• 한국세라믹학회지
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• 제35권6호
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• pp.543-550
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• 1998

에멀젼 증발법에 의해 구형의 산화텅스텐 분말을 제조하는 연구를 하였다. 분말의 특성은 TGA, X-ray 회절, SEM, image analysis 등을 이용하여 조사하였다. 텅스텐 이온이 함유된 수상과 등유, 계면활성제, 파라핀유로 이루어진 유기상을 고속으로 교반하여 에멀젼을 제조하였다. 에멀젼을 $160^{\circ}C$의 등유욕내에서 증발시틴 후 얻어진 침전물을 $160^{\circ}C$에서 하소하여 텅스텐 산화 분말을 제조하였다. 산화텅스텐 분말의 평균 입경은 $0.5\;\mu\textrm{m}$ 였으며 모양은 구형이었다. Watre-in-oil형 에멀젼으로 제조된 $W_{3}$는 oil-in-water 형의 것보다 응집도가 적었다. 계면활성제의 HLB값이 증가할수록, 에멀젼 중의 텅스텐 이온의 농도가 감소할수록 평균입도가 작아졌으며, $W_{3}$ 입자들의 응집도는 증가하였다. 계면활정제로 사용한 Span 80의 농도는 8 vol%가 적당했고, 에멀젼 제조시 교반속도는 5000rpm이 적당했다.

• 한국분말재료학회지
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• 제9권2호
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• pp.89-95
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• 2002

Spherical fine powders of tungsten oxide powders were prepared by the emulsion evaporation method. The characteristics of the powders prepared were examined by means of TGA, X-ray diffraction, SEM and image analysis. The emulsions were prepared by fast mixing of aqueous phase containing tugsten and the organic phase which composed of kerosene, surfactant, and paraffin oil. Precursors were made by evaporating the emulsionin the kerosene bath at $160^{\circ}C$, and then calcined at $650^{\circ}C$ in order to produce tungsten oxide powders. The average particle size of the tungsten oxide powders was $0.5\mutextrm{m}$ and their shapes were spherical at the both case of w/o and o/w type emulsions. As the HLB value of the surfactant increased and the concentration of tungsten ions decreased the mean particle siqe of tungsten oxide powders decreased whereas agglomerationsize increased. The optimum concentration of Span 80 was 8 percent by volume, and the optimum stirring speed in the emulsion formation was 5000 rpm in order to obtain fine and well dispersed $WO_3$ powders.

• Food Science and Biotechnology
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• 제18권1호
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• pp.157-161
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• 2009

Resveratrol-loaded poly($\varepsilon$-caprolactone) (PCL) nanoparticles were prepared by oil in water (O/W) emulsion solvent evaporation method. The morphology of the nanoparticles was evaluated using atomic force microscope (AFM), in which well-shaped and rigid nanoparticles were prepared. The mean particle size of nanoparticles prepared using only dichloromethane (DCM) ($523.5{\pm}36.7\;nm$) was larger than that prepared with a mixture of DCM and either ethanol (EtOH) ($494.5{\pm}29.2\;nm$) or acetone ($493.5{\pm}6.9\;nm$). The encapsulation efficiency of nanoparticles prepared only with DCM as dispersed phase ($78.3{\pm}7.7%$) was the highest of those prepared with solvent mixtures. An increase in the molecular weight of PCL led to an increase in encapsulation efficiency (from $78.3{\pm}7.7$ to $91.4{\pm}3.2%$). Pluronic F-127 produced the smallest mean size ($523.5{\pm}36.7\;nm$) with the narrowest particle size distribution. These results show that dispersed phase, molecular weight of wall materials, emulsion stabilizer could be important factors to affect the properties of nanoparticles.

• 약학회지
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• 제44권6호
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• pp.511-520
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• 2000

Various bupivacaine-loaded microspheres were prepared from poly (d,l-lactide) (PLA) or poly (d,l-lactic-co-glycolide) (PLGA) by a solvent evaporation method for the sustained release of drug. PLA and PLGA microspheres were prepared by w/o/w and w/o/o multiple emulsion solvent evaporation, respectively. The effects of process conditions such as emulsification speed, emulsifier type, emulsifier concentration and internal/external phase ratio on the characteristics of microspheres were investigated. The prepared microspheres were characterized for their drug loading, size distribution, surface morphology and release kinetics. Drug loading efficiency was higher in the microspheres prepared by w/o/o multiple emulsion than that by w/o/w multiple emulsion method, because the solubility of bupivacaine HCI was decreased in oil phase compared with water phase. The prepared microspheres had an average diameter between 1 and $2\;{\mu}M$ in all conditions of two methods. In morphology studies the PLA microspheres showed an irregular shape and smooth surface, but PLGA microspheres had a spherical shape and smooth surface. The release pattern of the drug from microspheres was evaluated on the basis of the burst effect and the extent of the release after 24h. The in vitro release of bupivacaine HCl from microspheres showed a large initial burst release and $60{\sim}80%$ release within one day in all conditions of two methods. The extents of the burst release against PLA and PLGA microspheres were $30{\sim}50%$ and $50{\sim}80%$ within 20min, respectively. This burst release seems to be due to the smaller size of microspheres and the solubility of drug in water.

• 한국응용과학기술학회지
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• 제21권4호
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• pp.279-288
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• 2004

Liquid crystal (LC) system was introduced into W/O emulsion in order to enhance the stability and moisturizing effect. The LC system, composed of beeswax, surfactant, and water was formed on the surface of emulsion droplet, which was investigated through a polarized microscope. The phenomenon that the viscosity in W/O emulsion system is decreased with time, was reduced by the formation of LC with the addition of beeswax. Centrifugal separation test showed that the stability of emulsion system was increased with the addition of beeswax to 3%. The color change of vitamin C was delayed in LC emulsion systems, which indicates stabilization effect against the oxidation of vitamin C. Evaporation rate in W/O emulsion was retarded by LC, so that high moisturizing effect is expected in W/O LC system.

• Archives of Pharmacal Research
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• 제23권4호
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• pp.385-390
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• 2000

To demonstrate the effect of formulation conditions on the controlled release of protein from poly(lactide-co-glycolide) (PLGA) microspheres for use as a parenteral drug carrier, ovalbumin (OVA) microspheres were prepared using the W/O/W multiple emulsion solvent evaporation and extraction method. Methylene chloride or ethyl acetate was applied as an organic phase and poly(vinyl alcohol) as a secondary emulsion stabilizer. Low loading efficiencies of less than 20％ were observed and the in vitro release of OVA showed a burst effect in all batches of different microspheres, followed by a gradual release over the next 6 weeks. Formulation processes affected the size and morphology, drug content, and the controlled release of OVA from PLGA microspheres.

• 한국세라믹학회지
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• 제27권5호
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• pp.661-667
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• 1990

Spinel powders were synthesized at the comparatively low-temperature range(800~90$0^{\circ}C$) by the emulsion-hot kerosene drying method and the effects of kerosene-evaporative conditions on powder characteristics were investigated. In emulsion drying, more unagglomerated and sinterable powders could be synthesized through rapid evaporation of emulsion at the higher kerosene temperature. The completion of formation reaction of spinel observed at the low-temperature range confirmed the high reactivity of powders. The relative theoretical density and the fracture toughness of spinel pellets sintered at 1$650^{\circ}C$ for 4hrs. were 98% and 2.1MN/m3/2, respectively.

• 한국콘텐츠학회논문지
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• 제15권1호
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• pp.324-330
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• 2015

초음파 전파 매개물은 초음파의 손실 없는 투과력을 위한 1차적인 목적 이외에 피부위에서 탐촉소자의 부드러운 이동을 위한 부가적인 목적이 있다. 본 연구는 진단용 초음파의 고분자 수화젤, 에멀전, 오일젤의 제형이 다른 초음파 전파매개물이 갖는 피부 윤활성, 피부 보습성, 건조속도 등의 초음파 매개물의 특징을 측정하여 이미 상용화 된 기성품과 비교하였다. 마찰계수는 고점도 에멀전에서 가장 높았으며 저점도 에멀전에서는 고분자 수화젤의 평균 마찰계수와 큰 차이를 보이지 않았다. 제제의 건조속도는 고분자 수화젤이 가장 높았으며 오일 함유량이 많을수록 수분증발이 나타나지 않았다. 피부수분함량에서는 저점도 에멀전이 높은 수분함량을 나타냈으며 수분함량 감소 정도가 가장 완만히 나타났다. 오일성분을 적절히 사용한 에멀전 형태의 초음파 전파매개물은 피부 보습효과, 피부 유연작용의 피부 건강측면과 피부-탐촉소자간의 피부 윤활성면에서 효과적인 제형임을 알 수 있었다.

• Journal of Pharmaceutical Investigation
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• 제36권4호
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• pp.245-251
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• 2006

The novel microsphere blending and multiple emulsion method by single process was tried to prepare sustained release microspheres which release a physiologically active substance for long periods of time. A drug was separately dissolved in each of two or more oils containing biodegradable polymers to give the primary oil phases. The primary oil phases were dispersed in single aqueous phase in succession. From the drug-dispersed solution, the organic solvent was removed to produce microspheres. The accelerated drug release from the microsphere formulation prepared by single process through the multiple emulsion method was very similar to a physical blending of separately prepared microspheres using the same polymers. But long term release was not same. In this study, leuprorelin acetate loaded poly(lactide-co-glycolide) microsphere formulation for one-month delivery was developed by the multi-emulsion method followed by solvent extraction/evaporation method.

• Bulletin of the Korean Chemical Society
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• 제33권10호
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• pp.3208-3212
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• 2012

Controlled drug delivery systems employing microparticles offer lots of advantages over conventional drug dosage formulations. Microencapsulation technique have been conducted with biodegradable polymers such as poly(lactic-co-glycolic acid) (PLGA) and poly(lactic acid) (PLA) for its adjustable biodegradability and biocompatibility. In this study, we evaluated two techniques, oil-in-water (o/w) emulsion solvent evaporation and spray drying, for preparation of polymeric microparticles encapsulating a newly synthesized drug, SS-AG20, for the long-term drug delivery of this low-molecular-weight drug with a very short half-life. Drug-loaded microparticles prepared by the solvent evaporation method showed a smoother morphology; however, relatively poor encapsulation efficiency and drastic initial burst were discovered as drawbacks. Spray-dried drug-loaded microparticles had an imperfect surface with pores and distorted portions so that its initial burst was critical (70.05-87.16%) when the preparation was carried out with a 5% polymeric solution. By increasing the concentration of the polymer, the morphology was refined and undesirable initial burst was circumvented (burst was reduced to 35.93-74.85%) while retaining high encapsulation efficiency. Moreover, by encapsulating the drug with various biodegradable polymers using the spray drying method, gradual and sustained drug release, for up to 2 weeks, was achieved.