• Radiation Oncology Journal
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• v.34 no.4
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• pp.239-249
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• 2016

Tumor hypoxia, a common feature occurring in nearly all human solid tumors is a major contributing factor for failures of anticancer therapies. Because ionizing radiation depends heavily on the presence of molecular oxygen to produce cytotoxic effect, the negative impact of tumor hypoxia had long been recognized. In this review, we will highlight some of the past attempts to overcome tumor hypoxia including hypoxic radiosensitizers and hypoxia-selective cytotoxin. Although they were (still are) a very clever idea, they lacked clinical efficacy largely because of 'reoxygenation' phenomenon occurring in the conventional low dose hyperfractionation radiotherapy prevented proper activation of these compounds. Recent meta-analysis and imaging studies do however indicate that there may be a significant clinical benefit in lowering the locoregional failures by using these compounds. Latest technological advancement in radiotherapy has allowed to deliver high doses of radiation conformally to the tumor volume. Although this technology has brought superb clinical responses for many types of cancer, recent modeling studies have predicted that tumor hypoxia is even more serious because 'reoxygenation' is low thereby leaving a large portion of hypoxic tumor cells behind. Wouldn't it be then reasonable to combine hypoxic radiosensitizers and/or hypoxia-selective cytotoxin with the latest radiotherapy? We will provide some preclinical and clinical evidence to support this idea hoping to revamp an enthusiasm for hypoxic radiosensitizers or hypoxia-selective cytotoxins as an adjunct therapy for radiotherapy.

• Journal of dental hygiene science
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• v.19 no.4
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• pp.220-227
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• 2019

Background: This descriptive study aimed to examine the relationship between the 4C core competencies and work ability among dental hygienists. Methods: From November 2018 to January 2019, data were collected-from 190 dental hygienists workong in dental clinics in Busan, Ulsan, and Gyeongsangnam province using structured questionnaires. For the general characteristics of the dental hygienists, frequency and percentage were calculated, and the level of the 4C core competencies and work ability of dental hygienists was calculated using means and standard deviations. A multiple regression analysis was conducted to analyze the effects of the 4C core competencies on work ability. Results: The mean scores for the 4C core competency levels of the dental hygienists were as follows: communication ability 3.34, critical thinking ability 3.41, creative problem-solving 3.40, and collaborative self-efficacy 3.27. Meanwhile the mean score for work ability level was 3.65. The predictive factors influencing work ability were communication ability and cooperative self-efficacy (p<0.001), and the sub-factors of critical thinking ability that affect work ability were sound conferences (p<0.01), intellectual fairness (p<0.05), intellectual enthusiasm (p<0.05), and self-confidence (p<0.001). Finally, the sub-factors of creative problem-solving ability that affect work ability were planning and execution (p<0.01) and performance evaluation (p<0.05). Conclusion: The current study showed that education programs covering the core competencies of dental hygienists, rather than the existing theoretical education program, should be developed and implemented to enhance 4C core competencies that affect work ability.

• Journal of The Korean Association of Information Education
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• v.9 no.2
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• pp.349-358
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• 2005

It is not sufficient to give a lecture in programming language without programming practice since lectures on programming must be given at lecture room with H/W and S/W for programming. In this paper, learning for Visual Basic programming has been designed and embodied with the leveled learning system in order to give an effective and positive result to both teacher and learner under the constructivism theory of education (Problem Based learning, Self-Directed learning) for the theoretical basis of the seventh education curriculum. We implemented a web courseware for Visual Basic programming using ActiveX and Tutor System. As the result of education using this courseware, it is verified as a leveled education method to adapt the learning ability of individual students, and it can raise the achievement, enthusiasm of learning and provide various opportunity of education with this various education methods. Also it enhances the problem solving ability and the logical thinking power by providing students with error correction learning.

• Journal of the Korean Geographical Society
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• v.32 no.4
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• pp.575-584
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• 1997

So how can we develop balanced growth in our country? The national development policy of our hovemment over the past 30 years has lead to the corpulence of Seoul at the expense of the provinces. Now ironically there are policy measures introduced to control the over-expansion of Seoul. Yet the current hardware stategies to control the center requires an additional sofware stategy to create a nationwide balance for development. The Regional Elite Quota System is one such sofware stategy which can adjust the unbalanced distribution of gifted student across the national university deucation system. One obvious solution that should be utillzed is the incredible enthusiasm for high education that exists in this country, perhaps the highest in the world. This has been the backbone of our national development and should be hamessed as a catalyst to produce more balanced national growth.

• Korean Journal of Biological Psychiatry
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• v.24 no.4
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• pp.167-174
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• 2017

Based on advances in biotechnology and neuroscience, neuromodulation is poised to gain clinical importance as a treatment modality for psychiatric disorders. In addition to old-established electroconvulsive therapy (ECT), clinicians are expected to understand newer forms of neurostimulation, such as deep brain stimulation (DBS), vagus nerve stimulation (VNS), repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS). Given the growing interest in non-invasive neuromodulation technologies, clinicians may seek sufficient information about neuromodulation to inform their clinical practice. A growing literature suggests that applications of non-invasive neuromodulation have evidence particularly for indications where treatments are currently insufficient, such as drug-resistant depression. However, positive neuromodulation studies require replication, and the precise interactions among stimulation, antidepressant medication, and psychotherapy are unknown. Further studies of long-term safety and the impact on the developing brain are needed. Non-invasive neuromodulatory devices could enable more individualized treatment. However, do-it-yourself (DIY) stimulation kits require a better understanding of the effects of more frequent patterns of stimulation and raise concerns about clinical supervision, regulation, and reimbursement. Wide spread enthusiasm for therapeutic potential of neuromodulation in clinical practice settings should be mitigated by the fact that there are still research gaps and challenges associated with non-invasive neuromodulatory devices.

• Journal of the Korean School Mathematics Society
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• v.10 no.3
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• pp.303-322
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• 2007

This study is to investigate student's processes of problem solving using open-ended Geometric problems to understand student's thinking and behavior. One 8th grader participated in performing her learning in 5 lessons for June in 2006. The result of the study was documented according to Polya's four problem solving stages as follows: First, the student tended to neglect the stage of "understanding" a problem in the beginning. However, the student was observed to make it simplify and relate to what she had teamed previously Second, "devising a plan" was not simply done. She attempted to solve the open-ended problems with more various ways and became to have the metacognitive knowledge, leading her to think back and correct her errors of solving a problem. Third, in process of "carrying out" the plan she controled her solving a problem to become a better solver based on failure of solving a problem. Fourth, she recognized the necessity of "looking back" stage through the open ended problems which led her to apply and generalize mathematical problems to the real life. In conclusion, it was found that the student enjoyed her solving with enthusiasm, building mathematical belief systems with challenging spirit and developing mathematical power.

• Archives of design research
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• v.16 no.3
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• pp.175-182
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• 2003

The objective of this study is to systematically understand the swiss graphic style and examine the design ideology of designers and the visual features, with the focus on the posters that played the largest role in the formation and settlement of the swiss graphic style. Although through other visual designs such as editorial design, from the outside beyond posters, the swiss graphic style has evolved to exert a large influence around the world, based on the posters that served as the main medium for expression by designers and that were used the most in instigating the public, this study aims to cast light on the swiss graphic style, which has become recognized as the textbook of the graphic design around the world since the mid 20th century. First, the study casts light on the meaning of the creation of the graphic style through the background and the formation process, aiming to examine the visual features of the swiss graphic style and how they are integrated through the posters of Swiss designers. The personal activities and efforts of individual designers contributed significantly to the formation and development of a certain design style; however this study intends to identify the other equally important elements: the underlying social and cultural influence, the legacy of previous design styles and ideologies, the collective enthusiasm of designers, and the active progress of experimental research.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.12
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• pp.5184-5190
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• 2010

This study chiefly aims to find out the efficient ways of organizing teams of architectural design projects. In order to reach this goal, this study analyzed (1) specialties of students' projects during semesters in architectural design studios, (2) teaching methods relevant to architectural design education, (3) division of role play in architectural studios and organizing method that students prefer. Besides, in order to clarify the principles of practical project team organization and to find out more efficient methods in team organization, this study executed archival research on (1) specialties of team organization rules and principles in architectural firms, (2) types and merits of projects teams, (3) efficient methods of dividing roles. For the students project of the studio, it is desirable to switch the roles of team leader and staff members of the team to make members' feeling of participating the decision making of the project progress. In architectural design team, since the high productivity was valued beyond individual preferences, the team organization and and work split was done on the basis of (1) experiences, (2) design ability, (3) schedule of the project, etc. However, for the continuous motivation and enthusiasm for the firms, it is required to study efficient ways of team organization.

• Journal for History of Mathematics
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• v.23 no.2
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• pp.1-21
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• 2010

The first Korean mathematical science journal was published by Yu, Il- Sun in 1905 and the name of this journal is "Mathematical Science magazine". This monthly journal was published for 2 years. But in the existing literature, there is no information about it. We discovered its existence and studied its contents. From the historical materials, pioneering contributions of Yu, Il-Sun to mathematics were provided. In this article, the first issue of this journal was fully analyzed. We could see his affection and enthusiasm for the journal that he started. More mathematical search efforts on finding historical math materials should be continued. More efforts should be made on finding historical math literatures. Related researches will be done. Those works will be worth to be shared in ICME-12 and ICM 2014.

• Journal of Internet of Things and Convergence
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• v.3 no.2
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• pp.33-39
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• 2017

The purpose of this study is to analyze the characteristics of talents required in electronic companies in the 4th industrial revolution. we conducted a network analysis on the key talent of the companies presented in over 100 job announcements to companies in the electronics industry. The results of the study are as follows. First, electronic companies showed the most favored creative talents, preferring collaborative talent and challenging talent. Second, looking at the core definitions of talent, change, response, problem solving, performance creation, communication, challenge, professionalism, enthusiasm, development, aggressiveness and spontaneity were used. In other words, key keywords emerging from the 4^th industrial revolution were being used continuously. Third, in the Centrality analysis, talented people who emphasize humanity also appeared. Based on the study, it suggested that manpower training of the 4^th Industrial Revolution.