in performance by gaining the constant envelope and the additional coding gain. We able to observe the performance improvement of the suggested system(at BER=10$^{-5}$ ) of 4.4 dB for the 16-QAM and 0.7 dB for the Q$^{2}$PSK under the exact spectrum efficiency.

• ETRI Journal
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• v.33 no.5
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• pp.679-688
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• 2011

A new discrete-amplitude pulse width modulation (DAPWM) scheme for a high-efficiency linear power amplifier is proposed. A radio frequency (RF) input signal is divided into an envelope and a phase modulated carrier. The low-frequency envelope is modulated so that it can be represented by a pulse whose area is proportional to its amplitude. The modulated pulse has at least two different pulse amplitude levels in order that the duty ratios of the pulse are kept large for small input. Then, an RF pulse train is generated by mixing the modulated envelope with the phase modulated carrier. The RF pulse train is amplified by a switching-mode power amplifier, and the original RF input signal is restored by a band pass filter. Because duty ratios of the RF pulse train are kept large in spite of a small input envelope, the DAPWM technique can reduce loss from harmonic components. Furthermore, it reduces filtering efforts required to suppress harmonic components. Simulations show that the overall efficiency of the pulsed power amplifier with DAPWM is about 60.3% for a mobile WiMax signal. This is approximately a 73% increase compared to a pulsed power amplifier with PWM.

• Applied Microscopy
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• v.28 no.2
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• pp.237-253
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• 1998

The structures of the fertilizedegg envelope in threespecies of cyprinidae, leoparddanio (Brachydanio frankei), cherry barb (Barbustitteya) and white cloudmountain fish (Tanichthys albonubes) were investigated by light and electron microscopy. The fertilized eggs of all three species have colorless, transparent, spherical and non-floted type. The egg envelopes have a single micropylewhich is thought to the pathway of sperm in the area of the animal pole. Also, an outer layersof both cherry barband white cloud mountain fish areadhesive types, but in that of leoparddanio has non-adhesivetype. In leopard danio, an outer surface ofegg envelope is covered by mushroom-likestructure, that of cherry barb is arranged by button-like structure, and that of white cloud mountain fish isarranged by rod-likestructure. Inboth leopard danioand cherrybarb, the eggenvelopes consist of three distinct layers; an outer layer, a middle layer and an inner layer, and that of white cloud mountain fish hastwo layers. An innerlayer of egg envelopein leopard danio consist of 10 layers, cherry barb has 8 layers, and white cloud mountain fish has $5\sim6$ layers.

• International Journal of Naval Architecture and Ocean Engineering
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• v.11 no.1
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• pp.344-352
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• 2019

Marine production strings are continuously affected by unstable internal fluid during operation. In this paper, the structural governing equation for marine production string self-induced vibration is constructed. A finite element analysis model is established based on Euler-Bernoulli theory and solved by the Newmark method. Furthermore, based on reliability theory, a self-design procedure is developed to determine the operability envelope for marine production string self-induced vibration. Case studies show: the response frequency of the production strings is consistent with the excitation frequency under harmonic fluctuation and mainly determined by the first-order natural frequency under stochastic fluctuation. The operability envelope for marine production string self-induced vibration is a near symmetrical trapezium. With the increasing of natural gas output, the permissible fluctuation coefficient dramatically decreases. A reasonable centralizer spacing, increasing top tension, and controlling natural gas output are of great significance to the risk control in marine production string operation.

• ETRI Journal
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• v.43 no.6
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• pp.991-1003
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• 2021

Automatic modulation classification is essential in radar emitter identification. We propose a cascade classifier by combining a support vector machine (SVM) and convolutional neural network (CNN), considering that noise might be taken as radar signals. First, the SVM distinguishes noise signals by the main ridge slice feature of signals. Second, the complex envelope features of the predicted radar signals are extracted and placed into a designed CNN, where a modulation classification task is performed. Simulation results show that the SVM-CNN can effectively distinguish radar signals from noise. The overall probability of successful recognition (PSR) of modulation is 98.52% at 20 dB and 82.27% at -2 dB with low computation costs. Furthermore, we found that the accuracy of intermediate frequency estimation significantly affects the PSR. This study shows the possibility of training a classifier using complex envelope features. What the proposed CNN has learned can be interpreted as an equivalent matched filter consisting of a series of small filters that can provide different responses determined by envelope features.

• International conference on construction engineering and project management
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• 2013.01a
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• pp.553-557
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• 2013

Roof and exterior wall are designed and constructed in a manner that prevents the accumulation of water within the wall and roof assembly in the formal building. However, in a freeform building there is no clear distinction between exterior wall and roof. In other words, the exterior walls and roof systems of the freeform building are integrated as a surface, unlike the formal building envelope. Therefore, freeform architecture needs a systemized envelope design method to perform functions of exterior wall and roof. However, in many cases, construction methods for roof and exterior wall are applied to freeform buildings without necessary alterations, which lead to incomplete design, leakage, cracks and other problems. Freeform architecture is thus designed and constructed differently from formal buildings. In order to more easily and inexpensively actualize freeform architecture, Building Information Modeling (hereinafter referred to as BIM) has recently been applied in the construction industry. The studies and case analysis are not sufficient to identify the implications and contributions of freeform buildings in future similar projects. Therefore, this research will study design and construction methods for freeform surfaces. This study attempts to analyze the pros and cons of each method for the concrete surface frame, and then presents the panel options for envelope system of the freeform architecture.

• Journal of Microbiology and Biotechnology
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• v.18 no.3
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• pp.585-590
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• 2008

Human tropic Porcine Endogenous Retroviruses (PERVs) are the major concern in zoonosis for xenotransplantation because PERVs cannot be eliminated by specific pathogen-free breeding. Recently, a PERV A/C recombinant with PERV-C bearing PERV-A gp70 showed a higher infectivity (approximately 500-fold) to human cells than PERV-A. Additionally, the chance of recombination between PERVs and HERVs is frequently stated as another risk of xenografting. Overcoming zoonotic barriers in xenotransplantation is more complicated by recombination. To achieve successful xenotransplantation, studies on the recombination in PERVs are important. Here, we cloned and sequenced proviral PERV env sequences from pig gDNAs to analyze natural recombination. The envelope is the most important element in retroviruses as a pivotal determinant of host tropisms. As a result, a total of 164 PERV envelope genes were cloned from pigs (four conventional pigs and two miniature pigs). Distribution analysis and recombination analysis of PERVs were performed. Among them, five A/B recombinant clones were identified. Based on our analysis, we determined the minimum natural recombination frequency among PERVs to be 3%. Although a functional recombinant envelope clone was not found, our data evidently show that the recombination event among PERVs may occur naturally in pigs with a rather high possibility.