• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2003년도 제2차 연례학술대회 발표논문집
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• pp.251-257
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• 2003

Metabolic engineering has become a new paradigm for the more efficient production of desired bioproducts. Metabolic engineering can be defined as directed modification of cellular metabolism and properties through the introduction, deletion, and modification of metabolic pathways by using recombinant DNA and other molecular biological tools. During the last decade, metabolic flux analysis(MFA) has become an essential tool fur metabolic engineering. By MFA, the intracellular metabolic fluxes can be quantified by the measurement of extracellular metabolite concentrations in combination with the stoichiometry of intracellular reactions and mass balances. The usefulness and functionality of MFA are demonstrated by applying to metabolic pathways in E. coli. First, a large-scale in silico E. coli model is constructed, and then the effects of carbon sources on intracellular flux distributions and succinic acid production were investigated on the basis of the uptake and secretion rates of the relevant metabolites. The results indicated that succinic acid yields increased in order of gluconate, glucose and sorbitol. Acetic acid and lactic acid were produced as major products rather than when gluconate and glucose were used carbon sources. The results indicated that among three carbon sources available, the most reduced substrate is sorbitol which yields efficient succinic acid production.

• 한국미생물·생명공학회지
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• 제21권4호
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• pp.354-365
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• 1993

A novel control method with automatic tuning of PID controller parameters has been developed for efficient regulation of dissolved oxygen concentration in fed-batch fermentations of Escherichia coli. Agitation speed and oxygen partial pressure in the inlet gas stream were chosen to be the manipulated variables. A heuristic reasoning allowed improved tuning decisions from the supervision of control performance indices and it coule obviate the needs for process assumptions or disturbance patterns. The control input consisted of feedback and feedforword parts. The feedback part was determined by PID control and the feedforward part is determined from the feed rate. The proportional gain was updated on-line by a set of heuristics rules based on the supervision of three performance indices. These indices were output error covariance, the average value of output error, and input covariance, which were calculated on-line using a moving window. The integral and derivative time constants were determined from the period of output response. The specific growth rate was maintained at a low level to avoid acetic acid accumulation and thus to achieve a high cell density. The specific growthe rate was estimated from the carbon dioxide evolution rate. In fed-batch fermentation, the simutaneous control of dissolved oxygen concentration (at 0.2; fraction of saturated value) and specific growth rate (at 0.25$hr^{-1}$) was satisfactory for the entire culture period in spite of the changes in the feed rate and the switching of control input.

• 상하수도학회지
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• 제32권4호
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• pp.317-324
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• 2018

SWRO-PRO hybrid desalination technology is recently getting more attention especially in large desalination markets such as USA, Middle East, Japan, Singapore, etc. because of its promising potential to recover a considerable amount of osmotic energy from brine (a high-concentration solution of salt, 60,000 - 80,000 mg/L) and also to minimize the impact of the discharged brine into a marine ecosystem. By the research and development of the core technologies of the SWRO-PRO desalination system in a national desalination research project (Global MVP) supported by Ministry of Land, Infrastructure, and Transport (MOLIT) and Korea Agency for Infrastructure Technology Advancement (KAIA), it is anticipated that around 25% of total energy consumption rate (generally 3 to $4kWh/m^3$) of the SWRO desalination can be reduced by recovering the brine's osmotic energy utilizing wastewater treatment effluent as a PRO feed solution and an isobaric pressure exchanger (PX, ERI) as a PRO energy converter. However, there are still several challenges needed to be overcome in order to ultimately commercialize the novel SWRO-PRO process. They include system optimization and integration, development of efficient PRO membrane and module, development of PRO membrane fouling control technology, development of design and operation technology for the system scaling-up, development of diverse business models, and so on. In this paper, the current status and progress of the pilot study of the newly developed SWRO-PRO hybrid desalination technology is discussed.

• 한국분말재료학회지
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• 제27권6호
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• pp.490-497
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• 2020

The 3D printing process provides a higher degree of freedom when designing ceramic parts than the conventional press forming process. However, the generation and growth of the microcracks induced during heat treatment is thought to be due to the occurrence of local tensile stress caused by the thermal decomposition of the binder inside the green body. In this study, an alumina columnar specimen, which is a representative ceramic material, is fabricated using the digital light process (DLP) 3D printing method. DTG analysis is performed to investigate the cause of the occurrence of microcracks by analyzing the debinding process in which microcracks are mainly generated. HDDA of epoxy acrylates, which is the main binder, rapidly debinded in the range of 200 to 500℃, and microcracks are observed because of real-time microscopic image observation. For mitigating the rapid debinding process of HDDA, other types of acrylates PETA, PUA, and MMA are added, and the effect of these additives on the debinding rate is investigated. By analyzing the DTG in the 25 to 300℃ region, it is confirmed that the PETA monomer and the PUA monomer can suppress the rapid decomposition rate of HDDA in this temperature range.

• 정보과학회 논문지
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• 제44권5호
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• pp.510-521
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• 2017

소프트웨어 개발 프로세스(Software Development Process: SDP)는 소프트웨어공학 교육에서 가장 기초적이며 중심적인 역할을 한다. 모든 소프트웨어는 개발의 시작부터 마지막까지를 모두 포함하는 특정 SDP에 기반해서 개발된다. 따라서, SDP 교육은 소프트웨어공학의 제반 기술에 대한 이해를 도울 수 있다. 본 논문은 대학의 소프트웨어공학 수업에서 활용할 수 있는 소프트웨어 개발 방법론(프로세스)인 OOPT(Object Oriented Process with Traceability)를 소개한다. OOPT는 객체지향 소프트웨어를 개발하기 위한 방법론으로서, 각 단계마다 구체적인 요구사항과 산출물을 정의하고 있으며, 단위/시스템 시험 및 추적성 분석 등의 추가적인 내용들도 포함하고 있다. 본 논문은 OOPT에 대한 적용 사례로서 다년간의 건국대학교 컴퓨터공학과 소프트웨어공학 관련 수업들을 소개하고 있으며, 향후 개선 및 발전 방향을 포함한다.

• 한국정밀공학회지
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• 제19권2호
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• pp.79-86
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• 2002

In end milling process the undeformed chip thickness and the cutting force components vary periodically with phase change of the tool. In this study, up end milling process is transformed to the equivalent oblique cutting. The varying undeformed chip thickness and the cutting force components in end milling process are replaced with the equivalent average ones. Then it can be possible to analyze the chip-tool friction and shear process in the shear plane of the end milling process by the equivalent oblique cutting system. According to this analysis, when cutting Inconel 718, 61, 64 and 55% of the total energy is consumed in the shear process with the helix angle 30$^{\circ}$, 40$^{\circ}$ and 50$^{\circ}$ respectively, and the balance is consumed in the friction process. With the helix angle of 40$^{\circ}$ the specific cutting energy consumed is smaller than with the helix angle 30$^{\circ}$ and 50$^{\circ}$.

• JSTS:Journal of Semiconductor Technology and Science
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• 제10권3호
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• pp.213-224
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• 2010

An optically controlled silicon MESFET (OPFET) was fabricated by diffusion process to enhance the quantum efficiency, which is the most important optoelectronic device performance usually affected by ion implantation process due to large number of process induced defects. The desired impurity distribution profile and the junction depth were obtained solely with diffusion, and etching processes monitored by atomic force microscope, spreading resistance profiling and C-V measurements. With this approach fabrication induced defects are reduced, leading to significantly improved performance. The fabricated OPFET devices showed proper I-V characteristics with desired pinch-off voltage and threshold voltage for normally-on devices. The peak photoresponsivity was obtained at 620 nm wavelength and the extracted external quantum efficiency from the photoresponse plot was found to be approximately 87.9%. This result is evidence of enhancement of device quantum efficiency fabricated by the diffusion process. It also supports the fact that the diffusion process is an extremely suitable process for fabrication of high performance optoelectronic devices. The maximum gain of OPFET at optical modulated signal was obtained at the frequency of 1 MHz with rise time and fall time approximately of 480 nS. The extracted transconductance shows the possible potential of device speed performance improvements for shorter gate length. The results support the use of a diffusion process for fabrication of high performance optoelectronic devices.

• Journal of Welding and Joining
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• 제32권2호
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• pp.22-28
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• 2014

To enhance productivity and provide high quality production material in a GMA welding process, weld quality, productivity and cost reduction affects the number of process variables. In addition, a reliable welding process and conditions must be implemented to reduce weld structure failure. In various industries the welding process mathematical model is not fully formulated for the process parameter and on the welding conditions, therefore only partial variables can be predicted. The research investigates the interaction between the welding parameters (welding speed, distance between electrodes, and flow rate of shielding gas) and bead geometry for predicting the weld bead geometry (bead width, bead height). Taguchi techniques are applied to bead shape to develope curve equation for predicting the optimized process parameters and quality characteristics by analyzing the S/N ratio. The experimental results and measured error is within the range of 10% presenting satisfactory accuracy. The curve equation was developed in such a way that you can predict the bead geometry of constructed machinery that can be used for making tandem welding process.

• 한국건설관리학회논문집
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• 제23권4호
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• pp.47-56
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• 2022

건설 프로젝트에서 공정계획은 사업 성패의 중요한 요인으로 작용한다. 그 중 공동주택 마감공사는 기초공사나 골조공사에 비해 작업 간의 간섭이 많다. 이로 인해 마감공사 시 공정관리 효율성 증대를 위한 Tact 공정관리기법이 적용되고 있다. Tact 공정관리는 작업 흐름이 일정하게 발생할 수 있도록 관리하며 마감 단위층을 통일시켜 작업속도를 균등화시킨다. 그러나 세부공종을 고려하지 않고 모든 작업이 균일하게 동기화되어 공사비가 증가하고 비효율적인 공정관리가 나타난다. 본 연구는 세부공종의 특성을 고려할 필요가 있다고 판단되어 기존 Tact 공정관리방식의 한계점을 파악하고 개선하고자 세부공종을 고려한 복합병행 Tact기법을 제안한다. 또한 기존 Tact기법과 복합병행 Tact기법을 비교분석하여 도출한 결과를 기반으로 복합병행 Tact기법의 타당성 및 실효성을 검증했다.

• 품질경영학회지
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• 제52권1호
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• pp.43-56
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• 2024

Purpose: The injection molding process, crucial for plastic shaping, encounters difficulties in sustaining product quality when replacing injection machines. Variations in machine types and outputs between different production lines or factories increase the risk of quality deterioration. In response, the study aims to develop a system that optimally adjusts conditions during the replacement of injection machines linked to molds. Methods: Utilizing a dataset of 12 injection process variables and 52 corresponding sensor variables, a predictive model is crafted using Decision Tree, Random Forest, and XGBoost. Model evaluation is conducted using an 80% training data and a 20% test data split. The dependent variable, classified into five characteristics based on temperature and pressure, guides the prediction model. Bayesian optimization, integrated into the selected model, determines optimal values for process variables during the replacement of injection machines. The iterative convergence of sensor prediction values to the optimum range is visually confirmed, aligning them with the target range. Experimental results validate the proposed approach. Results: Post-experiment analysis indicates the superiority of the XGBoost model across all five characteristics, achieving a combined high performance of 0.81 and a Mean Absolute Error (MAE) of 0.77. The study introduces a method for optimizing initial conditions in the injection process during machine replacement, utilizing Bayesian optimization. This streamlined approach reduces both time and costs, thereby enhancing process efficiency. Conclusion: This research contributes practical insights to the optimization literature, offering valuable guidance for industries seeking streamlined and cost-effective methods for machine replacement in injection molding.