• Journal of Institute of Control, Robotics and Systems
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• v.17 no.6
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• pp.552-557
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• 2011

This paper presents experimental results on the energy-bounding approach to a rate-mode bilateral teleoperation control that can guarantee the robust system stability in variable time-delayed telecommunication environments. Previously, rate-mode energy bounding approach [15] was proposed and verified with experimental results using the simulated remote slave model. In this paper, a real experimental setup using an industrial robot (Denso) as a remote slave robot composed and conducted similar experiments with previous paper. In order to guarantee stability of the Denso when contacting with high impedance wall, velocity based impedance control modified by position based is used. Experimental results show that the rate-mode energy bounding approach can guarantee stable bilateral teleoperation system in the free and contact motion with variable time delay.

• Molecules and Cells
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• v.43 no.1
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• pp.58-65
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• 2020

Fat mass and obesity-associated (FTO) gene helps to regulate energy homeostasis in mammals by controlling energy expenditure. In addition, FTO functions in the regulation of obesity and adipogenic differentiation; however, a role in osteogenic differentiation is unknown. This study investigated the effects of FTO on osteogenic differentiation of C3H10T1/2 cells and the underlying mechanism. Expression of osteogenic and endoplasmic reticulum (ER) stress markers were characterized by reverse-transcriptase polymerase chain reaction and western blotting. Alkaline phosphatase (ALP) staining was performed to assess ALP activity. BMP2 treatment increased mRNA expression of osteogenic genes and FTO. Overexpression of FTO increased expression of the osteogenic genes distal-less homeobox5 (Dlx5) and runt-related transcription factor 2 (Runx2). Activation of adenosine monophosphate-activated protein kinase (AMPK) increased FTO expression, and there was a positive feedback loop between FTO and p-AMPK. p-AMPK and FTO induced mild ER stress; however, tunicamycin-induced severe ER stress suppressed FTO expression and AMPK activation. In summary, FTO induces osteogenic differentiation of C3H10T1/2 cells upon BMP2 treatment by inducing mild ER stress via a positive feedback loop with p-AMPK. FTO expression and AMPK activation induce mild ER stress. By contrast, severe ER stress inhibits osteogenic differentiation by suppressing FTO expression and AMPK activation.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2008.11a
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• pp.247-252
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• 2008

This paper presents an active vibration control of cantilever beams under disturbances by a primary force. A direct velocity feedback control using a pair of PZT actuator and a velocity sensor is considered. Variation of the stability and performance with the locations of the sensor/actuator pair is investigated. It is found that the maximum gain varies with the locations of the sensor/actuator pair significantly. The maximum gain shows a symmetric distribution along the beam length with respect to the center point, although the boundary condition of the beam is unsymmetric. The control performance is affected by the location of the primary force as well as the location of the sensor/actuator pair. The active control system can more effectively reduce the vibration when the primary force is located close to the fixed boundary.

• Earthquakes and Structures
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• v.10 no.5
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• pp.1067-1087
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• 2016

In this paper, a decoupled proportional-integral-derivative (PID) control approach for seismic control of smart structures is presented. First, the state space equation of a structure is transformed into modal coordinates and parameters of the modal PID control are separately designed in a reduced modal space. Then, the feedback gain matrix of the controller is obtained based on the contribution of modal responses to the structural responses. The performance of the controller is investigated to adjust control force of piezoelectric friction dampers (PFDs) in a benchmark base isolated building. In order to tune the modal feedback gain of the controller, a suitable trade-off among the conflicting objectives, i.e., the reduction of maximum modal base displacement and the maximum modal floor acceleration of the smart base isolated structure, as well as the maximum modal control force, is created using a multi-objective cuckoo search (MOCS) algorithm. In terms of reduction of maximum base displacement and story acceleration, numerical simulations show that the proposed method performs better than other reported controllers in the literature. Moreover, simulation results show that the PFDs are able to efficiently dissipate the input excitation energy and reduce the damage energy of the structure. Overall, the proposed control strategy provides a simple strategy to tune the control forces and reduces the number of sensors of the control system to the number of controlled stories.

• International Journal of Control, Automation, and Systems
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• v.5 no.5
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• pp.547-558
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• 2007

This paper proposes a simpler solution to the stabilization problem of a special class of nonlinear underactuated mechanical systems which includes widely studied benchmark systems like Inertia Wheel Pendulum, TORA and Acrobot. Complex internal dynamics and lack of exact feedback linearizibility of these systems makes design of control law a challenging task. Stabilization of these systems has been achieved using Energy Shaping and damping injection and Backstepping technique. Former results in hybrid or switching architectures that make stability analysis complicated whereas use of backstepping some times requires closed form explicit solutions of highly nonlinear equations resulting from partial feedback linearization. It also exhibits the phenomenon of explosions of terms resulting in a highly complicated control law. Exploiting recently introduced Dynamic Surface Control technique and using control Lyapunov function method, a novel nonlinear controller design is presented as a solution to these problems. The stability of the closed loop system is analyzed by exploiting its two-time scale nature and applying concepts from Singular Perturbation Theory. The design procedure is shown to be simpler and more intuitive than existing designs. Design has been applied to important benchmark systems belonging to the class demonstrating controller design simplicity. Advantages over conventional Energy Shaping and Backstepping controllers are analyzed theoretically and performance is verified using numerical simulations.

• Transactions of the Korean hydrogen and new energy society
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• v.18 no.3
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• pp.292-300
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• 2007

A dynamic system model of a proton exchange membrane fuel cell(PEMFC) has been developed. The PEMFC of this study has large active area with water cooling in order to simulate the performance of the commercially viable PEMFC system for the transportation. A PEMFC stack model is a transient thermal model which is respond to the dynamic change of the coolant temperature and the flow rate. The dynamic cooling system model has been developed to determine the coolant flow rate and the coolant temperature. Prior to the system level study, thermal management criteria have been set up and brought to the control command of the cooling system. Since the system model is designed to evaluate the effect of thermal management on the system performance, it is attempted to determine the proper control algorithm of the cooling system so that the PEMFC system is working on the thermal management criteria. As a result of simulation, feedback controlled cooling system consumes less power and produce more power comparing with that of conventionally controlled cooling system.

• Nuclear Engineering and Technology
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• v.48 no.3
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• pp.660-672
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• 2016

In Part I of this paper, the two-temperature homogenized model for the fully ceramic microencapsulated fuel, in which tristructural isotropic particles are randomly dispersed in a fine lattice stochastic structure, was discussed. In this model, the fuel-kernel and silicon carbide matrix temperatures are distinguished. Moreover, the obtained temperature profiles are more realistic than those obtained using other models. Using the temperature-dependent thermal conductivities of uranium nitride and the silicon carbide matrix, temperature-dependent homogenized parameters were obtained. In Part II of the paper, coupled with the COREDAX code, a reactor core loaded by fully ceramic microencapsulated fuel in which tristructural isotropic particles are randomly dispersed in the fine lattice stochastic structure is analyzed via a two-temperature homogenized model at steady and transient states. The results are compared with those from harmonic- and volumetric-average thermal conductivity models; i.e., we compare $k_{eff}$ eigenvalues, power distributions, and temperature profiles in the hottest single channel at a steady state. At transient states, we compare total power, average energy deposition, and maximum temperatures in the hottest single channel obtained by the different thermal analysis models. The different thermal analysis models and the availability of fuel-kernel temperatures in the two-temperature homogenized model for Doppler temperature feedback lead to significant differences.

• Journal of Yeungnam Medical Science
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• v.30 no.1
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• pp.4-9
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• 2013

Leptin, a 16-kDa cytokine, is secreted by adipose tissue in response to the surplus of fat store. Thereby, the brain is informed about the body's energy status. In the hypothalamus, leptin triggers specific neuronal subpopulations (e.g., POMC and NPY neurons) and activates several intracellular signaling events, including the JAK/STAT, MAPK, PI3K, and mTOR pathway, which eventually translates into decreased food intake and increased energy expenditure. Leptin signal is inhibited by a feedback inhibitory pathway mediated by SOCS3. PTP1B involves another inhibitory pathway of leptin. Leptin potently promotes fat mass loss and body weight reduction in lean subjects. However, it is not widely used in the clinical field because of leptin resistance, which is a common feature of obesity characterized by hyperleptinemia and the failure of exogenous leptin administration to provide therapeutic benefit in rodents and humans. The potential mechanisms of leptin resistance include the following: 1) increases in circulating leptin-binding proteins, 2) reduced transport of leptin across the blood-brain barrier, 3) decreased leptin receptor-B (LRB), and/or 4) the provocation of processes that diminish cellular leptin signaling (inflammation, endoplasmic reticulum stress, feedback inhibition, etc.). Thus, interference of the cellular mechanisms that attenuate leptin signaling improves leptin action in cells and animal models, suggesting the potential utility of these processes as points of therapeutic intervention. Various experimental trials and compounds that improve leptin resistance are introduced in this paper.

• Nuclear Engineering and Technology
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• v.25 no.1
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• pp.136-147
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• 1993

The paper describes : ⅰ) Mathematical modeling of poloidal flux to define and calculate the tokamak plasma position based on a property of the plasma boundary which is always a flux surface. Controlling the plasma boundary position is therefore equivalent to equalizing the flux value on several points belonging to a curve tangent to the limiter. ⅱ) Experimental method for determining the outmost poloidal isoflux surface by a linear combination of measurements of magnetic fluxes, fields and field gradients, without requiring knowledge of internal plasma parameters for the feedback control, i.e., with neither corrections for variation in the poloidal beta and the plasma current distribution, nor compensations for the induced currents in the vacuum vessel. ⅲ) Feedback control algorithm for the regulation of plasma boundary position and its electronics hardware based on the PID control theory. ⅳ) Experimental results obtained from the RTP tokamak experiments using the present plasma control system.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.18 no.12
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• pp.1293-1300
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• 2008

This paper presents an active vibration control of cantilever beams under disturbances by a primary force. A direct velocity feedback control using a pair of PZT actuator and a velocity sensor is considered. Variation of the stability and performance with the locations of the sensor/actuator pair is investigated. It is found that the maximum gain varies with the locations of the sensor/actuator pair significantly. The maximum gain shows a symmetric distribution along the beam length with respect to the center point, although the boundary condition of the beam is unsymmetric. The control performance is affected by the location of the primary force as well as the location of the sensor/actuator pair. The active control system can more effectively reduce the vibration when the primary force is located close to the fixed boundary.